- Trapidil
-
- $56.00
-
2026-05-11
- CAS:15421-84-8
- Purity: 99.96%
- Supply Ability: 10g
- Trapidil
-
- $56.00
-
2026-05-11
- CAS:15421-84-8
- Purity: 99.96%
- Supply Ability: 10g
- Trapidil
-
- $40.00
-
2025-04-28
- CAS:15421-84-8
- Purity: 99.96%
- Supply Ability: 10g
|
| | 7-(DIETHYLAMINO)-5-METHYL-S-TRIAZOLO[1,5-A]PYRIMIDINE Basic information |
| Product Name: | 7-(DIETHYLAMINO)-5-METHYL-S-TRIAZOLO[1,5-A]PYRIMIDINE | | Synonyms: | 7-(DIETHYLAMINO)-5-METHYL-S-TRIAZOLO[1,5-A]PYRIMIDINE;7-Diethylamino-5-methyl[1,2,4]triazolo[1,5-a]pyrimidine;N,N-Diethyl-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-amine;Trapymin;N,N-Diethyl-5-methyl-[1,2,4]triazolo[5,1-b]pyrimidin-7-amine;7-(Diethylamino)-5-methyl-S-triazolo[1,5-a]pyrimidine ,98%;Avantrin;Trapymine | | CAS: | 15421-84-8 | | MF: | C10H15N5 | | MW: | 205.26 | | EINECS: | 239-434-2 | | Product Categories: | | | Mol File: | 15421-84-8.mol | ![7-(DIETHYLAMINO)-5-METHYL-S-TRIAZOLO[1,5-A]PYRIMIDINE Structure](CAS/GIF/15421-84-8.gif) |
| | 7-(DIETHYLAMINO)-5-METHYL-S-TRIAZOLO[1,5-A]PYRIMIDINE Chemical Properties |
| Melting point | 98-99.4° (Pfeifer); 102-104° from heptane (Tenor) | | density | 1.20±0.1 g/cm3(Predicted) | | storage temp. | Inert atmosphere,Room Temperature | | solubility | H2O: ≥15mg/mL | | pka | pKs = 2.79(at 25℃) | | form | powder | | color | white to tan | | Major Application | pharmaceutical (small molecule) | | InChI | InChI=1S/C10H15N5/c1-4-14(5-2)9-6-8(3)13-10-11-7-12-15(9)10/h6-7H,4-5H2,1-3H3 | | InChIKey | GSNOZLZNQMLSKJ-UHFFFAOYSA-N | | SMILES | C12=NC=NN1C(N(CC)CC)=CC(C)=N2 | | CAS DataBase Reference | 15421-84-8 |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26 | | WGK Germany | 3 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 | | Toxicity | LD50 in mice, rats (mg/kg): 115, 76 i.v.; 380, 235 orally; 155, 100 i.p.; 132, 100 s.c. (Fuller) |
| | 7-(DIETHYLAMINO)-5-METHYL-S-TRIAZOLO[1,5-A]PYRIMIDINE Usage And Synthesis |
| Chemical Properties | White or almost white, crystalline powder | | Originator | Rocornal,Mochida,Japan,1978 | | Uses | Vasodilator;PDGF antagonist | | Definition | ChEBI: Trapidil is a member of triazolopyrimidines. | | Manufacturing Process | 8.4 g of 5-methyl-7-chloro-s-triazolo-(1,5-a)-pyrimidine were suspended in 30
cc of water and 7.3 g of diethylamine added. After 2 hours heating with
stirring, the mixture was concentrated under vacuum. The residue was
recrystallized from n-heptane. This process yielded 8.1 g of the 5-methyl-7-
diethylamino-s-triazolo-(1,5-a)-pyrimidine having a melting point of 103°C to
104°C. The hydrochloride produced in the usual manner had a melting point
of 212°C. | | Therapeutic Function | Coronary vasodilator | | Biological Activity | Trapidil is an antiplatelet agent th at acts in part as a phosphodiesterase inhibitor and as a competitive inhibitor of the platelet-derived growth factor (PDGF) receptor. Trapidil, with its vasodilator and NO releasing effect may have some potential to diminish the tissue injury. Trapidil suppresses platelet-derived growth factor (PDGF)-induced vascular smooth muscle cell (VSMC) proliferation by inhibiting Raf-1/extracellular signal-regulated kinase (ERK) via cAMP/protein kinase A (PKA). In addn. to cAMP/PKA activation, trapidil inhibits RhoA/ROCK activation. | | Safety Profile | Poison by ingestion,
intraperitoneal, subcutaneous, and
intravenous routes. An experimental
teratogen. Other experimental reproductive
effects. A coronary vasodilator. When
heated to decomposition it emits toxic
fumes of NOx. See also MINES. |
| | 7-(DIETHYLAMINO)-5-METHYL-S-TRIAZOLO[1,5-A]PYRIMIDINE Preparation Products And Raw materials |
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