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4-Amino-1,3,5-trimethylpyrazole

4-Amino-1,3,5-trimethylpyrazole structure

CAS No.: 28466-21-9

Chemical Name:: 4-Amino-1,3,5-trimethylpyrazole

Synonyms: 1,3,5-TRIMETHYL-1H-PYRAZOL-4-AMINE;AKOS B000505;AKOS PAO-0230;1,3,5-?-1H--4-;BUTTPARK 29\06-78;TIMTEC-BB SBB006986;ART-CHEM-BB B000505;1,3,5-trimethylpyrazol-4-amine;1,3,5-Trimethyl-4-pyrazolamine;4-amino-1,3,5-trimethyl-pyrazol

CBNumber:: CB0412917

Molecular Formula:: C6H11N3

Molecular Weight:: 125.17

MDL Number:: MFCD00052883

MOL File:: 28466-21-9.mol

MSDS File:: SDS

Last updated:2026-09-12 18:48:20

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4-Amino-1,3,5-trimethylpyrazole Properties

Melting point	96 °C
Boiling point	236℃
Density	1.13
Flash point	97℃
storage temp.	under inert gas (nitrogen or Argon) at 2–8 °C
form	solid
pka	4.75±0.10(Predicted)
color	Brown
BRN	110739
InChI	InChI=1S/C6H11N3/c1-4-6(7)5(2)9(3)8-4/h7H2,1-3H3
InChIKey	SSDGMKHZMNTWLS-UHFFFAOYSA-N
SMILES	N1(C)C(C)=C(N)C(C)=N1
CAS DataBase Reference	28466-21-9(CAS DataBase Reference)
EWG's Food Scores	1

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07,GHS08,GHS09

Signal word

Danger

Hazard statements

H315-H319-H360-H410

Precautionary statements

P501-P273-P202-P201-P264-P280-P302+P352-P391-P308+P313-P337+P313-P305+P351+P338-P362+P364-P332+P313-P405

Hazard Codes

RTECS

UQ6125100

HS Code

2933199090

Toxicity

mouse,LD50,subcutaneous,> 500mg/kg (500mg/kg),Farmaco, Edizione Scientifica. Vol. 25, Pg. 592, 1970.

NFPA 704

	0
0		0

4-Amino-1,3,5-trimethylpyrazole price More Price(46)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Apolloscientific	OR8100	4-Amino-1,3,5-trimethyl-1H-pyrazole ≥95%	28466-21-9	250mg	$21	2026-06-04	Buy
Apolloscientific	OR8100	4-Amino-1,3,5-trimethyl-1H-pyrazole ≥95%	28466-21-9	1g	$41	2026-06-04	Buy
Apolloscientific	OR8100	4-Amino-1,3,5-trimethyl-1H-pyrazole ≥95%	28466-21-9	5g	$137	2026-06-04	Buy
Synthonix	T41491	1,3,5-Trimethyl-1H-pyrazol-4-amine 98%	28466-21-9	250mg	$28	2026-05-06	Buy
Synthonix	T41491	1,3,5-Trimethyl-1H-pyrazol-4-amine 98%	28466-21-9	1g	$34	2026-05-06	Buy

Product number	Packaging	Price	Buy
OR8100	250mg	$21	Buy
OR8100	1g	$41	Buy
OR8100	5g	$137	Buy
T41491	250mg	$28	Buy
T41491	1g	$34	Buy

4-Amino-1,3,5-trimethylpyrazole Chemical Properties,Uses,Production

Definition

ChEBI: 1,3,5-Trimethyl-1H-pyrazol-4-amine is a member of pyrazoles.

Synthesis

1125-30-0

28466-21-9

General procedure for the synthesis of 4-amino-1,3,5-trimethylpyrazole from 4-nitro-1,3,5-trimethylpyrazole: To a solution of 1,3,5-trimethyl-4-nitro-1H-pyrazole (2.1 g, 1.35 mmol) in ethanol (30 mL) was added powdered iron (14.85 g, 27 mmol) and 6N aqueous hydrochloric acid solution (0.23 mL. 0.67 mmol) and the mixture was refluxed for 16 hours. After completion of the reaction (monitored by TLC), the solvent was removed by evaporation under reduced pressure. The crude product was alkalized with 0.5 N aqueous sodium hydroxide and extracted with 10% methanol-dichloromethane (10%, 50 mL) solution. The organic layer was dried with anhydrous sodium sulfate, filtered and the solvent evaporated to afford 4-amino-1,3,5-trimethylpyrazole as a beige solid (1.68 g, 99% yield).' HNMR (400 MHz, DMSO-d6): δ 3.50 (s, 3H), 3.27 (bs, 2H), 2.03 (s, 3H), 1.94 (s, 3H).

References

[1] Patent: WO2015/25197, 2015, A1. Location in patent: Paragraph 00095
[2] Patent: WO2015/113452, 2015, A1. Location in patent: Page/Page column 55
[3] Patent: EP1203767, 2002, A1. Location in patent: Example 39
[4] Chemische Berichte, 1895, vol. 28, p. 688
[5] Journal fuer Praktische Chemie (Leipzig), 1896, vol. <2> 53, p. 127

