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2-(2-Amino-5-bromobenzoyl) pyridine

2-(2-Amino-5-bromobenzoyl) pyridine Structure
2-(2-Amino-5-bromobenzoyl) pyridine structure
CAS No.
1563-56-0
Chemical Name:
2-(2-Amino-5-bromobenzoyl) pyridine
Synonyms
C2HyBnN2O;Bromazepam Impurity A;Tocopherol Impurity 30;Bromazepam EP Impurity A;2-(2-AMINO-5-BROMOBENZOYL);2-amino-5-bromobenzoylpyridine;2-(2-Ao-5-bromobenzoyl) pyridine;2-(5-Bromo-2-aminobenzoyl)pyridine;2-(2-AMino-5-BroMobenzoyl) Pyridin;2-(5-Chloro-2-aminophenyl)pyridine
CBNumber:
CB0371601
Molecular Formula:
C12H9BrN2O
Molecular Weight:
277.12
MDL Number:
MFCD07780283
MOL File:
1563-56-0.mol
MSDS File:
SDS
Last updated:2026-09-12 18:48:19
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2-(2-Amino-5-bromobenzoyl) pyridine Properties

Melting point 98-100℃
Boiling point 451℃
Density 1.546
Flash point 227℃
storage temp. Keep in dark place,Inert atmosphere,Room temperature
solubility DMSO (Slightly), Methanol (Sparingly)
form Solid
pka 2.66±0.10(Predicted)
color Light Yellow to Yellow
InChI InChI=1S/C12H9BrN2O/c13-8-4-5-10(14)9(7-8)12(16)11-3-1-2-6-15-11/h1-7H,14H2
InChIKey KHVZPFKJBLTYCC-UHFFFAOYSA-N
SMILES C(C1=CC(Br)=CC=C1N)(C1=NC=CC=C1)=O

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
HS Code  2933399990
REACH Registrations Active

2-(2-Amino-5-bromobenzoyl) pyridine price More Price(50)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 37940 (2-Amino-5-bromophenyl)(pyridin-2-yl)methanone ≥98% 1563-56-0 1mg $51 2026-04-30 Buy
Cayman Chemical 37940 (2-Amino-5-bromophenyl)(pyridin-2-yl)methanone ≥98% 1563-56-0 5mg $229 2026-04-30 Buy
TRC TRC-A601785-50MG 2-(2-Amino-5-bromobenzoyl)pyridine 1563-56-0 50mg $88 2026-06-03 Buy
TRC TRC-A601785-250MG 2-(2-Amino-5-bromobenzoyl)pyridine 1563-56-0 250mg $368 2026-06-03 Buy
TRC TRC-A601785-1G 2-(2-Amino-5-bromobenzoyl)pyridine 1563-56-0 1g $692 2026-06-03 Buy
Product number Packaging Price Buy
37940 1mg $51 Buy
37940 5mg $229 Buy
TRC-A601785-50MG 50mg $88 Buy
TRC-A601785-250MG 250mg $368 Buy
TRC-A601785-1G 1g $692 Buy

2-(2-Amino-5-bromobenzoyl) pyridine Chemical Properties, Uses, Production

Chemical Properties

Yellow Solid

Uses

2-(2-Amino-5-bromobenzoyl)pyridine is used as an intermediate in the preparation of Bromazepam.

Biological Activity

2-(2-AMINO-5-BROMOBENZOYL) PYRIDINE (2ABBP) has been shown to have anti-inflammatory properties in rat liver microsomes and cell culture experiments. The mechanism of action may involve inhibition of cyclooxygenase enzymes, which are involved in prostaglandin synthesis. 2ABBP also binds to human serum albumin and chaperones, proteins that bind other proteins or small molecules.

