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3,5-Dichlorosalicylaldehyde

3,5-Dichlorosalicylaldehyde Structure
3,5-Dichlorosalicylaldehyde structure
CAS No.
90-60-8
Chemical Name:
3,5-Dichlorosalicylaldehyde
Synonyms
3,5-DICHLORO-2-HYDROXYBENZALDEHYDE;NSC 96393;AKOS B029257;TIMTEC-BB SBB003642;3,5-dichlorosalicyde;LABOTEST-BB LT00089371;3,5-DICHLORO SALICYLAL;Dichlorosalicylaldehyde;5-Dichlorosalicylaldehyde;3,5-Dichlorosalicyladehyde
CBNumber:
CB0465403
Molecular Formula:
C7H4Cl2O2
Molecular Weight:
191.01
MDL Number:
MFCD00003320
MOL File:
90-60-8.mol
MSDS File:
SDS
Last updated:2026-09-12 18:48:20
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3,5-Dichlorosalicylaldehyde Properties

Melting point 95-97 °C (lit.)
Boiling point 273.68°C (rough estimate)
Density 1.4410 (rough estimate)
refractive index 1.4590 (estimate)
storage temp. Inert atmosphere,Room Temperature
solubility ethanol: soluble5%, clear, faintly yellow to greenish-yellow
form Crystalline Powder
pka 6.27±0.23(Predicted)
color Pale yellow
Water Solubility Insoluble in water. Solubility in methanol is almost transparent.
Sensitive Air Sensitive
BRN 973391
InChI InChI=1S/C7H4Cl2O2/c8-5-1-4(3-10)7(11)6(9)2-5/h1-3,11H
InChIKey FABVMBDCVAJXMB-UHFFFAOYSA-N
SMILES C(=O)C1=CC(Cl)=CC(Cl)=C1O
CAS DataBase Reference 90-60-8(CAS DataBase Reference)
FDA UNII 9K38C4J9W8
EPA Substance Registry System Benzaldehyde, 3,5-dichloro-2-hydroxy- (90-60-8)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
target organs Respiratory system
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
WGK Germany  3
Hazard Note  Irritant
TSCA  TSCA listed
HS Code  29121900
Storage Class 11 - Combustible Solids
Hazard Classifications Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
NFPA 704
1
2 0

3,5-Dichlorosalicylaldehyde price More Price(74)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 261815 3,5-Dichlorosalicylaldehyde 99% 90-60-8 5g $40 2026-04-30 Buy
Sigma-Aldrich 261815 3,5-Dichlorosalicylaldehyde 99% 90-60-8 25g $130 2026-04-30 Buy
TCI Chemical D1170 3,5-Dichlorosalicylaldehyde >98.0%(GC)(T) 90-60-8 5g $19 2026-04-30 Buy
TCI Chemical D1170 3,5-Dichlorosalicylaldehyde >98.0%(GC)(T) 90-60-8 25g $74 2026-04-30 Buy
Strem Chemicals 06-0073 3,5-Dichloro-2-hydroxybenzaldehyde, min. 98% min.98% 90-60-8 25g $73 2026-04-30 Buy
Product number Packaging Price Buy
261815 5g $40 Buy
261815 25g $130 Buy
D1170 5g $19 Buy
D1170 25g $74 Buy
06-0073 25g $73 Buy

3,5-Dichlorosalicylaldehyde Chemical Properties, Uses, Production

Chemical Properties

pale yellow crystalline powder

Uses

3,5-Dichlorosalicylaldehyde has been used in the preparation of Schiff base ligands and (RS)-3,5-dichloro-2-[[(1-phenylethyl)imino]methyl]phenol.

Uses

3,5-Dichlorosalicylaldehyde has been used in the preparation of:

  • Schiff base ligands
  • (RS)-3,5-dichloro-2-[[(1-phenylethyl)imino]methyl]phenol

Synthesis

Hexamethylenetetramine

100-97-0

2,4-Dichlorophenol

120-83-2

3,5-DICHLOROSALICYLALDEHYDE

90-60-8

The general procedure for the synthesis of 3,5-dichlorosalicylaldehyde from urotropine and 2,4-dichlorophenol was as follows: first, 2,4-dichlorophenol (10.0 g, 61.3 mmol) and hexamethylenetetetramine (17.2 g, 122.6 mmol) were dissolved in 80 mL of methanesulfonic acid, and the reaction mixture was heated and stirred for 1.5 hours at 100 °C. After the reaction was completed, the reaction mixture was diluted with ethyl acetate, and the organic layer was washed sequentially with water and saturated sodium bicarbonate solution, and then dried with anhydrous magnesium sulfate. The solvent was removed by evaporation under reduced pressure to give the crude product. The crude product was purified by column chromatography using ethyl acetate/hexane gradient elution to afford the target compound 3,5-dichloro-2-hydroxybenzaldehyde (INT-01) as a yellow oil (7.5 g, 64% yield). The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3): δ11.39 (s, 1H), 7.64 (s, 1H), 7.52 (s, 1H). Liquid chromatography (LC) analytical conditions: C-18 column, 5 min to 95% acetonitrile/water gradient elution, flow rate 1.7 mL/min, detection wavelength 254 nm, column temperature 23 ℃, retention time (tr) = 3.95 min.

