ChemicalBook >> CAS DataBase List >>2-chloro-4-[trans-3-amino-2,2,4,4-tetramethylcyclobutoxy]benzonitrile

2-chloro-4-[trans-3-amino-2,2,4,4-tetramethylcyclobutoxy]benzonitrile

2-chloro-4-[trans-3-amino-2,2,4,4-tetramethylcyclobutoxy]benzonitrile structure

CAS No.: 1818885-54-9

Chemical Name:: 2-chloro-4-[trans-3-amino-2,2,4,4-tetramethylcyclobutoxy]benzonitrile

Synonyms: 4-((1r,3r)-3-amino-2,2,4,4-tetramethylcyclobutoxy)-2-chlorobenzonitrile;AR antagonist 1;AR antagonist 1, 10 mM in DMSO;2-chloro-4-[trans-3-amino-2,2,4,4-tetramethylcyclobutoxy]benzonitrile;4-(trans-3-Amino-2,2,4,4-tetramethylcyclobutoxy)-2-chlorobenzonitrile;4-[(trans-3-amino-2,2,2,2,4-tetramethylcyclobutyl)oxy]-2-chlorobenzenitrile;Benzonitrile, 4-[(trans-3-amino-2,2,4,4-tetramethylcyclobutyl)oxy]-2-chloro-;2-chloro-4-[trans-3-amino-2,2,4,4-tetramethylcyclobutoxy]benzonitrile - [C83929];AR antagonist1,Target Protein-binding Moiety,AR antagonist-1,Inhibitor,LNCaP,Linker,Ligands for Target Protein for PROTAC,inhibit,cancer,Ligands for E3 Ligase,VCaP,AR antagonist 1,PROTAC,tumor,E3 ligase-recruiting Moiety

CBNumber:: CB04896298

Molecular Formula:: C15H19ClN2O

Molecular Weight:: 278.78

MDL Number:: MFCD30803693

MOL File:: 1818885-54-9.mol

MSDS File:: SDS

Last updated:2026-07-27 17:00:41

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2-chloro-4-[trans-3-amino-2,2,4,4-tetramethylcyclobutoxy]benzonitrile Properties

Boiling point	394.9±42.0 °C(Predicted)
Density	1.18±0.1 g/cm3(Predicted)
storage temp.	Store at 0-8 °C
pka	10.14±0.70(Predicted)
Appearance	white to off-white solid

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319-H335
Precautionary statements	P264-P280-P302+P352-P321-P332+P313-P362-P305+P351+P338-P337+P313-P261-P271-P304+P340-P312-P403+P233-P405-P501

2-chloro-4-[trans-3-amino-2,2,4,4-tetramethylcyclobutoxy]benzonitrile price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
ChemScene	CS-0114683	AR antagonist 1 ≥98%	1818885-54-9	100mg	$138	2026-06-04	Buy
ChemScene	CS-0114683	AR antagonist 1 ≥98%	1818885-54-9	250mg	$166	2026-06-04	Buy
ChemScene	CS-0114683	AR antagonist 1 ≥98%	1818885-54-9	1g	$416	2026-06-04	Buy
Synthonix	C83929	2-chloro-4-[trans-3-amino-2,2,4,4-tetramethylcyclobutoxy]benzonitrile 97%	1818885-54-9	100mg	$170	2026-05-06	Buy
Synthonix	C83929	2-chloro-4-[trans-3-amino-2,2,4,4-tetramethylcyclobutoxy]benzonitrile 97%	1818885-54-9	250mg	$250	2026-05-06	Buy

Product number	Packaging	Price	Buy
CS-0114683	100mg	$138	Buy
CS-0114683	250mg	$166	Buy
CS-0114683	1g	$416	Buy
C83929	100mg	$170	Buy
C83929	250mg	$250	Buy

2-chloro-4-[trans-3-amino-2,2,4,4-tetramethylcyclobutoxy]benzonitrile Chemical Properties, Uses, Production

Uses

AR antagonist 1 (compound 29) is a potent androgen receptor (AR) antagonist and binds to E3 ligase ligands with weak binding affinities to VHL protein in the synthesis of PROTAC ARD-266 (HY-133020).

