Myxothiazol
- CAS No.
- 76706-55-3
- Chemical Name:
- Myxothiazol
- Synonyms
- Myxothiazo;Myxothiazol;5-dimethoxy-4-methyl-;myxothiazolfrommyxobacterium;MYXOTHIAZOL, VIAL WITH 10 MG*;MYXOTHIAZOL FROM MYXOBACTERIUM 95%;MYXOTHIAZOL, FROM MYXOCOCCUS FULVUS;myxothiazol from myxobacterium*myxococcus fulvus;7-(2’-(1,6-dimethyl-2,4-heptadienyl)(2,4’-bithiazol)-4-yl)-6-heptadienamide;2,6-Heptadienamide, 7-(2'-(1,6-dimethyl-2,4-heptadienyl)(2,4'-bithiazol)-4-yl)-3,5-dimethoxy-4-methyl-
- CBNumber:
- CB0453976
- Molecular Formula:
- C25H33N3O3S2
- Molecular Weight:
- 487.68
- MDL Number:
- MFCD00043397
- MOL File:
- 76706-55-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 679.6±65.0 °C(Predicted) |
|---|---|
| Density | 1.158±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | chloroform: soluble9.80 - 10.20mg/mL, clear, colorless to yellow |
| form | Solid |
| pka | 14.07±0.50(Predicted) |
| color | White to off-white |
| biological source | Myxococcus fulvus Mx f85 |
| InChIKey | XKTFQMCPGMTBMD-ZDBABOMLSA-N |
| SMILES | CO[C@@H](\C=C\c1csc(n1)-c2csc(n2)[C@@H](C)\C=C\C=C\C(C)C)[C@@H](C)\C(OC)=C\C(N)=O |
| FDA UNII | 6VY98BQ7NB |
| UNSPSC Code | 51111800 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H300 |
| Precautionary statements | P264-P270-P301+P310-P405-P501 |
| Hazard Codes | T+ |
| Risk Statements | 28 |
| Safety Statements | 28-36/37-45 |
| RIDADR | UN 3462 6.1/PG 1 |
| WGK Germany | 3 |
| RTECS | QH7580000 |
| F | 10 |
| HazardClass | 6.1(b) |
| PackingGroup | III |
| Storage Class | 6.1A - Combustible acute toxic Cat. 1 and 2 very toxic hazardous materials |
| Hazard Classifications | Acute Tox. 2 Oral |
Myxothiazol price More Price(9)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | T5580 | Myxothiazol from Myxococcus fulvus Mx f85, ≥98% (HPLC) | 76706-55-3 | 1mg | $122 | 2026-04-30 | Buy |
| Sigma-Aldrich | T5580 | Myxothiazol from Myxococcus fulvus Mx f85, ≥98% (HPLC) | 76706-55-3 | 5mg | $489 | 2026-04-30 | Buy |
| ChemScene | CS-0043613 | Myxothiazol 99.98% | 76706-55-3 | 1mg | $422 | 2026-06-04 | Buy |
| ChemScene | CS-0043613 | Myxothiazol 99.98% | 76706-55-3 | 5mg | $1192 | 2026-06-04 | Buy |
| ApexBio Technology | BA1028 | Myxothiazol | 76706-55-3 | 1mg | $378 | 2026-05-06 | Buy |
Myxothiazol Chemical Properties,Uses,Production
Uses
Myxothiazol has been used in as a mitochondrial electron transport chain (mETC) inhibitor in P19 murine embryonal carcinoma pluripotent cell line and to treat HeLa cells for integrated stress response activation.
Definition
ChEBI: A 2,4'-bi-1,3-thiazole substituted at the 4-position with a (1E,3S,4R,5E)-7-amino-3,5-dimethoxy-4-methyl-7-oxohepta-1,5-dien-1-yl] group and at the 2'-position with a (2S
Biochem/physiol Actions
Myxothiazol, an antibiotic with activity against fungi and insects, is a strong inhibitor of mitochondrial cytochrome b/c1-segment of respiratory chain. Myxothiazol binds to the quinol oxidation (Qo) site of the bc1 complex, blocking electron transfer to the Rieske iron-sulfur protein in the mitochondrial respiratory chain. Oxygen consumption blockage leads to a cytostatic effect that could be reversed. Myxothiazol, as other Epothilones, which are known for their anti tumor activity, contains a thiazole ring that is formed by the incorporation of cysteine into the polyketide backbone.
in vivo
Myxothiazol (i.p.; 0.56 mg/kg; daily for 4 days)-induced complex III inhibition can be induced in mice for four days in a row without overt hepatotoxicity or lethality[3].
| Animal Model: | C57Bl/J6 mice[3] |
| Dosage: | 0.56 mg/kg |
| Administration: | I.p.; 24 hours intervals for at most 4 times |
| Result: | A reversible complex III activity decrease to 50% of control value occurred at 2 h post-injection. At 74 h only minor histological changes in the liver were found, supercomplex formation was preserved and no significant changes in the expression of genes indicating hepatotoxicity or inflammation were found. |
Myxothiazol Preparation Products And Raw materials
Raw materials
Preparation Products
Myxothiazol Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Shanghai Macklin Biochemical Co.,Ltd. | 15221275939 15221275939 | shenlinxing@macklin.cn | China | 15775 | 55 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51389 | 80 |
| Artis Biotech Co. Ltd. | 18108108965 18108108965 | sales@artisbio.com | China | 2503 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 400-920-5774 | sales@glpbio.cn | China | 6705 | 58 |
| Guangdong wengjiang Chemical Reagent Co., Ltd. | 0751-2815688 13927872512 | 3007421951@qq.com | China | 9996 | 58 |
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
| Zhejiang Huida Biotech Co., LTD | 0571-89903022 18679456698 | zilong@hizyme.com | China | 8001 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
View Lastest Price from Myxothiazol manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-25 | Myxothiazol
76706-55-3
|
$2.00-6.00 | 1kg | 99% | 100kg | ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD |
-
- Myxothiazol
76706-55-3
- $2.00-6.00
- 99%
- ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
