2-[(Cyclopropylsulfonyl)amino]-N-(2-ethoxyphenyl)benzamide
![2-[(Cyclopropylsulfonyl)amino]-N-(2-ethoxyphenyl)benzamide Structure](CAS/20200331/GIF/1646499-97-9.gif)
- CAS No.
- 1646499-97-9
- Chemical Name:
- 2-[(Cyclopropylsulfonyl)amino]-N-(2-ethoxyphenyl)benzamide
- Synonyms
- ML 382;ML382, 10 mM in DMSO;2-cyclopropanesulfonamido-N-(2-ethoxyphenyl)benzamide;2-[(Cyclopropylsulfonyl)amino]-N-(2-ethoxyphenyl)benzamide;Benzamide, 2-[(cyclopropylsulfonyl)amino]-N-(2-ethoxyphenyl)-;ML382,Inhibitor,ML 382,nociceptor,pain,injury,DRG,inhibit,neurons,nervous,ML-382
- CBNumber:
- CB44902689
- Molecular Formula:
- C18H20N2O4S
- Molecular Weight:
- 360.43
- MDL Number:
- MOL File:
- 1646499-97-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Density | 1.34±0.1 g/cm3(Predicted) |
|---|---|
| storage temp. | Store at -20°C |
| solubility | Soluble in DMSO |
| form | A solid |
| pka | 8.30±0.20(Predicted) |
| color | White to off-white |
| InChIKey | RCSLEKLNDJJJLF-UHFFFAOYSA-N |
| SMILES | O=C(C1=C(C=CC=C1)NS(C2CC2)(=O)=O)NC3=C(C=CC=C3)OCC |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
2-[(Cyclopropylsulfonyl)amino]-N-(2-ethoxyphenyl)benzamide price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML3564 | ML382 ≥98% (HPLC) | 1646499-97-9 | 5 mg | $87.1 | 2026-04-30 | Buy |
| Sigma-Aldrich | SML3564 | ML382 ≥98% (HPLC) | 1646499-97-9 | 25 mg | $351 | 2026-04-30 | Buy |
| Cayman Chemical | 36668 | ML-382 ≥98% | 1646499-97-9 | 5mg | $110 | 2026-04-30 | Buy |
| Cayman Chemical | 36668 | ML-382 ≥98% | 1646499-97-9 | 10mg | $198 | 2026-04-30 | Buy |
| Cayman Chemical | 36668 | ML-382 ≥98% | 1646499-97-9 | 25mg | $414 | 2026-04-30 | Buy |
2-[(Cyclopropylsulfonyl)amino]-N-(2-ethoxyphenyl)benzamide Chemical Properties, Uses, Production
Uses
ML 382 acts as a potent and selective allosteric modulator of MrgX1, used in the stufy to improve the potency and efficacy of anti-chronic pain medicaments.
Biological Activity
ML382 is a positive allosteric modulator of Mas-related G-protein-coupled receptor X1 (MrgprX1, MrgX1, SNSR4), a G-protein coupled receptor (GPCR) selectively expressed in dorsal root ganglion (DRG) neurons. MrgX1 is believed to be a functional ortholog of mouse MrgC11, which has been shown to be involved in itch and pain. ML382 is selective for MrgX1 over MrgX2, MrgC11 and a panel of 68 other GPCRs, ion channels and transporters, with an EC50 value of 190 nm with an Emax value of 148% in the presence of the known ligand BAM8-22.
in vivo
ML382 (5 μM) significantly increases inhibition of ICa by a low concentration of BAM8–22 (0.5 μM) in DRG neurons from MrgprX1 mice. ML382 enhances the inhibition of spinal synaptic transmission by BAM8-22 in MrgprX1 mice. ML382 (25 μM, 125 μM, and 250 μM; 5 μL; i.th.;) dose-dependently attenuates heat hypersensitivity in MrgprX1 mice. ML382 (lumbar puncture injection; 25 μM, 5 μL) leads to a significant increase in postconditioning time spent in the ML382-paired chamber, compared with the preconditioning value. ML382 inhibits nerve injury-induced ongoing pain in MrgprX1 mice[1].
storage
Store at RT
2-[(Cyclopropylsulfonyl)amino]-N-(2-ethoxyphenyl)benzamide Preparation Products And Raw materials
Raw materials
Preparation Products
2-[(Cyclopropylsulfonyl)amino]-N-(2-ethoxyphenyl)benzamide Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4859 | 55 | |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 8000 | 62 |
| Beijing Solarbio Science & Tecnology Co., Ltd. | 17801761073 18101056239 | 3193328036@qq.com | China | 28150 | 68 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 400-920-5774 | sales@glpbio.cn | China | 6705 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11123 | 58 |
| Chunchuang (Wuhan) Technology Co., Ltd | 15727060112 | yutianchun2007@126.com | China | 9869 | 58 |
| Jinan Jiuli Biotechnology Co. , Ltd. | 15865264761 | 486064515@qq.com | China | 5000 | 58 |
