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Hexahydro-1,3,5-tris(hydroxyethyl)-s-triazine

Hexahydro-1,3,5-tris(hydroxyethyl)-s-triazine structure

CAS No.: 4719-04-4

Chemical Name:: Hexahydro-1,3,5-tris(hydroxyethyl)-s-triazine

Synonyms: actane;Hexahydrotriazine;Nipacide BK;Hexahydro-1;TRIS(N-HYDROXYETHYL) HEXAHYDROTRIAZINE;1,3,5-triazine-1,3,5(2h,4h,6h)-triethanol;Hexahydro-1,3,5-tris(2-hydroxyethyl)-s-triazine;1,3,5-Tris(2-hydroxyethyl)hexahydro-1,3,5-triazine;BK-8;eta75

CBNumber:: CB0425698

Molecular Formula:: C9H21N3O3

Molecular Weight:: 219.28

MDL Number:: MFCD01678788

MOL File:: 4719-04-4.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-09-09 19:30:26

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Hexahydro-1,3,5-tris(hydroxyethyl)-s-triazine Properties

Boiling point	360.1°C (rough estimate)
Density	1.1269 (rough estimate)
vapor pressure	0Pa at 25℃
refractive index	1.4830 (estimate)
storage temp.	2-8°C
solubility	Ethyl Acetate (Slightly, Sonicated), Water (Slightly)
form	Oil to Low-Melting Solid
pka	14.16±0.10(Predicted)
color	Off-White to Yellow
Water Solubility	Soluble (>=1 g/100 mL at 24 ºC)
Cosmetics Ingredients Functions	SKIN CONDITIONING SKIN PROTECTING
InChI	InChI=1S/C9H21N3O3/c13-4-1-10-7-11(2-5-14)9-12(8-10)3-6-15/h13-15H,1-9H2
InChIKey	HUHGPYXAVBJSJV-UHFFFAOYSA-N
SMILES	N1(CCO)CN(CCO)CN(CCO)C1
LogP	-2 at 24℃
CAS DataBase Reference	4719-04-4(CAS DataBase Reference)
FDA UNII	OU2JEB22IE
EPA Substance Registry System	Hexahydro-1,3,5-tris(2-hydroxyethyl)-s-triazine (4719-04-4)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H317
Precautionary statements	P264-P270-P301+P312-P330-P501-P261-P272-P280-P302+P352-P333+P313-P321-P363-P501
Hazard Codes	Xn
Risk Statements	22-43
Safety Statements	24-37
RIDADR	2810
TSCA	TSCA listed
HazardClass	6.1(b)
PackingGroup	III
Toxicity	LD50 oral in rat: 763mg/kg
REACH Registrations	Active
Limited Quantities	5.0 kg (11 lbs) (solid)
Excepted Quantities	Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)

Hexahydro-1,3,5-tris(hydroxyethyl)-s-triazine price More Price(21)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	TRC-T767345-1G	s-Triazine-1,3,5-triethanol	4719-04-4	1g	$265	2026-06-03	Buy
TRC	TRC-T767345-10G	s-Triazine-1,3,5-triethanol	4719-04-4	10g	$1584	2026-06-03	Buy
TRC	TRC-T767345-100MG	s-Triazine-1,3,5-triethanol	4719-04-4	100mg	$97	2026-06-03	Buy
Usbiological	022089	s-Triazine-1,3,5-triethanol ≥98%	4719-04-4	100mg	$347	2026-06-03	Buy
Usbiological	022089	s-Triazine-1,3,5-triethanol ≥98%	4719-04-4	250mg	$482	2026-06-03	Buy

Product number	Packaging	Price	Buy
TRC-T767345-1G	1g	$265	Buy
TRC-T767345-10G	10g	$1584	Buy
TRC-T767345-100MG	100mg	$97	Buy
022089	100mg	$347	Buy
022089	250mg	$482	Buy

Hexahydro-1,3,5-tris(hydroxyethyl)-s-triazine Chemical Properties,Uses,Production

Description

Grotan BK is a triazine derivative contained in cutting fluids. It is a formaldehyde releaser. Hexahydro-1,3,5-tris(hydroxyethyl)-s-triazine is a light-yellow liquid. It is a formaldehyde condensate product that is used as an antimicrobial agent in metal working fluids.

