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1-BROMO-2-BUTYNE

1-BROMO-2-BUTYNE Structure
1-BROMO-2-BUTYNE structure
CAS No.
3355-28-0
Chemical Name:
1-BROMO-2-BUTYNE
Synonyms
1-Bromobut-2-yne;1-Bromobut-2-butyne;2-BUTYNYL BROMIDE;1-Brom-2-Butin;1-BROMO-2-BUTYNE;Linagliptin INT4;1-Bromo-2-butynyl;1-broMo -2-Ding Que;1-Bromo-2-butyne99%;1-Bromobut-2-yne 95%
CBNumber:
CB0363349
Molecular Formula:
C4H5Br
Molecular Weight:
132.99
MDL Number:
MFCD00190233
MOL File:
3355-28-0.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-08-04 11:17:55
Product description Number Pack Size Price
1-Bromo-2-butyne 99% 427292 1g $34.3
1-Bromo-2-butyne 99% 427292 5g $158
1-Bromo-2-butyne >96.0%(GC) B2190 1g $32
1-Bromo-2-butyne >96.0%(GC) B2190 5g $88
1-Bromo-2-butyne Asreported 261615 250g $2718
More product size
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1-BROMO-2-BUTYNE Properties

Boiling point 40-41 °C/20 mmHg (lit.)
Density 1.519 g/mL at 25 °C (lit.)
refractive index n20/D 1.508(lit.)
Flash point 97 °F
storage temp. Inert atmosphere,Room Temperature
solubility Miscible with acetonitrile.
form Liquid
Specific Gravity 1.519
color Clear pale yellow-greenish
BRN 605306
InChI InChI=1S/C4H5Br/c1-2-3-4-5/h4H2,1H3
InChIKey LNNXOEHOXSYWLD-UHFFFAOYSA-N
SMILES C(Br)C#CC
CAS DataBase Reference 3355-28-0(CAS DataBase Reference)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Flame (GHS02)Exclamation Mark (GHS07)
GHS02,GHS07
Signal word  Warning
Hazard statements  H315-H319-H335-H226
Precautionary statements  P261-P303+P361+P353-P305+P351+P338-P405-P501a-P210-P233-P240-P241+P242+P243-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P403+P235-P501
PPE Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
Risk Statements  10
Safety Statements  16-24/25
RIDADR  UN 1993 3/PG 3
WGK Germany  3
F  10-23
HazardClass  3
PackingGroup  III
HS Code  29033990
Storage Class 3 - Flammable liquids
Hazard Classifications Flam. Liq. 3
Limited Quantities 1.0 L (0.3 gallon) (liquid)
Excepted Quantities Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml)
NFPA 704
3
2 0

1-BROMO-2-BUTYNE price More Price(56)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 427292 1-Bromo-2-butyne 99% 3355-28-0 1g $34.3 2026-04-30 Buy
Sigma-Aldrich 427292 1-Bromo-2-butyne 99% 3355-28-0 5g $158 2026-04-30 Buy
TCI Chemical B2190 1-Bromo-2-butyne >96.0%(GC) 3355-28-0 1g $32 2026-04-30 Buy
TCI Chemical B2190 1-Bromo-2-butyne >96.0%(GC) 3355-28-0 5g $88 2026-04-30 Buy
Usbiological 261615 1-Bromo-2-butyne Asreported 3355-28-0 250g $2718 2026-06-03 Buy
Product number Packaging Price Buy
427292 1g $34.3 Buy
427292 5g $158 Buy
B2190 1g $32 Buy
B2190 5g $88 Buy
261615 250g $2718 Buy

1-BROMO-2-BUTYNE Chemical Properties,Uses,Production

Chemical Properties

Clear pale yellow-greenish liquid

Uses

1-Bromo-2-butyne is used in the preparation of six to eight annulated ring compounds in reaction with indoles and pseudopterane (+/-)-Kallolide B, which is a marine natural product. Further, it acts as a precursor in the preparation of axially chiral teranyl compounds, alkylation of L-tryptophan methyl ester, 4-butynyloxybenzene sulfonyl chloride and mono-propargylated diene derivative. In addition to this, it is also used in the synthesis of isopropylbut-2-ynylamine, allenylcyclobutanol derivatives, allyl-[4-(but-2-ynyloxy)phenyl]sulfane, allenylindium and axially chiral teranyl compounds.

Preparation

1-bromo-2-butyne is obtained by reacting 2-butyn-1-ol and organic solvent, pyridine.First react bromoethane with metal magnesium in THF to prepare Grignard reagent, then add paraformaldehyde to Grignard reagent for Grignard reaction, separate and recover after Grignard reaction 2-butyn-1-ol, then mix 2-butyn-1-ol with organic solvent and pyridine, add phosphorus tribromide dropwise for bromination reaction, separate and recover the product after bromination reaction.

General Description

1-Bromo-2-butyne is a propargyl bromide derivative. It is one of the constitutional isomer of bromo butyne. Its Br-loss threshold photoionization breakdown diagram has been analyzed to derive dissociative photoionization thresholds to C4H5+ production. It participates in the preparation of linagliptin.

