4,5-Dimethoxy-1-indanone
- CAS No.
- 6342-80-9
- Chemical Name:
- 4,5-Dimethoxy-1-indanone
- Synonyms
- 4,5-Dimethoxy-1-indanone;4,5-DIMETHOXY-INDAN-1-ONE;4,5-Dimethoxy-1-indanone 97%;4,5-dimethoxy-2,3-dihydroinden-1-one;2,3-dihydro-4,5-dimethoxy-1H-Inden-1-one;4,5-DiMethoxy-2,3-dihydro-1H-inden-1-one;1H-Inden-1-one, 2,3-dihydro-4,5-diMethoxy-
- CBNumber:
- CB0375427
- Molecular Formula:
- C11H12O3
- Molecular Weight:
- 192.21
- MDL Number:
- MFCD00463187
- MOL File:
- 6342-80-9.mol
- MSDS File:
- SDS
| Melting point | 73-77 °C (lit.) |
|---|---|
| Boiling point | 160-161 °C(Press: 2 Torr) |
| Density | 1.179±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| form | solid |
| Appearance | Off-white to yellow Solid |
| InChI | 1S/C11H12O3/c1-13-10-6-4-7-8(11(10)14-2)3-5-9(7)12/h4,6H,3,5H2,1-2H3 |
| InChIKey | XQODIRIVQXQUFN-UHFFFAOYSA-N |
| SMILES | COc1ccc2C(=O)CCc2c1OC |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| PPE | Eyeshields, Gloves, type N95 (US) |
| WGK Germany | 3 |
| Storage Class | 11 - Combustible Solids |
4,5-Dimethoxy-1-indanone price More Price(25)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 568252 | 4,5-Dimethoxy-1-indanone 97% | 6342-80-9 | 1g | $68.4 | 2023-06-20 | Buy |
| Synthonix | D54576 | 4,5-Dimethoxy-2,3-dihydro-1H-inden-1-one 95+% | 6342-80-9 | 250mg | $36 | 2026-05-06 | Buy |
| Synthonix | D54576 | 4,5-Dimethoxy-2,3-dihydro-1H-inden-1-one 95+% | 6342-80-9 | 1g | $42 | 2026-05-06 | Buy |
| Synthonix | D54576 | 4,5-Dimethoxy-2,3-dihydro-1H-inden-1-one 95+% | 6342-80-9 | 5g | $160 | 2026-05-06 | Buy |
| aablocks | AA003KFE | 4,5-Dimethoxy-2,3-dihydro-1H-inden-1-one ≥97% | 6342-80-9 | 250mg | $10 | 2026-05-28 | Buy |
4,5-Dimethoxy-1-indanone Chemical Properties,Uses,Production
Uses
4,5-Dimethoxy-1-indanone acts as a reagent for the preparation of thiosemicarbazones derived from 1-indanone as new anti-trypanosoma cruzi agents.
Definition
ChEBI: 4,5-dimethoxy-2,3-dihydroinden-1-one is a member of indanones.
Synthesis
10538-48-4
6342-80-9
3-(2,3-dimethoxyphenyl)propionic acid (4.99 g, 23.7 mmol) was mixed with Eaton's reagent (47.5 mL, 3 g/mmol of raw material) and stirred at room temperature for 72 hours. Upon completion of the reaction, the mixture was slowly poured into ice water, neutralized to neutral, and subsequently extracted with ethyl acetate (3 x 75 mL). The organic layers were combined, dried with anhydrous sodium sulfate and concentrated under reduced pressure. The crude product was purified by fast column chromatography using a pre-packed 100 g silica gel column [eluent A: ethyl acetate; eluent B: n-hexane; gradient elution: 7% A/93% B (1 column volume), 7% A/93% B→60% A/40% B (10 column volumes), 60% A/40% B (2 column volumes); flow rate: 40 mL/min; detection wavelengths: 254 nm and 280 nm] to give 4,5-dimethoxy-1-indanone (2.01 g, 10.5 mmol, 44% yield) as a yellow solid.1H NMR (CDCl3, 600 MHz) δ 7.06 (1H, d, J = 8.4 Hz), 6.62 (1H, d, J = 8.4 Hz), 3.61 (3H, s), 3.57 (3H, s), 2.70 (2.70 (2.70), 2.70 (2.70), 2.70 (2.70), 2.70 (3H, s), 2.70 (3H, s). s), 2.70 (2H, t, J = 5.4 Hz), 2.25 (2H, t, J = 5.4 Hz).13C NMR (CDCl3, 150 MHz) δ 204.6, 157.1, 147.4, 145.0, 130.7, 119.4, 112.0, 59.8, 55.8, 36.0, 22.1.
References
[1] Canadian Journal of Chemistry, 1982, vol. 60, # 21, p. 2678 - 2686
[2] Synthetic Communications, 2001, vol. 31, # 13, p. 2029 - 2036
[3] Journal of Medicinal Chemistry, 2011, vol. 54, # 9, p. 3331 - 3347
[4] Journal of Medicinal Chemistry, 1987, vol. 30, # 8, p. 1303 - 1308
[5] Journal of Organic Chemistry, 1984, vol. 49, # 12, p. 2130 - 2135
4,5-Dimethoxy-1-indanone Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Hangzhou Sage Chemical Co., Ltd. | +86057186818502 13588463833 | info@sagechem.com | China | 10265 | 58 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 29985 | 65 |
| Shanghai BeiZhuo Biotech Co., Ltd. | 021-61119791,13386096464 | bzswkf@foxmail.com | China | 3916 | 50 |
| NINGBO INNO PHARMCHEM CO.,LTD. | 86-574-27787657 | info@dearchem.com | China | 4607 | 58 |
| LABTER PHARMATECH(BEIJING) CO.,LTD | 010-56330744 18310155299 | sales@labter.com.cn | China | 19999 | 55 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51389 | 80 |
| Nanjing XiZe Biotechnology CO., Ltd. | 025-66023220 15250997978 | 1511893459@qq.com | China | 4777 | 55 |
View Lastest Price from 4,5-Dimethoxy-1-indanone manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-03-20 | 4,5-DIMETHOXY-1-INDANONE
6342-80-9
|
1KG | 99% | 20 mt | Hebei Chuanghai Biotechnology Co., Ltd | ||
 |
2019-07-06 | 4,5-DIMETHOXY-1-INDANONE
6342-80-9
|
$1.00 | 1KG | 95%-99.99% | 1kg-10MT | Career Henan Chemical Co |
-
- 4,5-DIMETHOXY-1-INDANONE
6342-80-9
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- 4,5-DIMETHOXY-1-INDANONE
6342-80-9
- $1.00
- 95%-99.99%
- Career Henan Chemical Co
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