7-(Diethylamino)-5-methyl-s-triazolo[1,5-a]pyrimidine
![7-(Diethylamino)-5-methyl-s-triazolo[1,5-a]pyrimidine Structure](CAS/GIF/15421-84-8.gif)
- CAS No.
- 15421-84-8
- Chemical Name:
- 7-(Diethylamino)-5-methyl-s-triazolo[1,5-a]pyrimidine
- Synonyms
- TRAPIDIL;ar12008;Trapymin;Avantrin;rocornal;Trapymine;Trapidil CRS;Trapidil (AR12008);Trapidil >=98% (HPLC);Trapidil, 10 mM in DMSO
- CBNumber:
- CB0487317
- Molecular Formula:
- C10H15N5
- Molecular Weight:
- 205.26
- MDL Number:
- MFCD00193104
- MOL File:
- 15421-84-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 98-99.4° (Pfeifer); 102-104° from heptane (Tenor) |
|---|---|
| Density | 1.20±0.1 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | H2O: ≥15mg/mL |
| pka | pKs = 2.79(at 25℃) |
| form | powder |
| color | white to tan |
| Major Application | pharmaceutical (small molecule) |
| InChI | InChI=1S/C10H15N5/c1-4-14(5-2)9-6-8(3)13-10-11-7-12-15(9)10/h6-7H,4-5H2,1-3H3 |
| InChIKey | GSNOZLZNQMLSKJ-UHFFFAOYSA-N |
| SMILES | C12=NC=NN1C(N(CC)CC)=CC(C)=N2 |
| CAS DataBase Reference | 15421-84-8 |
| FDA UNII | EYG5Y6355E |
| ATC code | C01DX11 |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26 | |||||||||
| WGK Germany | 3 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| Toxicity | LD50 in mice, rats (mg/kg): 115, 76 i.v.; 380, 235 orally; 155, 100 i.p.; 132, 100 s.c. (Fuller) | |||||||||
| NFPA 704 |
|
7-(Diethylamino)-5-methyl-s-triazolo[1,5-a]pyrimidine price More Price(59)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | T1820000 | Trapidil European Pharmacopoeia (EP) Reference Standard | 15421-84-8 | 50 mg | $127 | 2026-04-30 | Buy |
| Sigma-Aldrich | SML0071 | Trapidil ≥98% (HPLC) | 15421-84-8 | 50mg | $474 | 2022-05-15 | Buy |
| TCI Chemical | T4243 | Trapidil | 15421-84-8 | 10MG | $107 | 2026-04-30 | Buy |
| TCI Chemical | T4243 | Trapidil | 15421-84-8 | 50MG | $357 | 2026-04-30 | Buy |
| Cayman Chemical | 33496 | Trapidil ≥98% | 15421-84-8 | 5mg | $69 | 2026-04-30 | Buy |
7-(Diethylamino)-5-methyl-s-triazolo[1,5-a]pyrimidine Chemical Properties, Uses, Production
Chemical Properties
White or almost white, crystalline powder
Originator
Rocornal,Mochida,Japan,1978
Uses
Vasodilator;PDGF antagonist
Definition
ChEBI: Trapidil is a member of triazolopyrimidines.
Manufacturing Process
8.4 g of 5-methyl-7-chloro-s-triazolo-(1,5-a)-pyrimidine were suspended in 30 cc of water and 7.3 g of diethylamine added. After 2 hours heating with stirring, the mixture was concentrated under vacuum. The residue was recrystallized from n-heptane. This process yielded 8.1 g of the 5-methyl-7- diethylamino-s-triazolo-(1,5-a)-pyrimidine having a melting point of 103°C to 104°C. The hydrochloride produced in the usual manner had a melting point of 212°C.
Therapeutic Function
Coronary vasodilator
Biological Activity
Trapidil is an antiplatelet agent th at acts in part as a phosphodiesterase inhibitor and as a competitive inhibitor of the platelet-derived growth factor (PDGF) receptor. Trapidil, with its vasodilator and NO releasing effect may have some potential to diminish the tissue injury. Trapidil suppresses platelet-derived growth factor (PDGF)-induced vascular smooth muscle cell (VSMC) proliferation by inhibiting Raf-1/extracellular signal-regulated kinase (ERK) via cAMP/protein kinase A (PKA). In addn. to cAMP/PKA activation, trapidil inhibits RhoA/ROCK activation.
Safety Profile
Poison by ingestion, intraperitoneal, subcutaneous, and intravenous routes. An experimental teratogen. Other experimental reproductive effects. A coronary vasodilator. When heated to decomposition it emits toxic fumes of NOx. See also MINES.
7-(Diethylamino)-5-methyl-s-triazolo[1,5-a]pyrimidine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Wuhan Diao Pharmaceutical Co., Ltd. | -- | 1879237340@qq.com | China | 3 | 58 |
| Tongchuang Pharma(Suzhou). Co., Ltd. | 0512-63263366 18912765016 | tongtf110@sina.com | China | 984 | 62 |
| Hunan Hui Bai Shi Biotechnology Co., Ltd. | 0731-85526065 13308475853 | ivy@hnhbsj.com | China | 7236 | 62 |
| Dalian Meilun Biotech Co., Ltd. | 0411-62910999 13889544652 | sales@meilune.com | China | 4765 | 58 |
| ShangHai YuanYe Biotechnology Co., Ltd. | 15026964105 | shyysw007@163.com | China | 4998 | 60 |
| Shanghai Synthfine Chemical Co.,Ltd | 15921303235 | sales@synthfine.com | China | 994 | 58 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7545 | 61 |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4853 | 58 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Quality Control Solutions Ltd. | 0755-66853366 13670046396 | orders@qcsrm.com | China | 18188 | 56 |
View Latest Price from 7-(Diethylamino)-5-methyl-s-triazolo[1,5-a]pyrimidine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-27 | Trapidil
15421-84-8
|
$56.00-152.00 | 99.96% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-07-27 | Trapidil
15421-84-8
|
$56.00-152.00 | 99.96% | 10g | TargetMol Chemicals Inc. | ||
 |
2025-04-28 | Trapidil
15421-84-8
|
$40.00-138.00 | 99.96% | 10g | TargetMol Chemicals Inc. |
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