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PU139

PU139 Structure
PU139 structure
CAS No.
158093-65-3
Chemical Name:
PU139
Synonyms
PU139;2-(4-Fluorophenyl)isothiazolo[5,4-b]pyridin-3(2H)-one;Isothiazolo[5,4-b]pyridin-3(2H)-one, 2-(4-fluorophenyl)-
CBNumber:
CB04718653
Molecular Formula:
C12H7FN2OS
Molecular Weight:
246.26
MDL Number:
MOL File:
158093-65-3.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-16 07:06:08
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PU139 Properties

Boiling point 434.3±51.0 °C(Predicted)
Density 1.473±0.06 g/cm3(Predicted)
storage temp. 4°C, away from moisture
solubility DMSO : 12.5 mg/mL (50.76 mM; ultrasonic and warming and heat to 60°C)
pka 0.43±0.20(Predicted)
form Solid
color Off-white to yellow

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319
Precautionary statements  P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

PU139 price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0087348 PU139 99.51% 158093-65-3 1mg $77 2026-06-04 Buy
ChemScene CS-0087348 PU139 99.51% 158093-65-3 5mg $162 2026-06-04 Buy
ChemScene CS-0087348 PU139 99.51% 158093-65-3 10mg $282 2026-06-04 Buy
ChemScene CS-0087348 PU139 99.51% 158093-65-3 25mg $536 2026-06-04 Buy
ChemScene CS-0087348 PU139 99.51% 158093-65-3 50mg $747 2026-06-04 Buy
Product number Packaging Price Buy
CS-0087348 1mg $77 Buy
CS-0087348 5mg $162 Buy
CS-0087348 10mg $282 Buy
CS-0087348 25mg $536 Buy
CS-0087348 50mg $747 Buy

PU139 Chemical Properties, Uses, Production

Uses

PU139 is a potent pan-histone acetyltransferase (HAT) inhibitor. PU139 blocks the HATs Gcn5, p300/CBP-associated factor (PCAF), CREB (cAMP response element-binding) protein (CBP) and p300 with IC50s of 8.39, 9.74, 2.49 and 5.35 μM, respectively[1][2].

Biological Activity

PU139 is a potent pan-histone acetyltransferase (HAT) inhibitor. PU139 blocks the HATs Gcn5, p300/CBP-associated factor (PCAF), CREB (cAMP response element-binding) protein (CBP) and p300 with IC50s of 8.39, 9.74, 2.49 and 5.35 μM, respectively[1][2]. PU139 inhibits cell growth with GI50s of <60 μM (A431, A549, A2780, HepG2, SW480, U-87 MG, HCT116 and SK-N-SH and MCF7 cells)[1].PU139 (0-100 μM; 24-72 hours) triggers caspase-independent cell death in the neuroblastoma cell line SK-N-SH[1]. PU139 (25 mg/kg; i.p.) synergizes with Doxorubicin used as a prototypic chemotherapeutic drug in growth inhibition[1].

in vivo

PU139 (25 mg/kg; i.p.) synergizes with Doxorubicin used as a prototypic chemotherapeutic drug in growth inhibition[1].

Animal Model:Male NMRI:nu/nu mice (Neuroblastoma xenografts)[1]
Dosage:25 mg/kg
Administration:Intraperitoneally (PU139) with Dxorubicin at 8mg/kg i.v.; Administered on days 14 and 21 as a single dose of each compound or, for combination therapy; both drugs were administered successively within 1h.
Result:Optimum growth inhibition following a single PU139 therapy was moderate, but significant as compared with the untreated group and confirmed the previous findings.

IC 50

GCN5: 8.39 μM (IC50); CREBBP: 2.49 μM (IC50); PCAF: 9.74 μM (IC50); p300: 5.35 μM (IC50)

References

[1]. Gajer JM, et al. Histone acetyltransferase inhibitors block neuroblastoma cell growth in vivo. Oncogenesis. 2015;4(2):e137. Published 2015 Feb 9. [2]. Carneiro VC, et al. Epigenetic changes modulate schistosome egg formation and are a novel target for reducing transmission of schistosomiasis. PLoS Pathog. 2014;10(5):e1004116. Published 2014 May 8.

PU139 Preparation Products And Raw materials

Raw materials

Preparation Products

PU139 Suppliers

Global Suppliers ( 21)
Supplier Tel Email Country ProdList Advantage
Hangzhou Kaitan Technology Co., Ltd. 18668996177 249358374@qq.com China 74 58
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9799 58
Shandong Lingqing Pharmaceutical Technology Co., Ltd. 18668996177 linkingpharm@126.com China 84 58
TargetMol Chemicals Inc. +1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6288 58
Baimei Jihua (Henan) Pharmaceutical Technology Co., Ltd 0371-88900765 18037465274 3430974218@qq.com China 14171 58
Bide Pharmatech Ltd. 400-1647117 13681763483 product02@bidepharm.com China 59929 58
Beijing Biocreative Technology Co., Ltd. 15522676233 3007606172@qq.com China 1246 58
TargetMol Chemicals Inc. 4008200310 15002144251 marketing@tsbiochem.com China 24951 58
Suzhou Zhixin Biotechnology Co., Ltd. 0512-65118909 18100677375 sales@szzxbio.com China 1057 58
Supplier Advantage
Hangzhou Kaitan Technology Co., Ltd. 58
Shanghai EFE Biological Technology Co., Ltd. 58
Shandong Lingqing Pharmaceutical Technology Co., Ltd. 58
TargetMol Chemicals Inc. 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 58
Baimei Jihua (Henan) Pharmaceutical Technology Co., Ltd 58
Bide Pharmatech Ltd. 58
Beijing Biocreative Technology Co., Ltd. 58
TargetMol Chemicals Inc. 58
Suzhou Zhixin Biotechnology Co., Ltd. 58

View Latest Price from PU139 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
PU139 pictures 2026-07-15 PU139
158093-65-3
 $48.00-182.00 99.96% 10g TargetMol Chemicals Inc.
  • PU139 pictures
  • PU139
    158093-65-3
  • $48.00-182.00
  • 99.96%
  • TargetMol Chemicals Inc.

PU139 Spectrum

PU139(158093-65-3)1HNMR

158093-65-3 (PU139) Related Search:

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6-pentadecylsalicylic acid

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PU139 Isothiazolo[5,4-b]pyridin-3(2H)-one, 2-(4-fluorophenyl)- 2-(4-Fluorophenyl)isothiazolo[5,4-b]pyridin-3(2H)-one 158093-65-3 API