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ChemicalBook >> CAS DataBase List >>Methanone, [4-?(2-?amino-?4-?thiazolyl)?-?2-?(1H-?1,?2,?4-?triazol-?1-?yl)?phenyl]?(3,?4,?5-?trimethoxyphenyl)?-

Methanone, [4-?(2-?amino-?4-?thiazolyl)?-?2-?(1H-?1,?2,?4-?triazol-?1-?yl)?phenyl]?(3,?4,?5-?trimethoxyphenyl)?-

Methanone, [4-?(2-?amino-?4-?thiazolyl)?-?2-?(1H-?1,?2,?4-?triazol-?1-?yl)?phenyl]?(3,?4,?5-?trimethoxyphenyl)?- Structure
Methanone, [4-?(2-?amino-?4-?thiazolyl)?-?2-?(1H-?1,?2,?4-?triazol-?1-?yl)?phenyl]?(3,?4,?5-?trimethoxyphenyl)?- structure
CAS No.
1016543-77-3
Chemical Name:
Methanone, [4-?(2-?amino-?4-?thiazolyl)?-?2-?(1H-?1,?2,?4-?triazol-?1-?yl)?phenyl]?(3,?4,?5-?trimethoxyphenyl)?-
Synonyms
S516;S516,S-516;Methanone, [4-(2-amino-4-thiazolyl)-2-(1H-1,2,4-triazol-1-yl)phenyl](3,4,5-trimethoxyphenyl)-
CBNumber:
CB04693714
Molecular Formula:
C21H19N5O4S
Molecular Weight:
437.47
MDL Number:
MOL File:
1016543-77-3.mol
MSDS File:
SDS
Last updated:2026-07-23 14:48:42
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Methanone, [4-?(2-?amino-?4-?thiazolyl)?-?2-?(1H-?1,?2,?4-?triazol-?1-?yl)?phenyl]?(3,?4,?5-?trimethoxyphenyl)?- Properties

Boiling point 739.8±70.0 °C(Predicted)
Density 1.42±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO: 12.5 mg/mL (28.57 mM)
form Solid
pka 3.75±0.10(Predicted)
color Light yellow to yellow
FDA UNII 4RQB78ZFF4

Methanone, [4-?(2-?amino-?4-?thiazolyl)?-?2-?(1H-?1,?2,?4-?triazol-?1-?yl)?phenyl]?(3,?4,?5-?trimethoxyphenyl)?- price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Biosynth RQB54377 S516 1016543-77-3 10mg $851.7 2026-06-05 Buy
Biosynth RQB54377 S516 1016543-77-3 25mg $1388.75 2026-06-05 Buy
Biosynth RQB54377 S516 1016543-77-3 50mg $2222 2026-06-05 Buy
ChemScene CS-0105868 S516 98.03% 1016543-77-3 5mg $303 2026-06-04 Buy
ChemScene CS-0105868 S516 98.03% 1016543-77-3 10mg $487 2026-06-04 Buy
Product number Packaging Price Buy
RQB54377 10mg $851.7 Buy
RQB54377 25mg $1388.75 Buy
RQB54377 50mg $2222 Buy
CS-0105868 5mg $303 Buy
CS-0105868 10mg $487 Buy

Methanone, [4-?(2-?amino-?4-?thiazolyl)?-?2-?(1H-?1,?2,?4-?triazol-?1-?yl)?phenyl]?(3,?4,?5-?trimethoxyphenyl)?- Chemical Properties, Uses, Production

Uses

S516 (Compound 22) is an active metabolite of CKD-516 and a potent tubulin polymerization inhibitor with an IC50 of 4.29 μM. S516 has marked antitumor activity[1].

in vivo

S516 (Compound 22; 5-10 mg/kg; intraperitoneal injection; mice) treatment has promising antitumor activity (inhibition ratio (IR)> 63%) in human LX-1 lung cancer and CX-1 colon cancer mouse xenografts[1].

Animal Model:Mice bearing 3LL lung cancer[1]
Dosage:5 mg/kg, 10 mg/kg
Administration:Intraperitoneal injection
Result:Had promising antitumor activity (inhibition ratio (IR)> 63%).

