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1,2,3,6-Tetrahydrophthalic anhydride

1,2,3,6-Tetrahydrophthalic anhydride Structure
1,2,3,6-Tetrahydrophthalic anhydride structure
CAS No.
85-43-8
Chemical Name:
1,2,3,6-Tetrahydrophthalic anhydride
Synonyms
TETRAHYDROPHTHALIC ANHYDRIDE;tetrahydrophthalic;thpa[qr];rikacidth[qr];Tetrahydroftalanhydrid;1,2,3,6-TetrahydrophthaL;3,6-Cyclopropylene-ΔTetrahydrophthalsureanhydrid;anhydridetetrahydrophtalique;tetrahydrophthalicanhydrides
CBNumber:
CB0501956
Molecular Formula:
C8H8O3
Molecular Weight:
152.15
MDL Number:
MFCD00065335
MOL File:
85-43-8.mol
MSDS File:
SDS
Last updated:2026-06-24 18:39:39
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1,2,3,6-Tetrahydrophthalic anhydride Properties

Melting point 101-102°C
Boiling point 195°C 5mm
Density 1,375 g/cm3
vapor pressure 0.021Pa at 20℃
refractive index 1.4810 (estimate)
Flash point 157°C
storage temp. Store below +30°C.
solubility soluble in DCM, Ethyl Acetate, Toluene
form Solid
pka 3.84[at 20 ℃]
color Off-White to Light Tan
PH 2.1 (20°C, 10g/L in H2O)
Water Solubility 29.4g/L at 20℃
InChI 1S/C8H8O3/c9-7-5-3-1-2-4-6(5)8(10)11-7/h1-2,5-6H,3-4H2
InChIKey KMOUUZVZFBCRAM-UHFFFAOYSA-N
SMILES O1C(=O)C2C(CC=CC2)C1=O
LogP 1.29 at 40℃
CAS DataBase Reference 85-43-8(CAS DataBase Reference)
Indirect Additives used in Food Contact Substances TETRAHYDROPHTHALIC ANHYDRIDE
FDA 21 CFR 177.2280; 177.2800
FDA UNII W9Q4666NOS
EPA Substance Registry System Tetrahydrophthalic anhydride (85-43-8)
UNSPSC Code 12352115
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319
Precautionary statements  P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313-P362
Risk Statements  41-42/43-52/53
Safety Statements  26-36/37/39
RIDADR  UN 2698 (TETRAHYDROPHTHALIC ANHYDRIDES with more than 0.05 % of maleic anhydride)
WGK Germany  WGK 1
Autoignition Temperature 400°C
TSCA  TSCA listed
HazardClass  8
PackingGroup  III
Storage Class 8A - Combustible, corrosive hazardous materials
Hazard Classifications Aquatic Chronic 3
Eye Dam. 1
Resp. Sens. 1
Skin Sens. 1
Hazardous Substances Data 85-43-8(Hazardous Substances Data)
REACH Registrations Active

1,2,3,6-Tetrahydrophthalic anhydride price More Price(20)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 8.00742 1,2,3,6-Tetrahydrophthalic anhydride for synthesis 85-43-8 100 g $38.8 2026-04-30 Buy
Sigma-Aldrich 8.00742 1,2,3,6-Tetrahydrophthalic anhydride for synthesis 85-43-8 1 kg $87.7 2026-04-30 Buy
Usbiological 410879 1,2,3,6-Tetrahydrophthalic Anhydride 85-43-8 10g $468 2026-06-03 Buy
Usbiological 410879 1,2,3,6-Tetrahydrophthalic Anhydride 85-43-8 100g $955 2026-06-03 Buy
TRC TRC-T294176-250G 1,2,3,6-Tetrahydrophthalic Anhydride 85-43-8 250g $793 2026-06-03 Buy
Product number Packaging Price Buy
8.00742 100 g $38.8 Buy
8.00742 1 kg $87.7 Buy
410879 10g $468 Buy
410879 100g $955 Buy
TRC-T294176-250G 250g $793 Buy

1,2,3,6-Tetrahydrophthalic anhydride Chemical Properties, Uses, Production

Chemical Properties

white flaky solid

Uses

Chemical intermediate for light-colored alkyds, polyesters, plasticizers, and adhesives; intermediate for pesticides; hardener for resins.

Definition

ChEBI: 1,2,3,6-tetrahydrophthalic anhydride is a cyclic dicarboxylic anhydride that is 1,3,3a,4,7,7a-hexahydro-2-benzofuran carrying oxo groups at positions 1 and 3. It is a cyclic dicarboxylic anhydride and a tetrahydrofurandione.

