Elubrixin tosylate
- CAS No.
- 960495-43-6
- Chemical Name:
- Elubrixin tosylate
- Synonyms
- Elubrixin tosylate;N-[4-Chloro-2-hydroxy-3-[(piperazin-1-yl)sulfonyl]phenyl]-N'-(2-chloro-3-fluorophenyl)urea p-toluene
- CBNumber:
- CB04848277
- Molecular Formula:
- C17H17Cl2FN4O4S. C7H8O3S
- Molecular Weight:
- 635.5
- MDL Number:
- MOL File:
- 960495-43-6.mol
- MSDS File:
- SDS
| form | Solid |
|---|---|
| color | White to off-white |
| FDA UNII | 13FVR7WD4P |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|---|---|
| Signal word | Warning |
| Hazard statements | H361-H373 |
| Precautionary statements | P260-P314-P501-P201-P202-P281-P308+P313-P405-P501 |
Elubrixin tosylate price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | KNB49543 | Elubrixin (tosylate) | 960495-43-6 | 25mg | $1164.25 | 2026-06-04 | Buy |
| Biosynth | KNB49543 | Elubrixin (tosylate) | 960495-43-6 | 50mg | $1620 | 2026-06-04 | Buy |
| ChemScene | CS-0087552 | Elubrixin tosylate 98.14% | 960495-43-6 | 5mg | $271 | 2026-06-04 | Buy |
| ChemScene | CS-0087552 | Elubrixin tosylate 98.14% | 960495-43-6 | 10mg | $422 | 2026-06-04 | Buy |
| ChemScene | CS-0087552 | Elubrixin tosylate 98.14% | 960495-43-6 | 25mg | $888 | 2026-06-04 | Buy |
Elubrixin tosylate Chemical Properties, Uses, Production
Uses
Elubrixin tosylate (SB-656933 tosylate) is a potent, selective, competitive, reversible and orally active CXCR2 antagonist and an IL-8 receptor antagonist. Elubrixin tosylate inhibits neutrophil CD11b upregulation (IC50 of 260.7 nM) and shape change (IC50 of 310.5 nM). Elubrixin tosylate has the potential for inflammatory diseases research, such as inflammatory bowel disease and airway inflammation[1][2][3].
IC 50
CXCR2; IL-8
References
[1] Mozaffari S, et al. Inflammatory bowel disease therapies discontinued between 2009 and 2014. Expert Opin Investig Drugs. 2015;24(7):949-56. DOI:10.1517/13543784.2015.1035432
[2] Lazaar AL, et al. SB-656933, a novel CXCR2 selective antagonist, inhibits ex vivo neutrophil activation and ozone-induced airway inflammation in humans. Br J Clin Pharmacol. 2011 Aug;72(2):282-93. DOI:10.1111/j.1365-2125.2011.03968.x
[3] Nicholson GC, et al. A novel flow cytometric assay of human whole blood neutrophil and monocyte CD11b levels: upregulation by chemokines is related to receptor expression, comparison with neutrophil shape change, and effects of a chemokine receptor (CXCR2) antagonist. Pulm Pharmacol Ther. 2007;20(1):52-9. DOI:10.1016/j.pupt.2005.11.009
Elubrixin tosylate Preparation Products And Raw materials
Raw materials
Preparation Products
Elubrixin tosylate Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11123 | 58 |
| Nanjing Shizhou Biology Technology Co.,Ltd | 025-85560043 13675144456 | sean.lv@synzest.com | China | 11432 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11963 | 58 |
| Nanjing Shizhou Biology Technology Co.,Ltd | 025-85560043 15850508050 | cindy.huang@synzest.com | China | 11975 | 58 |
| Shaanxi Didu Pharmaceutical Co., Ltd. | 029-81124775 17791530730 | 1079@dideu.com | China | 10000 | 58 |
| Guangzhou Ruidi Biotechnology Co., Ltd. | 020-82099279 18988941402 | sales@ubiochem.com | China | 9998 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 50068 | 58 |
