GSK-656933)
- CAS No.
- 688763-64-6
- Chemical Name:
- GSK-656933)
- Synonyms
- Elubrixin;GSK-656933);Elubrixin (SB-656933;Elubrixin, 10 mM in DMSO;N-[4-chloro-2-hydroxy-3-(piperazine-1-sulfonyl)phenyl]-N'-(2-chloro-3-fluorophenyl)urea;Urea, N-(2-chloro-3-fluorophenyl)-N'-[4-chloro-2-hydroxy-3-(1-piperazinylsulfonyl)phenyl]-;airway,Elubrixin,Inhibitor,inhibit,Interleukin Related,CXCR,SB 656933,IL-8,CXC chemokine receptors,neutrophil-mediated,CXCR2,anti-inflammatory,SB656933,CD11b,bowel
- CBNumber:
- CB44844752
- Molecular Formula:
- C17H17Cl2FN4O4S
- Molecular Weight:
- 463.31
- MDL Number:
- MFCD18633293
- MOL File:
- 688763-64-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Density | 1.609±0.06 g/cm3(Predicted) |
|---|---|
| pka | 5.98±0.10(Predicted) |
| FDA UNII | MW2AIJ8USP |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|---|---|
| Signal word | Warning |
| Hazard statements | H361-H373 |
| Precautionary statements | P260-P314-P501-P201-P202-P281-P308+P313-P405-P501 |
GSK-656933) price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0016571 | Elubrixin | 688763-64-6 | 5mg | $271 | 2026-06-04 | Buy |
| ChemScene | CS-0016571 | Elubrixin | 688763-64-6 | 10mg | $422 | 2026-06-04 | Buy |
| ChemScene | CS-0016571 | Elubrixin | 688763-64-6 | 25mg | $888 | 2026-06-04 | Buy |
| ChemScene | CS-0016571 | Elubrixin | 688763-64-6 | 50mg | $1408 | 2026-06-04 | Buy |
| ChemScene | CS-0016571 | Elubrixin | 688763-64-6 | 100mg | $2112 | 2026-06-04 | Buy |
GSK-656933) Chemical Properties, Uses, Production
Uses
Elubrixin (SB-656933) is a potent, selective, competitive, reversible and orally active CXCR2 antagonist and an IL-8 receptor antagonist. Elubrixin inhibits neutrophil CD11b upregulation (IC50 of 260.7 nM) and shape change (IC50 of 310.5 nM). Elubrixin has the potential for inflammatory diseases research, such as inflammatory bowel disease and airway inflammation[1][2][3].
IC 50
CXCR2; IL-8
References
[1] Mozaffari S, et al. Inflammatory bowel disease therapies discontinued between 2009 and 2014. Expert Opin Investig Drugs. 2015;24(7):949-56. DOI:10.1517/13543784.2015.1035432
[2] Lazaar AL, et al. SB-656933, a novel CXCR2 selective antagonist, inhibits ex vivo neutrophil activation and ozone-induced airway inflammation in humans. Br J Clin Pharmacol. 2011 Aug;72(2):282-93. DOI:10.1111/j.1365-2125.2011.03968.x
[3] Nicholson GC, et al. A novel flow cytometric assay of human whole blood neutrophil and monocyte CD11b levels: upregulation by chemokines is related to receptor expression, comparison with neutrophil shape change, and effects of a chemokine receptor (CXCR2) antagonist. Pulm Pharmacol Ther. 2007;20(1):52-9. DOI:10.1016/j.pupt.2005.11.009
GSK-656933) Preparation Products And Raw materials
Raw materials
Preparation Products
GSK-656933) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Chengdu Peter-like Biotechnology Co., Ltd. | 18108052721 | 2850505130@qq.com | China | 5037 | 58 |
| Huansheng Meisen Pharmaceutical Technology (Shandong) Co., Ltd | 0531-88762217 18301471076 | sales@acespharma.com | China | 3859 | 58 |
| Hubei wei shi reagent group ltd., company | 027-59102966 18717199209 | 2853877583@qq.com | China | 2896 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| Nantong QuanYi Biotechnology Co., Ltd | 0513-66337626 18051384581 | sales@chemhifuture.com | China | 5985 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11963 | 58 |
| Shanghai Amole Biotechnology Co., Ltd. | 13370042665 18916960931 | 2596183085@qq.com | China | 17234 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21533 | 55 |
