ChemicalBook >> CAS DataBase List >>2-Hydroxymethyl-3-methyl-4-(2,2,2-trifluoroethoxy)pyridine hydrochloride
2-Hydroxymethyl-3-methyl-4-(2,2,2-trifluoroethoxy)pyridine hydrochloride
- CAS No.
- 103577-66-8
- Chemical Name:
- 2-Hydroxymethyl-3-methyl-4-(2,2,2-trifluoroethoxy)pyridine hydrochloride
- Synonyms
- [3-Methyl-4-(2;2-Hydroxymethyl-3-me;ansoprazole Impurity 26;Lansoprazole Impurity 16;2-Hydroxymethyl-3Methyl-4-;Dexlansoprazole impurity H;Lansoprazole Hydroxymethyl;Lansoprazolehydroxylcompound;Lansoprazole hydroxy coMpound;2-Hydroxymethyl-3-methyl-4-(2
- CBNumber:
- CB0401058
- Molecular Formula:
- C9H10F3NO2
- Molecular Weight:
- 221.18
- MDL Number:
- MFCD07368269
- MOL File:
- 103577-66-8.mol
- MSDS File:
- SDS
Last updated:2025-07-24 18:13:42
| Product description | Number | Pack Size | Price |
| 3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinemethanol | M331050 | 100mg | $145 |
| [3-Methyl-4-(2,2,2-trifluoro-ethoxy)-pyridin-2-yl]-methanol | D278 | 1g | $14 |
| [3-Methyl-4-(2,2,2-trifluoro-ethoxy)-pyridin-2-yl]-methanol | J51311 | 25g | $60 |
| [3-Methyl-4-(2,2,2-trifluoro-ethoxy)-pyridin-2-yl]-methanol | D278 | 100g | $214 |
| 2-HYDROXYMETHYL-3-METHYL-4-(2,2,2-THIFLUOROETHOXY)PYRIDINE 95.00% | HCH0020043 | 1G | $286.65 |
| More product size | |||
| Melting point | 93-94 °C(Solv: isopropyl ether (108-20-3); hexane (110-54-3)) |
|---|---|
| Boiling point | 273.6±40.0 °C(Predicted) |
| Density | 1.303±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| pka | 13.17±0.10(Predicted) |
| form | Solid |
| color | Pale Beige to Light Brown |
| Stability | Light Sensitive |
| CAS DataBase Reference | 103577-66-8(CAS DataBase Reference) |
| FDA UNII | AJR7D4YGL7 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
2-Hydroxymethyl-3-methyl-4-(2,2,2-trifluoroethoxy)pyridine hydrochloride price More Price(22)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | M331050 | 3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinemethanol | 103577-66-8 | 100mg | $145 | 2021-12-16 | Buy |
| AK Scientific | D278 | [3-Methyl-4-(2,2,2-trifluoro-ethoxy)-pyridin-2-yl]-methanol | 103577-66-8 | 1g | $14 | 2021-12-16 | Buy |
| AK Scientific | J51311 | [3-Methyl-4-(2,2,2-trifluoro-ethoxy)-pyridin-2-yl]-methanol | 103577-66-8 | 25g | $60 | 2021-12-16 | Buy |
| AK Scientific | D278 | [3-Methyl-4-(2,2,2-trifluoro-ethoxy)-pyridin-2-yl]-methanol | 103577-66-8 | 100g | $214 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | HCH0020043 | 2-HYDROXYMETHYL-3-METHYL-4-(2,2,2-THIFLUOROETHOXY)PYRIDINE 95.00% | 103577-66-8 | 1G | $286.65 | 2021-12-16 | Buy |
2-Hydroxymethyl-3-methyl-4-(2,2,2-trifluoroethoxy)pyridine hydrochloride Chemical Properties,Uses,Production
Chemical Properties
Brown Solid
Uses
Intermediate in the preparation of Lansoprazole (L175000) impurity.
Synthesis
112525-75-4
103577-66-8
e) 34.8 g of 2-acetoxymethyl-3-methyl-4-(trifluoroethoxy)pyridine (equivalent to 18.7 g, 0.071 mol) obtained in the previous step was used as raw material, which was dissolved in 15 ml of a solvent mixture of methanol/water (1:1) at room temperature. The pH of the reaction system was adjusted with 33% aqueous sodium hydroxide solution to 13. The reaction was carried out at a temperature of 25 to 30 °C and a pH range of 12.5 to 13.5 and the progress of the reaction was monitored by HPLC. Upon completion of the reaction, the reaction mixture was neutralized with 36% hydrochloric acid and subsequently extracted with dichloromethane. The organic layer was dried and concentrated to 60 ml. The yield of the product 2-hydroxymethyl-3-methyl-4-(2,2,2-trifluoroethoxy)pyridine was 95-97% as determined by HPLC.
