ChemicalBook >> CAS DataBase List >>Ethyl (3S)-piperidine-3-carboxylate
Ethyl (3S)-piperidine-3-carboxylate
- CAS No.
- 37675-18-6
- Chemical Name:
- Ethyl (3S)-piperidine-3-carboxylate
- Synonyms
- ETHYL (S)-PIPERIDINE-3-CARBOXYLATE;H-S-3PIP-OET;(S)-nipecotate;(S)-ETHYL-NIPECOTATE;Ethyl L-nipecotate, 97%;ETHYL (S)-(+)-NIPECOTATE;(S)-(+)-ETHYL NIPECOTATE;(3s)-(+)-ethyl Nipecotate;(S)-1-BOC-ETHYL NIPECOTATE;(S)-Ethyl piperidine-3-ca...
- CBNumber:
- CB0380304
- Molecular Formula:
- C8H15NO2
- Molecular Weight:
- 157.21
- MDL Number:
- MFCD00792499
- MOL File:
- 37675-18-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
Last updated:2026-05-27 17:41:09
| Boiling point | 102-104 °C/7 mmHg(lit.) |
|---|---|
| Density | 1.043 g/mL at 25 °C |
| refractive index | n20/D 1.471 |
| Flash point | 77 °C |
| storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| form | clear liquid |
| pka | 9.35±0.10(Predicted) |
| color | Colorless to Almost colorless |
| Specific Gravity | 1.012 |
| optical activity | -3.4°(C=0.01 g/ml, CHCL3, 20°C, 589nm) |
| Sensitive | Light, Air & Moisture Sensitive |
| InChI | 1S/C8H15NO2/c1-2-11-8(10)7-4-3-5-9-6-7/h7,9H,2-6H2,1H3/t7-/m0/s1 |
| InChIKey | XIWBSOUNZWSFKU-ZETCQYMHSA-N |
| SMILES | CCOC(=O)[C@H]1CCCNC1 |
| CAS DataBase Reference | 37675-18-6(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H318 | |||||||||
| Precautionary statements | P280-P305+P351+P338 | |||||||||
| PPE | Eyeshields, Gloves, type ABEK (EN14387) respirator filter | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38-41 | |||||||||
| Safety Statements | 26-36/37/39-39-36 | |||||||||
| RIDADR | NA 1993 / PGIII | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 29339900 | |||||||||
| Storage Class | 10 - Combustible liquids | |||||||||
| Hazard Classifications | Eye Dam. 1 | |||||||||
| NFPA 704 |
|
Ethyl (3S)-piperidine-3-carboxylate price More Price(74)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 696439 | (S)-Ethyl piperidine-3-carboxylate 97% | 37675-18-6 | 1g | $81 | 2026-04-30 | Buy |
| TCI Chemical | N0679 | Ethyl (S)-(+)-3-Piperidinecarboxylate >98.0%(GC)(T) | 37675-18-6 | 5g | $96 | 2026-04-30 | Buy |
| TCI Chemical | N0679 | Ethyl (S)-(+)-3-Piperidinecarboxylate >98.0%(GC)(T) | 37675-18-6 | 25g | $341 | 2026-04-30 | Buy |
| AstaTech | 49559 | (S)-ETHYL PIPERIDINE-3-CARBOXYLATE 95% | 37675-18-6 | 1G | $23 | 2026-04-30 | Buy |
| AstaTech | 49559 | (S)-ETHYL PIPERIDINE-3-CARBOXYLATE 95% | 37675-18-6 | 5G | $33 | 2026-04-30 | Buy |
Ethyl (3S)-piperidine-3-carboxylate Chemical Properties,Uses,Production
Chemical Properties
Colorless liquid
Uses
Reactant for synthesis of:
- DPP-4 inhibitors
- JAK2 inhibitors
- Serotonin and noradrenaline reuptake inhibitors
- Human tryptase inhibitors
- Anti-thrombotic nicecotamides
Reactive for oxidative C-arylation of free (NH)-heterocycles via direct (sp3) C-H bond functionalization
Synthesis
183316-65-6
37675-18-6
The general procedure for the synthesis of ethyl (S)-3-piperidinecarboxylate from the compound (CAS:183316-65-6) was as follows: 20.0 g of ethyl piperidinate (70.16 g, 0.446 mmol) and D-tartaric acid (67 g, 1.0 eq.) were dissolved in preheated to 95% ethanol (350 mL). The resulting solution was cooled to room temperature and then filtered and the crystals were washed with pre-cooled 95% ethanol. Subsequently, the crystals were recrystallized in 95% ethanol (550 mL) to give tartrate (38.5 g, 56% yield). The resulting tartrate (38.5 g) was dissolved in water (300 mL), cooled to 0 °C and neutralized with 3M NaOH solution. The neutralized solution was extracted with dichloromethane (5 x 100 mL), the organic phases were combined and dried with anhydrous sodium sulfate, and finally concentrated under reduced pressure to give a clarified oily product (19.0 g, 89% yield). Mass spectrometry (CIMS) analysis showed MH+ = 158.