Synthesis

2-Bromopyridine

109-04-6

2-Amino-5-bromobenzoic acid

5794-88-7

2-(2-AMINO-5-BROMOBENZOYL) PYRIDINE

1563-56-0

General procedure for the synthesis of 2-(2-amino-5-bromo-benzoyl)pyridine from 2-bromopyridine and 2-amino-5-bromobenzoic acid: 2-bromopyridine (173.93 g, 1101 mmol, 4.4 eq.) was slowly added to a mixture of 2.5 M n-butyllithium hexane solution (400 mL, 1000 mmol, 4 eq.) and ethyl ether (1 L) at -40 °C. 4.4 eq.). The reaction mixture was stirred at -40 °C for 1 h. A solution of 2-amino-5-bromobenzoic acid (54.14 g, 250.6 mmol, 1 eq.) in tetrahydrofuran (THF, 1 L) was added dropwise. The reaction system was slowly warmed to 0 °C and stirring was continued at this temperature for 2 hours. Subsequently, chlorotrimethylsilane (625 mL, 4924 mmol, 20 eq.) was added to quench the reaction. The mixture was stirred at room temperature for 30 minutes, then cooled to 0 °C and quenched with 3N hydrochloric acid (625 mL). The aqueous layer was separated and the organic layer was extracted once with 3N hydrochloric acid. The combined aqueous phases were neutralized with solid sodium hydroxide pellets while cooling in an ice bath. The neutralized aqueous phase was extracted with ether (3 x 1L). The combined ether extracts were dried with anhydrous sodium sulfate, filtered and concentrated to give a black oil. The crude product was purified by fast chromatography (silica gel column, 1 L, eluent 20-30% ethyl acetate/hexane) to afford the target compound 2-(2-amino-5-bromo-benzoyl)pyridine as a brown solid (62 g, 224 mmol, 89.3% yield).

References

[1] Patent: EP1183243, 2006, B1. Location in patent: Page/Page column 11
[2] Patent: WO2014/154762, 2014, A1. Location in patent: Page/Page column 62
[3] Patent: US2014/296230, 2014, A1. Location in patent: Paragraph 0303-0306
[4] Patent: CN108264499, 2018, A. Location in patent: Paragraph 0050-0051; 0075; 0076; 0077-0079

2-(2-Amino-5-bromobenzoyl) pyridine Preparation Products And Raw materials

Raw materials

2-Bromopyridine 2-Amino-5-bromobenzoic acid

Preparation Products

Bromazepam

2-(2-Amino-5-bromobenzoyl) pyridine Suppliers

Global Suppliers ( 223)
Supplier Tel Email Country ProdList Advantage
YICHANG TIANRUI BIOPHARM CO., LTD 13469840438 caiweiguo@renfu.com.cn China 48 58
Viwit Pharmaceutical Co., Ltd. 0632-0632-2980981 15063270987 service.china3@viwit.com China 121 55
Shouguang Xinghai Chemical Co. LTD 15666881566 449211804@qq.com China 48 58
Shanghai Shanyuan pharmaceutical technology co., LTD 021-31761238 13167072949 3146446224@qq.com China 1420 55
Jiangsu Jingye Pharmaceutical 0519-82765788 18001496617 2807841045@qq.com China 108 58
Shanghai Yatan Pharmaceutical Research and Development Co. LTD 15512780135 songqw@neutanpharma.com China 177 58
Shanghai ZaiQi Bio-Tech Co., Ltd. +86-021-54824098 15317552526 sales@chemzq.com China 254 55
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Shijiazhuang Sdyano Fine Chemical Co., Ltd. 0311-89250318 13582355795 master@sjzsdyn.com China 2776 65
Supplier Advantage
YICHANG TIANRUI BIOPHARM CO., LTD 58
Viwit Pharmaceutical Co., Ltd. 55
Shouguang Xinghai Chemical Co. LTD 58
Shanghai Shanyuan pharmaceutical technology co., LTD 55
Jiangsu Jingye Pharmaceutical 58
Shanghai Yatan Pharmaceutical Research and Development Co. LTD 58
Shanghai ZaiQi Bio-Tech Co., Ltd. 55
J & K SCIENTIFIC LTD. 76
Energy Chemical 61
Shijiazhuang Sdyano Fine Chemical Co., Ltd. 65

