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4-(Trifluoromethoxy)benzyl bromide

4-(Trifluoromethoxy)benzyl bromide structure

CAS No.: 50824-05-0

Chemical Name:: 4-(Trifluoromethoxy)benzyl bromide

Synonyms: 1-(BROMOMETHYL)-4-(TRIFLUOROMETHOXY)BENZENE;TIMTEC-BB SBB006578;Pretomanid Impurity 4;4-(Trifluoromethoxy)benzyl;TrifluoroMethoxy BroMobenzyl;4-trifluoromethoxybromobenzyl;P-TritluromethoxybenzylBromide;4-trifluoromethoxylbenzylbromide;4-(TRIFLUOROMETHOXY)BENZYL BROMIDE;4-(Trifluoromethyloxy）benzylbromide

CBNumber:: CB0452065

Molecular Formula:: C8H6BrF3O

Molecular Weight:: 255.03

MDL Number:: MFCD00061238

MOL File:: 50824-05-0.mol

MSDS File:: SDS

Last updated:2026-01-13 11:13:22

Product description	Number	Pack Size	Price
4-(Trifluoromethoxy)benzyl bromide 97%	370622	1g	$92.5
4-(Trifluoromethoxy)benzyl bromide 97%	370622	5g	$147
4-(Trifluoromethoxy)benzyl Bromide >98.0%(GC)	T1781	1g	$35
4-(Trifluoromethoxy)benzyl Bromide >98.0%(GC)	T1781	5g	$92
4-(Trifluoromethoxy)benzyl Bromide	T774440	25g	$350
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4-(Trifluoromethoxy)benzyl bromide Properties

Melting point	22-24°C
Boiling point	82-84 °C10 mm Hg(lit.)
Density	1.594 g/mL at 25 °C(lit.)
refractive index	n20/D 1.48(lit.)
Flash point	202 °F
storage temp.	Refrigerated.
solubility	soluble in Chloroform, Methanol
form	Liquid or Low Melting Solid
Specific Gravity	1.594
color	Clear faintly yellow
Sensitive	Lachrymatory
BRN	2521451
InChI	InChI=1S/C8H6BrF3O/c9-5-6-1-3-7(4-2-6)13-8(10,11)12/h1-4H,5H2
InChIKey	JDNPUJCKXLOHOW-UHFFFAOYSA-N
SMILES	C1(CBr)=CC=C(OC(F)(F)F)C=C1
CAS DataBase Reference	50824-05-0(CAS DataBase Reference)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS05

Signal word

Danger

Hazard statements

H314

Precautionary statements

P280-P303+P361+P353-P304+P340+P310-P305+P351+P338-P363-P405

PPE

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

Hazard Codes

Risk Statements

Safety Statements

26-27-28-36/37/39-45

RIDADR

UN 3265 8/PG 2

WGK Germany

Hazard Note

Corrosive/Lachrymatory

HazardClass

PackingGroup

III

HS Code

29093090

Storage Class

8A - Combustible corrosive hazardous materials

Hazard Classifications

Eye Dam. 1
Skin Corr. 1B

NFPA 704

	1
3		1

4-(Trifluoromethoxy)benzyl bromide price More Price(26)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	370622	4-(Trifluoromethoxy)benzyl bromide 97%	50824-05-0	1g	$92.5	2026-03-19	Buy
Sigma-Aldrich	370622	4-(Trifluoromethoxy)benzyl bromide 97%	50824-05-0	5g	$147	2026-03-19	Buy
TCI Chemical	T1781	4-(Trifluoromethoxy)benzyl Bromide >98.0%(GC)	50824-05-0	1g	$35	2026-03-19	Buy
TCI Chemical	T1781	4-(Trifluoromethoxy)benzyl Bromide >98.0%(GC)	50824-05-0	5g	$92	2026-03-19	Buy
TRC	T774440	4-(Trifluoromethoxy)benzyl Bromide	50824-05-0	25g	$350	2021-12-16	Buy

Product number	Packaging	Price	Buy
370622	1g	$92.5	Buy
370622	5g	$147	Buy
T1781	1g	$35	Buy
T1781	5g	$92	Buy
T774440	25g	$350	Buy

4-(Trifluoromethoxy)benzyl bromide Chemical Properties,Uses,Production

Uses

4-Trifluoromethoxybenzyl Bromide is a useful synthetic intermediate. It is used to prepare (nitro)[(trifluoromethoxy)benzyloxy]dihydroimidazo[2,1-b][1,3]oxazines with antitubercular activities. It is also used to synthesize tetrahydronaphthalenols with anti-allergic activities.

Chemical Properties

Colorless to light yellow liqui

Uses

4-(Trifluoromethoxy)benzyl bromide may be used in the synthesis of bioreductive drug, (6S)-2-nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (PA-824).

General Description

Polymerizations of 4-(trifluoromethoxy)benzyl bromide, via Friedel-Crafts polymerization using aluminum chloride as a catalyst has been reported.

Synthesis

1736-74-9

50824-05-0

Synthesis of 1-(bromomethyl)-4-(trifluoromethoxy)benzene: Phosphorus tribromide (6 g, 22.2 mmol) was slowly added dropwise to a solution of (4-(trifluoromethoxy)phenyl)methanol (3.6 g, 18.8 mmol) in dichloromethane (60 mL) at 0-10 °C and stirred for 30 min. The reaction mixture was then continued to stir at room temperature for 3 hours. Upon completion of the reaction, the reaction was terminated by the addition of water (30 mL) and the mixture was washed sequentially with aqueous sodium bicarbonate (2 x 30 mL) and brine (30 mL). The organic layer was dried with anhydrous sodium sulfate and concentrated under reduced pressure to give 4-trifluoromethoxybenzyl bromide (3.5 g, 66% yield) as a yellow oil.

