1,3-Dimethoxy-2-propanol
- CAS No.
- 623-69-8
- Chemical Name:
- 1,3-Dimethoxy-2-propanol
- Synonyms
- 1,3-Dimethoxypropan-2-ol;1,3-DiMethoxy-2-prop;3-Dimethoxy-2-propanol;glycerin dimethyl ether;1,3-dimethoxy-2-propano;1,3-DIMETHOXY-2-PROPANOL;2-Propanol,1,3-dimethoxy-;glycerol,1,3-dimethylether;Glycerol α,γ-dimethyl ether;Glyceryl-1,3-dimethyl ether
- CBNumber:
- CB0458401
- Molecular Formula:
- C5H12O3
- Molecular Weight:
- 120.15
- MDL Number:
- MFCD01076303
- MOL File:
- 623-69-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 169°C (estimate) |
|---|---|
| Density | 1.0085 |
| refractive index | 1.4192 |
| storage temp. | Sealed in dry,Room Temperature |
| pka | 13.68±0.20(Predicted) |
| form | liquid |
| color | Colourless |
| Cosmetics Ingredients Functions | HAIR CONDITIONING |
| CAS DataBase Reference | 623-69-8(CAS DataBase Reference) |
| FDA UNII | A0JF0DT9XK |
| NIST Chemistry Reference | 2-Propanol, 1,3-dimethoxy-(623-69-8) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302+H312+H332-H315-H319-H335 |
| Precautionary statements | P261-P280-P305+P351+P338 |
| Risk Statements | 10 |
| Safety Statements | 16 |
| RIDADR | 1987 |
| HS Code | 2909498090 |
1,3-Dimethoxy-2-propanol price More Price(44)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | D6094 | 1,3-Dimethoxypropan-2-ol min. 97.0 % | 623-69-8 | 5G | $39 | 2026-04-30 | Buy |
| TCI Chemical | D6094 | 1,3-Dimethoxypropan-2-ol min. 97.0 % | 623-69-8 | 25G | $116 | 2026-04-30 | Buy |
| Apolloscientific | OR911780 | 1,3-Dimethoxypropan-2-ol >98% | 623-69-8 | 25g | $22 | 2026-06-04 | Buy |
| Apolloscientific | OR911780 | 1,3-Dimethoxypropan-2-ol >98% | 623-69-8 | 100g | $79 | 2026-06-04 | Buy |
| Apolloscientific | OR911780 | 1,3-Dimethoxypropan-2-ol >98% | 623-69-8 | 500g | $233 | 2026-06-04 | Buy |
1,3-Dimethoxy-2-propanol Chemical Properties, Uses, Production
Uses
1,3-Dimethoxy-2-propanol is a possbile antiknock additive for gasoline and diesel fuel. It is also used to prepare heteroarylcarbamoylbenzene derivatives as glucokinase activators.
Synthesis
67-56-1
106-89-8
623-69-8
According to an improved method described in the literature [15], 1,3-dimethoxy-2-propanol was synthesized by sodium hydroxide catalysis using methanol and 1-chloro-2,3-epoxypropane as raw materials. The procedure was as follows: 165 mL of anhydrous methanol and 11.4 g of sodium hydroxide were added to a 250 mL three-neck flask. The mixture was stirred and heated to reflux to form a homogeneous solution. 1-Chloro-2,3-epoxypropane (25.0 g) was added slowly and dropwise over a period of 1 hour. The reaction solution was kept at reflux for 6 hours. Upon completion of the reaction, the mixture was cooled to room temperature and the pH was adjusted with concentrated hydrochloric acid to 7. The precipitated sodium chloride was removed by filtration and the filtrate was fractionated under reduced pressure to afford 1,3-dimethoxy-2-propanol (29.8 g, 91.9% yield). The product was identified by 1H NMR (300 MHz, CDCl3): δ 3.92-3.99 (m, 1H, CH), 3.40-3.49 (m, 4H, CH2), 3.39 (s, 6H, CH3), and 2.59 (s, 1H, OH, the position and intensity of this peak varied with the concentration of the sample).13C NMR (75 MHz, CDCl3): δ 73.9 (CH2), 69.1 (CH), 59.0 (CH3). ESI-HRMS: m/z [M + Na]+ Calculated value: 143.0684 (C5H12O3 + Na), measured value: 143.0684. Elemental analysis results (C5H12O3): Calculated value: C 49.98%, H 10.07%; measured value: C 49.97%, H 9.84%.
References
[1] Chinese Chemical Letters, 2013, vol. 24, # 12, p. 1106 - 1108
[2] Organic Letters, 2017, vol. 19, # 11, p. 2789 - 2792
[3] Patent: WO2011/60228, 2011, A1. Location in patent: Page/Page column 69-70
[4] Atti della Accademia Nazionale dei Lincei, Classe di Scienze Fisiche, Matematiche e Naturali, Rendiconti, 1897, vol. <5> 6 II, p. 350
[5] Green Chemistry, 2015, vol. 17, # 8, p. 4326 - 4333
1,3-Dimethoxy-2-propanol Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nanbu County Chengxin Technology Co., Ltd. | 0838-5675166 15883665058 | nbcxkj@126.com | China | 956 | 55 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| TAIYUAN RHF CO.,LTD. | +86 351 7031519 | sales@RHFChem.com | China | 2334 | 56 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 45000 | 61 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Syntechem Co.,Ltd | info@syntechem.com | China | 12973 | 57 | |
| Sichuan Kulinan Technology Co., Ltd | 400-1166-196 18981987031 | cdhxsj@163.com | China | 11674 | 57 |
| Tianjin heowns Biochemical Technology Co., Ltd. | 400 638 7771 | sales@heowns.com | China | 14412 | 57 |
| Shanghai Sunway Pharmaceutical Technology Co., Ltd | 13761987713 | hxzheng@sunwaypharm.cn | China | 8663 | 57 |
| Chengdu Ai Keda Chemical Technology Co., Ltd. | 4008-755-333 18080918076 | 800078821@qq.com | China | 9706 | 55 |
View Latest Price from 1,3-Dimethoxy-2-propanol manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-05-23 | 1,3-Dimethoxy-2-propanol
623-69-8
|
$60.00 | 1kg | 99% | 20 tons | Hebei Zhuanglai Chemical Trading Co Ltd | |
 |
2022-02-22 | 1,3-Dimethoxy-2-propanol
623-69-8
|
1KG | 98.1% | 100 tons | Honest Joy Holdings Limited | ||
 |
2021-08-12 | 1,3-Dimethoxy-2-propanol
623-69-8
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd |
-
- 1,3-Dimethoxy-2-propanol
623-69-8
- $60.00
- 99%
- Hebei Zhuanglai Chemical Trading Co Ltd
-
- 1,3-Dimethoxy-2-propanol
623-69-8
- $0.00
- 98.1%
- Honest Joy Holdings Limited
-
- 1,3-Dimethoxy-2-propanol
623-69-8
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