General Description

Clear colorless to light yellow slight viscous liquid. Highly toxic and a strong irritant to skin, eyes and mucous membranes. Corrosive to skin and metal. Used in making polyester, alkyd resins, and plasticizers.

Air & Water Reactions

Reacts exothermically with water to form memtetrahydrophthalic acid.

Reactivity Profile

CIS-1,2,3,6-TETRAHYDROPHTHALIC ANHYDRIDE; >98% is combustible. Reacts with oxidizers. Reacts exothermically with water. These reactions are usually slow, but can become violent when local heating accelerates their rate. Acids accelerate the reaction with water. Incompatible with acids, strong oxidizing agents, alcohols, amines, and bases.

Hazard

Strong irritant to eyes and skin.

Health Hazard

TOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.

Fire Hazard

Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Some are oxidizers and may ignite combustibles (wood, paper, oil, clothing, etc.). Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated.

Flammability and Explosibility

Non flammable

Safety Profile

Moderately toxic by intraperitoneal route. Mildly toxic by ingestion. A corrosive irritant to skin, eyes, and mucous membranes. Combustible when exposed to heat or flame. Will react with water or steam to produce heat; can react with oxidizing materials. To fight fre, use water, foam, CO2, dry chemical. When heated to decomposition it emits acrid smoke and irritating fumes. See also ANHYDRIDES.

Synthesis

o-Xylene

95-47-6

dimethyl cyclohex-3-ene-1,6-dicarboxylate

7500-55-2

1,2-Cyclohexanedicarboxylic acid, 4-(3,4-dimethylphenyl)-, 1,2-dimethyl ester

1352221-13-6

1,2,3,6-Tetrahydrophthalic anhydride

85-43-8

2.0 g of lanthanum nitrate hexahydrate was dissolved in 100 mL of deionized water, and the resulting solution was added dropwise to a suspension formed from 5.0 g of H-type Y-zeolite (Tosoh Corporation, HSZ-320H0A, Si/Al ratio = 2.8) with 200 mL of deionized water at room temperature. Subsequently, the mixture was heated at 90 °C for 3 hours. Upon completion of the reaction, the solid product was separated by centrifugation, washed five times with 45 mL of deionized water, and dried at 85 °C overnight. The dried solid was calcined in an air atmosphere at 500 °C for 2 h to obtain the alkylation catalyst (hereinafter referred to as La/HY). The content of La in the catalyst was determined to be 5.6 wt% by ICP analysis. The alkylation reaction was carried out in a SUS autoclave equipped with a 50 mL glass liner. To the glass liner were added 0.10 g of the above La/HY catalyst (100 wt% relative to the unsaturated compounds), 0.16 g of tridecane (internal standard), 0.1 g (0.53 mmol) of methyl 1-cyclohexene-4,5-dicarboxylate (hereinafter referred to as CEDA) as the unsaturated compounds, and 3.0 g (28.30 mmol) of o-xylene as the aromatic compound. The system was sealed under nitrogen atmosphere after three displacements with nitrogen. The reaction was initiated by immersing the autoclave in an oil bath preheated to 180 °C. The reaction was carried out in a water bath. After 2 hours of reaction, the reactor was cooled with water to release the internal gases. The alkylation products 3,4-dimethoxycarbonylcyclohexyl-3',4'-dimethylbenzene (hereinafter referred to as CDMB) and 1-cyclohexene-4,5-dicarboxylic anhydride, etc., in the reaction solution were quantitatively analyzed by gas chromatography with an FID detector as an internal standard method. The results showed that the yield of CDMB was 49.6% and the selectivity was 51.0%.CDMB is a new compound with the following physical properties: boiling point: 166 °C/66 Pa; 1H NMR (500 MHz, CDCl3): δ 1.44-1.48 (m, 1H), 1.69-1.76 (m, 1H), 1.95-2.04 (m, 2H), 2.13-2.16 (m, 1H), 2.22 (s, 3H), 2.24 (s, 3H), 2.33-2.38 (m, 1H), 2.48-2.56 (m, 2H), 3.37-3.96 (m, 1H), 3.71 (s, 3H*2), 6.92 (d, J=7.7 Hz, 1H), 6.96 (s, 1H), 7.06 (d, J=7.7 Hz, 1H) 7.06 (d, J=7.7 Hz, 1H); 13C NMR (500 MHz, CDCl3): δ 19.3, 19.8, 24.5, 33.2, 35.5, 39.0, 42.0, 43.3, 51.8, 123.9, 128.2, 129.7, 134.4, 136.5, 143.4, 173.8, 174.2; IR (d, J=7.7 Hz, 1H). 174.2; IR (neat, cm-1): 3450, 3000, 2950, 2860, 1734.