View Latest Price from 2-(2-Amino-5-bromobenzoyl) pyridine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-(2-Amino-5-bromobenzoyl)pyridine pictures 2026-08-25 2-(2-Amino-5-bromobenzoyl)pyridine
1563-56-0
 $1.10-9.90 1kg 99%min 100kg ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
2-(2-AMINO-5-BROMOBENZOYL) PYRIDINE pictures 2026-08-20 2-(2-AMINO-5-BROMOBENZOYL) PYRIDINE
1563-56-0
 $1.10 1g 99.00% 100 Tons Min Dideu Industries Group Limited
2-(2-Amino-5-bromobenzoyl)pyridine pictures 2026-04-27 2-(2-Amino-5-bromobenzoyl)pyridine
1563-56-0
 1kg 98% 100tons Shandong Vital Biotechnology Co., Ltd.

2-(2-Amino-5-bromobenzoyl) pyridine Spectrum

2-(2-AMINO-5-BROMOBENZOYL) PYRIDINE(1563-56-0)1HNMR

1563-56-0 (2-(2-Amino-5-bromobenzoyl) pyridine) Related Search:

2-bromo-N-[4-bromo-2-(pyridin-2-ylcarbonyl)phenyl]acetamide 3-AMino-6-broMo-4-(pyridin-2-yl)quinolin-2(1H)-one Bromazepam Impurity 3 Bromazepam Impurity 2 2-Chloromethyl-3,4-dimethoxypyridinium chloride
2-Chloromethyl-3-methyl-4-(3-methoxypropoxy)pyridine hydrochloride 2-(2-Aminobenzoyl)pyridine N-[4-Bromo-2-(2-pyridylcarbonyl)phenyl]-2-chloroacetamide 2-(3-Bromobenzoyl)pyridine 2-(2-Amino-5-bromobenzoyl) pyridine
2-(2-Benzamido-5-bromobenzoyl)pyridine 2-(2-amino-5-bromobenzoyl)pyridine (intermediate of bromazepam)

1of3

Bromazepam EP Impurity A 4-bromo-2-[(pyridin-2-yl)carbonyl]aniline (2-amino-5-bromophenyl)-pyridin-2-ylmethanone (2-azanyl-5-bromo-phenyl)-pyridin-2-yl-methanone (2-Amino-5-bromophenyl)(2-pyridinyl)methanone Methanone, (2-amino-5-bromophenyl)-2-pyridinyl- Pyridine, 2-(2-amino-5-bromobenzoyl) 2-amino-5-bromobenzoylpyridine 2-(2-Amino-5-Bromobenzoyl) Pyridine 1-(2,4-Dichlorophenyl)ethanone 2-AMino-5-broMophenyl 2-pyridyl Ketone 2-(5-Bromo-2-aminobenzoyl)pyridine 2-(2-AMino-5-BroMobenzoyl) Pyridin Bromazepam Impurity A 2-(2-Ao-5-bromobenzoyl) pyridine 2-(2-Pyridylcarbonyl)-4-bromobenzeneamine 4-Bromo-2-[(2-pyridyl)carbonyl]aniline 2-(Pyridin-2-Yl-Carbonyl)-4-Bromoaniline 2-(2-AMINO-5-BROMOBENZOYL) C2HyBnN2O Tocopherol Impurity 30 2-(5-Chloro-2-aminophenyl)pyridine 2-(2-Amino-5-bromobenzoyl) pyridine 1563-56-0 C12H9BrN2O C152H9BrN2O (intermediate of bromazepam) Aromatics Heterocycles Intermediates & Fine Chemicals Pharmaceuticals