References

[1] Lee J, et al. Identification of CKD-516: a potent tubulin polymerization inhibitor with marked antitumor activity against murine and human solid tumors. J Med Chem. 2010 Sep 9;53(17):6337-54. DOI:10.1021/jm1002414

Methanone, [4-?(2-?amino-?4-?thiazolyl)?-?2-?(1H-?1,?2,?4-?triazol-?1-?yl)?phenyl]?(3,?4,?5-?trimethoxyphenyl)?- synthesis

1016544-80-1
17356-08-0
1016543-77-3
Synthesis of Methanone, [4-?(2-?amino-?4-?thiazolyl)?-?2-?(1H-?1,?2,?4-?triazol-?1-?yl)?phenyl]?(3,?4,?5-?trimethoxyphenyl)?- from Ethanone, 2-?bromo-?1-?[3-?(1H-?1,?2,?4-?triazol-?1-?yl)?-?4-?(3,?4,?5-?trimethoxybenzoyl)?phenyl]?- and Carbamimidothioic acid

Methanone, [4-?(2-?amino-?4-?thiazolyl)?-?2-?(1H-?1,?2,?4-?triazol-?1-?yl)?phenyl]?(3,?4,?5-?trimethoxyphenyl)?- Preparation Products And Raw materials

Raw materials

Preparation Products

Methanone, [4-?(2-?amino-?4-?thiazolyl)?-?2-?(1H-?1,?2,?4-?triazol-?1-?yl)?phenyl]?(3,?4,?5-?trimethoxyphenyl)?- Suppliers

Global Suppliers ( 17)
Supplier Tel Email Country ProdList Advantage
Shanghai Beckham Medical Technology Co., Ltd 13816613772 huahero21@sina.com China 2994 55
Shanghai YuanYe Biotechnology Co., Ltd. 15026964105 2881489226@qq.com China 89667 60
Shanghai Chaolan Chemical Technology Center QQ：65489617 13301690235 Sales@ATKchemical.com China 9729 58
Fan De(Beijing) Biotechnology Co., Ltd. 15911056312 liming@bio-fount.com China 9718 58
TargetMol Chemicals Inc. +1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11123 58
Shanghai hongqu biomedical technology co. LTD 88888888888 hongquchem@qq.com China 5123 58
Suzhou Chenrui Biotechnology Co. LTD 17625585511 1580084073@qq.com China 992 58
Shanghai Dexuan Pharmaceutical Technology Co., Ltd dexuanyiyao@126.com dexuanyiyao@126.com China 9470 58
cjbscvictory 13348960310 13348960310 3003867561@qq.com China 10233 58
Supplier Advantage
Shanghai Beckham Medical Technology Co., Ltd 55
Shanghai YuanYe Biotechnology Co., Ltd. 60
Shanghai Chaolan Chemical Technology Center 58
Fan De(Beijing) Biotechnology Co., Ltd. 58
TargetMol Chemicals Inc. 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
Shanghai hongqu biomedical technology co. LTD 58
Suzhou Chenrui Biotechnology Co. LTD 58
Shanghai Dexuan Pharmaceutical Technology Co., Ltd 58
cjbscvictory 58

View Latest Price from Methanone, [4-?(2-?amino-?4-?thiazolyl)?-?2-?(1H-?1,?2,?4-?triazol-?1-?yl)?phenyl]?(3,?4,?5-?trimethoxyphenyl)?- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
S516 pictures 2026-07-22 S516
1016543-77-3
 $228.00-943.00 97.44% 10g TargetMol Chemicals Inc.
  • S516 pictures
  • S516
    1016543-77-3
  • $228.00-943.00
  • 97.44%
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1016543-77-3 (Methanone, [4-?(2-?amino-?4-?thiazolyl)?-?2-?(1H-?1,?2,?4-?triazol-?1-?yl)?phenyl]?(3,?4,?5-?trimethoxyphenyl)?-) Related Search:

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S516,S-516 Methanone, [4-(2-amino-4-thiazolyl)-2-(1H-1,2,4-triazol-1-yl)phenyl](3,4,5-trimethoxyphenyl)- S516 1016543-77-3