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4-(Trifluoromethoxy)benzyl bromide

4-(Trifluoromethoxy)benzyl bromide structure

CAS No.: 50824-05-0

Chemical Name:: 4-(Trifluoromethoxy)benzyl bromide

Synonyms: 1-(BROMOMETHYL)-4-(TRIFLUOROMETHOXY)BENZENE;TIMTEC-BB SBB006578;Pretomanid Impurity 4;4-(Trifluoromethoxy)benzyl;TrifluoroMethoxy BroMobenzyl;4-trifluoromethoxybromobenzyl;P-TritluromethoxybenzylBromide;4-trifluoromethoxylbenzylbromide;4-(TRIFLUOROMETHOXY)BENZYL BROMIDE;4-(Trifluoromethyloxy）benzylbromide

CBNumber:: CB0452065

Molecular Formula:: C8H6BrF3O

Molecular Weight:: 255.03

MDL Number:: MFCD00061238

MOL File:: 50824-05-0.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-27 22:41:13

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4-(Trifluoromethoxy)benzyl bromide Properties

Melting point	22-24°C
Boiling point	82-84 °C10 mm Hg(lit.)
Density	1.594 g/mL at 25 °C(lit.)
refractive index	n20/D 1.48(lit.)
Flash point	202 °F
storage temp.	Refrigerated.
solubility	soluble in Chloroform, Methanol
form	Liquid or Low Melting Solid
Specific Gravity	1.594
color	Clear faintly yellow
Sensitive	Lachrymatory
BRN	2521451
InChI	InChI=1S/C8H6BrF3O/c9-5-6-1-3-7(4-2-6)13-8(10,11)12/h1-4H,5H2
InChIKey	JDNPUJCKXLOHOW-UHFFFAOYSA-N
SMILES	C1(CBr)=CC=C(OC(F)(F)F)C=C1
CAS DataBase Reference	50824-05-0(CAS DataBase Reference)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS05

Signal word

Danger

Hazard statements

H314

Precautionary statements

P280-P303+P361+P353-P304+P340+P310-P305+P351+P338-P363-P405

PPE

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

Hazard Codes

Risk Statements

Safety Statements

26-27-28-36/37/39-45

RIDADR

UN 3265 8/PG 2

WGK Germany

Hazard Note

Corrosive/Lachrymatory

HazardClass

PackingGroup

III

HS Code

29093090

Storage Class

8A - Combustible corrosive hazardous materials

Hazard Classifications

Eye Dam. 1
Skin Corr. 1B

NFPA 704

	1
3		1

4-(Trifluoromethoxy)benzyl bromide price More Price(47)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	370622	4-(Trifluoromethoxy)benzyl bromide 97%	50824-05-0	1g	$92.5	2026-04-30	Buy
Sigma-Aldrich	370622	4-(Trifluoromethoxy)benzyl bromide 97%	50824-05-0	5g	$147	2026-04-30	Buy
TCI Chemical	T1781	4-(Trifluoromethoxy)benzyl Bromide >98.0%(GC)	50824-05-0	1g	$35	2026-04-30	Buy
TCI Chemical	T1781	4-(Trifluoromethoxy)benzyl Bromide >98.0%(GC)	50824-05-0	5g	$92	2026-04-30	Buy
TRC	TRC-T774440-5G	4-Trifluoromethoxybenzyl Bromide	50824-05-0	5g	$140	2026-06-03	Buy

Product number	Packaging	Price	Buy
370622	1g	$92.5	Buy
370622	5g	$147	Buy
T1781	1g	$35	Buy
T1781	5g	$92	Buy
TRC-T774440-5G	5g	$140	Buy

4-(Trifluoromethoxy)benzyl bromide Chemical Properties, Uses, Production

Uses

4-Trifluoromethoxybenzyl Bromide is a useful synthetic intermediate. It is used to prepare (nitro)[(trifluoromethoxy)benzyloxy]dihydroimidazo[2,1-b][1,3]oxazines with antitubercular activities. It is also used to synthesize tetrahydronaphthalenols with anti-allergic activities.

Chemical Properties

Colorless to light yellow liqui

Uses

4-(Trifluoromethoxy)benzyl bromide may be used in the synthesis of bioreductive drug, (6S)-2-nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (PA-824).

General Description

Polymerizations of 4-(trifluoromethoxy)benzyl bromide, via Friedel-Crafts polymerization using aluminum chloride as a catalyst has been reported.

Synthesis

1736-74-9

50824-05-0

Synthesis of 1-(bromomethyl)-4-(trifluoromethoxy)benzene: Phosphorus tribromide (6 g, 22.2 mmol) was slowly added dropwise to a solution of (4-(trifluoromethoxy)phenyl)methanol (3.6 g, 18.8 mmol) in dichloromethane (60 mL) at 0-10 °C and stirred for 30 min. The reaction mixture was then continued to stir at room temperature for 3 hours. Upon completion of the reaction, the reaction was terminated by the addition of water (30 mL) and the mixture was washed sequentially with aqueous sodium bicarbonate (2 x 30 mL) and brine (30 mL). The organic layer was dried with anhydrous sodium sulfate and concentrated under reduced pressure to give 4-trifluoromethoxybenzyl bromide (3.5 g, 66% yield) as a yellow oil.

