8,9-DIHYDROXY-1,5,6,10B-TETRAHYDROPYRROLO[2,1-A]ISOQUINOLIN-3(2H)-ONE
- CAS No.
- 1021950-79-7
- Chemical Name:
- 8,9-DIHYDROXY-1,5,6,10B-TETRAHYDROPYRROLO[2,1-A]ISOQUINOLIN-3(2H)-ONE
- Synonyms
- Trolline;Oleracein E;Trolline((±)-Trolline);8,9-DIHYDROXY-1,5,6,10B-TETRAHYDROPYRROLO[2,1-A]ISOQUINOLIN-3(2H)-ONE;Pyrrolo[2,1-a]isoquinolin-3(2H)-one, 1,5,6,10b-tetrahydro-8,9-dihydroxy-
- CBNumber:
- CB03611201
- Molecular Formula:
- C12H13NO3
- Molecular Weight:
- 219.24
- MDL Number:
- MFCD22690448
- MOL File:
- 1021950-79-7.mol
8,9-DIHYDROXY-1,5,6,10B-TETRAHYDROPYRROLO[2,1-A]ISOQUINOLIN-3(2H)-ONE Chemical Properties,Uses,Production
Description
Oleracein E is a a tetrahydroisoquinoline possessing potent antioxidant activity. Pretreatment with OE (10 μM, 2 h) decreased lactic acid dehydrogenase (LDH) release and the apoptosis rate in rotenone (5 μM, 24 h)-treated SH-SY5Y human neuroblastoma cells. Further mechanistic study indicated that OE reduced reactive oxygen species (ROS) levels, inhibited extracellular signal-regulated kinase (ERK) 1/2 phosphorylation, reduced rotenone-induced up-regulation of the proapoptotic protein Bax, and prevented cytochrome C release and caspase-3 activation.
Uses
(±)-Trolline ((±)-Oleracein E), an isoquinoline alkaloid, exhibits antibacterial activity against respiratory bacteria and antiviral activity against influenza virus A and B. (±)-Trolline significantly induces HSC apoptosis. (±)-Trolline can be used for the research of liver fibrosis[1].
References
[1] Bai F, et, al. Trolline Ameliorates Liver Fibrosis by Inhibiting the NF-κB Pathway, Promoting HSC Apoptosis and Suppressing Autophagy. Cell Physiol Biochem. 2017;44(2):436-446. DOI:10.1159/000485009
8,9-DIHYDROXY-1,5,6,10B-TETRAHYDROPYRROLO[2,1-A]ISOQUINOLIN-3(2H)-ONE Preparation Products And Raw materials
Raw materials
Preparation Products
8,9-DIHYDROXY-1,5,6,10B-TETRAHYDROPYRROLO[2,1-A]ISOQUINOLIN-3(2H)-ONE Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Alfa Chemistry | Info@alfa-chemistry.com | United States | 24072 | 58 | |
TargetMol Chemicals Inc. | support@targetmol.com | United States | 38663 | 58 | |
LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43340 | 58 |
Sichuan Wei Keqi Biological Technology Co., Ltd. | 028-81700200 18116577057 | 3003855609@qq.com | China | 7787 | 56 |
Wuxi Zhongkun Biochemical Technology Co., Ltd. | 0510-85629785 18013409632 | sales@reading-chemicals.com | China | 15178 | 58 |
Wuhan ChemFaces Biochemical Co., Ltd. | 18607101326 15172504745 | aileen@chemfaces.com | China | 6905 | 55 |
Nanjing Digger Medical Technology Co. Ltd. | 025-025-51191215 18013836722 | 2399235533@qq.com | China | 4933 | 58 |
Henan Weituxi Chemical Technology Co., Ltd. | 0371-0371-63284658 18135795563 | 2885349392@qq.com | China | 9980 | 58 |
BioBioPha Co., Ltd. | 0871-65217109 | y.liu@mail.biobiopha.com | China | 1388 | 58 |
Shanghai Binsui Biotechnology Co., Ltd. | 18301908279 18301908279 | 1292752157@qq.com | China | 8483 | 58 |