ChemicalBook >> CAS DataBase List >>2-Hydroxymethyl-3-methyl-4-(2,2,2-trifluoroethoxy)pyridine hydrochloride
2-Hydroxymethyl-3-methyl-4-(2,2,2-trifluoroethoxy)pyridine hydrochloride
- CAS No.
- 103577-66-8
- Chemical Name:
- 2-Hydroxymethyl-3-methyl-4-(2,2,2-trifluoroethoxy)pyridine hydrochloride
- Synonyms
- [3-Methyl-4-(2;2-Hydroxymethyl-3-me;ansoprazole Impurity 26;Lansoprazole Impurity 16;2-Hydroxymethyl-3Methyl-4-;Dexlansoprazole impurity H;Lansoprazole Hydroxymethyl;Lansoprazolehydroxylcompound;Lansoprazole hydroxy coMpound;2-Hydroxymethyl-3-methyl-4-(2
- CBNumber:
- CB0401058
- Molecular Formula:
- C9H10F3NO2
- Molecular Weight:
- 221.18
- MDL Number:
- MFCD07368269
- MOL File:
- 103577-66-8.mol
- MSDS File:
- SDS
Last updated:2026-06-15 22:31:22
| Melting point | 93-94 °C(Solv: isopropyl ether (108-20-3); hexane (110-54-3)) |
|---|---|
| Boiling point | 273.6±40.0 °C(Predicted) |
| Density | 1.303±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 13.17±0.10(Predicted) |
| color | Pale Beige to Light Brown |
| Stability | Light Sensitive |
| CAS DataBase Reference | 103577-66-8(CAS DataBase Reference) |
| FDA UNII | AJR7D4YGL7 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| REACH Registrations | Active |
2-Hydroxymethyl-3-methyl-4-(2,2,2-trifluoroethoxy)pyridine hydrochloride price More Price(46)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 283478 | [3-Methyl-4-(2,2,2-trifluoro-ethoxy)-pyridin-2-yl]-methanol Asreported | 103577-66-8 | 500mg | $375 | 2026-06-03 | Buy |
| Usbiological | 283478 | [3-Methyl-4-(2,2,2-trifluoro-ethoxy)-pyridin-2-yl]-methanol Asreported | 103577-66-8 | 1g | $525 | 2026-06-03 | Buy |
| Usbiological | 283478 | [3-Methyl-4-(2,2,2-trifluoro-ethoxy)-pyridin-2-yl]-methanol Asreported | 103577-66-8 | 2g | $719 | 2026-06-03 | Buy |
| Usbiological | 283478 | [3-Methyl-4-(2,2,2-trifluoro-ethoxy)-pyridin-2-yl]-methanol Asreported | 103577-66-8 | 5g | $988 | 2026-06-03 | Buy |
| TRC | TRC-M331050-5G | 3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinemethanol | 103577-66-8 | 5g | $110 | 2026-06-03 | Buy |
2-Hydroxymethyl-3-methyl-4-(2,2,2-trifluoroethoxy)pyridine hydrochloride Chemical Properties, Uses, Production
Chemical Properties
Brown Solid
Uses
Intermediate in the preparation of Lansoprazole (L175000) impurity.
Synthesis
112525-75-4
103577-66-8
e) 34.8 g of 2-acetoxymethyl-3-methyl-4-(trifluoroethoxy)pyridine (equivalent to 18.7 g, 0.071 mol) obtained in the previous step was used as raw material, which was dissolved in 15 ml of a solvent mixture of methanol/water (1:1) at room temperature. The pH of the reaction system was adjusted with 33% aqueous sodium hydroxide solution to 13. The reaction was carried out at a temperature of 25 to 30 °C and a pH range of 12.5 to 13.5 and the progress of the reaction was monitored by HPLC. Upon completion of the reaction, the reaction mixture was neutralized with 36% hydrochloric acid and subsequently extracted with dichloromethane. The organic layer was dried and concentrated to 60 ml. The yield of the product 2-hydroxymethyl-3-methyl-4-(2,2,2-trifluoroethoxy)pyridine was 95-97% as determined by HPLC.