References

[1] Patent: US2013/41174, 2013, A1. Location in patent: Paragraph 0051; 0072

1,2,3,6-Tetrahydrophthalic anhydride synthesis

108-31-6
106-99-0
85-43-8
Synthesis of 1,2,3,6-Tetrahydrophthalic anhydride from Maleic anhydride and 1,3-Butadiene

1,2,3,6-Tetrahydrophthalic anhydride Preparation Products And Raw materials

Raw materials

1,3-Butadiene Maleic anhydride o-Xylene dimethyl cyclohex-3-ene-1,6-dicarboxylate Tridecane
cyclohex-4-ene-1,2-dicarboxylic acid 3-Sulfolene Methanol 1,2-Butadiene

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Preparation Products

Captan 3,4,5,6-Tetrahydrophthalic anhydride Tetramethrin N-Hydroxymethyl-3,4,5,6-tetrahydrophthalimide Hexahydrophthalic anhydride
cis-4-Cyclohexene-1,2-dicarboxylic acid Tetrahydrophthalimide diethyl cyclohex-4-ene-1,2-dicarboxylate dimethyl cyclohex-3-ene-1,6-dicarboxylate

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1,2,3,6-Tetrahydrophthalic anhydride Suppliers

Global Suppliers ( 237)
Supplier Tel Email Country ProdList Advantage
Puyang Shengtong Juyuan New Materials Co.,Ltd. 03935331669 13652127192 china_wulin@foxmail.com China 16 58
Puyang Huicheng Electronic Material Co. Ltd. 0393-0393-8910800 15039333257 info@huichengchem.com China 588 64
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
ShangHai DEMO Chemical Co.,Ltd 400-021-7337 2355568890 sales@demochem.com China 2569 57
Beijing HwrkChemical Technology Co., Ltd 89508211 18501085097 sales.bj@hwrkchemical.com China 9407 55
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Beijing Ouhe Technology Co., Ltd 13552068683 13522913783 2355560935@qq.com China 11777 60
shanghai science Bio-Pharmceutical.co,ltd. 021-021-57872719 13761402923 245662540@qq.com China 299 60
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Chemsky（shanghai）International Co.,Ltd. 021-50135380 shchemsky@sina.com China 32273 50
Supplier Advantage
Puyang Shengtong Juyuan New Materials Co.,Ltd. 58
Puyang Huicheng Electronic Material Co. Ltd. 64
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
ShangHai DEMO Chemical Co.,Ltd 57
Beijing HwrkChemical Technology Co., Ltd 55
Energy Chemical 61
Beijing Ouhe Technology Co., Ltd 60
shanghai science Bio-Pharmceutical.co,ltd. 60
Shanghai Hanhong Scientific Co.,Ltd. 64
Chemsky（shanghai）International Co.,Ltd. 50

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Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
1,2,3,6-Tetrahydrophthalic anhydride pictures 2026-09-17 1,2,3,6-Tetrahydrophthalic anhydride
85-43-8
 $75.00-100.00 1kg 99% 5000 HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
Tetrahydrophthalic Anhydride pictures 2026-09-16 Tetrahydrophthalic Anhydride
85-43-8
 $1030.00 1000KG ≥99.6% 2000MT/month Puyang Shengtong Juyuan New Materials Co., Ltd.
1,2,3,6-Tetrahydrophthalic anhydride pictures 2026-08-21 1,2,3,6-Tetrahydrophthalic anhydride
85-43-8
 $1705.00-1715.00 10tons 99% 1000tons Hebei Dangtong Import and export Co LTD

1,2,3,6-Tetrahydrophthalic anhydride Spectrum

1,2,3,6-Tetrahydrophthalic anhydride(85-43-8)1HNMR

85-43-8 (1,2,3,6-Tetrahydrophthalic anhydride) Related Search:

