CDK5 inhibitor 20-223 (CP 668863)
- CAS No.
- 865317-30-2
- Chemical Name:
- CDK5 inhibitor 20-223 (CP 668863)
- Synonyms
- CDK5 inhibitor;CDK5 inhibitor 20-223;CDK5 inhibitor 20-223 (CP 668863);2-Naphthaleneacetamide, N-(5-cyclobutyl-1H-pyrazol-3-yl)-;CDK5 inhibitor 20223,CDK5 inhibitor 20 223,CDK-5 inhibitor 20-223
- CBNumber:
- CB04844633
- Molecular Formula:
- C19H19N3O
- Molecular Weight:
- 305.37
- MDL Number:
- MFCD32857141
- MOL File:
- 865317-30-2.mol
- MSDS File:
- SDS
CDK5 inhibitor 20-223 (CP 668863) price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | QJB31730 | CDK5 inhibitor | 865317-30-2 | 25mg | $915 | 2026-06-04 | Buy |
| Biosynth | QJB31730 | CDK5 inhibitor | 865317-30-2 | 50mg | $1464.5 | 2026-06-04 | Buy |
| Biosynth | QJB31730 | CDK5 inhibitor | 865317-30-2 | 100mg | $2343 | 2026-06-04 | Buy |
| ChemScene | CS-0085638 | CDK5 inhibitor 20-223 99.62% | 865317-30-2 | 5mg | $217 | 2026-06-04 | Buy |
| ChemScene | CS-0085638 | CDK5 inhibitor 20-223 99.62% | 865317-30-2 | 10mg | $347 | 2026-06-04 | Buy |
CDK5 inhibitor 20-223 (CP 668863) Chemical Properties, Uses, Production
Uses
CDK5 inhibitor 20-223 is a potent CDK2 and CDK5 inhibitor with IC50s of 6.0 and 8.8 nM, respectively. CDK5 inhibitor 20-223 is an effective anti-colorectal cancer (CRC) agent[1].
in vivo
CDK5 inhibitor 20-223 (8mg/kg; subcutaneously; for 14 injections) shows anti-tumor activity in human CRC xenograft tumors in nude mice[1].
| Animal Model: | Athymic nude mice[1] |
| Dosage: | 8 mg/kg |
| Administration: | Injections were given subcutaneously daily for the first week and every other day for two more weeks for a total of 14 injections. |
| Result: | Reduced tumor growth and tumor weight in vivo. |
IC 50
CDK2: 6.0 nM (IC50); CDK5: 8.8 nM (IC50)
References
[1] Caroline M Robb, et al. Characterization of CDK(5) Inhibitor, 20-223 (Aka CP668863) for Colorectal Cancer Therapy. Oncotarget. 2017 Dec 28;9(4):5216-5232. DOI:10.18632/oncotarget.23749
CDK5 inhibitor 20-223 (CP 668863) Preparation Products And Raw materials
Raw materials
Preparation Products
CDK5 inhibitor 20-223 (CP 668863) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 9780 | 55 |
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11123 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 | psaitong@jm-bio.com | China | 27626 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11963 | 58 |
| Nanjing Shizhou Biology Technology Co.,Ltd | 025-85560043 15850508050 | cindy.huang@synzest.com | China | 11975 | 58 |
| Shandong Dayou Pharmaceutical Research and Development Co., Ltd. | hanfangpharma@126.com 15165037910 | hanfangpharma@126.com | China | 25800 | 58 |
| RD International Technology Co., Limited | 18024082417 | market@ubiochem.com | China | 9831 | 58 |
View Latest Price from CDK5 inhibitor 20-223 (CP 668863) manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-27 | CDK5 inhibitor 20-223
865317-30-2
|
10g | TargetMol Chemicals Inc. |
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- CDK5 inhibitor 20-223
865317-30-2
- $0.00
- TargetMol Chemicals Inc.