References
[1] Journal of Medicinal Chemistry, 1992, vol. 35, # 3, p. 438 - 450
[2] Patent: EP1681056, 2006, A1. Location in patent: Page/Page column 8
2-Hydroxymethyl-3-methyl-4-(2,2,2-trifluoroethoxy)pyridine hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Global Suppliers ( 281)
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| TAIYUAN RHF CO.,LTD. | +86 351 7031519 | sales@RHFChem.com | China | 2334 | 56 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
View Latest Price from 2-Hydroxymethyl-3-methyl-4-(2,2,2-trifluoroethoxy)pyridine hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-06-30 | 2-Hydroxymethyl-3-methyl-4-(2, 2, 2-trifluoroethoxy)pyridine hydrochloride
103577-66-8
|
1kg | 98% | 1000kgs | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2025-04-04 | 2-Hydroxymethyl-3-methyl-4-(2,2,2-trifluoroethoxy)pyridine hydrochloride
103577-66-8
|
1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. | ||
 |
2021-12-22 | 2-hydroxymethyl-3-methyl-4 -(2,2, 2-trifluoroethoxy) pyridine
103577-66-8
|
$2.00 | 1KG | 99% | 5ton/Month | Qiuxian Baitai New Material Co., LTD |
-
- 2-Hydroxymethyl-3-methyl-4-(2, 2, 2-trifluoroethoxy)pyridine hydrochloride
103577-66-8
- $0.00
- 98%
- Shaanxi Dideu New Materials Co. Ltd
-
- 2-Hydroxymethyl-3-methyl-4-(2,2,2-trifluoroethoxy)pyridine hydrochloride
103577-66-8
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- 2-hydroxymethyl-3-methyl-4 -(2,2, 2-trifluoroethoxy) pyridine
103577-66-8
- $2.00
- 99%
- Qiuxian Baitai New Material Co., LTD
103577-66-8 (2-Hydroxymethyl-3-methyl-4-(2,2,2-trifluoroethoxy)pyridine hydrochloride) Related Search:
2-trifluoro-ethoxy)-pyridin-2-yl]-Methanol
Lansoprazole hydroxy coMpound
3-Methyl-4-(2,2,2-Trifluoroethoxy)-2-Pyridinemethanol
2-hydroxymethyl-3-methyl-4-(2,2,2-trifluoroethyoxy)pyridine hydrochloride
3-METHYL-4-(2,2,2-TRIFLUOROETHOXY)-2-PY&
2-PyridineMethanol,3-Methyl-4-(2,2,2-trifluoroethoxy)-
2-HYDROXYMETHYL-3-METHYL-4-(2,2,2-THIFLUOROETHOXY)PYRIDINE
2-HYDROXYMETHYL-3-METHYL-4-(2,2,2-TRIFLUOROETHOXY) PYRIDINE
[3-METHYL-4-(2,2,2-TRIFLUORO-ETHOXY)-PYRIDIN-2-YL]-METHANOL
[3-METHYL-4-(2,2,2-TRIFLUOROETHOXY)PYRIDIN-2-YL]METHONOL
3,5-dimethyl-4-(2,2,2-trifluoroethoxy)-1H-pyridin-2-one
2-Hydroxymethyl-3-Methyl-4-(2,2,2-Trifluoroethoxy)-2-Pyridine
2-Hydroxymethyl-3Methyl-4-
2-Hydroxymethyl-3-methyl-4-(2,2,2-trifluoroethoxy)pyridine hydrochloride
3-Methyl-4-(2,2,2-trifluoroethoxy)pyridine-2-methanol
Lansoprazole Hydroxymethyl Impurity
Lansoprazole Impurity 16
2-Hydroxymethyl-3-me
[3-Methyl-4-(2
Dexlansoprazole impurity H
3-2-Hydroxymethyl-3-methyl-4-(2,2,2-trifluoroethoxy)pyridine hydrochloride
2-Hydroxymethyl-3-methyl-4-(2,2,2-trifluoroethoxy)pyridine hydrochloride ISO 9001：2015 REACH
2-Hydroxymethyl-3-methyl-4-(2
Lansoprazole Hydroxymethyl
2-Hydroxy methyl-3-methyl-4-(2,2,2-trifluoro ethoxy) pyridine Hcl (Hydrxy)
ansoprazole Impurity 26
(3-Methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl)methanol (Lansoprazole Impurity)
Lansoprazolehydroxylcompound
103577-66-8
103577-66-9
C9H10F3NO2
C9H10NO2F3