References
[1] Journal of Medicinal Chemistry, 1992, vol. 35, # 3, p. 438 - 450
[2] Patent: EP1681056, 2006, A1. Location in patent: Page/Page column 8
2-Hydroxymethyl-3-methyl-4-(2,2,2-trifluoroethoxy)pyridine hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 279)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21590 | 55 |
| Shanghai Time Chemicals CO., Ltd. | +86-021-57951555 +8617317452075 | jack.li@time-chemicals.com | China | 1803 | 55 |
| Zhejiang ZETian Fine Chemicals Co. LTD | +8618957127338 | stella@zetchem.com | China | 2994 | 58 |
| Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14332 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49977 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29794 | 58 |
| SIMAGCHEM CORP | +86-5922680277 +86-13806087780 | sale@simagchem.com | China | 17346 | 58 |
| Qiuxian Baitai New Material Co., LTD | +8618330912755 | sale2@hbyalin.com | China | 1658 | 58 |
| Hebei Zhanyao Biotechnology Co. Ltd | 15369953316 +8615369953316 | admin@zhanyaobio.com | China | 2123 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23541 | 58 |
View Lastest Price from 2-Hydroxymethyl-3-methyl-4-(2,2,2-trifluoroethoxy)pyridine hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-04-04 | 2-Hydroxymethyl-3-methyl-4-(2,2,2-trifluoroethoxy)pyridine hydrochloride
103577-66-8
|
US $0.00-0.00 / kg | 1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. | |
 |
2021-12-22 | 2-hydroxymethyl-3-methyl-4 -(2,2, 2-trifluoroethoxy) pyridine
103577-66-8
|
US $2.00 / g | 1KG | 99% | 5ton/Month | Qiuxian Baitai New Material Co., LTD | |
 |
2021-10-21 | 2-Hydroxymethyl-3-methyl-4-(2,2,2-trifluoroethoxy)pyridine hydrochloride
103577-66-8
|
US $10.00 / KG | 1KG | 99% | 20 tons | Hebei Zhanyao Biotechnology Co. Ltd |
-
- 2-Hydroxymethyl-3-methyl-4-(2,2,2-trifluoroethoxy)pyridine hydrochloride
103577-66-8
- US $0.00-0.00 / kg
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- 2-hydroxymethyl-3-methyl-4 -(2,2, 2-trifluoroethoxy) pyridine
103577-66-8
- US $2.00 / g
- 99%
- Qiuxian Baitai New Material Co., LTD
-
- 2-Hydroxymethyl-3-methyl-4-(2,2,2-trifluoroethoxy)pyridine hydrochloride
103577-66-8
- US $10.00 / KG
- 99%
- Hebei Zhanyao Biotechnology Co. Ltd
103577-66-8(2-Hydroxymethyl-3-methyl-4-(2,2,2-trifluoroethoxy)pyridine hydrochloride)Related Search:
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2-Hydroxymethyl-3-methyl-4-(2,2,2-trifluoroethoxy)pyridine hydrochloride
3-Methyl-4-(2,2,2-trifluoroethoxy)pyridine-2-methanol
Lansoprazole Hydroxymethyl Impurity
Lansoprazole Impurity 16
2-Hydroxymethyl-3-me
[3-Methyl-4-(2
Dexlansoprazole impurity H
3-2-Hydroxymethyl-3-methyl-4-(2,2,2-trifluoroethoxy)pyridine hydrochloride
2-Hydroxymethyl-3-methyl-4-(2,2,2-trifluoroethoxy)pyridine hydrochloride ISO 9001：2015 REACH
2-Hydroxymethyl-3-methyl-4-(2
Lansoprazole Hydroxymethyl
2-Hydroxy methyl-3-methyl-4-(2,2,2-trifluoro ethoxy) pyridine Hcl (Hydrxy)
ansoprazole Impurity 26
(3-Methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl)methanol (Lansoprazole Impurity)
Lansoprazolehydroxylcompound
103577-66-8
103577-66-9
C9H10F3NO2
C9H10NO2F3