References

[1] Patent: US2007/270434, 2007, A1. Location in patent: Page/Page column 17
[2] J. Gen. Chem. USSR (Engl. Transl.), 1965, vol. 35, p. 1631 - 1637
[3] Zhurnal Obshchei Khimii, 1965, vol. 35, p. 1628 - 1636
[4] Journal of Medicinal Chemistry, 2005, vol. 48, # 2, p. 556 - 568
[5] Organometallics, 2014, vol. 33, # 21, p. 5940 - 5943

4-(Trifluoromethoxy)benzyl bromide Preparation Products And Raw materials

Raw materials

(Trifluoromethoxy)benzene 4-(Trifluoromethoxy)benzyl alcohol Dichloromethane Phosphorus tribromide

Preparation Products

4-(Trifluoromethyl)phenylacetic acid 4-(Trifluoromethoxy)benzoic acid

4-(Trifluoromethoxy)benzyl bromide Suppliers

Global( 386)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Beijing Toachem Chemical Co.,Ltd	+8618311365218	sales@toachem.com	China	205	58
Hebei Chuanghai Biotechnology Co., Ltd	+8615531151365	mina@chuanghaibio.com	China	18126	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20125	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29640	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-2158073036	info@dakenam.com	China	13815	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21592	55
Nanjing ChemLin Chemical Industry Co., Ltd.	025-83697070	product@chemlin.com.cn	CHINA	3009	60
Fluoropharm Co., Ltd.	+86-0571-85586753 +86-13336034509	sales@fluoropharm.com	China	1445	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29825	58

Supplier	Advantage
Beijing Toachem Chemical Co.,Ltd	58
Hebei Chuanghai Biotechnology Co., Ltd	58
Henan Fengda Chemical Co., Ltd	58
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55
Nanjing ChemLin Chemical Industry Co., Ltd.	60
Fluoropharm Co., Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58

View Lastest Price from 4-(Trifluoromethoxy)benzyl bromide manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-02-02	4-(Trifluoromethoxy)benzyl bromide 50824-05-0	US $0.00-0.00 / KG	10mg	99%	2000tons	Shaanxi Dideu Medichem Co. Ltd
2025-09-25	4-(Trifluoromethoxy)benzyl bromide 50824-05-0	US $8.00-0.80 / KG	1KG	99%	g-kg-tons, free sample is available	Henan Fengda Chemical Co., Ltd
2025-06-27	4-(Trifluoromethoxy)benzyl bromide 50824-05-0	US $30.00-10.00 / KG	50KG	99%	500000kg	Hebei Chuanghai Biotechnology Co., Ltd

4-(Trifluoromethoxy)benzyl bromide
50824-05-0
US $0.00-0.00 / KG
99%
Shaanxi Dideu Medichem Co. Ltd

4-(Trifluoromethoxy)benzyl bromide
50824-05-0
US $8.00-0.80 / KG
99%
Henan Fengda Chemical Co., Ltd

4-(Trifluoromethoxy)benzyl bromide
50824-05-0
US $30.00-10.00 / KG
99%
Hebei Chuanghai Biotechnology Co., Ltd

4-(Trifluoromethoxy)benzyl bromide Spectrum

4-(Trifluoromethoxy)benzyl bromide(50824-05-0)MS 4-(Trifluoromethoxy)benzyl bromide(50824-05-0)¹HNMR 4-(Trifluoromethoxy)benzyl bromide(50824-05-0)¹³CNMR 4-(Trifluoromethoxy)benzyl bromide(50824-05-0)IR1 4-(Trifluoromethoxy)benzyl bromide(50824-05-0)Raman

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Benzyl alcohol Rocuronium bromide Allyl bromide Benzyl bromide 3-FLUORO-4-(TRIFLUOROMETHOXY)BENZYL BROMIDE

3-CHLORO-4-(TRIFLUOROMETHOXY)BENZYL BROMIDE,3-CHLORO-4-(TRIFLUOROMETHOXY)BENZYL BROMIDE, 98%(MIN,GC) 2,6-DICHLORO-4-(TRIFLUOROMETHOXY)BENZYL BROMIDE 2-METHOXY-4-(TRIFLUOROMETHOXY)BENZYL BROMIDE

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4-(TRIFLUOROMETHOXY)BENZYL BROMIDE ALPHA-BROMO-4-(TRIFLUOROMETHOXY)TOLUENE TIMTEC-BB SBB006578 P-TritluromethoxybenzylBromide 4-(Trifluoromethoxy)benzyl 4-(Trifluoromethoxy)benzyl bromide 97% 4-(Trifluoromethoxy)benzylbromide97% Anti-Trifluoride Mathoxyphenyl Bromine Benzyl 4-(Trifluoromethyloxy）benzylbromide TrifluoroMethoxy BroMobenzyl 4-(Trifluoromethoxy)benzyl bromide,98% 4-BroMoMethylphenyl (trifluoroMethyl) ether 1-(Bromomethyl)-4-(trifluoromethoxy)benzene, 4-(Bromomethyl)phenyl trifluoromethyl ether Pretomanid Impurity 4 Benzene, 1-(bromomethyl)-4-(trifluoromethoxy)- 4-trifluoromethoxybromobenzyl TIANFUCHEM--50824-05-0--4-(Trifluoromethoxy)benzyl bromide 4-trifluoromethoxylbenzylbromide 1-(BROMOMETHYL)-4-(TRIFLUOROMETHOXY)BENZENE 50824-05-0 52084-05-0 C8H6BrOF3 BENZYL HALIDE Ethers Oxygen Compounds Organic Building Blocks Building Blocks Aromatic Halides (substituted) Miscellaneous Ethers Organic Building Blocks Oxygen Compounds Trifluoro-methoxy-benzene series