5-HYDROXYINDOLE-3-ACETIC ACID
- CAS No.
- 54-16-0
- Chemical Name:
- 5-HYDROXYINDOLE-3-ACETIC ACID
- Synonyms
- 5-HIAA;HIAA;2-(5-hydroxy-1H-indol-3-yl)acetic acid;5-oxyindoleaceticacid;5-HYDROXY-3-INDOLEACETIC ACID;5&＃039;5-HO-IAA;NSC 90432;Nature Product;TIMTEC-BB SBB003639
- CBNumber:
- CB0362913
- Molecular Formula:
- C10H9NO3
- Molecular Weight:
- 191.18
- MDL Number:
- MFCD00005639
- MOL File:
- 54-16-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 5-Hydroxyindole-3-acetic acid ≥98% (HPLC), crystalline | H8876 | 100mg | $39.7 |
| 5-Hydroxyindole-3-acetic acid ≥98% (HPLC), crystalline | H8876 | 1g | $196 |
| 5-Hydroxyindole-3-acetic acid analytical standard | 55697 | 50 mg | $212 |
| 5-Hydroxyindole-3-acetic Acid >98.0%(HPLC)(T) | H0355 | 1g | $374 |
| 5-Hydroxyindole-3-acetic Acid >98.0%(HPLC)(T) | H0355 | 100mg | $50 |
| More product size | |||
| Melting point | 161-164 °C (dec.) (lit.) |
|---|---|
| Boiling point | 326.92°C (rough estimate) |
| Density | 1.2722 (rough estimate) |
| refractive index | 1.5310 (estimate) |
| storage temp. | -20°C |
| solubility | Soluble in ethanol (50 mg/ml). |
| form | crystalline |
| pka | 4.54±0.30(Predicted) |
| color | off-white to purple |
| Sensitive | Light Sensitive |
| BRN | 168797 |
| Stability | Air Sensitive, Light Sensitive |
| Major Application | clinical testing |
| InChI | 1S/C10H9NO3/c12-7-1-2-9-8(4-7)6(5-11-9)3-10(13)14/h1-2,4-5,11-12H,3H2,(H,13,14) |
| InChIKey | DUUGKQCEGZLZNO-UHFFFAOYSA-N |
| SMILES | OC(=O)Cc1c[nH]c2ccc(O)cc12 |
| CAS DataBase Reference | 54-16-0 |
| EWG's Food Scores | 1 |
| NCI Dictionary of Cancer Terms | 5-hydroxyindoleacetic acid |
| FDA UNII | YHC763JY1P |
| UNSPSC Code | 41116107 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P271-P280 | |||||||||
| Safety Statements | 22-24/25 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | NL3650000 | |||||||||
| F | 8-10-23 | |||||||||
| HS Code | 29339980 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
5-HYDROXYINDOLE-3-ACETIC ACID price More Price(68)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | H8876 | 5-Hydroxyindole-3-acetic acid ≥98% (HPLC), crystalline | 54-16-0 | 100mg | $39.7 | 2026-04-30 | Buy |
| Sigma-Aldrich | H8876 | 5-Hydroxyindole-3-acetic acid ≥98% (HPLC), crystalline | 54-16-0 | 1g | $196 | 2026-04-30 | Buy |
| Sigma-Aldrich | 55697 | 5-Hydroxyindole-3-acetic acid analytical standard | 54-16-0 | 50 mg | $212 | 2026-04-30 | Buy |
| TCI Chemical | H0355 | 5-Hydroxyindole-3-acetic Acid >98.0%(HPLC)(T) | 54-16-0 | 1g | $374 | 2026-04-30 | Buy |
| TCI Chemical | H0355 | 5-Hydroxyindole-3-acetic Acid >98.0%(HPLC)(T) | 54-16-0 | 100mg | $50 | 2026-04-30 | Buy |
5-HYDROXYINDOLE-3-ACETIC ACID Chemical Properties,Uses,Production
Description
5-hydroxy Indole-3-acetic acid (5-HIAA) is the primary metabolite of serotonin (5-HT; ). It is formed when 5-HT is metabolized by monamine oxidase and aldehyde dehydrogenase in the liver. 5-HIAA is excreted in urine and has been used as a biomarker for detection of neuroendocrine tumors and an internal standard for the quantification of serotonin metabolism in rat brain using mass spectrometry. 5-HIAA has also been associated with autism, insomnia, and chronic migraine.
