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Hexahydrophthalic anhydride

Hexahydrophthalic anhydride Structure
Hexahydrophthalic anhydride structure
CAS No.
85-42-7
Chemical Name:
Hexahydrophthalic anhydride
Synonyms
HHPA;cyclohexane-1,2-dicarboxylic anhydride;Hexahydrophthalic Anhydride (HHPA);1,2-CYCLOHEXANEDICARBOXYLIC ANHYDRIDE;Hexahydro-isobenzofuran-1,3-dione;1,3-Isobenzofurandione, hexahydro-;NT 907;C6H10(CO)2O;Araldite HT 907;RRSYY(Selfotel)-1
CBNumber:
CB7468504
Molecular Formula:
C8H10O3
Molecular Weight:
154.16
MDL Number:
MFCD00064863
MOL File:
85-42-7.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-08-25 18:36:05
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Hexahydrophthalic anhydride Properties

Melting point 32-34 °C(lit.)
Boiling point 158 °C17 mm Hg(lit.)
Density 1.18
vapor pressure 0.31Pa at 25℃
refractive index 1.4620 (estimate)
RTECS NP6895168
Flash point >230 °F
storage temp. Store below +30°C.
solubility Chloroform, Methanol (Slightly)
form Solid
pka 4.14[at 20 ℃]
color White to Off-White
Water Solubility 4.2g/L at 20℃
Sensitive Moisture Sensitive
BRN 83213
Henry's Law Constant 4.7×10-1 mol/(m3Pa) at 25℃, HSDB (2015)
Exposure limits ACGIH TLV-CEILING:0.005 mg/m3,Inhalable fraction and vapor
Stability Moisture Sensitive
InChI 1S/C8H10O3/c9-7-5-3-1-2-4-6(5)8(10)11-7/h5-6H,1-4H2/t5-,6+
InChIKey MUTGBJKUEZFXGO-OLQVQODUSA-N
SMILES O=C1OC(=O)[C@H]2CCCC[C@@H]12
LogP -4.14 at 20℃
Substances of Very High Concern (SVHC) Candidate List Cyclohexane-1,2-dicarboxylic anhydride (85-42-7)
CAS DataBase Reference 85-42-7(CAS DataBase Reference)
EWG's Food Scores 2-3
FDA UNII B52Z7TNV87
NIST Chemistry Reference 1,2-Cyclohexane dicarboxylic anhydride(85-42-7)
EPA Substance Registry System Hexahydrophthalic anhydride (85-42-7)
UNSPSC Code 12352115
NACRES NA.23

SAFETY

Risk and Safety Statements

Symbol(GHS)  Corrosion (GHS05)Health Hazard (GHS08)
GHS05,GHS08
Signal word  Danger
Hazard statements  H317-H318-H334
Precautionary statements  P261-P280-P284-P304+P340-P305+P351+P338+P310
PPE dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Hazard Codes  Xn
Risk Statements  41-42/43
Safety Statements  23-24-26-37/39
RIDADR  3335
WGK Germany  1
Autoignition Temperature 395°C (DIN 51794)
TSCA  TSCA listed
HS Code  29172090
Storage Class 11 - Combustible Solids
Hazard Classifications Eye Dam. 1
Resp. Sens. 1
Skin Sens. 1
Hazardous Substances Data 85-42-7(Hazardous Substances Data)
REACH Registrations Active
NFPA 704
1
2 0

Hexahydrophthalic anhydride price More Price(23)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 123463 1,2-Cyclohexanedicarboxylic anhydride, predominantly cis 95% 85-42-7 100g $51.8 2026-04-30 Buy
Sigma-Aldrich 123463 1,2-Cyclohexanedicarboxylic anhydride, predominantly cis 95% 85-42-7 500g $91.3 2026-04-30 Buy
TRC TRC-H294020-25G Hexahydro-1,3-isobenzofurandione 85-42-7 25g $259 2026-06-03 Buy
TRC TRC-H294020-2.5G Hexahydro-1,3-isobenzofurandione 85-42-7 2.5g $204 2026-06-03 Buy
TRC TRC-H294020-100G Hexahydro-1,3-isobenzofurandione 85-42-7 100g $381 2026-06-03 Buy
Product number Packaging Price Buy
123463 100g $51.8 Buy
123463 500g $91.3 Buy
TRC-H294020-25G 25g $259 Buy
TRC-H294020-2.5G 2.5g $204 Buy
TRC-H294020-100G 100g $381 Buy

Hexahydrophthalic anhydride Chemical Properties, Uses, Production

Description

Hexahydrophthalic anhydride (HHPA) is widely used for electronics applications, e.g. HHPA cured epoxy resins have excellent dielectric properties, high-temperature stability, and high glass transition temperatures. HHPA is used as a curing agent in adhesive coatings and sealant materials, e.g. for the second-generation two-part epoxy adhesive synthesis. Hexahydrophthalic anhydride is also used in the manufacture of alkyd and polyester resins, insecticides, and rust preventives.

References

[1] Guy Rabilloud, High Performance Polymers. Vol. 1 Conductive Adhesives, 1997
[2] John Burke Sullivan and Gary R. Krieger, Clinical Environmental Health and Toxic Exposures, 2001
[3] B. A. G. Jönsson, H. Welinder, C. Hansson and B. Ståhlbom, Occupational exposure to hexahydrophthalic anhydride: air analysis, percutaneous absorption, and biological monitoring, International Archives of Occupational and Environmental Health 1993, vol. 65, 43-47

Chemical Properties

White crystalline powder

Uses

Intermediate for alkyds, plasticizers, insect repellents, and rust inhibitors; hardener in epoxy resins.

