FARNESYLPYROPHOSPHATE
- CAS No.
- 13058-04-3
- Chemical Name:
- FARNESYLPYROPHOSPHATE
- Synonyms
- FPP;trans, trans-farnesyl diphosphate;FARNESYL PYROPHOSPHATE AMMONIUM SALT;FPP 3NH3;FPP 3NH4;FARNESYL-PP;FARNESYLDIPHOSPHATE;FARNESYLPYROPHOSPHATE;FARNESYL DIPHOSPHATE-TA;(E,E)-farnesyl diphosphate
- CBNumber:
- CB0378488
- Molecular Formula:
- C15H28O7P2
- Molecular Weight:
- 382.33
- MDL Number:
- MFCD00189688
- MOL File:
- 13058-04-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | >107°C (dec.) |
|---|---|
| Boiling point | 533.8±60.0 °C(Predicted) |
| Density | 1.233±0.06 g/cm3(Predicted) |
| Flash point | 11 °C |
| storage temp. | -20°C |
| solubility | Methanol (Slightly, Sonicated), Water (Slightly) |
| form | methanol:ammonia solution |
| pka | 1.07±0.50(Predicted) |
| color | White to Brown |
| Stability | Hygroscopic, Light Sensitive, Temperature Sensitive |
| InChI | 1S/C15H28O7P2/c1-13(2)7-5-8-14(3)9-6-10-15(4)11-12-21-24(19,20)22-23(16,17)18/h7,9,11H,5-6,8,10,12H2,1-4H3,(H,19,20)(H2,16,17,18)/b14-9+,15-11+ |
| InChIKey | VWFJDQUYCIWHTN-YFVJMOTDSA-N |
| SMILES | C\C(C)=C\CC\C(C)=C\CC\C(C)=C\COP(O)(=O)OP(O)(O)=O |
| FDA UNII | 79W6B01D07 |
| UNSPSC Code | 12352204 |
| NACRES | NA.83 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS02,GHS06,GHS08 |
|---|---|
| Signal word | Danger |
| Hazard statements | H225-H301+H311+H331-H315-H319-H370 |
| Precautionary statements | P210-P280-P301+P310-P303+P361+P353-P304+P340+P311-P305+P351+P338 |
| target organs | Eyes,Central nervous system |
| Hazard Codes | F,T |
| Risk Statements | 11-23/24/25-39/23/24/25 |
| Safety Statements | 7-16-36/37-45 |
| RIDADR | UN 1230 3/PG 2 |
| WGK Germany | 1 |
| Storage Class | 3 - Flammable liquids |
| Hazard Classifications | Acute Tox. 3 Dermal Acute Tox. 3 Inhalation Acute Tox. 3 Oral Aquatic Chronic 3 Eye Irrit. 2 Flam. Liq. 2 Skin Irrit. 2 STOT SE 1 |
FARNESYLPYROPHOSPHATE price More Price(7)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | F6892 | Farnesyl pyrophosphate ammonium salt methanol:ammonia solution, ≥95% (TLC) | 13058-04-3 | 1vial | $119 | 2026-04-30 | Buy |
| Sigma-Aldrich | F6892 | Farnesyl pyrophosphate ammonium salt methanol:ammonia solution, ≥95% (TLC) | 13058-04-3 | 5vials | $409 | 2026-04-30 | Buy |
| aablocks | AA000ULF | P-(3,7,11-Trimethyl-2,6,10-dodecatrien-1-yl) trihydrogen (diphosphate) 98%(ammoniasalt) | 13058-04-3 | 1mg | $283 | 2026-05-25 | Buy |
| aablocks | AA000ULF | P-(3,7,11-Trimethyl-2,6,10-dodecatrien-1-yl) trihydrogen (diphosphate) 98%(ammoniasalt) | 13058-04-3 | 5mg | $692 | 2026-05-25 | Buy |
| aablocks | AA000ULF | P-(3,7,11-Trimethyl-2,6,10-dodecatrien-1-yl) trihydrogen (diphosphate) 98%(ammoniasalt) | 13058-04-3 | 10mg | $1038 | 2026-05-25 | Buy |
FARNESYLPYROPHOSPHATE Chemical Properties, Uses, Production
Uses
Farnesyl pyrophosphate ammonium salt has been used:
- as a prenylation agonist in human osteogenic sarcoma cells in collagen-based cell invasion assays
- in the prenylation of the hepatocyte growth factor (HGF) in human umbilical vein endothelial cells (HUVECs)
- as a substrate in prenyltransferases assay in diatom Haslea ostrearia
Definition
ChEBI: 2-trans,6-trans-farnesyl diphosphate is the trans,trans-stereoisomer of farnesyl diphosphate. It has a role as an Escherichia coli metabolite and a mouse metabolite. It is a conjugate acid of a 2-trans,6-trans-farnesyl diphosphate(3-).
General Description
Farnesyl pyrophosphate is a 15-carbon isoprenoid synthesized from geranyl pyrophosphate (GPP) by the action of enzyme farnesyl pyrophosphate synthase (FPPS).
Biochem/physiol Actions
Farnesyl pyrophosphate (FPP) is the precursor for the biosynthesis of cholesterol, ubiquinone and dolicol. It is part of the intracellular mevalonate pathway. FPP is essential for cell survival and is used for prenylation of several low molecular mass G proteins, including Ras. Inhibition of prenylation results in loss of oncogenic potential of Ras proteins. Inhibition of prenylation may serve as therapeutic potential for management of synaptic plasticity and Alzheimer′s disease.
Purification Methods
Purify the pyrophosphate by chromatography on Whatman No3 MM paper in a system of isopropanol-isobutanol/ammonia/water (40:20:1:30) (v/v). Store it as the Li or NH4 salt at 0o. See geranylgeranyl pyrophosphate below.
FARNESYLPYROPHOSPHATE Preparation Products And Raw materials
Raw materials
Preparation Products
FARNESYLPYROPHOSPHATE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Shanghai Macklin Biochemical Co.,Ltd. | 15221275939 15221275939 | shenlinxing@macklin.cn | China | 15775 | 55 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51389 | 80 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 8000 | 62 |
| Rhawn Reagent | 400-400-1332688 18019345275 | huyue@rhawn.cn | China | 14942 | 58 |
| Shanghai Baoyisheng Biotechnology Co., LTD | 15221020695 ; | 502277408@qq.com | China | 456 | 58 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 | sales@rrkchem.com | China | 57336 | 58 |
| Zhejiang Huida Biotech Co., LTD | 0571-89903022 18679456698 | zilong@hizyme.com | China | 8001 | 58 |
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