Thiosemicarbazide
- CAS No.
- 79-19-6
- Chemical Name:
- Thiosemicarbazide
- Synonyms
- HYDRAZINECARBOTHIOAMIDE;TSC;Aminothiourea;n-aminothiourea;TSZ;3-thiosemicarbazide;CHP3;NSC 2213;ai3-16319;NSC 31792
- CBNumber:
- CB0132714
- Molecular Formula:
- CH5N3S
- Molecular Weight:
- 91.14
- MDL Number:
- MFCD00007620
- MOL File:
- 79-19-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 180-183 °C (dec.)(lit.) |
|---|---|
| Boiling point | 208.6±23.0 °C(Predicted) |
| Density | 1.221 (estimate) |
| bulk density | 500-600kg/m3 |
| vapor pressure | 1.15Pa at 25℃ |
| refractive index | 1.5800 (estimate) |
| storage temp. | Store at +15°C to +25°C. |
| solubility | DMSO : 125 mg/mL (1371.52 mM; Need ultrasonic) |
| pka | pK1:1.5(+1) (25°C,μ=0.1) |
| form | Powder |
| color | White to light yellow |
| PH | 5-7 (50g/l, H2O, 20℃) |
| biological source | rabbit |
| Water Solubility | soluble |
| Merck | 14,9361 |
| BRN | 506320 |
| Henry's Law Constant | 1.5×104 mol/(m3Pa) at 25℃, HSDB (2015) |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| InChI | 1S/CH5N3S/c2-1(5)4-3/h3H2,(H3,2,4,5) |
| InChIKey | BRWIZMBXBAOCCF-UHFFFAOYSA-N |
| SMILES | NNC(N)=S |
| LogP | -1.67 |
| CAS DataBase Reference | 79-19-6(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | 6056O8W6ET |
| NIST Chemistry Reference | Hydrazinecarbothioamide(79-19-6) |
| EPA Substance Registry System | Thiosemicarbazide (79-19-6) |
| UNSPSC Code | 12352203 |
| NACRES | NA.41 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H300-H412 | |||||||||
| Precautionary statements | P264-P270-P273-P301+P310-P405-P501 | |||||||||
| PPE | Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges | |||||||||
| Hazard Codes | T+ | |||||||||
| Risk Statements | 28-52/53-26/27/28 | |||||||||
| Safety Statements | 22-26-36/37-45-61-28A-36/37/39 | |||||||||
| RIDADR | UN 2811 6.1/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | VT4200000 | |||||||||
| F | 8-9-23 | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29309070 | |||||||||
| HS Code | 29335995 | |||||||||
| Storage Class | 6.1A - Combustible acute toxic Cat. 1 and 2 very toxic hazardous materials |
|||||||||
| Hazard Classifications | Acute Tox. 2 Oral Aquatic Chronic 3 |
|||||||||
| Hazardous Substances Data | 79-19-6(Hazardous Substances Data) | |||||||||
| Toxicity | LD50 orally in adult Norway rats: 13 mg/kg, Dieke, Proc. Soc. Exp. Biol. Med. 70, 688 (1949) | |||||||||
| REACH Registrations | Active | |||||||||
| Limited Quantities | 0.5 Kg (solid) | |||||||||
| Excepted Quantities | Max Inner Pack (1g or 1ml) and Max Outer Pack (500g or 500ml) | |||||||||
| NFPA 704 |
|
Thiosemicarbazide price More Price(48)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 89050 | Thiosemicarbazide puriss. p.a., 98% | 79-19-6 | 25g | $53.5 | 2026-04-30 | Buy |
| Sigma-Aldrich | 89050 | Thiosemicarbazide puriss. p.a., 98% | 79-19-6 | 100g | $71.6 | 2026-04-30 | Buy |
| Sigma-Aldrich | SAB1301171 | ANTI-TESC (C-TERM) antibody produced in rabbit IgG fraction of antiserum, buffered aqueous solution | 400 μL | $496 | 2025-07-31 | Buy | |
| Sigma-Aldrich | 8.21119 | Thiosemicarbazide for synthesis | 79-19-6 | 1kg | $252 | 2022-05-15 | Buy |
| TCI Chemical | T0221 | Thiosemicarbazide >98.0%(T) | 79-19-6 | 25g | $56 | 2026-04-30 | Buy |
Thiosemicarbazide Chemical Properties, Uses, Production
Chemical Properties
Thiosemicarbazide is an odorless, white crystalline powder. It is soluble in water and ethanol; its solubility in cold water is 1%–2%, and in warm water is approximately 10%. Needle-like crystals can be obtained from aqueous solutions. It readily reacts with aldehydes and ketones to form specific crystalline products; it also readily reacts with carboxylic acids.
Uses
Used in TLC to stain alpha-keto acidsThiosemicarbazide is used as a reagent for ketones as well as chemical intermediate. It is involved in the detection of metals. It is also used in photography. Further, it is effective for controlling bacterial leaf blight in rice. In addition to this, it is used to prepare 1,3,4-thiadiazoles.
Uses
As a reagent for detection of metals.
