N-[3-Chloro-4-[(5-chloro-2-pyridinyl)oxy]phenyl]-2-pyridinecarboxamide
![N-[3-Chloro-4-[(5-chloro-2-pyridinyl)oxy]phenyl]-2-pyridinecarboxamide Structure](CAS/20200119/GIF/1630936-95-6.gif)
- CAS No.
- 1630936-95-6
- Chemical Name:
- N-[3-Chloro-4-[(5-chloro-2-pyridinyl)oxy]phenyl]-2-pyridinecarboxamide
- Synonyms
- ML-396;VU 0422288;ML396 >=98% (HPLC);VU0422288 (Synonyms: ML396);N-(3-Chloro-4-((5-chloropyridin-2-yl)oxy)phenyl)picolinamide;N-[3-Chloro-4-[(5-chloro-2-pyridinyl)oxy]phenyl]-2-pyridinecarboxamide;2-Pyridinecarboxamide, N-[3-chloro-4-[(5-chloro-2-pyridinyl)oxy]phenyl]-
- CBNumber:
- CB04902919
- Molecular Formula:
- C17H11Cl2N3O2
- Molecular Weight:
- 360.19
- MDL Number:
- MFCD28411626
- MOL File:
- 1630936-95-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 154-158°C |
|---|---|
| Boiling point | 422.6±45.0 °C(Predicted) |
| Density | 1.445±0.06 g/cm3(Predicted) |
| storage temp. | -20°C Freezer |
| solubility | Chloroform (Slightly), DMSO (Slightly) |
| form | Solid |
| pka | 10.42±0.70(Predicted) |
| color | Light Red to Red |
| InChI | 1S/C17H11Cl2N3O2/c18-11-4-7-16(21-10-11)24-15-6-5-12(9-13(15)19)22-17(23)14-3-1-2-8-20-14/h1-10H,(H,22,23) |
| InChIKey | MZRLPXFGQKQHST-UHFFFAOYSA-N |
| SMILES | O=C(NC1=CC=C(OC2=NC=C(Cl)C=C2)C(Cl)=C1)C3=NC=CC=C3 |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H319 | |||||||||
| Precautionary statements | P264-P280-P301+P312-P305+P351+P338-P337+P313-P501 | |||||||||
| WGK Germany | WGK 3 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Eye Irrit. 2 |
|||||||||
| NFPA 704 |
|
N-[3-Chloro-4-[(5-chloro-2-pyridinyl)oxy]phenyl]-2-pyridinecarboxamide price More Price(28)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 29167 | ML-396 ≥98% | 1630936-95-6 | 1mg | $36 | 2026-04-30 | Buy |
| Cayman Chemical | 29167 | ML-396 ≥98% | 1630936-95-6 | 5mg | $120 | 2026-04-30 | Buy |
| Cayman Chemical | 29167 | ML-396 ≥98% | 1630936-95-6 | 10mg | $219 | 2026-04-30 | Buy |
| Cayman Chemical | 29167 | ML-396 ≥98% | 1630936-95-6 | 25mg | $462 | 2026-04-30 | Buy |
| TRC | TRC-V787590-5MG | VU 0422288 | 1630936-95-6 | 5mg | $149 | 2026-06-03 | Buy |
N-[3-Chloro-4-[(5-chloro-2-pyridinyl)oxy]phenyl]-2-pyridinecarboxamide Chemical Properties, Uses, Production
Uses
VU 0422288 is a metabotropic glutamate receptor 7 (mGlu7) positive allosteric modulators.
Biological Activity
ML396 is a potent positive allosteric modulator or metabotropic glutamate receptors group III (mGlu group III PAM). ML396 was used to study the biology of mGlu7.
in vivo
VU0422288 (30 mg/kg; i.p.; once daily for 17 days) rescues synaptic plasticity defects and learning and memory phenotypes, reduces the number of apneas in Mecp2+/- mice, while VU0422288 has no effect in Mecp2+/+animals[2].
VU0422288 (10 mg/kg; i.p.; single dose) exhibis a plasma/brain partitioning coefficient of 1.67 in adult male Sprague-Dawley rats, with predicted unbound brain concentration of about 40 nM[2].
IC 50
mGluR4: 108 nM (EC50); mGluR7: 146 nM (EC50); mGluR8: 128 nM (EC50)
storage
Store at +4°C
N-[3-Chloro-4-[(5-chloro-2-pyridinyl)oxy]phenyl]-2-pyridinecarboxamide Preparation Products And Raw materials
Raw materials
Preparation Products
N-[3-Chloro-4-[(5-chloro-2-pyridinyl)oxy]phenyl]-2-pyridinecarboxamide Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| MQ (shanghai) Pharmaceuticals Co., Ltd. | 13761635123 | sales@linyuepharm.com | China | 5731 | 55 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 400-920-5774 | sales@glpbio.cn | China | 6705 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11123 | 58 |
| Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd | 15317229551 | 15151849396@163.com | China | 964 | 58 |
| ShangHai ChuanQian Chemcial Technique Centre | 15869524721 | 3525679403@qq.com | China | 4565 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44871 | 58 |
| Jinan Jiuli Biotechnology Co. , Ltd. | 15865264761 | 486064515@qq.com | China | 5000 | 58 |
