Hexahydro-1,3,5-tris(hydroxyethyl)-s-triazine
- CAS No.
- 4719-04-4
- Chemical Name:
- Hexahydro-1,3,5-tris(hydroxyethyl)-s-triazine
- Synonyms
- actane;Hexahydrotriazine;Nipacide BK;Hexahydro-1;TRIS(N-HYDROXYETHYL) HEXAHYDROTRIAZINE;1,3,5-triazine-1,3,5(2h,4h,6h)-triethanol;Hexahydro-1,3,5-tris(2-hydroxyethyl)-s-triazine;1,3,5-Tris(2-hydroxyethyl)hexahydro-1,3,5-triazine;BK-8;eta75
- CBNumber:
- CB0425698
- Molecular Formula:
- C9H21N3O3
- Molecular Weight:
- 219.28
- MDL Number:
- MFCD01678788
- MOL File:
- 4719-04-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| s-Triazine-1,3,5-triethanol | TRC-T767345-1G | 1g | $265 |
| s-Triazine-1,3,5-triethanol | TRC-T767345-10G | 10g | $1584 |
| s-Triazine-1,3,5-triethanol | TRC-T767345-100MG | 100mg | $97 |
| s-Triazine-1,3,5-triethanol ≥98% | 022089 | 100mg | $347 |
| s-Triazine-1,3,5-triethanol ≥98% | 022089 | 250mg | $482 |
| More product size | |||
| Boiling point | 360.1°C (rough estimate) |
|---|---|
| Density | 1.1269 (rough estimate) |
| vapor pressure | 0Pa at 25℃ |
| refractive index | 1.4830 (estimate) |
| storage temp. | 2-8°C |
| solubility | Ethyl Acetate (Slightly, Sonicated), Water (Slightly) |
| form | Oil to Low-Melting Solid |
| pka | 14.16±0.10(Predicted) |
| color | Off-White to Yellow |
| Water Solubility | Soluble (>=1 g/100 mL at 24 ºC) |
| Cosmetics Ingredients Functions |
SKIN CONDITIONING SKIN PROTECTING |
| InChI | InChI=1S/C9H21N3O3/c13-4-1-10-7-11(2-5-14)9-12(8-10)3-6-15/h13-15H,1-9H2 |
| InChIKey | HUHGPYXAVBJSJV-UHFFFAOYSA-N |
| SMILES | N1(CCO)CN(CCO)CN(CCO)C1 |
| LogP | -2 at 24℃ |
| CAS DataBase Reference | 4719-04-4(CAS DataBase Reference) |
| FDA UNII | OU2JEB22IE |
| EPA Substance Registry System | Hexahydro-1,3,5-tris(2-hydroxyethyl)-s-triazine (4719-04-4) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H317 |
| Precautionary statements | P264-P270-P301+P312-P330-P501-P261-P272-P280-P302+P352-P333+P313-P321-P363-P501 |
| Hazard Codes | Xn |
| Risk Statements | 22-43 |
| Safety Statements | 24-37 |
| RIDADR | 2810 |
| TSCA | TSCA listed |
| HazardClass | 6.1(b) |
| PackingGroup | III |
| Toxicity | LD50 oral in rat: 763mg/kg |
| REACH Registrations | Active |
| Limited Quantities | 5.0 kg (11 lbs) (solid) |
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) |
Hexahydro-1,3,5-tris(hydroxyethyl)-s-triazine price More Price(21)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | TRC-T767345-1G | s-Triazine-1,3,5-triethanol | 4719-04-4 | 1g | $265 | 2026-06-03 | Buy |
| TRC | TRC-T767345-10G | s-Triazine-1,3,5-triethanol | 4719-04-4 | 10g | $1584 | 2026-06-03 | Buy |
| TRC | TRC-T767345-100MG | s-Triazine-1,3,5-triethanol | 4719-04-4 | 100mg | $97 | 2026-06-03 | Buy |
| Usbiological | 022089 | s-Triazine-1,3,5-triethanol ≥98% | 4719-04-4 | 100mg | $347 | 2026-06-03 | Buy |
| Usbiological | 022089 | s-Triazine-1,3,5-triethanol ≥98% | 4719-04-4 | 250mg | $482 | 2026-06-03 | Buy |
Hexahydro-1,3,5-tris(hydroxyethyl)-s-triazine Chemical Properties,Uses,Production
Description
Grotan BK is a triazine derivative contained in cutting fluids. It is a formaldehyde releaser. Hexahydro-1,3,5-tris(hydroxyethyl)-s-triazine is a light-yellow liquid. It is a formaldehyde condensate product that is used as an antimicrobial agent in metal working fluids.
