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1H-1,2,4-Triazole-3-thiol

1H-1,2,4-Triazole-3-thiol Structure
1H-1,2,4-Triazole-3-thiol structure
CAS No.
3179-31-5
Chemical Name:
1H-1,2,4-Triazole-3-thiol
Synonyms
3-MERCAPTO-1,2,4-TRIAZOLE;MTZ;1,2,4-TRIAZOLE-3-THIOL;1,2,4-triazole-3(5)-thiol;3H-1,2,4-Triazole-3-thione, 1,2-dihydro-;MERCAPTOTRIAZOL;H-1,2,4-Triazole-3-thiol;ent61291;Mercapto-1,2,4-t;mercaptotriazole
CBNumber:
CB0481618
Molecular Formula:
C2H3N3S
Molecular Weight:
101.13
MDL Number:
MFCD00005229
MOL File:
3179-31-5.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-28 18:27:15
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1H-1,2,4-Triazole-3-thiol Properties

Melting point 221-224 °C(lit.)
Boiling point 132.6±23.0 °C(Predicted)
Density 1.385 (estimate)
vapor pressure 1.707-1.71Pa at 25℃
refractive index 1.5800 (estimate)
storage temp. Inert atmosphere,Room Temperature
solubility H2O: soluble50g/L
form solid
pka 9.24±0.20(Predicted)
color White to Off-White
PH 4.0 (85g/l, H2O, 20℃)
Water Solubility Soluble in hot water.
BRN 107731
InChI 1S/C2H3N3S/c6-2-3-1-4-5-2/h1H,(H2,3,4,5,6)
InChIKey AFBBKYQYNPNMAT-UHFFFAOYSA-N
SMILES Sc1nc[nH]n1
LogP -0.398 at 21℃ and pH5
CAS DataBase Reference 3179-31-5(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII RUS62L885R
EPA Substance Registry System 3-Mercapto-1,2,4-triazole (3179-31-5)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H319
Precautionary statements  P264-P270-P280-P301+P312-P305+P351+P338-P337+P313
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xn,Xi
Risk Statements  22-36-36/37/38
Safety Statements  26-33-39-7/8-37/39
WGK Germany  1
RTECS  XZ5267500
F  10-23
Hazard Note  Irritant
TSCA  TSCA listed
HS Code  29339990
Storage Class 11 - Combustible Solids
Hazard Classifications Acute Tox. 4 Oral
Eye Irrit. 2
REACH Registrations Active
NFPA 704
1
2 0

1H-1,2,4-Triazole-3-thiol price More Price(54)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 104558 1H-1,2,4-Triazole-3-thiol 97% 3179-31-5 10g $32.6 2026-04-30 Buy
TCI Chemical M0814 3-Mercapto-1,2,4-triazole >98.0%(GC)(T) 3179-31-5 25g $40 2026-04-30 Buy
TCI Chemical M0814 3-Mercapto-1,2,4-triazole >98.0%(GC)(T) 3179-31-5 100g $103 2026-04-30 Buy
TRC TRC-D679075-500MG 2,4-Dihydro-[1,2,4]triazole-3-thione 3179-31-5 500mg $78 2026-06-03 Buy
TRC TRC-D679075-250MG 2,4-Dihydro-[1,2,4]triazole-3-thione 3179-31-5 250mg $65 2026-06-03 Buy
Product number Packaging Price Buy
104558 10g $32.6 Buy
M0814 25g $40 Buy
M0814 100g $103 Buy
TRC-D679075-500MG 500mg $78 Buy
TRC-D679075-250MG 250mg $65 Buy

1H-1,2,4-Triazole-3-thiol Chemical Properties, Uses, Production

Chemical Properties

WHITE TO SLIGHTLY YELLOW FINE CRYSTALLINE POWDER

Uses

1H-1,2,4-Triazole-3-thiol was used in a study to design a surface enhanced Raman scattering based probe for fast and accurate detection of DNA markers.

General Description

1H-1,2,4-Triazole-3-thiol is a mercapto-substituted 1,2,4-triazole ligand and exhibits tautomerism in solution. 1H-1,2,4-Triazole-3-thiol forms novel luminescent polymers with cadmium(II) salts. 1H-1,2,4-Triazole-3-thiol undergoes regioselective S-alkylation to form a series of S-substituted derivatives.