Chemical Properties

Light Yellow Solid

Uses

Hexahydro-l,3,5-tris-(2-hydroxyethyl)triazin is used in organic synthesis; as a bactericide in cooling fluids and various cosmetic products; formaldehyde liberator.

General Description

Viscous yellow liquid.

Air & Water Reactions

Water soluble.

Reactivity Profile

Hexahydro-1,3,5-tris(hydroxyethyl)-s-triazine is an amine and an alcohol. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.

Health Hazard

Hexahydro-1,3,5-tris(hydroxyethyl)-s-triazine (TA, CAS 4719-04-4) is a widely used biocide added to water-based metalworking fluids (MWF) to control microbial populations. However, uncontrolled concentrations of this biocide within metalworking fluids may induce allergic pneumonitis. The mechanism may involve TA eliminating other competing microorganisms while simultaneously inducing the emergence of biocide-resistant mycobacteria, leading to their excessive proliferation within the fluid's sedimentation tanks ^[6]. Furthermore, TA rapidly releases formaldehyde in diluted aqueous solutions. This substance exhibits strong irritant and corrosive effects on rabbit skin, eyes, and upper respiratory tract, attributed to the formation of irritant formaldehyde and 2-aminoethanol. As formaldehyde is released from TA, this substance is classified as a Category 4 carcinogen alongside formaldehyde. The aerosol form of TA is classified as a Category 2 carcinogen. As no data currently exist on the systemic bioavailability of TA released through hydrolysis in tissues, nor is there experimental evidence indicating formaldehyde reaches germ cells, TA has been categorised as a Category 3B germ cell mutagen. Skin contact is not anticipated to contribute significantly to systemic toxicity^[7].

Fire Hazard

Hexahydro-1,3,5-tris(hydroxyethyl)-s-triazine is probably combustible.

Flammability and Explosibility

Not classified

Contact allergens

Grotan BK is a triazine derivative contained as a bio cide in cutting fluids. It is a formaldehyde releaser. Dermatitis, delayed-type allergic conjunctivitis, and asthma were described.

Synthesis

50-00-0

141-43-5

Hexahydro-1,3,5-tris(hydroxyethyl)-s-triazine

4719-04-4

General procedure for the synthesis of hydroxyethyl hexahydrohomotriazine from formaldehyde and 2-aminoethanol: To 6.1 g (0.1 mol) of 2-aminoethanol was added 3.0 g (0.1 mol as formaldehyde) of a 20 mL methanol solution of paraformaldehyde, and the mixture was stirred for 48 h at room temperature. Upon completion of the reaction, the solvent was removed by rotary evaporator and the residue was distilled under reduced pressure to give 6.3 g (86% yield) of light yellow viscous liquid. The physicochemical properties of the obtained compound (I) were in accordance with the data reported in literature [9].

Toxics Screening Level

The initial threshold screening level (ITSL) for 1,3,5-triazine-1,3,5(2H,4H,6H)-triethanol (CAS # 4719-04-4) is 0.015 μg/m3 with an annual averaging time.

References

[1] Helvetica Chimica Acta, 2007, vol. 90, # 9, p. 1765 - 1780
[2] Russian Journal of Applied Chemistry, 2015, vol. 88, # 7, p. 1174 - 1177
[3] Zh. Prikl. Khim. (S.-Peterburg, Russ. Fed.), 2015, vol. 88, # 7, p. 1083 - 1086,4
[4] Zhurnal Obshchei Khimii, 1953, vol. 23, p. 1771,1773; engl. Ausg. S. 1869, 1871
[5] Chemische Berichte, 1949, vol. 82, p. 316,326
[6] PRETTY J, GLASER R, III J J, et al. A technique for the identification and direct analysis of hexahydro-1,3,5-tris(2-hydroxyethyl)-s-triazine in metalworking fluids using electrospray-mass spectrometry[J]. Analyst, 2004, 11: 1150-1155. DOI:10.1039/B404578E.
[7] HARTWIG A. N,N’,N”-Tris(β-hydroxyethyl)hexahydro-1,3,5-triazine: MAK Value Documentation, addendum - Translation of the German version from 2023.[J]. The MAK collection for occupational health and safety, 2025, 10 3: Doc049. DOI:10.34865/mb471904kske10\_3ad.