Chemical Properties
Light Yellow Solid
Uses
Hexahydro-l,3,5-tris-(2-hydroxyethyl)triazin is used in organic synthesis; as a bactericide in cooling fluids and various cosmetic products; formaldehyde liberator.
General Description
Viscous yellow liquid.
Air & Water Reactions
Water soluble.
Reactivity Profile
Hexahydro-1,3,5-tris(hydroxyethyl)-s-triazine is an amine and an alcohol. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.
Health Hazard
Hexahydro-1,3,5-tris(hydroxyethyl)-s-triazine (TA, CAS 4719-04-4) is a widely used biocide added to water-based metalworking fluids (MWF) to control microbial populations. However, uncontrolled concentrations of this biocide within metalworking fluids may induce allergic pneumonitis. The mechanism may involve TA eliminating other competing microorganisms while simultaneously inducing the emergence of biocide-resistant mycobacteria, leading to their excessive proliferation within the fluid's sedimentation tanks [6]. Furthermore, TA rapidly releases formaldehyde in diluted aqueous solutions. This substance exhibits strong irritant and corrosive effects on rabbit skin, eyes, and upper respiratory tract, attributed to the formation of irritant formaldehyde and 2-aminoethanol. As formaldehyde is released from TA, this substance is classified as a Category 4 carcinogen alongside formaldehyde. The aerosol form of TA is classified as a Category 2 carcinogen. As no data currently exist on the systemic bioavailability of TA released through hydrolysis in tissues, nor is there experimental evidence indicating formaldehyde reaches germ cells, TA has been categorised as a Category 3B germ cell mutagen. Skin contact is not anticipated to contribute significantly to systemic toxicity[7].
Fire Hazard
Hexahydro-1,3,5-tris(hydroxyethyl)-s-triazine is probably combustible.
Flammability and Explosibility
Not classified
Contact allergens
Grotan BK is a triazine derivative contained as a bio cide in cutting fluids. It is a formaldehyde releaser. Dermatitis, delayed-type allergic conjunctivitis, and asthma were described.
Synthesis
50-00-0
141-43-5
4719-04-4
General procedure for the synthesis of hydroxyethyl hexahydrohomotriazine from formaldehyde and 2-aminoethanol: To 6.1 g (0.1 mol) of 2-aminoethanol was added 3.0 g (0.1 mol as formaldehyde) of a 20 mL methanol solution of paraformaldehyde, and the mixture was stirred for 48 h at room temperature. Upon completion of the reaction, the solvent was removed by rotary evaporator and the residue was distilled under reduced pressure to give 6.3 g (86% yield) of light yellow viscous liquid. The physicochemical properties of the obtained compound (I) were in accordance with the data reported in literature [9].
Toxics Screening Level
The initial threshold screening level (ITSL) for 1,3,5-triazine-1,3,5(2H,4H,6H)-triethanol (CAS # 4719-04-4) is 0.015 μg/m3 with an annual averaging time.