References

[1] Patent: US2007/270434, 2007, A1. Location in patent: Page/Page column 17
[2] J. Gen. Chem. USSR (Engl. Transl.), 1965, vol. 35, p. 1631 - 1637
[3] Zhurnal Obshchei Khimii, 1965, vol. 35, p. 1628 - 1636
[4] Journal of Medicinal Chemistry, 2005, vol. 48, # 2, p. 556 - 568
[5] Organometallics, 2014, vol. 33, # 21, p. 5940 - 5943

4-(Trifluoromethoxy)benzyl bromide Preparation Products And Raw materials

Raw materials

(Trifluoromethoxy)benzene 4-(Trifluoromethoxy)benzyl alcohol Dichloromethane Phosphorus tribromide

Preparation Products

4-(Trifluoromethyl)phenylacetic acid 4-(Trifluoromethoxy)benzoic acid

4-(Trifluoromethoxy)benzyl bromide Suppliers

Global Suppliers ( 404)

Supplier	Tel	Email	Country	ProdList	Advantage
SHANG FLUORO	021-65170832 15601903708	qinba_1@163.com	China	401	60
Jinkai (Liaoning) Life Technology Co., LTD	021-64272437	customer-service@kingchem.com	China	201	58
Shandong Shining Pharm Co.,Ltd	18866891188 18866891188	zhaojiangxia@shiningpharm.com	China	203	58
Hubei Smer Pharmaceutical Technology Co., Ltd.	15527913960	826455094@qq.com	China	490	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
Liaoning Tianhua Chemical Co., Ltd.	0418-6530555 2855550		China	338	69
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81
ShangHai DEMO Chemical Co.,Ltd	400-021-7337 2355568890	sales@demochem.com	China	2569	57

Supplier	Advantage
SHANG FLUORO	60
Jinkai (Liaoning) Life Technology Co., LTD	58
Shandong Shining Pharm Co.,Ltd	58
Hubei Smer Pharmaceutical Technology Co., Ltd.	58
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
Liaoning Tianhua Chemical Co., Ltd.	69
Alfa Aesar	84
TCI (Shanghai) Development Co., Ltd.	81
ShangHai DEMO Chemical Co.,Ltd	57

View Latest Price from 4-(Trifluoromethoxy)benzyl bromide manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-02	4-(Trifluoromethoxy)benzyl bromide 50824-05-0	$8.00	1KG	99%		Henan Fengda Chemical Co., Ltd
2026-02-02	4-(Trifluoromethoxy)benzyl bromide 50824-05-0		10mg	99%	2000tons	Shaanxi Dideu Medichem Co. Ltd
2025-06-27	4-(Trifluoromethoxy)benzyl bromide 50824-05-0	$10.00-30.00	50KG	99%	500000kg	Hebei Chuanghai Biotechnology Co., Ltd

4-(Trifluoromethoxy)benzyl bromide
50824-05-0
$8.00
99%
Henan Fengda Chemical Co., Ltd

4-(Trifluoromethoxy)benzyl bromide
50824-05-0
99%
Shaanxi Dideu Medichem Co. Ltd

4-(Trifluoromethoxy)benzyl bromide
50824-05-0
$10.00-30.00
99%
Hebei Chuanghai Biotechnology Co., Ltd

4-(Trifluoromethoxy)benzyl bromide Spectrum

4-(Trifluoromethoxy)benzyl bromide(50824-05-0)MS 4-(Trifluoromethoxy)benzyl bromide(50824-05-0)¹HNMR 4-(Trifluoromethoxy)benzyl bromide(50824-05-0)¹³CNMR 4-(Trifluoromethoxy)benzyl bromide(50824-05-0)IR1 4-(Trifluoromethoxy)benzyl bromide(50824-05-0)Raman

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4-(TRIFLUOROMETHOXY)BENZYL BROMIDE ALPHA-BROMO-4-(TRIFLUOROMETHOXY)TOLUENE TIMTEC-BB SBB006578 P-TritluromethoxybenzylBromide 4-(Trifluoromethoxy)benzyl 4-(Trifluoromethoxy)benzyl bromide 97% 4-(Trifluoromethoxy)benzylbromide97% Anti-Trifluoride Mathoxyphenyl Bromine Benzyl 4-(Trifluoromethyloxy）benzylbromide TrifluoroMethoxy BroMobenzyl 4-(Trifluoromethoxy)benzyl bromide,98% 4-BroMoMethylphenyl (trifluoroMethyl) ether 1-(Bromomethyl)-4-(trifluoromethoxy)benzene, 4-(Bromomethyl)phenyl trifluoromethyl ether Pretomanid Impurity 4 Benzene, 1-(bromomethyl)-4-(trifluoromethoxy)- 4-trifluoromethoxybromobenzyl TIANFUCHEM--50824-05-0--4-(Trifluoromethoxy)benzyl bromide 4-trifluoromethoxylbenzylbromide 1-(BROMOMETHYL)-4-(TRIFLUOROMETHOXY)BENZENE 50824-05-0 52084-05-0 C8H6BrOF3 BENZYL HALIDE Ethers Oxygen Compounds Organic Building Blocks Building Blocks Aromatic Halides (substituted) Miscellaneous Ethers Organic Building Blocks Oxygen Compounds Trifluoro-methoxy-benzene series