3-Amino-4-chlorophenol
- CAS No.
- 16026-77-0
- Chemical Name:
- 3-Amino-4-chlorophenol
- Synonyms
- 4-chloro-3-amino phenol;3-Amino-4-chlorophenol;Phenol, 3-amino-4-chloro-;3-AMINO-4-CHLOROPHENOL 97;3-Amino-4-chlorophenol 97%;3-
AMino- 4- chlorophenol
- CBNumber:
- CB0499798
- Molecular Formula:
- C6H6ClNO
- Molecular Weight:
- 143.57
- MDL Number:
- MFCD03427127
- MOL File:
- 16026-77-0.mol
- MSDS File:
- SDS
| Melting point | 151-154 °C (lit.) |
|---|---|
| Boiling point | 282.8±20.0 °C(Predicted) |
| Density | 1.406±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| pka | 9.57±0.18(Predicted) |
| form | Powder |
| color | Pale orange to brown |
| Water Solubility | Slightly soluble in water. |
| InChI | 1S/C6H6ClNO/c7-5-2-1-4(9)3-6(5)8/h1-3,9H,8H2 |
| InChIKey | FWUALUHYKLDYAN-UHFFFAOYSA-N |
| SMILES | Nc1cc(O)ccc1Cl |
| CAS DataBase Reference | 16026-77-0(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H301-H315-H319-H335 | |||||||||
| Precautionary statements | P280a-P301+P310a-P405-P501a-P261-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
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| NFPA 704 |
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3-Amino-4-chlorophenol price More Price(47)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 552488 | 3-Amino-4-chlorophenol 97% | 16026-77-0 | 1g | $73.3 | 2023-06-20 | Buy |
| Sigma-Aldrich | 552488 | 3-Amino-4-chlorophenol 97% | 16026-77-0 | 5g | $184 | 2023-06-20 | Buy |
| Activate Scientific | AS48869 | 3-Amino-4-chlorophenol 98% | 16026-77-0 | 1g | $34 | 2026-06-04 | Buy |
| Activate Scientific | AS48869 | 3-Amino-4-chlorophenol 98% | 16026-77-0 | 5g | $106 | 2026-06-04 | Buy |
| Activate Scientific | AS48869 | 3-Amino-4-chlorophenol 98% | 16026-77-0 | 25g | $394 | 2026-06-04 | Buy |
3-Amino-4-chlorophenol Chemical Properties, Uses, Production
Uses
3-Amino-4-chlorophenol may be used in the synthesis of hydroxymethyl rhodamines (HMRs).
General Description
3-Amino-4-chlorophenol is formed as a product from the photochemical decomposition of 2,5-dichloroaniline.
Synthesis
610-78-6
16026-77-0
Step 1. Reduction reaction: 4-chloro-3-nitrophenol (6.0 g, 34.6 mmol) and acetic acid (60 mL) were added to a 100-mL round-bottom flask equipped with a magnetic stir bar. Iron powder (325 mesh, 19.31 g, 346 mmol) was then added and the reaction mixture was heated with stirring at 100 °C for 30 min. After completion of the reaction, the mixture was cooled to room temperature and diluted with deionized water (40 mL). Step 2. Post-treatment: The diluted mixture was filtered through a diatomaceous earth pad and washed thoroughly with deionized water. The filtrate was extracted with ethyl acetate and the organic phases were combined and concentrated under reduced pressure. Step 3. Purification: Heptane (~100 mL) was added to the concentrated residue, followed by evaporation under reduced pressure to remove residual acetic acid and water, and the process was repeated. The final residue was dissolved in acetonitrile and concentrated again under reduced pressure. The resulting solid was suspended in heptane and concentrated under reduced pressure to afford 3-amino-4-chlorophenol (4.38 g, 88% yield) as a lavender to amber solid. The mass spectrum (ESI, cation mode) showed m/z 144 [M + 1].
References
[1] Journal of Organic Chemistry, 2013, vol. 78, # 9, p. 4530 - 4542
[2] Bioorganic and Medicinal Chemistry Letters, 2018, vol. 28, # 21, p. 3454 - 3457
[3] Patent: WO2015/74064, 2015, A2. Location in patent: Paragraph 0227
[4] Journal of the Brazilian Chemical Society, 2016, vol. 27, # 2, p. 372 - 381
3-Amino-4-chlorophenol Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
| Changzhou Huanling Chemical Co., Ltd. | 89803005 18206112582 | info@huanlingchem.com | China | 983 | 68 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| China DongFan Chemical Co.,LTD | 86-0571-85151182 | China | 5681 | 66 | |
| TaiZhou ZhiCheng Chemicals & Technology Co., LTD. | 0523-82837785 13914525028 | info@jszchg.com | China | 244 | 60 |
| Shanghai T&W Pharmaceutical Co., Ltd. | +86 21 61551611 | China | 9874 | 58 |
View Latest Price from 3-Amino-4-chlorophenol manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-08-12 | 3-Amino-4-chlorophenol
16026-77-0
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd | ||
 |
2020-01-03 | 3-Amino-4-chlorophenol
16026-77-0
|
$1.00 | 1KG | 95-99% | 1ton | Career Henan Chemical Co |
-
- 3-Amino-4-chlorophenol
16026-77-0
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- 3-Amino-4-chlorophenol
16026-77-0
- $1.00
- 95-99%
- Career Henan Chemical Co
