trans-1,2-Cyclohexanedicarboxylic acid
- CAS No.
- 2305-32-0
- Chemical Name:
- trans-1,2-Cyclohexanedicarboxylic acid
- Synonyms
- TRANS-HEXAHYDRO-PHTHALIC ACID;TRANS-CYCLOHEXANE-1,2-DICARBOXYLIC ACID;trans-Cyclohexane-1,2-dicarboxylic acid, trans-Hexahydrophthalic acid;Lura;trans-CycL;REMAINDER CIS;RSYY（Avanafil)-15;ohexane-1,2-dicarboxyL;Lurasidone InterMediate(1);1,2-cyclohexanedicarboxylic
- CBNumber:
- CB0376262
- Molecular Formula:
- C8H12O4
- Molecular Weight:
- 172.18
- MDL Number:
- MFCD00001464
- MOL File:
- 2305-32-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 228-230 °C (lit.) |
|---|---|
| Boiling point | 262.49°C (rough estimate) |
| Density | 1.2104 (rough estimate) |
| refractive index | 1.4450 (estimate) |
| storage temp. | Store below +30°C. |
| solubility | Acetone (Slightly), DMSO (Slightly) |
| form | Solid |
| pka | pK1:4.18;pK2: 5.93 (20°C) |
| color | White |
| Water Solubility | 2g/L(20 ºC) |
| BRN | 3200609 |
| InChI | 1S/C8H12O4/c9-7(10)5-3-1-2-4-6(5)8(11)12/h5-6H,1-4H2,(H,9,10)(H,11,12)/t5-,6-/m0/s1 |
| InChIKey | QSAWQNUELGIYBC-WDSKDSINSA-N |
| SMILES | OC(=O)[C@@H]1CCCC[C@H]1C(O)=O |
| CAS DataBase Reference | 2305-32-0(CAS DataBase Reference) |
| NIST Chemistry Reference | 1,2-Cyclohexanedicarboxylic acid, trans-(2305-32-0) |
| EPA Substance Registry System | 1,2-Cyclohexanedicarboxylic acid, (1R,2R)-rel- (2305-32-0) |
| UNSPSC Code | 12352106 |
| NACRES | NA.23 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313 | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | GU9065000 | |||||||||
| TSCA | TSCA listed | |||||||||
| HS Code | 29172000 | |||||||||
| Storage Class | 13 - Non Combustible Solids | |||||||||
| NFPA 704 |
|
trans-1,2-Cyclohexanedicarboxylic acid price More Price(54)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 8.41088 | trans-Cyclohexane-1,2-dicarboxylic acid for synthesis | 2305-32-0 | 5G | $157 | 2026-04-30 | Buy |
| Sigma-Aldrich | 147516 | trans-1,2-Cyclohexanedicarboxylic acid 95% | 2305-32-0 | 25g | $311 | 2023-01-07 | Buy |
| TCI Chemical | C0474 | trans-1,2-Cyclohexanedicarboxylic Acid >98.0%(GC)(T) | 2305-32-0 | 25g | $142 | 2026-04-30 | Buy |
| TCI Chemical | C0474 | trans-1,2-Cyclohexanedicarboxylic Acid >98.0%(GC)(T) | 2305-32-0 | 500g | $1335 | 2026-04-30 | Buy |
| Usbiological | 269012 | 1,2-Cyclohexane dicarboxylic acid Asreported | 2305-32-0 | 2g | $352 | 2026-06-03 | Buy |
trans-1,2-Cyclohexanedicarboxylic acid Chemical Properties, Uses, Production
Synthesis
trans-1,2-cyclohexanedicarboxylic acid was prepared from phthalic anhydride via catalytic hydrogenation, resolution, and acidification. The resulting product had an optical purity (ee value) of 99.8% and a total yield of 40%, meeting both quality and industrialization requirements. The reaction formula is as follows:
Figure: Synthetic route diagram of trans-1,2-cyclohexanedicarboxylic acid
Chemical Properties
white crystalline powder
Uses
trans-1,2-cyclohexanedicarboxylic acid be used as organic intermediates.
Uses
trans-1,2-Cyclohexanedicarboxylic Acid is used as a reagent in the synthesis of enantiopure (α-cyanoalkyl)(tetrahydropyrido[4,3-b]indolecarbonyl)cyclohexanecarboxamides and its analogs as selective cathepsin K inhibitors for the treatment of osteoarthritis. Also used as a reagent in the synthesis of novel cyclopentanedicarboxamide sodium channel blockers as a potential treatment for chronic pain.
Purification Methods
It is purified by recrystallisation from EtOH or H2O. It is formed by hydrolyzing the anhydride with water. The dimethyl ester has m 95-96o (from *C6H6/pet ether). [Abell J Org Chem 22 769 1957, Smith & Byrne J Am Chem Soc 72 4406 1950, Linstead et al. J Am Chem Soc 64 2093 1942, Beilstein 9 III 3812, 9 IV 2801.] The 1R,2R-(-)-trans-cyclohexane-1,2-acid [46022-05-3] has m 171-182o and [ ] D -20o (c 1, Me2CO). cis-Cyclohexane-1,2-dicarboxylic anhydride (cis-hexahydrophthalic anhydride) [85-42-7, 13149-00-3] M 154.2, m 32-34o, b 158o/17mm. It has been obtained by heating the trans-acid or anhydride at 200o. Crystallise it from *C6H6/Et2O or distil it. [Kohler & Jansen J Am Chem Soc 60 2145 1938, Abell J Org Chem 22 769 1957, Beilstein 17 II 452, 17 III/IV 5931.]
trans-1,2-Cyclohexanedicarboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Loudi Xinjiyuan Chemistry Co., Ltd. | 0738-8280700 18073853168 | 1613791657@qq.com | China | 20 | 60 |
| Shanghai Wanyue Biological Medicine Co., LTD | 17502177640 | 977963479@qq.com | China | 19 | 58 |
| Shaanxi DIDU pharmaceutical and Chemical Co., Ltd | 029-029-029-81148696 18161915376 | 1027@dideu.com | China | 9989 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
View Latest Price from trans-1,2-Cyclohexanedicarboxylic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-18 | trans-1,2-Cyclohexanedicarboxylic acid
2305-32-0
|
1G | 98% | 2000 | Shenzhen Nexcon Pharmatechs Ltd. | ||
 |
2026-06-30 | trans-1,2-Cyclohexanedicarboxylic acid
2305-32-0
|
1kg | 99% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2026-03-20 | trans-1,2-Cyclohexanedicarboxylic acid
2305-32-0
|
$1.00 | 1KG | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd |
-
- trans-1,2-Cyclohexanedicarboxylic acid
2305-32-0
- 98%
- Shenzhen Nexcon Pharmatechs Ltd.
-
- trans-1,2-Cyclohexanedicarboxylic acid
2305-32-0
- $0.00
- 99%
- Shaanxi Dideu New Materials Co. Ltd
-
- trans-1,2-Cyclohexanedicarboxylic acid
2305-32-0
- $1.00
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
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