Synthesis

Formic acid

64-18-6

thiosemicarbazide

79-19-6

1H-1,2,4-Triazole-3-thiol

3179-31-5

1. In a 100 mL reaction flask, formic acid (24.2 g, 0.52 mol), water (25 mL) and aminothiourea (20 g, 0.22 mol) were added sequentially. The mixture was heated to 105 °C and the reaction was maintained for 30 min. 2. Upon completion of the reaction, the reaction solution was slowly cooled to room temperature and subsequently placed at -10°C for slow crystallization. 3. Upon completion of crystallization, the solid product was collected by filtration and dried to afford aldimine thiourea (22.3 g white solid, 85% yield). 4. To a 250 mL single-necked flask was added aldimine thiourea (12 g, 0.1 mol), water (130 mL) and sodium carbonate (21.2 g, 0.25 mol). The mixture was heated to 100 °C and the reaction was kept for 4 hours. 5. At the end of the reaction, the reaction solution was slowly cooled to room temperature and the pH was adjusted to 4-5 with dilute hydrochloric acid. 6. The reaction solution was placed at -10°C with slow stirring to induce slow precipitation of the product. 7. 7. The solid product was collected by filtration and dried to give 3-mercapto-1,2,4-triazole (5.6 g white solid, 55% yield).

References

[1] Patent: CN108689951, 2018, A. Location in patent: Paragraph 0355; 0356; 0357; 0358

1H-1,2,4-Triazole-3-thiol synthesis

64-18-6
79-19-6
3179-31-5
Synthesis of 1H-1,2,4-Triazole-3-thiol from Formic acid and Thiosemicarbazide

1H-1,2,4-Triazole-3-thiol Preparation Products And Raw materials

Raw materials

4,5-dihydro-3,4,4-trimethyloxazolium iodide 1-formylthiosemicarbazide Thiosemicarbazide Sodium carbonate Formic acid

Preparation Products

2,4,5-Triphenylimidazole (4H-[1,2,4]triazol-3-ylsulfanyl)-acetic acid Methyl ester 1H-1,2,4-Triazole, 3-[(phenylmethyl)thio]- 3-[(4-nitrobenzyl)sulfanyl]-4H-1,2,4-triazole 3-(2,4,6-trimethylphenyl)thio-1H-1,2,4-triazole

1H-1,2,4-Triazole-3-thiol Suppliers

Global Suppliers ( 479)
Supplier Tel Email Country ProdList Advantage
Wuhan penglei Biotechnology Co., Ltd 13554168242 445014292@qq.com China 281 58
Hunan Ruipinsheng New Materials co.,Ltd 18573359078 huangruimin@rpsxcl.com China 37 58
Jinan Shengqi Pharmaceutical Co., Ltd 0531-82687819 15610111696 xgc01@orgachem.com China 176 58
Wuhan kamik Technology Co., Ltd 18162538168 201981259@qq.com China 7778 58
Hubei Word Chemical Technology Co., Ltd. 15972179313 15972179313 2562513574@qq.com China 948 58
Nanjing Tiangong Industrial Co., Ltd 18083705188; 18083705188 sales@tg-chemical.com China 129 58
Wuhan Tongyi Su Biotechnology Co., Ltd. 15071019375 634847344@qq.com China 876 58
Shandong Suihua Biotechnology Co., Ltd. 15169101773 15169101773 519904247@qq.com China 1077 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
PharmaBlock Sciences (Nanjing),Inc. 025-86918202 4000255188 sales@pharmablock.com China 5000 55
Supplier Advantage
Wuhan penglei Biotechnology Co., Ltd 58
Hunan Ruipinsheng New Materials co.,Ltd 58
Jinan Shengqi Pharmaceutical Co., Ltd 58
Wuhan kamik Technology Co., Ltd 58
Hubei Word Chemical Technology Co., Ltd. 58
Nanjing Tiangong Industrial Co., Ltd 58
Wuhan Tongyi Su Biotechnology Co., Ltd. 58
Shandong Suihua Biotechnology Co., Ltd. 58
J & K SCIENTIFIC LTD. 76
PharmaBlock Sciences (Nanjing),Inc. 55

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View Latest Price from 1H-1,2,4-Triazole-3-thiol manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
1H-1,2,4-Triazole-3-thiol pictures 2026-09-16 1H-1,2,4-Triazole-3-thiol
3179-31-5
 $800.00-999.00 1ton 99% 5000 HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
1H-1,2,4-Triazole-3-thiol pictures 2026-09-16 1H-1,2,4-Triazole-3-thiol
3179-31-5
 1KG 99%min 1000kgs WUHAN FORTUNA CHEMICAL CO., LTD
3-Mercapto-1,2,4-triazo pictures 2026-07-28 3-Mercapto-1,2,4-triazo
3179-31-5
 $35.00 25kg 99 20tons Wuhan Pinestone Fortune International Trading Co., Ltd.

