Lorlatinib acetate
- CAS No.
- 1924207-18-0
- Chemical Name:
- Lorlatinib acetate
- Synonyms
- Lorlatinib acetate
- CBNumber:
- CB04189031
- Molecular Formula:
- C23H23FN6O4
- Molecular Weight:
- 466.47
- MDL Number:
- MFCD28144520
- MOL File:
- 1924207-18-0.mol
- MSDS File:
- SDS
| storage temp. | room temp |
|---|---|
| solubility | DMSO: 2mg/mL, clear |
| form | powder |
| color | white to beige |
| optical activity | [α]/D -95 to -115°, c =0.5 in methanol |
| InChIKey | IIXWYSCJSQVBQM-LLVKDONJSA-N |
| SMILES | NC1=C(O[C@@H](C2=C3C=CC(F)=C2)C)C=C(C4=C(C#N)N(C)N=C4CN(C)C3=O)C=N1 |
| FDA UNII | TE9WI16FEU |
| UNSPSC Code | 51111800 |
| NACRES | NA.77 |
Lorlatinib acetate price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PZ0271 | PF-06463922 acetate ≥98% (HPLC) | 1924207-18-0 | 5 mg | $100 | 2025-07-31 | Buy |
| Sigma-Aldrich | PZ0039 | Lorlatinib ≥98% (HPLC) | 1924207-18-0 | 5MG | $117.8 | 2025-07-31 | Buy |
| Sigma-Aldrich | PZ0039 | Lorlatinib ≥98% (HPLC) | 1924207-18-0 | 25MG | $423 | 2025-07-31 | Buy |
| Biosynth | ZBD20718 | Lorlatinib acetate | 1924207-18-0 | 50mg | $1298 | 2026-06-05 | Buy |
Lorlatinib acetate Chemical Properties, Uses, Production
Uses
PF-06463922 acetate has been used as an inhibitor of anaplastic lymphoma kinase (ALK) to analyze the expression of adrenomedullin using qPCR.
Biological Activity
PF-06463922 is a potent, selective brain-penetrable inhibitor of both anaplastic lymphoma kinase (ALK) and c-ros Oncogene 1 (ROS1) with strong activity against all known ALK and ROS1 mutants identified in patients with crizotinib-resistant disease. PF-06463922 is in clinical trials for the treatment of non–small cell lung cancer (NSCLC).
in vivo
In rats, Lorlatinib (PF-06463922) displays low plasma clearance, a moderate volume of distribution, a reasonable half-life, low propensity for p-glycoprotein 1-mediated efflux and a bioavailability of 100%[1]. In vivo, Lorlatinib shows cytoreductive antitumor efficacy in the NIH3T3 xenograft models expressing human CD74-ROS1 and Fig-ROS1 via inhibition in ROS1 phosphorylation and the downstream signaling molecules, as well as inhibition of the cell cycle protein Cyclin D1 in tumors. Lorlatinib also demonstrates marked antitumor activity in mice bearing tumor xenografts expressing EML4-ALK, EML4-ALK-L1196M, EML4-ALK-G1269A, EML4-ALK-G1202R or NPM-ALK[2].
Lorlatinib acetate Preparation Products And Raw materials
Raw materials
Preparation Products
Lorlatinib acetate Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 8000 | 62 |
| Twochem Co.Ltd. | 021-58111628 15800915896 | sales@twochem.com | China | 1782 | 58 |
| Tianjin Kaifu Pharmaceutical Technology Co., Ltd. | 18081075745 | chemflowtech@sina.com | China | 1883 | 58 |
| Chunchuang (Wuhan) Technology Co., Ltd | 15727060112 | yutianchun2007@126.com | China | 9867 | 58 |
| Beijing Biocreative Technology Co., Ltd. | 15522676233 | 3007606172@qq.com | China | 1246 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| Shanghai Shengxiu Biotechnology Co., Ltd. | 13761144602 | 3896578657@qq.com | China | 4644 | 58 |
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