References

[1] Patent: WO2015/109011, 2015, A1. Location in patent: Paragraph 0205; 0206
[2] Patent: WO2015/109014, 2015, A1. Location in patent: Paragraph 0204; 0205
[3] Patent: US2015/197500, 2015, A1. Location in patent: Paragraph 0263; 0264
[4] Chemical & Pharmaceutical Bulletin, 1983, vol. 31, # 5, p. 1751 - 1753
[5] Journal of the Chemical Society, 1941, p. 547,549

3,5-Dichlorosalicylaldehyde Preparation Products And Raw materials

Raw materials

Hexamethylenetetramine Methanesulfonic acid Trifluoroacetic acid 2,4-Dichlorophenol

Preparation Products

6,8-Dichloro-2H-chromen-2-one 3,5-Dichloro-2-hydroxybenzaldehyde hydrazone 6,8-Dichloro-2H-chromene-3-carbaldehyde

3,5-Dichlorosalicylaldehyde Suppliers

Global Suppliers ( 328)
Supplier Tel Email Country ProdList Advantage
PSN Pharmaceutical Technology Co., Ltd. 18136588612 sales@jspsn.com China 70 58
Suqian Gaosai Biomedical Technology Co., Ltd 15250728346 465418843@qq.com China 29 58
changzhoubaotuobiochemical&pharm、LTD. 0519-13912326059 13912326059 alona1979@163.com China 45 58
Shandong Xinying Shun New Materials Co., Ltd 0531-13220555910 15168808500 lijinbo112@163.com China 510 58
Shaanxi Renheng Yide Biotechnology Co., Ltd 15319940549 15319940549 241757027@qq.com China 152 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 3bsc@sina.com China 15813 69
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Supplier Advantage
PSN Pharmaceutical Technology Co., Ltd. 58
Suqian Gaosai Biomedical Technology Co., Ltd 58
changzhoubaotuobiochemical&pharm、LTD. 58
Shandong Xinying Shun New Materials Co., Ltd 58
Shaanxi Renheng Yide Biotechnology Co., Ltd 58
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
3B Pharmachem (Wuhan) International Co.,Ltd. 69
Alfa Aesar 84
TCI (Shanghai) Development Co., Ltd. 81

View Latest Price from 3,5-Dichlorosalicylaldehyde manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
3，5-Dichlorosalicylaldehyde pictures 2026-09-18 3，5-Dichlorosalicylaldehyde
90-60-8
 $1800.00 1kg 99% GC 10tons Hubei Deli Pharmaceutical Technology Co., Ltd.
3,5-DICHLOROSALICYLALDEHYDE pictures 2026-05-28 3,5-DICHLOROSALICYLALDEHYDE
90-60-8
 $10.70 10KG 99% 10000kg Hebei Chuanghai Biotechnology Co,.LTD
3,5-DICHLOROSALICYLALDEHYDE pictures 2026-03-20 3,5-DICHLOROSALICYLALDEHYDE
90-60-8
 1KG 99% 20 mt Hebei Chuanghai Biotechnology Co., Ltd

3,5-Dichlorosalicylaldehyde Spectrum

3,5-DICHLOROSALICYLALDEHYDE(90-60-8)MS3,5-DICHLOROSALICYLALDEHYDE(90-60-8)13CNMR3,5-DICHLOROSALICYLALDEHYDE(90-60-8)IR13,5-DICHLOROSALICYLALDEHYDE(90-60-8)IR23,5-DICHLOROSALICYLALDEHYDE(90-60-8)IR33,5-DICHLOROSALICYLALDEHYDE(90-60-8)Raman

90-60-8 (3,5-Dichlorosalicylaldehyde) Related Search:

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Salicylaldehyde 3,5,6-Trichlorosalicylic acid 3,5-Dichlorosalicylic acid S(-)-RACLOPRIDE L-TARTRATE Cys-Asp-Pro-Gly-Tyr-Ile-Gly-Ser-Arg
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1of4

Benzaldehyde,3,5-dichloro-2-hydroxy- Salicylaldehyde, 3,5-dichloro- Salicylaldehyde,3,5-dichloro- AKOS B029257 3,5-DICHLORO SALICYLAL LABOTEST-BB LT00089371 3,5-dichlorosalicyde 3,5-Dichlorosalicyladehyde 3,5-Dichlorosalicylaldehyde, 98+% 3,5-dichlorosalicyaldehyde 3,5-DICHLORO-2-HYDROBENZALDEHYDE 3,5-Dichloro-2-hydroxybenzaldehyde, 97+% 5-Dichlorosalicylaldehyde 3,5-Dichlorosalicylaldehyde, 98+% 5GR NSC 96393 3,5-Dichlorosalicylaldehyde 99% Dichlorosalicylaldehyde 3,5-Dichlorosalicylaldehyde[3,5-Dichloro-2-hydroxybenzaldehyde] TIMTEC-BB SBB003642 2-Hydroxy-3,5-dichlorobenzaldehyde 3,5-dichloro-2-hydroxy-benzaldehyd 2-(1-iminoethoxy)ethanesulfonic acid 3,5-Dichlorosalicylaldehyde > 3,5-Dichloro-3-fluoroacetophenone 3,5-DICHLORO-2-HYDROXYBENZALDEHYDE 3,5-Dichlorosalicylaldehyde 90-60-8 Cl2C6H2OHCHO Organic Building Blocks ALDEHYDE C7 Carbonyl Compounds Building Blocks Aldehydes Aromatic Aldehydes & Derivatives (substituted) Benzaldehyde Aldehydes C7 Carbonyl Compounds