1H-1,2,4-Triazole-3-thiol Spectrum

1H-1,2,4-Triazole-3-thiol(3179-31-5)MS1H-1,2,4-Triazole-3-thiol(3179-31-5)1HNMR1H-1,2,4-Triazole-3-thiol(3179-31-5)13CNMR1H-1,2,4-Triazole-3-thiol(3179-31-5)IR11H-1,2,4-Triazole-3-thiol(3179-31-5)IR21H-1,2,4-Triazole-3-thiol(3179-31-5)Raman

3179-31-5 (1H-1,2,4-Triazole-3-thiol) Related Search:

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1of4

1H-1,2,4-triazole-5-sulfonyl chloride 1H-1,2,4-Triazole-3-thiol intermediate 3-THIOL-1H-1,2,4-TRIAZOLE 4-triazole,3-mercapto-1h-2 4-triazole-3-thione,1,2-dihydro-3h-2 1,3,4-Triazole-2-thiol 2-Mercapto-1,3,5-triazole 5-Mercapto-1,3,4-triazole 1H-1,2,4-Triazole-3(2H)-thione 5-Mercapto-1H-1,2,4-triazole 1H-1,2,4-Triazole-3-thiol,97% 3-Mercapto-1,2,4-tri 2,3-dihydro-1H-1,2,4-triazole-3-thione Mercapto-1,2,4-Triazol 4-Triazole-3-thiol 1H-1,2,4-Triazole-3-thiol 1,2,4-Triazole-3(5)-thiol 1H-1,2,4-Triazole-3-thiol 97% 3-Mercapto-1,2,4-trizole 3 - Mercapto - 1, 4-trichlorobenzene three azole nitrogen Mercapto-1,2,4-t mercaptotriazole 1,2,4-TRIAZOLE-5-THIOL 1,2,4-Triazol-3-thiol 1,2,4-SODIUM TRIAZOLE MERCAPTOTRIAZOL 1H-1,2,4-Triazole-3-thiol, 97% 10GR 3-MERCAPTO-1,2,4-TRIAZOLE FOR SYNTHESIS 3-Mercapto-1H-1,2,4-triazole, 1H-1,2,4-Triazole-3-thiol, 3-Sulphanyl-1H-1,2,4-triazole 3-Thio-1H-1,2,4-triazole -1,2,4- three3-Mercaptotriazole 3-Mercapto-1,2,4-triazole, 97.0%(GC&T 3-Mercapto-1,2,4-triazoL ent61291 1H-1,2,4-TRIAZOLE-3-MERCAPTAN 1H-1,2,4-TRIAZOLE-3-THIOL 1H-1,2,4-TRIAZOLO-3-MERCAPTAN 1H-1,2,4-TRIAZOL-3-YL HYDROSULFIDE 1H-1,2,4-TRIAZOL-3-THIOL 3-MERCAPTO-1H-1,2,4-TRIAZOLE 3-MERCAPTANO-1,2,4-TRIAZOLE 3-mercapto-1,2,4-triazole*photographic grade 1,2,4,1H-Triazole-3-thiol 3-MERCAPTO-1,2,4-TRIAZOLE 98+% 3H-1,2,4-Triazole-3-thione, 1,2-dihydro- TIMTEC-BB SBB004364 S-TRIAZOLE-3-THIOL 1,2,4-triazol-thiol-(3) 1,2-dihydro-3h-1,2,4-triazole-3-thione 2,4-Triazole-3-thione,1,2-dihydro-3H-1 3-Mercapto-1,2,4-triazole> 2,4-Dihydro-[1,2,4]triazole-3-thione 1H-1,2,4-Triazole-3-thiol 3179-31-5 3-Thiol-1H-1,2,4-thiazole 1H-1,2,4-Triazole-3-thiol Sodium5-mercapto-1,2,3-triazole MTZ 1,2,4-triazole-3(5)-thiol 1,2,4-TRIAZOLE-3-THIOL