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1,2-Benzisothiazol-3(2H)-one

1,2-Benzisothiazol-3(2H)-one Structure
1,2-Benzisothiazol-3(2H)-one structure
CAS No.
2634-33-5
Chemical Name:
1,2-Benzisothiazol-3(2H)-one
Synonyms
BIT;1,2-BENZISOTHIAZOLIN-3-ONE;BENZISOTHIAZOLINONE;BIT-85;Benzo[d]isothiazol-3(2H)-one;BENZISOTHIAZOLONE;proxel;MFR;BIT-20;Benzisothiazolin-3-one
CBNumber:
CB1496512
Molecular Formula:
C7H5NOS
Molecular Weight:
151.19
MDL Number:
MFCD00044001
MOL File:
2634-33-5.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-06-24 18:39:39
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1,2-Benzisothiazol-3(2H)-one Properties

Melting point 154-158 °C(lit.)
Boiling point 360°C (rough estimate)
Density 1.2170 (rough estimate)
vapor pressure 0Pa at 25℃
refractive index 1.5500 (estimate)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility Soluble in dichloromethane, dimethyl sulfoxide, methanol.
pka 10.19±0.20(Predicted)
form Solid
color White to Light yellow to Light orange
biological source rabbit
Water Solubility 1.288g/L at 20℃
Major Application cleaning products
cosmetics
environmental
food and beverages
personal care
Cosmetics Ingredients Functions ANTIMICROBIAL
InChI 1S/C7H5NOS/c9-7-5-3-1-2-4-6(5)10-8-7/h1-4H,(H,8,9)
InChIKey DMSMPAJRVJJAGA-UHFFFAOYSA-N
SMILES Oc1nsc2ccccc12
LogP 0.7 at 20℃
CAS DataBase Reference 2634-33-5
FDA 21 CFR 175.105; 176.170; 176.180;176.300; 177.2600
Indirect Additives used in Food Contact Substances 1,2-BENZISOTHIAZOLIN-3-ONE
EWG's Food Scores 3-7
FDA UNII HRA0F1A4R3
EPA Substance Registry System 1,2-Benzisothiazolin-3-one (2634-33-5)
UNSPSC Code 41116107
NACRES NA.41

SAFETY

Risk and Safety Statements

Symbol(GHS)  Corrosion (GHS05)Exclamation Mark (GHS07)Environment (GHS09)
GHS05,GHS07,GHS09
Signal word  Danger
Hazard statements  H302-H315-H317-H318-H400
Precautionary statements  P261-P273-P280-P301+P312-P302+P352-P305+P351+P338
PPE dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Hazard Codes  Xn,N
Risk Statements  22-38-41-43-50
Safety Statements  24-26-37/39-61
RIDADR  UN 3077 9/PG 3
WGK Germany  2
RTECS  DE4620000
TSCA  TSCA listed
HazardClass  9
HazardClass  IRRITANT
PackingGroup  Ⅲ
HS Code  29339900
Storage Class 11 - Combustible Solids
Hazard Classifications Acute Tox. 4 Oral
Aquatic Acute 1
Eye Dam. 1
Skin Irrit. 2
Skin Sens. 1
Hazardous Substances Data 2634-33-5(Hazardous Substances Data)
Toxicity LD50 oral in rat: 1020mg/kg
REACH Registrations Active
NFPA 704
1
2 0

1,2-Benzisothiazol-3(2H)-one price More Price(55)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SAB4502639 Anti-SIRP α1, C-Terminal antibody produced in rabbit affinity isolated antibody 100μG $560 2026-04-30 Buy
Sigma-Aldrich 561487 1,2-Benzisothiazol-3(2H)-one 97% 2634-33-5 5g $81.5 2026-04-30 Buy
Sigma-Aldrich 561487 1,2-Benzisothiazol-3(2H)-one 97% 2634-33-5 25g $237 2026-04-30 Buy
TCI Chemical B2430 1,2-Benzisothiazol-3(2H)-one >98.0%(GC) 2634-33-5 25g $47 2026-04-30 Buy
TCI Chemical B2430 1,2-Benzisothiazol-3(2H)-one >98.0%(GC) 2634-33-5 100g $126 2026-04-30 Buy
Product number Packaging Price Buy
SAB4502639 100μG $560 Buy
561487 5g $81.5 Buy
561487 25g $237 Buy
B2430 25g $47 Buy
B2430 100g $126 Buy

1,2-Benzisothiazol-3(2H)-one Chemical Properties,Uses,Production

Description

BIT (1,2-Benzisothiazol-3(2H)-one) is an irritant and also a skin sensitizer. Occupational allergie contact dermatitis has been reported mainly related to the use of cutting oils and greases in paint manufacturers, pottery mouldmakers, acrylic emulsion manufacturers, plumbers, printers and lithoprinters, paper makers, an analyticallaboratory, a rubber factory, and in employees manufacturing air fresheners.

