ChemicalBook >> CAS DataBase List >>8,9-DIHYDROXY-1,5,6,10B-TETRAHYDROPYRROLO[2,1-A]ISOQUINOLIN-3(2H)-ONE

8,9-DIHYDROXY-1,5,6,10B-TETRAHYDROPYRROLO[2,1-A]ISOQUINOLIN-3(2H)-ONE

CAS No.
1021950-79-7
Chemical Name:
8,9-DIHYDROXY-1,5,6,10B-TETRAHYDROPYRROLO[2,1-A]ISOQUINOLIN-3(2H)-ONE
Synonyms
Trolline;Oleracein E;Trolline((±)-Trolline);8,9-DIHYDROXY-1,5,6,10B-TETRAHYDROPYRROLO[2,1-A]ISOQUINOLIN-3(2H)-ONE;Pyrrolo[2,1-a]isoquinolin-3(2H)-one, 1,5,6,10b-tetrahydro-8,9-dihydroxy-
CBNumber:
CB03611201
Molecular Formula:
C12H13NO3
Molecular Weight:
219.24
MDL Number:
MFCD22690448
MOL File:
1021950-79-7.mol
Last updated:2025-04-18 09:51:35

8,9-DIHYDROXY-1,5,6,10B-TETRAHYDROPYRROLO[2,1-A]ISOQUINOLIN-3(2H)-ONE price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Crysdot CD11364357 8,9-Dihydroxy-1,5,6,10b-tetrahydropyrrolo[2,1-a]isoquinolin-3(2H)-one 97% 1021950-79-7 1g $709 2021-12-16 Buy
Product number Packaging Price Buy
CD11364357 1g $709 Buy

8,9-DIHYDROXY-1,5,6,10B-TETRAHYDROPYRROLO[2,1-A]ISOQUINOLIN-3(2H)-ONE Chemical Properties,Uses,Production

Description

Oleracein E is a a tetrahydroisoquinoline possessing potent antioxidant activity. Pretreatment with OE (10 μM, 2 h) decreased lactic acid dehydrogenase (LDH) release and the apoptosis rate in rotenone (5 μM, 24 h)-treated SH-SY5Y human neuroblastoma cells. Further mechanistic study indicated that OE reduced reactive oxygen species (ROS) levels, inhibited extracellular signal-regulated kinase (ERK) 1/2 phosphorylation, reduced rotenone-induced up-regulation of the proapoptotic protein Bax, and prevented cytochrome C release and caspase-3 activation.

Uses

(±)-Trolline ((±)-Oleracein E), an isoquinoline alkaloid, exhibits antibacterial activity against respiratory bacteria and antiviral activity against influenza virus A and B. (±)-Trolline significantly induces HSC apoptosis. (±)-Trolline can be used for the research of liver fibrosis[1].

References

[1] Bai F, et, al. Trolline Ameliorates Liver Fibrosis by Inhibiting the NF-κB Pathway, Promoting HSC Apoptosis and Suppressing Autophagy. Cell Physiol Biochem. 2017;44(2):436-446. DOI:10.1159/000485009

8,9-DIHYDROXY-1,5,6,10B-TETRAHYDROPYRROLO[2,1-A]ISOQUINOLIN-3(2H)-ONE Preparation Products And Raw materials

Raw materials

Preparation Products

8,9-DIHYDROXY-1,5,6,10B-TETRAHYDROPYRROLO[2,1-A]ISOQUINOLIN-3(2H)-ONE Suppliers

Global( 25)Suppliers
Supplier Tel Email Country ProdList Advantage
Alfa Chemistry
Info@alfa-chemistry.com United States 24072 58
TargetMol Chemicals Inc.
support@targetmol.com United States 38663 58
LEAPCHEM CO., LTD.
+86-852-30606658 market18@leapchem.com China 43340 58
Sichuan Wei Keqi Biological Technology Co., Ltd. 028-81700200 18116577057 3003855609@qq.com China 7787 56
Wuxi Zhongkun Biochemical Technology Co., Ltd. 0510-85629785 18013409632 sales@reading-chemicals.com China 15178 58
Wuhan ChemFaces Biochemical Co., Ltd. 18607101326 15172504745 aileen@chemfaces.com China 6905 55
Nanjing Digger Medical Technology Co. Ltd. 025-025-51191215 18013836722 2399235533@qq.com China 4933 58
Henan Weituxi Chemical Technology Co., Ltd. 0371-0371-63284658 18135795563 2885349392@qq.com China 9980 58
BioBioPha Co., Ltd. 0871-65217109 y.liu@mail.biobiopha.com China 1388 58
Shanghai Binsui Biotechnology Co., Ltd. 18301908279 18301908279 1292752157@qq.com China 8483 58
8,9-DIHYDROXY-1,5,6,10B-TETRAHYDROPYRROLO[2,1-A]ISOQUINOLIN-3(2H)-ONE Trolline((±)-Trolline) Trolline Pyrrolo[2,1-a]isoquinolin-3(2H)-one, 1,5,6,10b-tetrahydro-8,9-dihydroxy- Oleracein E 1021950-79-7