1,2-Benzisothiazol-3(2H)-one
- CAS No.
- 2634-33-5
- Chemical Name:
- 1,2-Benzisothiazol-3(2H)-one
- Synonyms
- BIT;1,2-BENZISOTHIAZOLIN-3-ONE;BENZISOTHIAZOLINONE;BIT-85;Benzo[d]isothiazol-3(2H)-one;BENZISOTHIAZOLONE;proxel;1,2-benzisothiazoline-3-one;MFR;1,2-Benzisothiazolin
- CBNumber:
- CB1496512
- Molecular Formula:
- C7H5NOS
- Molecular Weight:
- 151.19
- MDL Number:
- MFCD00044001
- MOL File:
- 2634-33-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Anti-SIRP α1, C-Terminal antibody produced in rabbit affinity isolated antibody | SAB4502639 | 100μG | $560 |
| 1,2-Benzisothiazol-3(2H)-one 97% | 561487 | 5g | $81.5 |
| 1,2-Benzisothiazol-3(2H)-one 97% | 561487 | 25g | $237 |
| 1,2-Benzisothiazol-3(2H)-one >98.0%(GC) | B2430 | 25g | $47 |
| 1,2-Benzisothiazol-3(2H)-one >98.0%(GC) | B2430 | 100g | $126 |
| More product size | |||
| Melting point | 154-158 °C(lit.) |
|---|---|
| Boiling point | 360°C (rough estimate) |
| Density | 1.2170 (rough estimate) |
| vapor pressure | 0Pa at 25℃ |
| refractive index | 1.5500 (estimate) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | Soluble in dichloromethane, dimethyl sulfoxide, methanol. |
| pka | 10.19±0.20(Predicted) |
| form | Solid |
| color | White to Light yellow to Light orange |
| biological source | rabbit |
| Water Solubility | 1.288g/L at 20℃ |
| Major Application |
cleaning products cosmetics environmental food and beverages personal care |
| Cosmetics Ingredients Functions | ANTIMICROBIAL |
| InChI | 1S/C7H5NOS/c9-7-5-3-1-2-4-6(5)10-8-7/h1-4H,(H,8,9) |
| InChIKey | DMSMPAJRVJJAGA-UHFFFAOYSA-N |
| SMILES | Oc1nsc2ccccc12 |
| LogP | 0.7 at 20℃ |
| CAS DataBase Reference | 2634-33-5 |
| Indirect Additives used in Food Contact Substances | 1,2-BENZISOTHIAZOLIN-3-ONE |
| FDA 21 CFR | 176.300; 177.2600 |
| EWG's Food Scores | 3-7 |
| FDA UNII | HRA0F1A4R3 |
| EPA Substance Registry System | 1,2-Benzisothiazolin-3-one (2634-33-5) |
| UNSPSC Code | 41116107 |
| NACRES | NA.41 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS05,GHS07,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H315-H317-H318-H400 | |||||||||
| Precautionary statements | P261-P273-P280-P301+P312-P302+P352-P305+P351+P338 | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Faceshields, Gloves | |||||||||
| Hazard Codes | Xn,N | |||||||||
| Risk Statements | 22-38-41-43-50 | |||||||||
| Safety Statements | 24-26-37/39-61 | |||||||||
| RIDADR | UN 3077 9/PG 3 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | DE4620000 | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | IRRITANT | |||||||||
| HazardClass | 9 | |||||||||
| PackingGroup | Ⅲ | |||||||||
| HS Code | 29339900 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Aquatic Acute 1 Eye Dam. 1 Skin Irrit. 2 Skin Sens. 1 |
|||||||||
| Hazardous Substances Data | 2634-33-5(Hazardous Substances Data) | |||||||||
| Toxicity | LD50 oral in rat: 1020mg/kg | |||||||||
| REACH Registrations | Active | |||||||||
| NFPA 704 |
|
1,2-Benzisothiazol-3(2H)-one price More Price(41)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SAB4502639 | Anti-SIRP α1, C-Terminal antibody produced in rabbit affinity isolated antibody | 100μG | $560 | 2026-04-30 | Buy | |
| Sigma-Aldrich | 561487 | 1,2-Benzisothiazol-3(2H)-one 97% | 2634-33-5 | 5g | $81.5 | 2026-04-30 | Buy |
| Sigma-Aldrich | 561487 | 1,2-Benzisothiazol-3(2H)-one 97% | 2634-33-5 | 25g | $237 | 2026-04-30 | Buy |
| TCI Chemical | B2430 | 1,2-Benzisothiazol-3(2H)-one >98.0%(GC) | 2634-33-5 | 25g | $47 | 2026-04-30 | Buy |
| TCI Chemical | B2430 | 1,2-Benzisothiazol-3(2H)-one >98.0%(GC) | 2634-33-5 | 100g | $126 | 2026-04-30 | Buy |
1,2-Benzisothiazol-3(2H)-one Chemical Properties,Uses,Production
Description
BIT (1,2-Benzisothiazol-3(2H)-one) is an irritant and also a skin sensitizer. Occupational allergie contact dermatitis has been reported mainly related to the use of cutting oils and greases in paint manufacturers, pottery mouldmakers, acrylic emulsion manufacturers, plumbers, printers and lithoprinters, paper makers, an analyticallaboratory, a rubber factory, and in employees manufacturing air fresheners.