Preparation
Thiosemicarbazide is produced from hydrazine hydrate and ammonium thiocyanate as raw materials, with acetaldehyde used as a catalyst. The chemical equations are as follows:
2H₂NNH₂·H₂O + H₂SO₄ → (H₂NNH₂)₂·H₂SO₄ + 2H₂O
(H₂NNH₂)₂·H₂SO₄ + 2NH₄SCN → 2H₂NNH₂·HSCN + (NH₄)₂SO₄
Definition
ChEBI: Hydrazinecarbothioamide is a member of the class of thioureas that is thiourea in which a hydrogen of one of the amino groups is replaced by an amino group. It is a member of hydrazines, a thiocarboxamide and a member of thioureas.
General Description
N-Aminothiourea is a white crystalline powder and is odorless. N-Aminothiourea is used as a reagent for ketones and certain metals, for photography and as a rodenticide. N-Aminothiourea is also effective for control of bacterial leaf blight of rice. Not a registered pesticide in the U.S. N-Aminothiourea is a chemical intermediate for herbicides and a reagent for detection of metals.
Reactivity Profile
Isocyanates and thioisocyanates are incompatible with many classes of compounds, reacting exothermically to release toxic gases. Reactions with amines, aldehydes, alcohols, alkali metals, ketones, mercaptans, strong oxidizers, hydrides, phenols, and peroxides can cause vigorous releases of heat. Acids and bases initiate polymerization reactions in these materials. Some isocyanates react with water to form amines and liberate carbon dioxide. Base-catalysed reactions of isocyanates with alcohols should be carried out in inert solvents. Such reactions in the absence of solvents often occur with explosive violence, [Wischmeyer(1969)].
Health Hazard
N-Aminothiourea is highly toxic by ingestion. May induce goiter and cause delayed toxic effects in blood and skin. May be mutagenic in human cells.
Fire Hazard
When heated to decomposition, very toxic fumes of sulfur oxides and nitrogen oxides are emitted.
Flammability and Explosibility
Non flammable
Safety Profile
Poison by ingestion, intraperitoneal, and intravenous routes. Questionable carcinogen with experimental tumorigenic data. Human mutation data reported. When heated to decomposition it emits very toxic fumes of NOx and SOx.
Potential Exposure
Thiosemicarbazide is a dithiocarbamide compound is used as an intermedialte for pharmaceuticals and herbicides; as a reagent for ketones and certain metals; in certain photography and dye operations; as a rodenticide. It is also effective for control of bacterial leaf blight of rice.
Shipping
UN2771 Thiosemicarbazide, pesticides, solid, toxic, Hazard Class: 6.1; Labels: 6.1-Poisonous materials. UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.
Purification Methods
Crystallise thiosemicarbazide from H2O (solubility is 20.3% w/w at 80o). The hydrochloride has m 190-191o(dec, 184o also reported). It forms salts with heavy metals. [Beilstein 3 H 195, 3 I 79, 3 II 134, 3 III 315, 3 IV 374.]
Incompatibilities
Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.) and strong reducing agents; contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. May react with nitrates.
References
[1] Kurihara, H., et al. “Synthesis of Cyanohydrazine Derivatives from Thiosemicarbazide. Alkylating Reaction of Thiosemicarbazide Using Phase-Transfer Catalyst.” Nippon Kagaku Kaishi, 83 1, 1997, pp. 412–18, https://doi.org/10.1246/NIKKASHI.1997.412.
[2] Varvaresou, Athanasia, et al. “ChemInform Abstract: Synthesis and Biological Evaluation of Indole Containing Derivatives of Thiosemicarbazide and Their Cyclic 1,2,4-Triazole and 1,3,4-Thiadiazole Analogues.” ChemInform, 31 15, 2010, https://doi.org/10.1002/chin.200015117.
Thiosemicarbazide Preparation Products And Raw materials
Raw materials
Preparation Products
1of4
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hubei zhonglong Kangsheng Fine Chemical Co., Ltd | 027-027-83850178 18162590268 | 1984393783@qq.com | China | 4740 | 58 |
| Hubei Hicks Biochemical Co., Ltd | 17362916295; 17362916295 | w17362916295@163.com | China | 3985 | 58 |
| Huai Hua Binfengchem Co., Ltd | 0745-2866851 17711757908 | 3907837691@qq.com | China | 4744 | 58 |
| Jinan Shengqi Pharmaceutical Co., Ltd | 0531-82687819 15610111696 | xgc01@orgachem.com | China | 176 | 58 |
| Fuxin Kaituo Fine Chemical Technology Co., Ltd | 15714082442 | 3757845877@qq.com | China | 343 | 58 |
| Wuhan Nuobiguo Biotechnology Co., Ltd. | 15972140806 15972140806 | 3850656479@qq.com | China | 294 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| MedicalChem(Yancheng)Manuf.Co.,Ltd | +86-515-84383180 | sales@medicalchem.com | China | 80 | 69 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
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View Latest Price from Thiosemicarbazide manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-17 | thiosemicarbazide
79-19-6
|
$800.00-999.00 | 1ton | 99% | 5000 | HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD | |
 |
2026-09-17 | thiosemicarbazide
79-19-6
|
0.99 | RongNa Biotechnology Co.,Ltd | ||||
 |
2026-09-17 | N-Aminothiourea
79-19-6
|
1KG | 99% | 200mt | Jinan Finer Chemical Co., Ltd |
-
- thiosemicarbazide
79-19-6
- $800.00-999.00
- 99%
- HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
-
- thiosemicarbazide
79-19-6
- 0.99
- RongNa Biotechnology Co.,Ltd
-
- N-Aminothiourea
79-19-6
- $0.00
- 99%
- Jinan Finer Chemical Co., Ltd