4-Amino-1,3,5-trimethylpyrazole Preparation Products And Raw materials

Raw materials

1,3,5-Trimethyl-4-nitro-1H-pyrazole Ethanol Water Iron Hydrochloric acid

Preparation Products

4-Amino-1,3,5-trimethylpyrazole Suppliers

Global( 132)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Harvest Chemical Industrial Co., Ltd.	15721252604 17321035817	sales@harvest-chem.com	China	2829	64
Hubei Lidu New Material Technology Co., Ltd	19307245857	1931978409@qq.com	China	383	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Jia Xing Isenchem Co.,Ltd	0573-85285100 18627885956	isenchem@163.com	China	9389	66
Pure Chemistry Scientific Inc.	001-857-928-2050 or 1-888-588-9418	sales@chemreagents.com	United States	10174	62
Nanjing Chemlin Chemical Co., Ltd	025-83697070 13770331960	info@chemlin.com.cn	China	16305	64
Shanghai Hanhong Scientific Co.,Ltd.	021-54306202 13764082696	info@hanhongsci.com	China	42917	64
Shanghai Ennopharm Co., Ltd.	+86 (21) 6435-5022		China	4263	65

Supplier	Advantage
Shanghai Harvest Chemical Industrial Co., Ltd.	64
Hubei Lidu New Material Technology Co., Ltd	58
J & K SCIENTIFIC LTD.	76
Alfa Aesar	84
Energy Chemical	61
Jia Xing Isenchem Co.,Ltd	66
Pure Chemistry Scientific Inc.	62
Nanjing Chemlin Chemical Co., Ltd	64
Shanghai Hanhong Scientific Co.,Ltd.	64
Shanghai Ennopharm Co., Ltd.	65

View Lastest Price from 4-Amino-1,3,5-trimethylpyrazole manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2021-08-12	4-AMINO-1,3,5-TRIMETHYLPYRAZOLE 28466-21-9	$10.00-15.00	1KG	99%+ HPLC		Zhuozhou Wenxi import and Export Co., Ltd
	2019-07-06	4-AMINO-1,3,5-TRIMETHYLPYRAZOLE 28466-21-9	$1.00	1KG	98%	1kg,5kg,100kg	Career Henan Chemical Co

4-AMINO-1,3,5-TRIMETHYLPYRAZOLE
28466-21-9
$10.00-15.00
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

4-AMINO-1,3,5-TRIMETHYLPYRAZOLE
28466-21-9
$1.00
98%
Career Henan Chemical Co

4-Amino-1,3,5-trimethylpyrazole Spectrum

4-AMINO-1,3,5-TRIMETHYLPYRAZOLE(28466-21-9)¹HNMR

28466-21-9(4-Amino-1,3,5-trimethylpyrazole)Related Search:

4-AMINO-1,3,5-TRIMETHYLPYRAZOLE 1,3,5-Trimethylpyrazole 2-(3,5-DIMETHYL-4-NITRO-PYRAZOL-1-YL)-PROPIONIC ACID ETHYL ESTER 1-Acetyl-3(5)-(heptafluoro-1-propyl)-5(3)-methyl-4-(nitro)pyrazole 2-(3,5-Dimethyl-4-nitro-pyrazol-1-yl)-propionic acid hydrazide

1,3,5-Trimethyl-4-nitro-1H-pyrazole 1-Ethyl-3-methyl-4-nitro-1H-pyrazole-5-carboxylic acid (3,5-DIMETHYL-4-NITRO-PYRAZOL-1-YL)-ACETIC ACID HYDRAZIDE 1-ACETYL-3(5)-[1-(HEPTAFLUOROPROP-1-OXY)TETRAFLUOROETHYL]-5(3)-METHYL-4-(NITRO)PYRAZOLE 3-(DIMETHYLAMINO)-2-(1,3-DIMETHYL-4-NITRO-1H-PYRAZOL-5-YL)ACRYLALDEHYDE O-METHYLOXIME

N-[2-(1,3-DIMETHYL-4-NITRO-1H-PYRAZOL-5-YL)VINYL]-4-FLUOROANILINE ETHYL 2-OXO-2-[(1,3,5-TRIMETHYL-1H-PYRAZOL-4-YL)AMINO]ACETATE N-(2,4-DIMETHOXYPHENYL)-N-[2-(1,3-DIMETHYL-4-NITRO-1H-PYRAZOL-5-YL)VINYL]AMINE 4-CHLORO-2-([2-(1,3-DIMETHYL-4-NITRO-1H-PYRAZOL-5-YL)VINYL]AMINO)BENZENOL 1-ACETYL-3(5)-TRIFLUOROMETHYL-4-NITRO-5(3)-(PHENYL)PYRAZOLE

N-[2-(1,3-DIMETHYL-4-NITRO-1H-PYRAZOL-5-YL)VINYL]-4-(TRIFLUOROMETHOXY)ANILINE 1-ACETYL-3(5)-TRIFLUOROMETHYL-5(3)-METHYL-4-(NITRO)PYRAZOLE 1-Acetyl-3(5)-(heptafluoro-1-propyl)-4-nitro-5(3)-(phenyl)pyrazole

1of4

TIMTEC-BB SBB006986 AKOS PAO-0230 AKOS B000505 1,3,5-TRIMETHYL-1H-PYRAZOL-4-YLAMINE BUTTPARK 29\06-78 ART-CHEM-BB B000505 1H-pyrazol-4-amine, 1,3,5-trimethyl- 4-Amino-1,3,5-trimethylpyrazole hydrochloride 1,3,5-Trimethyl-4-pyrazolamine 1,3,5-trimethylpyrazol-4-amine Pyrazole, 4-amino-1,3,5-trimethyl- 4-Amino-2,3,5-trimethyl-2H-pyrazole 1,3,5-triMethyl-4-aMino-1H-pyrazole (1,3,5-trimethylpyrazol-4-yl)amine 4-amino-1,3,5-trimethyl-pyrazol 1,3,5-?-1H--4- 1,3,5-TRIMETHYL-1H-PYRAZOL-4-AMINE 4-Amino-1,3,5-trimethylpyrazole 28466-21-9 AMINO