1-BROMO-2-BUTYNE synthesis

764-01-2
7789-60-8
3355-28-0
Synthesis of 1-BROMO-2-BUTYNE from 2-Butyn-1-ol and Phosphorus tribromide

1-BROMO-2-BUTYNE Preparation Products And Raw materials

Raw materials

Preparation Products

1-PHTHALIMIDO-2-BUTYNE 2-Butyn-1-amine, N-2-propyn-1-yl- DI-BUT-2-YNYL-AMINE 8-bromo-7-(but-2-ynyl)-3-methyl-1H-purine-2,6(3H,7H)-dione

1-BROMO-2-BUTYNE Suppliers

Global( 434)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai Rochi Pharmaceutical Co.,Ltd.
21-38751876 +8615000076078 info@rochipharma.com China 504 58
Hebei Chuanghai Biotechnology Co., Ltd 		+86-15350571055 Sibel@chuanghaibio.com China 8737 58
Shaanxi Dideu Medichem Co. Ltd 		+86-029-81138252 +86-173 9270 1263 1057@dideu.com China 3961 58
Hebei Chuanghai Biotechnology Co,.LTD 		+86-86-13131129325 sales1@chuanghaibio.com China 5216 58
Hebei Dangtong Import and export Co LTD 		+86-86-4001020630 +86-13910575315 admin@hbdangtong.com China 996 58
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652 info@fdachem.com China 20111 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21533 55
Shanghai Yingrui Biopharma Co., Ltd. 		+86-21-33585366 - 03@ sales03@shyrchem.com CHINA 736 60
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32997 60
Anqing Chico Pharmaceutical Co., Ltd. 		15380796838 chloewu@chicopharm.cn CHINA 340 58
Supplier Advantage
Shanghai Rochi Pharmaceutical Co.,Ltd.
58
Hebei Chuanghai Biotechnology Co., Ltd 		58
Shaanxi Dideu Medichem Co. Ltd 		58
Hebei Chuanghai Biotechnology Co,.LTD 		58
Hebei Dangtong Import and export Co LTD 		58
Henan Fengda Chemical Co., Ltd 		58
Henan Tianfu Chemical Co.,Ltd. 		55
Shanghai Yingrui Biopharma Co., Ltd. 		60
ATK CHEMICAL COMPANY LIMITED 		60
Anqing Chico Pharmaceutical Co., Ltd. 		58

Related articles

View Lastest Price from 1-BROMO-2-BUTYNE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
1-BROMO-2-BUTYNE pictures 2026-08-17 1-BROMO-2-BUTYNE
3355-28-0
 $1.00-100.00 1KG 99% Henan Fengda Chemical Co., Ltd
1-BROMO-2-BUTYNE pictures 2026-08-03 1-BROMO-2-BUTYNE
3355-28-0
 1kg 98% 1000kg Shaanxi Dideu New Materials Co. Ltd
1-BROMO-2-BUTYNE pictures 2026-07-01 1-BROMO-2-BUTYNE
3355-28-0
 $20.00-30.00 1kg 99% 20Tons Hebei Dangtong Import and export Co LTD
  • 1-BROMO-2-BUTYNE pictures
  • 1-BROMO-2-BUTYNE
    3355-28-0
  • $20.00-30.00
  • 99%
  • Hebei Dangtong Import and export Co LTD

1-BROMO-2-BUTYNE Spectrum

1-BROMO-2-BUTYNE(3355-28-0)MS1-BROMO-2-BUTYNE(3355-28-0)1HNMR1-BROMO-2-BUTYNE(3355-28-0)IR1

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1-BROMO-2-BUTYNE 2-BUTYNYL BROMIDE 1-Bromobut-2-yne 95% 1-BROMO-2-BUTYNE, 98%1-BROMO-2-BUTYNE, 98%1-BROMO-2-BUTYNE, 98%1-BROMO-2-BUTYNE, 98% 1-BROMO-2-BUTYNE 98% 1-Bromo-2-butyne,98% But-2-yn-1-yl bromide 1-broMo -2-Ding Que 1-BroMo-2-butyne, 96.0%(GC) Linagliptin INT4 1-Bromo-2-butyne (Linagliptin) 1-BROMO-2-BUTYNE, 2-BUTYNYL BROMIDE 1-Bromo-2-butyne > 1-BROMO-2-BUTYNE ISO 9001：2015 REACH Linagliptin intermediates，1-bromo-2-butyne 1-Brom-2-Butin Rilpivirine Impurity 18 1-Bromo-2-butynyl 1-Bromo-2-butyne99% 1-BROMO-2-BUTYNE Linagliptin I 1-Bromobut-2-yne 1-Bromobut-2-butyne 3355-28-0 2563355-28-0 CH3CCCH2Br Br1C4H5 CH3C8801CCH2Br C4H5Br Organic Building Blocks Halogenated Hydrocarbons Acetylenes Functionalized Acetylenes Alkynyl Building Blocks Intermediates Acetylenes Functionalized Acetylenes Alkynyl Halogenated Hydrocarbons Organic Building Blocks