References
[1] Helvetica Chimica Acta, 2007, vol. 90, # 9, p. 1765 - 1780
[2] Russian Journal of Applied Chemistry, 2015, vol. 88, # 7, p. 1174 - 1177
[3] Zh. Prikl. Khim. (S.-Peterburg, Russ. Fed.), 2015, vol. 88, # 7, p. 1083 - 1086,4
[4] Zhurnal Obshchei Khimii, 1953, vol. 23, p. 1771,1773; engl. Ausg. S. 1869, 1871
[5] Chemische Berichte, 1949, vol. 82, p. 316,326
[6] PRETTY J, GLASER R, III J J, et al. A technique for the identification and direct analysis of hexahydro-1,3,5-tris(2-hydroxyethyl)-s-triazine in metalworking fluids using electrospray-mass spectrometry[J]. Analyst, 2004, 11: 1150-1155. DOI:10.1039/B404578E.
[7] HARTWIG A. <i>N</i>,<i>N’</i>,<i>N”</i>-Tris(β-hydroxyethyl)hexahydro-1,3,5-triazine: MAK Value Documentation, addendum - Translation of the German version from 2023.[J]. The MAK collection for occupational health and safety, 2025, 10 3: Doc049. DOI:10.34865/mb471904kske10\_3ad.
Hexahydro-1,3,5-tris(hydroxyethyl)-s-triazine Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jinan Qinmu Fine Chemical Co.,Ltd. | +8618660799346 | sales@qinmuchem.com | China | 1008 | 58 |
| Wuhan Silworld Chemical Co.,Ltd | +86-027-85613400 +86-15827173649 | info@silworldchemical.com | China | 178 | 58 |
| Nanjing Huazhou New Material Co., Ltd. | +86-25-57888115; +8618913378169 | howard.wu@chinaredsun.com | China | 15 | 58 |
| Hebei Fengjia New Material Co., Ltd | +86-0311-87836622 +86-18712993135 | sales01@tairunfaz.com | China | 8051 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8618531123677 | faithe@yan-xi.com | China | 5853 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-86-13131129325 +8613131129325 | sales1@chuanghaibio.com | China | 5228 | 58 |
| Hebei Jingbo New Material Technology Co., Ltd | +8619931165850 | hbjbtech@163.com | China | 1000 | 58 |
| Hebei Zhuanglai Chemical Trading Co.,Ltd | +8613343047651 | admin@zlchemi.com | China | 3692 | 58 |
| Hebei Longbang Technology Co., LTD | +86-18633929156 | admin@hblongbang.com | China | 972 | 58 |
| Shandong Deshang Chemical Co., Ltd. | +86-0531-8875-2665 +8613153039501 | info@deshangchem.com | China | 661 | 58 |
Related articles
- Analysis and application research of hexahydro-1,3,5-tris(hydroxyethyl)-s-triazine
- Hexahydro-1,3,5-tris(2-hydroxyethyl)-s-triazine is a widely used biocide in metalworking fluids that resists direct quantifica....
- Apr 23，2026
View Lastest Price from Hexahydro-1,3,5-tris(hydroxyethyl)-s-triazine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2026-06-05 | Hexahydro-1,3,5-tris(hydroxyethyl)-s-triazine
4719-04-4
|
0.99 | RongNa Biotechnology Co.,Ltd | ||||
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2026-05-28 | Hexahydro-1,3,5-tris(hydroxyethyl)-s-triazine
4719-04-4
|
$2.00-5.00 | 1KG | 99% | 10000kg | Hebei Chuanghai Biotechnology Co,.LTD | |
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2026-02-25 | Hexahydro-1,3,5-tris(hydroxyethyl)-s-triazine
4719-04-4
|
$68.00-72.00 | 10kg | 99.99% | 100Tons | Hebei Dangtong Import and export Co LTD |
-
- Hexahydro-1,3,5-tris(hydroxyethyl)-s-triazine
4719-04-4
- 0.99
- RongNa Biotechnology Co.,Ltd
-
- Hexahydro-1,3,5-tris(hydroxyethyl)-s-triazine
4719-04-4
- $2.00-5.00
- 99%
- Hebei Chuanghai Biotechnology Co,.LTD
-
- Hexahydro-1,3,5-tris(hydroxyethyl)-s-triazine
4719-04-4
- $68.00-72.00
- 99.99%
- Hebei Dangtong Import and export Co LTD
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