3,4,5,6-Tetrahydrophthalic anhydride exo-3,6-Epoxy-1,2,3,6-tetrahydrophthalic anhydride 4,10-Dioxatricyclo[5.2.1.0(2,6)]dec-8-ene-3,5-dione Phthalic anhydride 1,2,3,6-Tetrahydro-4-methylphthalic anhydride
Carbic anhydride cis-1,2,3,6-Tetrahydrophthalic anhydride Chlorendic anhydride 5-Norbornene-2,3-dicarboxylic anhydride 1,2,3,6-Tetrahydrophthalic anhydride
Tetrahydromethyl-1,3-isobenzofurandione Methyl-5-norbornene-2,3-dicarboxylic anhydride Bicyclo[2.2.2]oct-7-ene-2,3,5,6-tetracarboxylic acid dianhydride endo-Bicyclo[2.2.2]oct-5-ene-2,3-dicarboxylic anhydride 5,6-dimethyl-3a,4,7,7a-tetrahydroisobenzofuran-1,3-dione
5-methyl-6-(3-methyl-2-butenyl)cyclohex-4-ene-1,2-dicarboxylic anhydride 1,14-Dimethyl-4,10-dioxatetracyclo[5.5.2.0(2,6).0(8,12)]tetradec-13-ene-3,5,9,11-tetraone 4-Acetyl-7-phenyl-3a,4,7,7a-tetrahydro-2-benzofuran-1,3-dione

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Δ4-Tetrahydrophthalic anhydride Δ4-Tetrahydrophthalic anhydride 1,2,3,6-Tetrahydro phthalic anhydride (THPA) 1,3-Isobenzofurandione, 3a,4,7,7a-tetrahydro- Tetrahydrophthalsureanhydrid 1,2,3,6-tetrahydrophthalicanhydride[qr] 1,3-Isobenzofurandione, 3a,4,7,7a-tetrahydro-, cis- 1,3-isobenzofurandione,3a,4,7,7a-tetrahydro-[qr] 3a,4,7,7a-tetrahydro-1,3-benzofurandione 3a,4,7,7a-tetrahydro-3-isobenzofurandione 3-Isobenzofurandione,3a,4,7,7a-tetrahydro-1 4-Cyclohexene-1,2-dicarboxylic acid anhydride 4-Cyclohexene-1,2-dicarboxylic anhydride, cis- 4-cyclohexene-1,2-dicarboxylicacidanhydride 4-cyclohexene-1,2-dicarboxylicanhydride[qr] Anhydrid kyseliny tetrahydroftalove anhydridetetrahydrophtalique anhydridkyselinytetrahydroftalove anhydridkyselinytetrahydroftalove[czech][qr] Butadiene-maleic anhydride adduct butadiene-maleicanhydrideadduct Cyclohex-4-en-1,2-dicarbonsaeureanhydrid Cyclohex-4-en-1,2-dicarboxylic acid anhydride Cyclohex-4-ene-1,2-dicarboxylic anhydride delta(4)-tetrahydrophthalicanhydride delta(Sup4)-Tetrahydrophthalic anhydride delta(sup4)-tetrahydrophthalicanhydride delta(sup4)-tetrahydrophthalicanhydride[qr] delta-4-Tetrahydrophthalic anhydride Maleic anhydride adduct of butadiene maleicanhydrideadductofbutadiene maleicanhydrideadductofbutadiene[qr] Memtetrahydro phtalic anhydride memtetrahydrophtalicanhydride[qr] Phthalic anhydride, 1,2,3,6-tetrahydro- phthalicanhydride,1,2,3,6-tetrahydro-[qr] Tetrahydrophthalic Anhydride (THPA) 4,7-Dihydroisobenzofuran-1,3(3aH,7aH)-dione 1,2,3,6-Tetrahydrophthalic anhydride 1,2,3,6-TETRAHYDROPHTHALIC ANHYDRIDE FOR cis-1,2,3,6-Tetrahydrophthalic anhydrid 1,2,3,6-TetrahydrophthaL 3,6-Cyclopropylene-&Delta 1,2,3,6-Tetrahydrophthalic acid anhydride 1,2,3,6-tetrahydrophthalicacidanhydride 1,2,3,6-tetrahydro-phthalicanhydrid CIS-1,2,3,6-TETRAHYDROPHTHALIC ANHYDRIDE; >98% cis-cyclohex-4-ene-1,2-dicarboxylic anhydride rikacidth[qr] Tetrahydroftalanhydrid tetrahydroftalanhydrid[czech][qr] tetrahydrophthalic tetrahydrophthalicacidanhydride[qr] tetrahydrophthalicanhydrides thpa[qr] TETRAHYDROPHTHALIC ANHYDRIDE 85-43-8 Pyridines