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cis-1,2-Cyclohexanedicarboxylic anhydride

CAS No.
13149-00-3
Chemical Name:
cis-1,2-Cyclohexanedicarboxylic anhydride
Synonyms
HHPA;CIS-CYCLOHEXANE-1,2-DICARBOXYLIC ANHYDRIDE;CIS-HHPA;Perospirone Impurity 6;Paracetamol Impurity 36;CIS-HEXAHYDROPHTHALIC ANHYDRIDE;Hexahydro-2-benzofuran-1,3-dione;HEXAHYDROPHTHALIC ACID ANHYDRIDE;HHPA,Hexahydrophthalic anhydride;cis-Hexahydroisobenzofuran-1,3-dione
CBNumber:
CB2228246
Molecular Formula:
C8H10O3
Molecular Weight:
154.16
MDL Number:
MFCD00005926
MOL File:
13149-00-3.mol
MSDS File:
SDS
Last updated:2026-09-12 18:50:31

cis-1,2-Cyclohexanedicarboxylic anhydride Properties

Melting point 32-34 °C(lit.)
Boiling point 158 °C17 mm Hg(lit.)
Density 1.23
refractive index 1.4750 (estimate)
Flash point >230 °F
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
solubility Chloroform (Slightly), Methanol (Slightly)
form Crystalline Low Melting Solid
color White to almost white
Sensitive Moisture Sensitive
BRN 83214
Exposure limits TLV-CEILING: 0.005 mg/m3, Inhalable fraction and vapor
Stability Moisture Sensitive
Substances of Very High Concern (SVHC) Candidate List cis-cyclohexane-1,2-dicarboxylic anhydride (13149-00-3)
CAS DataBase Reference 13149-00-3(CAS DataBase Reference)
FDA UNII B52Z7TNV87

SAFETY

Risk and Safety Statements

Symbol(GHS)  Corrosion (GHS05)Health Hazard (GHS08)
GHS05,GHS08
Signal word  Danger
Hazard statements  H317-H318-H334
Precautionary statements  P261-P272-P280-P284-P302+P352+P333+P313+P363-P304+P340+P342+P311-P305+P351+P338+P310-P501-P280a-P304+P340-P305+P351+P338-P501a
Hazard Codes  Xn
Risk Statements  41-42/43
Safety Statements  23-24-26-37/39
WGK Germany  1
10-21
HS Code  29420000
NFPA 704
1
2 0

cis-1,2-Cyclohexanedicarboxylic anhydride price More Price(32)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical C0478 cis-1,2-Cyclohexanedicarboxylic Anhydride >99.0%(GC) 13149-00-3 25g $17 2026-04-30 Buy
TCI Chemical C0478 cis-1,2-Cyclohexanedicarboxylic Anhydride >99.0%(GC) 13149-00-3 100g $33 2026-04-30 Buy
TRC TRC-H294030-5G (3aR,7aS)-rel-Hexahydro-1,3-isobenzofurandione 13149-00-3 5g $183 2026-06-03 Buy
TRC TRC-H294030-50G (3aR,7aS)-rel-Hexahydro-1,3-isobenzofurandione 13149-00-3 50g $293 2026-06-03 Buy
TRC TRC-H294030-25G (3aR,7aS)-rel-Hexahydro-1,3-isobenzofurandione 13149-00-3 25g $252 2026-06-03 Buy
Product number Packaging Price Buy
C0478 25g $17 Buy
C0478 100g $33 Buy
TRC-H294030-5G 5g $183 Buy
TRC-H294030-50G 50g $293 Buy
TRC-H294030-25G 25g $252 Buy

cis-1,2-Cyclohexanedicarboxylic anhydride Chemical Properties,Uses,Production

Chemical Properties

white to almost white cryst. low melting solid

Uses

(3aR,7aS)-rel-Hexahydro-1,3-isobenzofurandione is a reagent used in the synthesis of Pregabalin (P704800), a GABA analogue used as an anticonvulsant. Also used to prepare P2X7 receptor antagonists.

Purification Methods

It has been obtained by heating the trans-acid or anhydride at 200o. Crystallise it from *C6H6/Et2O or distil it. [Kohler & Jansen J Am Chem Soc 60 2145 1938, Abell J Org Chem 22 769 1957, Beilstein 17 II 452, 17 III/IV 5931.]