IC 50

VHL

References

[1] Han X, et al. Discovery of Highly Potent and Efficient PROTAC Degraders of Androgen Receptor (AR) by Employing Weak Binding Affinity VHL E3 Ligase Ligands. J Med Chem. 2019 Dec 26;62(24):11218-11231. DOI:10.1021/acs.jmedchem.9b01393

2-chloro-4-[trans-3-amino-2,2,4,4-tetramethylcyclobutoxy]benzonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

2-chloro-4-[trans-3-amino-2,2,4,4-tetramethylcyclobutoxy]benzonitrile Suppliers

Global Suppliers ( 30)

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Jian Chao Chemical Technology Co., Ltd.	150-2103-5486 18017383231	983544897@qq.com	China	9335	55
ShangHai Caerulum Pharma Discovery Co., Ltd.	18149758185 18149758185	sales-cpd@caerulumpharma.com	China	3493	58
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9799	58
Shanghai SuperLan Chemcial Technique Centre	0-2022843681 15618226720	chaolaichem@foxmail.com	China	9996	58
Aikon International Limited	025-58859352 19370895928	sales01@aikonchem.com	China	15078	58
Jurong Coupling Biotechnology Co., Ltd.	19231718652	278191416@qq.com	China	483	58
TargetMol Chemicals Inc.	+1-781-999-5354; +1-00000000000	marketing@targetmol.com	United States	32431	58
Zhejiang Huida Biotech Co., LTD	0571-89903022 18679456698	zilong@hizyme.com	China	8001	58
Chunchuang (Wuhan) Technology Co., Ltd	15727060112	yutianchun2007@126.com	China	9867	58
Shanghai Sunway Pharmaceutical Technology Co.,Ltd.	13611835272 13611835272	mmwang@sunwaypharm.com	China	44090	58

Supplier	Advantage
Shanghai Jian Chao Chemical Technology Co., Ltd.	55
ShangHai Caerulum Pharma Discovery Co., Ltd.	58
Shanghai EFE Biological Technology Co., Ltd.	58
Shanghai SuperLan Chemcial Technique Centre	58
Aikon International Limited	58
Jurong Coupling Biotechnology Co., Ltd.	58
TargetMol Chemicals Inc.	58
Zhejiang Huida Biotech Co., LTD	58
Chunchuang (Wuhan) Technology Co., Ltd	58
Shanghai Sunway Pharmaceutical Technology Co.,Ltd.	58

View Latest Price from 2-chloro-4-[trans-3-amino-2,2,4,4-tetramethylcyclobutoxy]benzonitrile manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-07-27	AR antagonist 1 1818885-54-9	$30.00-77.00		99.07%	10g	TargetMol Chemicals Inc.
	2026-07-27	AR antagonist 1 1818885-54-9	$30.00-77.00		99.07%	10g	TargetMol Chemicals Inc.

AR antagonist 1
1818885-54-9
$30.00-77.00
99.07%
TargetMol Chemicals Inc.

AR antagonist 1
1818885-54-9
$30.00-77.00
99.07%
TargetMol Chemicals Inc.

2-chloro-4-[trans-3-amino-2,2,4,4-tetramethylcyclobutoxy]benzonitrile Spectrum

2-chloro-4-[trans-3-amino-2,2,4,4-tetramethylcyclobutoxy]benzonitrile(1818885-54-9)¹HNMR

1818885-54-9 (2-chloro-4-[trans-3-amino-2,2,4,4-tetramethylcyclobutoxy]benzonitrile) Related Search:

Benzonitrile, 4-[(cis-4-aminocyclohexyl)oxy]-2-chloro- hydrochloride 2-Chloro-4-(piperidin-4-yloxy)benzonitrile 2-chloro-4-[trans-3-amino-2,2,4,4-tetramethylcyclobutoxy]benzonitrile 4-((1r,3r)-3-amino-2,2,4,4-tetramethylcyclobutoxy)-2-chlorobenzonitrile hydrochloride

Benzonitrile, 4-[(trans-4-aminocyclohexyl)oxy]-2-chloro-

1of2

2-chloro-4-[trans-3-amino-2,2,4,4-tetramethylcyclobutoxy]benzonitrile AR antagonist 1 Benzonitrile, 4-[(trans-3-amino-2,2,4,4-tetramethylcyclobutyl)oxy]-2-chloro- AR antagonist1,Target Protein-binding Moiety,AR antagonist-1,Inhibitor,LNCaP,Linker,Ligands for Target Protein for PROTAC,inhibit,cancer,Ligands for E3 Ligase,VCaP,AR antagonist 1,PROTAC,tumor,E3 ligase-recruiting Moiety 4-(trans-3-Amino-2,2,4,4-tetramethylcyclobutoxy)-2-chlorobenzonitrile AR antagonist 1, 10 mM in DMSO 2-chloro-4-[trans-3-amino-2,2,4,4-tetramethylcyclobutoxy]benzonitrile - [C83929] 4-[(trans-3-amino-2,2,2,2,4-tetramethylcyclobutyl)oxy]-2-chlorobenzenitrile 4-((1r,3r)-3-amino-2,2,4,4-tetramethylcyclobutoxy)-2-chlorobenzonitrile 1818885-54-9