References
[1] Patent: US2004/122018, 2004, A1. Location in patent: Page 208
Ethyl (3S)-piperidine-3-carboxylate Preparation Products And Raw materials
Global( 257)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| ITIC MEDCHEM(SUZHOU) CO.,LTD. | 0512-68323967 18015559028 | sales@iticmedchem.com | China | 528 | 61 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TAIYUAN RHF CO.,LTD. | +86 351 7031519 | sales@RHFChem.com | China | 2334 | 56 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Shijiazhuang Sdyano Fine Chemical Co., Ltd. | 0311-89250318 13582355795 | master@sjzsdyn.com | China | 2776 | 65 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
View Lastest Price from Ethyl (3S)-piperidine-3-carboxylate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-03-20 | Ethyl (3S)-piperidine-3-carboxylate
37675-18-6
|
$10.00 | 1KG | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2025-12-24 | Ethyl (3S)-piperidine-3-carboxylate
37675-18-6
|
1KG | 99.0% | 1000 tons | Shaanxi Dideu Medichem Co. Ltd | ||
 |
2024-04-23 | Ethyl (3S)-piperidine-3-carboxylate
37675-18-6
|
$5.00 | 1kg | 99.92% | 50000tons | Ouhuang Engineering Materials (Hubei) Co., Ltd |
-
- Ethyl (3S)-piperidine-3-carboxylate
37675-18-6
- $10.00
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- Ethyl (3S)-piperidine-3-carboxylate
37675-18-6
- $0.10
- 99.0%
- Shaanxi Dideu Medichem Co. Ltd
-
- Ethyl (3S)-piperidine-3-carboxylate
37675-18-6
- $5.00
- 99.92%
- Ouhuang Engineering Materials (Hubei) Co., Ltd
37675-18-6(Ethyl (3S)-piperidine-3-carboxylate)Related Search:
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(S)-(+)-ETHYL NIPECOTATE
(S)-ETHYL-NIPECOTATE
3-Piperidinecarboxylicacid, ethyl ester, (S)-
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(S)-ETHYL PIPERIDINE-3-CARBOXYLATE
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(S)-NIPECOTIC ACID ETHYL ESTER
(S)-PIPERIDINE-3-CARBOXYLIC ACID ETHYL ESTER
(S)-(+)-3-PIPERIDINECARBOXYLIC ACID ETHYL ESTER
ETHYL (S)-(+)-NIPECOTATE
H-S-3PIP-OET
ETHYL (S)-(+)-3-PIPERIDINECARBOXYLATE
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Ethyl (3S)-piperidine-3-carboxylate
(3S)-Ethyl piperidine-3-carboxylate
(S)-Ethyl piperidine-3-ca...
Ethyl (S)-nipecotate, (3S)-3-(Ethoxycarbonyl)piperidine
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Ethyl (S)-(+)-Nipecotate
(S)-(+)-Nipecotic Acid Ethyl Ester
(S)-(+)-3-Piperidinecarboxylic Acid Ethyl Ester
(S)-nipecotate
Ethyl(S)-(+)-3-Piperidinecarboxylate>
3-Piperidinecarboxylic acid, ethyl ester, (3S)-
(S)-Piperidine-3-carboxylic acid et
(S)-Ethyl piperidine-3-carboxylate
ETHYL (S)-PIPERIDINE-3-CARBOXYLATE
37675-18-6
7675-18-6
3675-18-6
Chiral Building Blocks
Esters (Chiral)
Piperidine
Heterocyclic Compounds
Chiral Building Blocks
Esters (Chiral)
Synthetic Organic Chemistry
Nitrogen cyclic compounds