46022-05-3
13149-00-3
Synthesis of cis-1,2-Cyclohexanedicarboxylic anhydride from (1R,2R)-(-)-1,2-Cyclohexanedicarboxylic acid
Global( 224)Suppliers
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Beijing HwrkChemical Technology Co., Ltd 89508211 18501085097 sales.bj@hwrkchemical.com China 9407 55
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Puyang Huicheng Electronic Material Co. Ltd. 0393-0393-8910800 15039333257 info@huichengchem.com China 588 64
Adamas Reagent, Ltd. 400-6009262 15618770481 yhx@titansci.com China 14098 59
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Syntechem Co.,Ltd info@syntechem.com China 12973 57
Tianjin heowns Biochemical Technology Co., Ltd. 400 638 7771 sales@heowns.com China 14412 57

View Lastest Price from cis-1,2-Cyclohexanedicarboxylic anhydride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
CIS-1,2-CYCLOHEXANEDICARBOXYLIC ANHYDRIDE pictures 2026-03-20 CIS-1,2-CYCLOHEXANEDICARBOXYLIC ANHYDRIDE
13149-00-3
1KG 99% 20 mt Hebei Chuanghai Biotechnology Co., Ltd
Cis-1,2-Cyclohexanedicarboxylic Anhydride pictures 2021-07-13 Cis-1,2-Cyclohexanedicarboxylic Anhydride
13149-00-3
$10.00-15.00 1KG 99%+ HPLC Zhuozhou Wenxi import and Export Co., Ltd
Cis-1,2-Cyclohexanedicarboxylic Anhydride pictures 2021-07-10 Cis-1,2-Cyclohexanedicarboxylic Anhydride
13149-00-3
$10.00-15.00 1KG 99%+ HPLC Zhuozhou Wenxi import and Export Co., Ltd
2-Cyano-3-ethoxy-2-proenoicacidethylester 3-Isobenzofuranedione,hexahydro-,cis-1 cis-cyclohexane-1,2-dicarboxylicacidanhydride Hexahydro-2-benzofuran-1,3-dione (3aS)-3aα,4,5,6,7,7aα-Hexahydroisobenzofuran-1,3-dione (3aα,7aα)-Octahydroisobenzofuran-1,3-dione 3aα,4,5,6,7,7aα-Hexahydroisobenzofuran-1,3-dione (1R)-Cyclohexane-1β,2α-dicarboxylic anhydride (3aR)-1,3,3aβ,4,5,6,7,7aα-Octahydroisobenzofuran-1,3-dione (3aR,7aR)-3a,4,5,6,7,7a-Hexahydroisobenzofuran-1,3-dione cis-1,2-Cyclohexanedicarboxylic anhydride,99% cis-1,2-Cyclohexanedicarboxylic anhydride, 98%% cis-1,2-Cyclohexanedicarboxylic anhydride, 99% 1KG cis-1,2-Cyclohexanedicarboxylic anhydride, 99% 250GR cis-1,2-Cyclohexanedicarboxylic anhydride, 99% 5GR cis-Hexahydroisobenzofuran-1,3-dione HHPA),cis-1,2-Cyclohexanedicarboxylican cis-Cyclohexan-1,2-dicarbonsureanhydrid CIS-1,2-CYCLOHEXANEDICARBOXYLIC ANHYDRIDE (HHPA) 1,3-Isobenzofurandione, hexahydro-, (3aR,7aS)-rel- CIS-1,2-CYCLOHEXANEDECARBOXYLICANHYDRIDE CIS-HEXAHYDROPHTHALIC ANHYDRIDE CIS-HHPA CIS-CYCLOHEXANE-1,2-DICARBOXYLIC ANHYDRIDE HEXAHYDROPHTHALIC ACID ANHYDRIDE HHPA,Hexahydrophthalic anhydride (3aR,7aS)-Hexahydro-isobenzofuran-1,3-dione 1,3-Isobenzofurandione, hexahydro-, cis- cis-Hexahydrophthalic anhydride cis-HHPA cis-1,2-CyclohexanedicarboxylicAnhydride> 1,2-Cyclohexanedicarboxylic anhydride, cis CYCLOHEXANE-1,2-DICARBOXYLIC ANHYDRI Perospirone Impurity 6 (3aS,7aR)-3a,4,5,6,7,7a-hexahydro-2-benzofuran-1,3-dione Paracetamol Impurity 36 cis-1,2-Cyclohexanedicarboxylic acid anhydride HHPA cis-1,2-Cyclohexanedicarboxylic anhydride 13149-00-3 Building Blocks Carbonyl Compounds Carboxylic Acid Anhydrides Organic Building Blocks Pharmaceutical Intermediates