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2-Hydroxyisobutyric acid

2-Hydroxyisobutyric acid structure

CAS No.: 594-61-6

Chemical Name:: 2-Hydroxyisobutyric acid

Synonyms: 2-HYDROXY-2-METHYLPROPANOIC ACID;2-hydroxyisobutyrate;Propanoic acid, 2-hydroxy-2-methyl-;ALPHA-HYDROXYISOBUTYRIC ACID;α-Hydroxyisobutyric acid;|á-Hydroxyisobutyric acid;2-hydroxy-2-methylpropanoate;2-HYDROXY-2-METHYLPROPIONIC ACID;(CH3)2COHCOOH;METHYL LACTIC ACID

CBNumber:: CB0379920

Molecular Formula:: C4H8O3

Molecular Weight:: 104.1

MDL Number:: MFCD00004459

MOL File:: 594-61-6.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-06-03 11:24:09

Product description	Number	Pack Size	Price
α-Hydroxyisobutyric acid 99%	323594	25g	$23.8
α-Hydroxyisobutyric acid 98%	164976	25g	$45.6
2-Hydroxyisobutyric Acid >98.0%(T)	M0360	25g	$23
2-Hydroxyisobutyric Acid >98.0%(T)	M0360	100g	$56
2-Hydroxyisobutyric Acid ≥95%	43901	50g	$36
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2-Hydroxyisobutyric acid Properties

Melting point	76-80 °C(lit.)
Boiling point	84 °C1.5 mm Hg(lit.)
Density	11412
refractive index	1.4761 (estimate)
Flash point	114°C/12mm
storage temp.	Sealed in dry,Room Temperature
solubility	water: soluble10%, clear to very slightly hazy, colorless
pka	pK1:3.717 (25°C,μ=0.1)
form	Solid
color	White to Off-White
Water Solubility	Soluble in water, ether, alcohol, methanol and hot benzene.
BRN	1744739
Cosmetics Ingredients Functions	FRAGRANCE
InChI	1S/C4H8O3/c1-4(2,7)3(5)6/h7H,1-2H3,(H,5,6)
InChIKey	BWLBGMIXKSTLSX-UHFFFAOYSA-N
SMILES	CC(C)(O)C(O)=O
LogP	-0.360
CAS DataBase Reference	594-61-6(CAS DataBase Reference)
EWG's Food Scores	1
FDA UNII	DMW250U2HF
NIST Chemistry Reference	Propanoic acid, 2-hydroxy-2-methyl-(594-61-6)
EPA Substance Registry System	Propanoic acid, 2-hydroxy-2-methyl- (594-61-6)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS05,GHS07

Signal word

Danger

Hazard statements

H315-H318-H335

Precautionary statements

P261-P264-P280-P304+P340+P312-P305+P351+P338+P310-P403+P233

target organs

Respiratory system

PPE

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Risk Statements

37/38-41-36/37/38

Safety Statements

26-39-25-36

WGK Germany

Hazard Note

Irritant

TSCA

TSCA listed

HS Code

29181980

Storage Class

11 - Combustible Solids

Hazard Classifications

Eye Dam. 1
Skin Irrit. 2
STOT SE 3

REACH Registrations

Active

NFPA 704

	1
2		0

2-Hydroxyisobutyric acid price More Price(85)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	323594	α-Hydroxyisobutyric acid 99%	594-61-6	25g	$23.8	2026-04-30	Buy
Sigma-Aldrich	164976	α-Hydroxyisobutyric acid 98%	594-61-6	25g	$45.6	2026-04-30	Buy
TCI Chemical	M0360	2-Hydroxyisobutyric Acid >98.0%(T)	594-61-6	25g	$23	2026-04-30	Buy
TCI Chemical	M0360	2-Hydroxyisobutyric Acid >98.0%(T)	594-61-6	100g	$56	2026-04-30	Buy
Cayman Chemical	43901	2-Hydroxyisobutyric Acid ≥95%	594-61-6	50g	$36	2026-04-30	Buy

Product number	Packaging	Price	Buy
323594	25g	$23.8	Buy
164976	25g	$45.6	Buy
M0360	25g	$23	Buy
M0360	100g	$56	Buy
43901	50g	$36	Buy

2-Hydroxyisobutyric acid Chemical Properties,Uses,Production

Chemical Properties

white to off-white needle-like crystals or

Uses

2-Hydroxyisobutyric acid is used as background electrolyte for separation and detection of the metal ions by on-line cyclic voltammetry.

