BI 907828
- CAS No.
- 2095116-40-6
- Chemical Name:
- BI 907828
- Synonyms
- Brigimadlin;BI 907828;Brigimadlin（BI 907828）;BI-907828 (BRIDIMADLIN);spiro[3H-indol-3,2'(1'H)-pyrrolo[2',3':4,5]pyrrolo[1,2-b]indazol]-7'-carbonsure, 6-chlor-3'-(3-chlor-2-fluorophenyl)-1'-(cyclopropylmethyl)-1,2,3',3'a,10',10'a-hexahydro-6'-methyl-2-oxo-, (3S,3'S,3a'S,10a'S)-;(3S,3'S,3a'S,10a'S)-6-Chloro-3'-(3-chloro-2-fluorophenyl)-1'-(cyclopropylmethyl)-6'-methyl-2-oxo-3',3a',10',10a'-tetrahydro-1'H-spiro[indoline-3,2'-pyrrolo[2',3':4,5]pyrrolo[1,2-b]indazole]-7'-carboxylic acid;(2′S,3′S,3′aS,10′aS)-6-Chloro-3′-(3-chloro-2-fluorophenyl)-1′-(cyclopropylmethyl)-1,2,3′,3′a,10′,10′a-hexahydro-6′-methyl-2-oxospiro[3H-indole-3,2′(1′H)-pyrrolo[2′,3′:4,5]pyrrolo[1,2-b]indazole]-7′-carboxylic acid (ACI)
- CBNumber:
- CB04773025
- Molecular Formula:
- C31H25Cl2FN4O3
- Molecular Weight:
- 591.46
- MDL Number:
- MOL File:
- 2095116-40-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 788.0±60.0 °C(Predicted) |
|---|---|
| Density | 1.68±0.1 g/cm3(Predicted) |
| pka | 3.29±0.40(Predicted) |
| form | Solid |
| color | White to off-white |
| InChIKey | AMTXDBGKYPDTTA-XUOXQPGYNA-N |
| SMILES | C(C1CC1)N1[C@@]2([H])CC3=C4C=CC(C(=O)O)=C(C)C4=NN3[C@@]2([H])[C@H](C2C=CC=C(Cl)C=2F)[C@@]21C(NC1=CC(Cl)=CC=C21)=O |&1:5,21,23,32,r| |
| FDA UNII | 9A934ZAN94 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS08,GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H372-H300-H413-H360Df |
| Precautionary statements | P260-P264-P270-P314-P501-P264-P270-P301+P310-P321-P330-P405-P501 |
BI 907828 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 44353 | BI-907828 ≥98% | 2095116-40-6 | 1mg | $47 | 2026-04-30 | Buy |
| Cayman Chemical | 44353 | BI-907828 ≥98% | 2095116-40-6 | 5mg | $223 | 2026-04-30 | Buy |
| Cayman Chemical | 44353 | BI-907828 ≥98% | 2095116-40-6 | 10mg | $400 | 2026-04-30 | Buy |
| Cayman Chemical | 44353 | BI-907828 ≥98% | 2095116-40-6 | 25mg | $646 | 2026-04-30 | Buy |
| ChemScene | CS-0641160 | Brigimadlin 99.88% | 2095116-40-6 | 1mg | $213 | 2026-06-04 | Buy |
BI 907828 Chemical Properties,Uses,Production
Description
Brigimadlin is an E3 ubiquitin-protein ligase Mdm2 inhibitor with potential as an antineoplastic agent.
Uses
Brigimadlin (BI 907828) is an orally active E3 ubiquitin-protein ligase MDM-2 inhibitor, preventing MDM-2 from negatively regulating the tumor suppressor p53. Brigimadlin can be used for antineoplastic research[1][2][3][4].
in vivo
Brigimadlin (15 and 50 mg/kg, p.o., once a week) inhibits tumor growth and increases median survival in orthotopic xenografts of both a MDM2 amplified (BT48) and a normal CN (BT67), TP53 wild-type BTSC model[3].
Brigimadlin (50 mg/kg, p.o., a single dose) increasees PD biomarkers (CDKN1a and GDF15) in the brain in orthotopic GBM patient-derived BTSC models (BT48 and BT67) in SCID mice, and has low systemic clearance[3].
References
[1] Gollner Andreas, et al. Preparation of spiroindolepyrrolidinone derivatives for use as MDM2-p53 inhibitors: World Intellectual Property Organization, WO2017060431. 2017-04-13.
[2] WHO Drug Information-World Health Organization (WHO).
[3] Hao X, et al. BI-907828, a novel potent MDM2 inhibitor, inhibits glioblastoma brain tumor stem cells in vitro and prolongs survival in orthotopic xenograft mouse models. Neuro Oncol. 2023 May 4;25(5):913-926. DOI:10.1093/neuonc/noac271
[4] Yoo C, et al. Brightline-2: a phase IIa/IIb trial of brigimadlin (BI 907828) in advanced biliary tract cancer, pancreatic ductal adenocarcinoma or other solid tumors. Future Oncol. 2024 Jan 12. DOI:10.2217/fon-2023-0963
BI 907828 Preparation Products And Raw materials
Raw materials
Preparation Products
BI 907828 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Tachizaki Biomedical Research Center | 18014399201 | sales@chemlab-tachizaki.com | China | 2936 | 58 |
| Nantong QuanYi Biotechnology Co., Ltd | 0513-66337626 18051384581 | sales@chemhifuture.com | China | 5987 | 58 |
| Chengdu Novel Biomedical Co., Ltd. | 028-85255396 18302801538 | cdnovell@163.com | China | 2444 | 58 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 18149758185 | sales-cpd@caerulumpharma.com | China | 3493 | 58 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 8000 | 62 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Chunchuang (Wuhan) Technology Co., Ltd | 15727060112 | yutianchun2007@126.com | China | 9867 | 58 |
| Bide Pharmatech Ltd. | 400-1647117 13681763483 | product02@bidepharm.com | China | 59929 | 58 |
View Lastest Price from BI 907828 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-27 | Brigimadlin
2095116-40-6
|
$162.00-392.00 | 98.17% | 10g | TargetMol Chemicals Inc. |
-
- Brigimadlin
2095116-40-6
- $162.00-392.00
- 98.17%
- TargetMol Chemicals Inc.