Chemical Properties
Yellow Powder
Uses
Antimicrobial agent.
Uses
Isothiazolinone BIT is widely used in industry as a preservative in water-based solutions, such as pastes, paints and cutting oils. It exists at different concentrations in the different Proxel AB, GXL, CRL, XL2, XL, HL, TN, and in Mergal K-10.
Definition
ChEBI: Benzo[d]isothiazol-3-one is an organic heterobicyclic compound based on a fused 1,2-thiazole and benzene bicyclic ring skeleton, with the S atom positioned adjacent to one of the positions of ring fusion. It has a role as a disinfectant, a platelet aggregation inhibitor, an environmental contaminant, a xenobiotic, a drug allergen and a sensitiser. It is an organonitrogen heterocyclic compound and an organic heterobicyclic compound.
Application
1,2-benzisothiazol-3(2H)-one (BIT) has been widely used in high concentrations for microbial growth control in many domestic and industrial processes, its potential eco-risk should be assessed.
General Description
1,2-Benzisothiazol-3(2H)-one is a commonly used biocide in industrial and consumer products, which possesses antimicrobial activity against gram positive and gram negative bacteria. It is mainly used in packaging, adhesives, detergents, disinfectants, sunscreen lotions, paints and lubricants.
Flammability and Explosibility
Not classified
Contact allergens
1,2-Benzisothiazol-3(2H)-one, both an irritant and a skin sensitizer, is widely used in industry as a preservative in water-based solutions such as pastes, paints, and cutting oils. Occupational dermatitis has been reported mainly due to cutting fluids and greases, in paint manufacturers, pottery moldmakers, acrylic emulsions manufacturers, plumber,printers and lithoprinters, paper makers, analytical laboratory, rubber factory, and employees manufacturing air fresheners. It is also a preservative in vinyl gloves.
Safety Profile
Moderately toxic by ingestion.When heated to decomposition it emits toxic vapors ofNOx and SOx.
Toxicity evaluation
Isothiazolinones, such as 1,2-benzisothiazol-3(2H)-one (BIT), are widely used as biocides for bacterial growth control in many domestic and industrial processes. Despite their advantages as biocides, they are highly toxic and pose a potential risk to the environment. BIT could seriously inhibit the growth of Scenedesmus sp. LX1, Chlorella sp. HQ, and Chlamydomonas reinhardtii with half maximal effective concentrations at 72 h (72h-EC50) of 1.70, 0.41, and 1.16 mg/L, respectively. The primary inhibition mechanism was the BIT-induced damage to microalgal photosynthetic systems.
Toxics Screening Level
The Initial Threshold Screening Level (ITSL) for 1,2-benzisothiazol-3(2H)-one of 0.1 μg/m3 with annual averaging time is being rescinded.
1,2-Benzisothiazol-3(2H)-one Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jinan Finer Chemical Co., Ltd | +86-531-88989536 +86-15508631887 | sales@finerchem.com | China | 2950 | 58 |
| WUXI HONOR SHINE CHEMICAL CO.,LTD | +86-0510-83593312 +8619805123561 | sales@honorshinechem.com | China | 69 | 58 |
| Hebei Anda Technology Co., LTD | +86-19831998802 | 106@hebeianda.cn | China | 278 | 58 |
| Suzhou Genemill Biotechnology Co.,Ltd | +8615862502491 | aimeegao@genemill.com | China | 39 | 58 |
| Changzhou AniKare Pharmatech Co., Ltd. | +86-0519-8359-8696 +8618018249389 | sales@anikare.com | China | 9969 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8738 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +8617392709771 | 1097@dideu.com | China | 3996 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-86-13131129325 +8613131129325 | sales1@chuanghaibio.com | China | 5231 | 58 |
| Shandong Juchuang Chemical Co., LTD | +16837774622 | admin@juchuangchem.com | China | 295 | 58 |
| Hebei Zhuanglai Chemical Trading Co.,Ltd | +8613343047651 | admin@zlchemi.com | China | 3692 | 58 |
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View Lastest Price from 1,2-Benzisothiazol-3(2H)-one manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-05-28 | 1,2-Benzisothiazolin-3-one
2634-33-5
|
0.99 | RongNa Biotechnology Co.,Ltd | ||||
 |
2026-05-28 | 1,2-benzisothiazolin-3-one
2634-33-5
|
US $12.00 / KG | 1KG | 99.8% | 5000kg | Hebei Chuanghai Biotechnology Co,.LTD | |
 |
2026-03-20 | 1,2-Benzisothiazolin-3-one
2634-33-5
|
US $10.00 / KG | 1KG | 99.5% | 100 | Hebei Chuanghai Biotechnology Co., Ltd |
-
- 1,2-Benzisothiazolin-3-one
2634-33-5
- 0.99
- RongNa Biotechnology Co.,Ltd
-
- 1,2-benzisothiazolin-3-one
2634-33-5
- US $12.00 / KG
- 99.8%
- Hebei Chuanghai Biotechnology Co,.LTD
-
- 1,2-Benzisothiazolin-3-one
2634-33-5
- US $10.00 / KG
- 99.5%
- Hebei Chuanghai Biotechnology Co., Ltd