Hexahydro-1,3,5-tris(hydroxyethyl)-s-triazine synthesis

Synthesis of Hexahydro-1,3,5-tris(hydroxyethyl)-s-triazine from Formaldehyde and Monoethanolamine

Hexahydro-1,3,5-tris(hydroxyethyl)-s-triazine Preparation Products And Raw materials

Raw materials

deodorant 1,3-Oxazolidine 1,3,5-trioxane Monoethanolamine 2-(1,3,5-Dithiazinan-5-yl)ethanol

Formaldehyde

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Preparation Products

finishing agent for polyester fiber

Hexahydro-1,3,5-tris(hydroxyethyl)-s-triazine Suppliers

Global( 240)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Tianjin Kewejinhong Environmental Protection Technology Co. LTD	--		China	20	58
Foshan Liyuan Chemical Co., Ltd	13889923167 13690318880	1170464690@qq.com	China	56	58
Wuhan Silworld Chemical Co.,Ltd	027-85613400 18707177243	info@silworldchemical.com	China	292	58
Dalian Tianwei Chemical Co.,Ltd.	0411-82384176; 18641134053	914565705@qq.com	China	20	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Chemsky（shanghai）International Co.,Ltd.	021-50135380	shchemsky@sina.com	China	32273	50
Shandong Xiya Chemical Co., Ltd	13355009207 13355009207	3007715519@qq.com	China	18722	57
Sichuan Kulinan Technology Co., Ltd	400-1166-196 18981987031	cdhxsj@163.com	China	11674	57
China Langchem Inc.	0086-21-58956006		China	7798	57

Supplier	Advantage
Tianjin Kewejinhong Environmental Protection Technology Co. LTD	58
Foshan Liyuan Chemical Co., Ltd	58
Wuhan Silworld Chemical Co.,Ltd	58
Dalian Tianwei Chemical Co.,Ltd.	58
J & K SCIENTIFIC LTD.	76
Energy Chemical	61
Chemsky（shanghai）International Co.,Ltd.	50
Shandong Xiya Chemical Co., Ltd	57
Sichuan Kulinan Technology Co., Ltd	57
China Langchem Inc.	57

Analysis and application research of hexahydro-1,3,5-tris(hydroxyethyl)-s-triazine
Hexahydro-1,3,5-tris(2-hydroxyethyl)-s-triazine is a widely used biocide in metalworking fluids that resists direct quantifica....
Apr 23,2026

View Lastest Price from Hexahydro-1,3,5-tris(hydroxyethyl)-s-triazine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-13	Hexahydro-1,3,5-tris(hydroxyethyl)-s-triazine 4719-04-4			0.99		RongNa Biotechnology Co.,Ltd
2026-09-09	MEA TRIAZINE 4719-04-4		1KG	99%	2000000 KG	Shanghai Sunwise Chemical Co., Ltd
2026-08-21	Hexahydro-1,3,5-tris(hydroxyethyl)-s-triazine 4719-04-4	$68.00-72.00	10kg	99.99%	100Tons	Hebei Dangtong Import and export Co LTD

Hexahydro-1,3,5-tris(hydroxyethyl)-s-triazine
4719-04-4
0.99
RongNa Biotechnology Co.,Ltd

MEA TRIAZINE
4719-04-4
99%
Shanghai Sunwise Chemical Co., Ltd

Hexahydro-1,3,5-tris(hydroxyethyl)-s-triazine
4719-04-4
$68.00-72.00
99.99%
Hebei Dangtong Import and export Co LTD

