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8-Bromo-1,6-naphthyridine

8-Bromo-1,6-naphthyridine Structure
8-Bromo-1,6-naphthyridine structure
CAS No.
17965-74-1
Chemical Name:
8-Bromo-1,6-naphthyridine
Synonyms
8-Bromo-1,6phthyridine;8-Bromo-1,6-naphthyridine;1,6-Naphthyridine, 8-bromo-
CBNumber:
CB0418722
Molecular Formula:
C8H5BrN2
Molecular Weight:
209.04
MDL Number:
MFCD00234384
MOL File:
17965-74-1.mol
MSDS File:
SDS
Last updated:2026-09-12 18:48:20
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8-Bromo-1,6-naphthyridine Properties

Boiling point 312.0±22.0 °C(Predicted)
Density 1.656±0.06 g/cm3(Predicted)
storage temp. Storage temp. 2-8°C
pka 1.45±0.30(Predicted)
Appearance Off-white to light yellow Solid
CAS DataBase Reference 17965-74-1

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
HS Code  2933998090

8-Bromo-1,6-naphthyridine price More Price(52)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Apolloscientific OR30599 8-Bromo-1,6-naphthyridine 95% 17965-74-1 50mg $111 2026-06-04 Buy
Apolloscientific OR30599 8-Bromo-1,6-naphthyridine 95% 17965-74-1 250mg $156 2026-06-04 Buy
Apolloscientific OR30599 8-Bromo-1,6-naphthyridine 95% 17965-74-1 500mg $255 2026-06-04 Buy
Apolloscientific OR30599 8-Bromo-1,6-naphthyridine 95% 17965-74-1 1g $387 2026-06-04 Buy
Apolloscientific OR30599 8-Bromo-1,6-naphthyridine 95% 17965-74-1 5g $1532 2026-06-04 Buy
Product number Packaging Price Buy
OR30599 50mg $111 Buy
OR30599 250mg $156 Buy
OR30599 500mg $255 Buy
OR30599 1g $387 Buy
OR30599 5g $1532 Buy

8-Bromo-1,6-naphthyridine Chemical Properties, Uses, Production

Synthesis

1,6-NAPHTHYRIDINE

253-72-5

8-BROMO-1,6-NAPHTHYRIDINE

17965-74-1

1. Carbon tetrachloride (35 mL) solution of bromine (2.25 mL, 43.7 mmol) was added dropwise to carbon tetrachloride (200 mL) solution of 1,6-naphthyridine (4.73 g, 36.4 mmol) under stirring conditions through a charging funnel. 2. The reaction mixture was heated to reflux for 1 hour. 3. Under reflux conditions, slowly add a dropwise solution of pyridine (2.94 mL, 36.4 mmol) in carbon tetrachloride (30 mL) to the reaction mixture and continue refluxing overnight. 4. Upon completion of the reaction, the reaction mixture was cooled and filtered. 5. Digest the solid with 1 M sodium hydroxide solution (200 mL) for 1 hour. 6. The basic aqueous phase was extracted with dichloromethane (2 x 200 mL), the organic phases were combined, dried over anhydrous sodium sulfate and concentrated. 7. The oil obtained was purified by column chromatography (eluent: 10% ethyl acetate/dichloromethane) to afford 8-bromo-1,6-naphthyridine (2.03 g, 27% yield) as yellow crystals with a melting point of 79-81°C. The solid was extracted with sodium hydroxide solution (2 x 200 mL) for 1 hour.

References

[1] Chemical & Pharmaceutical Bulletin, 1986, vol. 34, # 5, p. 2018 - 2023
[2] Patent: EP1147083, 2004, B1. Location in patent: Page 47
[3] Synthesis, 2007, # 8, p. 1185 - 1196

8-Bromo-1,6-naphthyridine Preparation Products And Raw materials

Raw materials

1,6-Naphthyridine Pyridine Carbon tetrachloride

Preparation Products

8-Bromo-1,6-naphthyridine Suppliers

Global Suppliers ( 78)
Supplier Tel Email Country ProdList Advantage
Tetranov Biopharm 13526569071 sales@leadmedpharm.com China 7881 64
Accela ChemBio Co.,Ltd. 021-50795510 4000665055 marketing@accelachem.com China 10972 64
Shanghai Sphchem Co., Ltd. 021-56491756 13512199871 2819742715@qq.com China 3994 55
Dtchem Laboratories,（Gan Su）Co.,Ltd. 18993961550 18993966060 sales@techbiochem.com China 774 61
Bide Pharmatech Ltd. 400-164-7117 18317119277 product02@bidepharm.com China 40000 60
ShangHai AmK Pharmaceutical Technology Co., Ltd. 微信 18019252918 18019252918 sale@amkchem.com China 14982 55
JW & Y Pharmlab Co., Ltd. 021-64340559 xinyu_shi@jwypharmlab.com.cn China 11999 58
Shanghai Carlow Chemicals Co., Ltd. 21-33526724 18930996265 info@carlowchem.com China 1820 50
Shanghai YuanYe Biotechnology Co., Ltd. 15026964105 2881489226@qq.com China 89667 60
Changzhou Hopschain Chemical Co.,Ltd. 85528066 13775048983 sales@hopschem.com China 31548 55
Supplier Advantage
Tetranov Biopharm 64
Accela ChemBio Co.,Ltd. 64
Shanghai Sphchem Co., Ltd. 55
Dtchem Laboratories,（Gan Su）Co.,Ltd. 61
Bide Pharmatech Ltd. 60
ShangHai AmK Pharmaceutical Technology Co., Ltd. 55
JW & Y Pharmlab Co., Ltd. 58
Shanghai Carlow Chemicals Co., Ltd. 50
Shanghai YuanYe Biotechnology Co., Ltd. 60
Changzhou Hopschain Chemical Co.,Ltd. 55

8-Bromo-1,6-naphthyridine Spectrum

8-BROMO-1,6-NAPHTHYRIDINE(17965-74-1)1HNMR

17965-74-1 (8-Bromo-1,6-naphthyridine) Related Search:

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1,6-Naphthyridine, 8-bromo- 8-Bromo-1,6phthyridine 8-Bromo-1,6-naphthyridine 17965-74-1