Chemical Properties
beige crystalline powder
Uses
5-Hydroxyindole-3-acetic acid is an impurity of chlorpheniramine (C424300), an antihistaminic agent.
Uses
5-Hydroxyindole-3-acetic acid is a major serotonin metabolite.
Definition
ChEBI: A member of the class of indole-3-acetic acids that is indole-3-acetic acid substituted by a hydroxy group at C-5.
General Description
5-Hydroxyindole-3-acetic acid (5-HIAA) is the catabolic end product of serotonin pathway. 5-HIAA is present in body fluids like cerebrospinal fluid (CSF), blood and urine. The expression levels of 5-HIAA is different among the normal and cancer patients. Sepiapterin reductase deficiency results in low level of 5-HIAA in CSF. 5-HIAA level is low in CSF in patients with bipolar 1 disorder with childhood attention-deficit hyperactivity disorder (ADHD).
Mechanism of action
The primary product of the metabolism of serotonin. Formed by the oxidative deamination of serotonin by monoamine oxidase, presumably the A isozyme, 5-HIAA is subsequently cleared by an active transport mechanism. Unlike serotonin, 5-HIAA is not a neurotransmitter and thus its formation contributes to the termination of the synaptic actions of serotonin. Inhibition of monoamine oxidase activity enhances and prolongs the actions of serotonin.
References
[1] JEAN-BENOT CORCUFF. Urinary sampling for 5HIAA and metanephrines determination: revisiting the recommendations.[J]. Endocrine Connections, 2017, 6 6: R87-R98. DOI: 10.1530/ec-17-0071
[2] YANNICK VERMEIREN . Monoaminergic neurotransmitter alterations in postmortem brain regions of depressed and aggressive patients with Alzheimer’s disease[J]. Neurobiology of Aging, 2014, 35 12: Pages 2691-2700. DOI: 10.1016/j.neurobiolaging.2014.05.031
5-HYDROXYINDOLE-3-ACETIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| CONIER CHEM AND PHARMA LIMITED | sales@conier.com | China | 49906 | 58 | |
| career henan chemical co | +86-0371-86658258 | factory@coreychem.com | China | 29780 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569266 +86-17392581500 | 1015@dideu.com | China | 3861 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +86-189 4982 3763 | sales@tnjchem.com | China | 34526 | 58 |
| AFINE CHEMICALS LIMITED | +86-571-85134551 +86-18958018566 | info@afinechem.com | China | 15050 | 58 |
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 17705817739 | info@dycnchem.com | China | 52693 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 +8619957148339 | market18@leapchem.com | China | 24569 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 38999 | 58 |
View Lastest Price from 5-HYDROXYINDOLE-3-ACETIC ACID manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-29 | 5-Hydroxyindole-3-acetic acid
54-16-0
|
$29.00 | 98.48% | 10g | TargetMol Chemicals Inc. | ||
 |
2020-02-17 | (5-hydroxyindol-3-yl)acetic acid
54-16-0
|
$1.00 | 1KG | 98% HPLC | 10 tons | Career Henan Chemical Co |
-
- 5-Hydroxyindole-3-acetic acid
54-16-0
- $29.00
- 98.48%
- TargetMol Chemicals Inc.
-
- (5-hydroxyindol-3-yl)acetic acid
54-16-0
- $1.00
- 98% HPLC
- Career Henan Chemical Co
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