Hexahydro-1,3,5-tris(hydroxyethyl)-s-triazine Spectrum

Hexahydro-1,3,5-tris(hydroxyethyl)-s-triazine(4719-04-4)¹HNMR

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1,3,5-Triazine 2-(Methylsulfonyl)ethanol Wood mold remover

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HEXAHYDRO-1,3,5-TRIS(2-HYDROXYETHYL)-TRIAZINE HEXAHYDRO-1,3,5-TRIS(HYDROXYETHYL)-S-TRIAZINE HEXAHYDRO-1,3,5-TRIS(HYDROXYETHYL)TRIAZINE 2,2’,2’’-(hexahydro-1,3,5-triazine-1,3,5-triyl)triethanol Triethanol = Hexahydro - 1,3,5, - Tri - Hydroxyethyl - S-Triazine s-Triazine-1,3,5-triethanol 1,3,5-TRI-(2-HYDROXYETHYL)-HEXAHYDRO-1,3,5-TRIAZINE 2,2',2''-(1,3,5-Triazinane-1,3,5-triyl)triethanol 2,2',2''-(1,3,5-Triazinane-1,3,5-triyl) triethanol HEXAHYDRO-1,3,5 1,3,5-Tris(2-hydroxyethyl)-1,3,5-triazacyclohexane Acticide GR Bactraclean Bioban GK Busan 1506 Cobate C Hexahydro-1,3,5-tri(2-hydroxyethyl)-s-triazine KM 200 N,N',N''-Tris(2-hydroxyethyl)hexahydro-s-triazine N,N',N''-Tris(β-hydroxyethyl)hexahydro-s-triazine Nipacide BK NSC 516387 PerMacheM OB 2 Protectol HT Roksol busan1060 eta75 grotanb grotanbk kalpurte km200(alcohol) onyxide200 roksolt1-7 s-triazine-1,3,5(2h,4h,6h)-triethanol 1,3,5-tris-(2-Hydroxyethyl)hexahydro triazine Trizin Triadine10 1,3,5-Tris(2-hydroxyethyl) hexahydro-s-triazine Hexahydro-1,3,5-tris(2-hydroxyethyl)-s-triazine anticorrosive 1^<#^> NNNTRIS2HYDROXYETHYLHEXAHYDRO135TRIAZINE 1,3,5-TRIHYDROXYETHYLHEXAHYDROTRIAZINE N,N,N-TRIS(HYDROXYETHYL)-HEXAHYDRO-TRIAZINE HEXAHYDRO-1,3,5-TRIS(HYDROXYETHYL)TRIAZIN 2,2′,2′′-(Hexahydro-1,3,5-triazin-1,3,5-triyl)triethanol Triazine-1,3,5(2H,4H,6H)-triethanol, s-: (Onyxide 200)) 2,2',2"-(hexahydro-1,3,5-triazine-1,3,5-triyl)triethanol 1,3,5-tris(2-hydroxyethyl)hexahydro-1,3,5-triazine 1,3,5-Triazine-1,3,5(2H,4H,6H)-tris(ethanol) 2,2',2''-[1,3,5-Triazine-1,3,5(2H,4H,6H)-triyl]triethanol Hexahydro-1,3,5-triazine-1,3,5-triethanol Hexahydro-s-triazine-1,3,5-trisethanol Tris-(b-hydroxyethyl)-hexahydrotriazin, 1,3,5-tris(2-hydroxyethyl)hexahydro-1,3,5-triazine, 2,2',2"-(hexahydro-1,3,5-triazine-1,3,5-triyl)triethanol Hexahydro-1,3,5-tris-(2-hydroxyethyl)-1,3,5-triazine 1,3,5-triazine-1,3,5(2h,4h,6h)-triethanol BK Hexahydro-1,3,5-tris(hydroxyethyL )-s-triazine Monoethanoloamine (MEA) triazine H2S scavenger