Chemical Properties

Yellow Powder

Uses

Antimicrobial agent.

Uses

Isothiazolinone BIT is widely used in industry as a preservative in water-based solutions, such as pastes, paints and cutting oils. It exists at different concentrations in the different Proxel AB, GXL, CRL, XL2, XL, HL, TN, and in Mergal K-10.

Definition

ChEBI: Benzo[d]isothiazol-3-one is an organic heterobicyclic compound based on a fused 1,2-thiazole and benzene bicyclic ring skeleton, with the S atom positioned adjacent to one of the positions of ring fusion. It has a role as a disinfectant, a platelet aggregation inhibitor, an environmental contaminant, a xenobiotic, a drug allergen and a sensitiser. It is an organonitrogen heterocyclic compound and an organic heterobicyclic compound.

Application

1,2-benzisothiazol-3(2H)-one (BIT) has been widely used in high concentrations for microbial growth control in many domestic and industrial processes, its potential eco-risk should be assessed.

General Description

1,2-Benzisothiazol-3(2H)-one is a commonly used biocide in industrial and consumer products, which possesses antimicrobial activity against gram positive and gram negative bacteria. It is mainly used in packaging, adhesives, detergents, disinfectants, sunscreen lotions, paints and lubricants.

Flammability and Explosibility

Not classified

Contact allergens

1,2-Benzisothiazol-3(2H)-one, both an irritant and a skin sensitizer, is widely used in industry as a preservative in water-based solutions such as pastes, paints, and cutting oils. Occupational dermatitis has been reported mainly due to cutting fluids and greases, in paint manufacturers, pottery moldmakers, acrylic emulsions manufacturers, plumber,printers and lithoprinters, paper makers, analytical laboratory, rubber factory, and employees manufacturing air fresheners. It is also a preservative in vinyl gloves.

Safety Profile

Moderately toxic by ingestion.When heated to decomposition it emits toxic vapors ofNOx and SOx.

Toxicity evaluation

Isothiazolinones, such as 1,2-benzisothiazol-3(2H)-one (BIT), are widely used as biocides for bacterial growth control in many domestic and industrial processes. Despite their advantages as biocides, they are highly toxic and pose a potential risk to the environment.  BIT could seriously inhibit the growth of Scenedesmus sp. LX1, Chlorella sp. HQ, and Chlamydomonas reinhardtii with half maximal effective concentrations at 72 h (72h-EC50) of 1.70, 0.41, and 1.16 mg/L, respectively. The primary inhibition mechanism was the BIT-induced damage to microalgal photosynthetic systems.

Toxics Screening Level

The Initial Threshold Screening Level (ITSL) for 1,2-benzisothiazol-3(2H)-one of 0.1 μg/m3 with annual averaging time is being rescinded.

1,2-Benzisothiazol-3(2H)-one synthesis

2527-57-3
5697-20-1
2634-33-5
Synthesis of 1,2-Benzisothiazol-3(2H)-one from 2,2'-dithiobisbenzamide and 2-sulfanylbenzamide

1,2-Benzisothiazol-3(2H)-one Preparation Products And Raw materials

Raw materials

Preparation Products

3-Chloro-1,2-benzisothiazole 3-(1-Piperazinyl)-1,2-benzisothiazole 2-(benzo[d]isothiazol-3-ylaMino)ethanol 3-(3-Oxo-1,2-benzisothiazol-2(3H)-yl)propanoic acid

1,2-Benzisothiazol-3(2H)-one Suppliers

Global( 686)Suppliers
Supplier Tel Email Country ProdList Advantage
Jinan Wald Chemical Co., Ltd. 0531-88773586 13210588999 304264064@qq.com China 192 58
Hangzhou Jingyou Chemical Co., Ltd. 87211835 13957193240 sales@jingyouchem.com China 211 58
Shanghai Witofly Chemical Co. ,Ltd. 02150630626 17717886015 sales@witofly.com China 1864 55
Dalian Tianwei Chemical Co.,Ltd. 0411-82384176; 18641134053 914565705@qq.com China 20 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 3bsc@sina.com China 15813 69
future industrial shanghai co., ltd 400-0066400 13621662912 sales@jonln.com China 1989 65
shilang(zhuoli group)-pharma(nanjing) co.,ltd. 86-25-87797880,81,82 -809 shilang@shilang-pharma.com China 40 55
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
Supplier Advantage
Jinan Wald Chemical Co., Ltd. 58
Hangzhou Jingyou Chemical Co., Ltd. 58
Shanghai Witofly Chemical Co. ,Ltd. 55
Dalian Tianwei Chemical Co.,Ltd. 58
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
3B Pharmachem (Wuhan) International Co.,Ltd. 69
future industrial shanghai co., ltd 65
shilang(zhuoli group)-pharma(nanjing) co.,ltd. 55
Alfa Aesar 84