Uses

2-Hydroxyisobutyric acid is used as an electrolyte in the separation of the metal ions by on-line cyclic voltammetry. It is also used as a building block for the synthesis of polymers. Its conjugate base, 2-hydroxybutyrate is utilized to catabolize L-threonine as well as synthesize glutathione. Further, it is used as an indicator for the early detection insulin resistance in non-diabetic subjects.

Uses

α-Hydroxyisobutyric acid was used as background electrolyte for separation and detection of the metal ions by on-line cyclic voltammetry.

Definition

ChEBI: A 2-hydroxy monocarboxylic acid that is isobutyric acid bearing a hydroxy substituent at position 2. It is a metabolite of methyl tertiary-butyl ether.

Synthesis Reference(s)

The Journal of Organic Chemistry, 23, p. 1488, 1958 DOI: 10.1021/jo01104a022

General Description

α-Hydroxyisobutyric acid (2-hydroxyisobutyric acid) is the building block for polymer synthesis. It forms complexes with Eu(III) and has been studied by time resolved fluorescence spectroscopy.

2-Hydroxyisobutyric acid synthesis

Synthesis of 2-Hydroxyisobutyric acid from Mesaconic acid

2-Hydroxyisobutyric acid Preparation Products And Raw materials

Raw materials

1,2-BENZENEDISULFONYL DICHLORIDE

Preparation Products

Cyclohexyl methacrylate Ethyl 2-hydroxyisobutyrate 2-Methyl-2-hydroxypropionamide 1-Chlorocarbonyl-1-methylethyl acetate α-Hydroxyisobutyric acid butyl ester

2-Hydroxyisobutyric acid Suppliers

Global( 441)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD	+86-15225627621 +86-13213167925	jiuyitime@fdachem.com	China	16505	58
Hebei Chuanghai Biotechnology Co., Ltd	+86-15350571055	Sibel@chuanghaibio.com	China	8737	58
RongNa Biotechnology Co.,Ltd	+86-86-13583358881 +8618560316533	Brad@rongnabiotech.com	China	3371	58
Hebei Chuanghai Biotechnology Co,.LTD	+86-86-13131129325	sales1@chuanghaibio.com	China	5218	58
Hebei Zhuanglai Chemical Trading Co Ltd	+86-16264648883	niki@zlchemi.com	China	7240	58
Shanghai Daken Advanced Materials Co.,Ltd	+86-2158073036	info@dakenam.com	China	14032	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21531	55
Shanghai Time Chemicals CO., Ltd.	+86-021-57951555 +8618017249410	jack.li@time-chemicals.com	China	1796	55
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29766	58
Jinan Finer Chemical Co., Ltd	+86-531-88989536 +86-15508631887	sales@finerchem.com	China	2949	58

Supplier	Advantage
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD	58
Hebei Chuanghai Biotechnology Co., Ltd	58
RongNa Biotechnology Co.,Ltd	58
Hebei Chuanghai Biotechnology Co,.LTD	58
Hebei Zhuanglai Chemical Trading Co Ltd	58
Shanghai Daken Advanced Materials Co.,Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55
Shanghai Time Chemicals CO., Ltd.	55
career henan chemical co	58
Jinan Finer Chemical Co., Ltd	58

Related Qustion

Ask a question

Q:What causes high 2-hydroxyisobutyric acid and is it toxicity?Zora - Dec 2，2025

A: 2-hydroxyisobutyric acid is an organic acid metabolite of the gasoline additive methyl tertiary-butyl ether (MTBE) and a human xenobiotic metabolite. 2-hydroxyisobutyric acid have been shown to be to cause hepatic, kidney and central nervous system toxicity, peripheral neurotoxicity, and cancer in animals.

View Lastest Price from 2-Hydroxyisobutyric acid manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-08-08	2-Hydroxyisobutyric acid 594-61-6	$10.00	1ASSAYS	99%	1 ton	RongNa Biotechnology Co.,Ltd
2026-08-07	2-Hydroxyisobutyric acid 594-61-6		1KG	98%min	30tons/month	WUHAN FORTUNA CHEMICAL CO., LTD
2026-07-02	2-Hydroxyisobutyric acid 594-61-6	$10.00-50.00	1kg	99%，Electronic grade(Single metal impurity≤ 10ppb)	100kg	ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

2-Hydroxyisobutyric acid
594-61-6
$10.00
99%
RongNa Biotechnology Co.,Ltd

2-Hydroxyisobutyric acid
594-61-6
$0.00
98%min
WUHAN FORTUNA CHEMICAL CO., LTD

2-Hydroxyisobutyric acid
594-61-6
$10.00-50.00
99%，Electronic grade(Single metal impurity≤ 10ppb)
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

2-Hydroxyisobutyric acid Spectrum

2-Hydroxyisobutyric acid(594-61-6)MS 2-Hydroxyisobutyric acid(594-61-6)¹HNMR 2-Hydroxyisobutyric acid(594-61-6)¹³CNMR 2-Hydroxyisobutyric acid(594-61-6)IR1 2-Hydroxyisobutyric acid(594-61-6)IR2 2-Hydroxyisobutyric acid(594-61-6)IR3 2-Hydroxyisobutyric acid(594-61-6)Raman

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Propanoic acid, 2-methyl-2-hydroxy- A-HYDROXY-ISO-BUTYRIC ACID 2-MethyllaCLic Acid alpha-Hydroxyisobutyric acid 98% 2-Hydroxyisobutyric acid for synthesis RARECHEM AL BO 0199 alpha-Hydroxyisobutanoic acid Hydroxydimethylacetic acid Hydroxyisobutyricacid Lactic acid, 2-methyl- Lactic acid, 2-methyl-, L- (CH3)2COHCOOH 2-hydroxy-2-methyl-propanoicaci 2,2-DIMETHYLGLYCOLIC ACID 2-HYDROXY-2-METHYLPROPIONIC ACID 2-HYDROXYISOBUTYRIC ACID 2-METHYLLACTIC ACID METHYL LACTIC ACID 2-Hydroxy-#niso-butyric acid 2 2-Hydroxyisobutyric Acid 2,4-dichlorodibenzoyl peroxide 2-HYDROXYISOBUTYRIC ACID (2-HYDROXY-2-METHYLPROPIONIC ACID) 2-Hydroxyisobutyricacid,99% PROPANOICACID,2-HYDROXY-2- Hydroxy-2-methylpropanoic acid, 2-: (2-Methyllactic acid) 2-Hydroxy-2-methylpropionic acid, 2-Methyllactic acid 2-Hydroxyisobutyric acid,98% α-Hydroxyisobutyric acid,2-Hydroxy-2-methylpropionic acid, 2-Methyllactic acid 2-Hydroxyisobutanoic acid 2-Hydroxyisobutyric acid, 99% (dry wt.), water <2% 2-Hydroxyisobutyric |á-Hydroxyisobutyric acid 2-Hydroxyisobutyric acid, 98% 25GR 2-HydroxyisobutyricAcid> 2-hydroxyisobutyricaci 2-methyl-2-hydroxypropanoic acid 2-Hydroxyisobutyric Acid, ≥ 98.0% 2-Methyl-2-hydroxypropionic acid 2-Hydroxyisobutyric acid - [H72872] 2-hydroxy-2-methylpropanoate 2-HYDROXY-2-METHYLPROPANOIC ACID 2-hydroxyisobutyrate ALPHA-HYDROXYISOBUTYRIC ACID Propanoic acid, 2-hydroxy-2-methyl- α-Hydroxyisobutyric acid Lactic Acid Impurity 154 594-61-6 C4H8O3 CH32CHOHCOOH Building Blocks Carboxylic Acids Carbonyl Compounds C1 to C5 Organic Building Blocks Carboxylic Acids Chemical Synthesis Organic Building Blocks FINE Chemical & INTERMEDIATES