Related articles

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  • Apr 22,2022

View Lastest Price from 1,2-Benzisothiazol-3(2H)-one manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
1,2-Benzisothiazolin-3-one pictures 2026-09-11 1,2-Benzisothiazolin-3-one
2634-33-5
 0.99 RongNa Biotechnology Co.,Ltd
1,2-benzothiazol-3-one pictures 2026-06-30 1,2-benzothiazol-3-one
2634-33-5
 1kg 98% 1000kg Shaanxi Dideu New Materials Co. Ltd
1,2-benzisothiazolin-3-one pictures 2026-05-28 1,2-benzisothiazolin-3-one
2634-33-5
 $12.00 1KG 99.8% 5000kg Hebei Chuanghai Biotechnology Co,.LTD

1,2-Benzisothiazol-3(2H)-one Spectrum

1,2-Benzisothiazol-3(2H)-one(2634-33-5)MS1,2-Benzisothiazol-3(2H)-one(2634-33-5)1HNMR1,2-Benzisothiazol-3(2H)-one(2634-33-5)13CNMR1,2-Benzisothiazol-3(2H)-one(2634-33-5)IR11,2-Benzisothiazol-3(2H)-one(2634-33-5)IR2

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Benzisothiazolin-3-on (BIT) 2$l^{4}-thia-6-azatricyclo[5.4.0.0^{2,6}]undeca-1(7),8,10-trien-5-one 1,2-benzo-isothiazolin-3-ketone Acticide BIT Apizas AP-DS Bestcide 200K Bioban BIT 20DPG Canguard BIT Canguard BIT 20DPG Benzisothiazolin-3-one (BIT) 1,2-Benzisothiazol Benzo[d]isothiazol-3(2H)-one, 98% 99% Benziothiazolinone solution Anti-SIRP α1, C-Terminal antibody produced in rabbit brain Ig-like molecule with tyrosine-based activation motifs inhibitory receptor SHPS-1 Macrophage fusion receptor Benziothiazolinone Solution, 1000ppm 1,2-Benzisothiazoline-3-on 1,2-Benzisothiazolin-3-one BIT IN STOCK 2,3-dihydro-3-oxo-1,2-benzisothiazole BIT20/Proxel Gxl proxelpl 1,2-Benzisothiazol-3-ol Benzocil Proxel AB 1-Thia-2-azaindan-3-one 2,3-Dihydro-1,2-benzisothiazole-3-one Proxel XL proxil 1,2-Benzisothiazol-3(2H)-one ,98% 1,2-Benzisothiazolin 1,2-Benzisothiazol-3(2H)-one [for BiocheMical Research] 2-Benzisothiazolin-3-one 1,2-Benzisothiazol-3(2H-)-one Benziothiazolinone solution,100ppm 1,2-BENZISOTHAZOL-3(2H)-ONE 1,2-BENZISOTHIAZOL-3(2H)-ONE 1,2-BENZISOTHIAZOL-3-ONE (BIT) 1,2-Benzisothiazoline-3(2H)-one 1,2-BENZISOTHIAZOL-3(2H)-ONE HYDRATE 1,2-BENZISOTHIAZOLIN-3-ONE (BIT) 98.5% 1,2-Benisothiazolin-3-One-2-Sodium Salt 1,2-Benzisothiazolin-3-One(Bit) 1,2-Bezisothiazolin-3-One(Bit) 1.2-Benzisothiazol-3(2H)-on 1,2-Benzisothiazolone 3-Hydroxy-1,2-benzisothiazole BIOCIDE--BIT 1,2-BENZISOTHLAZOLIN-3-ONE 1,2-BENZOISOTHIAZOLINE-3-ONE 1,2-BENZISOTHIAZOLINON-3-ONE PROXELHL 2-Hydrobenzo[d]isothiazol-3-one 1,2-benzisothiazol-3(2H)-one 1,2-benzisothiazolin-3-one 1,2-Benzisothiazol-3(2H)-one [for Biochemical Research]> 1,2-Benzisothiazol-3(2H)-one > -3(2H)-one