Uses

HPPA, in combination with triethaylamine (TEA), can be used as a polymerization initiator in the preparation of polyester based resins. It can also be used as a hardener to cure 1,4-butanediol diglycidyl ether which can be used as an epoxy based system for electronic devices.

Definition

ChEBI: A cyclic dicarboxylic anhydride that is the cyclic anhydride of hexahydrophthalic acid.

Application

Predominantly cis 1,2-cyclohexanedicarboxylic anhydride (HHPA) is a cyclic anhydride that can be used for a variety of applications such as: plasticizer, rust inhibitor, and a curing agent for epoxy based resins.
HPPA, in combination with triethaylamine (TEA), can be used as a polymerization initiator in the preparation of polyester based resins. It can also be used as a hardener to cure 1,4-butanediol diglycidyl ether which can be used as an epoxy based system for electronic devices.

General Description

Predominantly cis 1,2-cyclohexanedicarboxylic anhydride (HHPA) is a cyclic anhydride that can be used for a variety of applications such as: plasticizer, rust inhibitor, and a curing agent for epoxy based resins.

Hazard

Toxic by inhalation, strong irritant to eyes and skin.

Flammability and Explosibility

Non flammable

Synthesis

Hexahydrophthalic anhydride is obtained by reacting ciscyclohexane-1, 2-dicarboxylic acid with oxalyl chloride.Combine ciscyclohexane-1, 2-dicarboxylic acid (1 mmol, 172 mg) and oxalyl chloride (1.2 mmol, 152 mg, 0.103 ml) in dry toluene (5 mL) and add a drop of freshly distilled DMF. Purge the reaction vessel with argon and heat the reaction under stirring for 3 h. Stop the stirring, decant the toluene solution and filter. Evaporate the volatiles. Transform into crystalline form by trituration with diethyl ether. 1H NMR (400 MHz, CDCl3) | 3.18 - 3.12 (m, 2H 2CH) 1.96 - 1.83 (m, 4H 2CH2) 1.57 - 1.49 (m, 4H 2CH2). HRMS (ESI), calcd for C8H10NaO3 [M+Na]+ 175.0522, found 175.0527; calcd for C9H14NaO4 [M+CH3 OH+Na]+ 209.0784, found 209.0788.
Synthesis_85-42-7
Fig The synthetic method of Hexahydrophthalic anhydride.

Purification Methods

It has been obtained by heating the trans-acid or anhydride at 200o. Crystallise it from *C6H6/Et2O or distil it. [Kohler & Jansen J Am Chem Soc 60 2145 1938, Abell J Org Chem 22 769 1957, Beilstein 17 II 452, 17 III/IV 5931.]

Hexahydrophthalic anhydride synthesis

38765-78-5
85-42-7
Synthesis of Hexahydrophthalic anhydride from 2-Cyclohexene-1,2-dicarboxylic acid

Hexahydrophthalic anhydride Preparation Products And Raw materials

Raw materials

Tetrachlorophthalic anhydride 2-Cyclohexene-1,2-dicarboxylic acid 3,4,5,6-tetrahydrophthalic acid cis-Hexahydrophthalic acid 3,4,5,6-Tetrahydrophthalic anhydride
1,2,3,6-Tetrahydrophthalic anhydride

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Preparation Products

1(3H)-Isobenzofuranone,hexahydro- 1,2-Bis(7-Methyloctyl)cyclohexyl-1,2-dicarboxylate

Hexahydrophthalic anhydride Suppliers

Global Suppliers ( 397)
Supplier Tel Email Country ProdList Advantage
Changzhou Success Chemical Co., Ltd. 18961148122; 18961148122 278954761@qq.com China 34 58
Puyang Shengtong Juyuan New Materials Co.,Ltd. 03935331669 13652127192 china_wulin@foxmail.com China 16 58
Jiangsu Xinsu New Materials Co., Ltd 0512-66387919 15251950002 15251950002@163.com China 7338 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
Beijing HwrkChemical Technology Co., Ltd 89508211 18501085097 sales.bj@hwrkchemical.com China 9407 55
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Beijing Ouhe Technology Co., Ltd 13552068683 13522913783 2355560935@qq.com China 11777 60
Puyang Huicheng Electronic Material Co. Ltd. 0393-0393-8910800 15039333257 info@huichengchem.com China 588 64
Shandong Xiya Chemical Co., Ltd 13355009207 13355009207 3007715519@qq.com China 18722 57
Supplier Advantage
Changzhou Success Chemical Co., Ltd. 58
Puyang Shengtong Juyuan New Materials Co.,Ltd. 58
Jiangsu Xinsu New Materials Co., Ltd 58
J & K SCIENTIFIC LTD. 76
Alfa Aesar 84
Beijing HwrkChemical Technology Co., Ltd 55
Energy Chemical 61
Beijing Ouhe Technology Co., Ltd 60
Puyang Huicheng Electronic Material Co. Ltd. 64
Shandong Xiya Chemical Co., Ltd 57

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Hexahydrophthalic Anhydride pictures 2026-09-18 Hexahydrophthalic Anhydride
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Hexahydrophthalic anhydride pictures 2026-09-18 Hexahydrophthalic anhydride
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Hexahydrophthalic anhydride Spectrum

Hexahydrophthalic anhydride(85-42-7)1HNMRHexahydrophthalic anhydride(85-42-7)IRHexahydrophthalic anhydride(85-42-7)RamanHexahydrophthalic anhydride(85-42-7)FT-IR

85-42-7 (Hexahydrophthalic anhydride ) Related Search:

Succinic anhydride Cyclohexane Methyl tetrahydrophthalic anhydride Di-tert-butyl dicarbonate cis-1,2,3,6-Tetrahydrophthalic anhydride
3-Fluorophthalic anhydride Tetrachlorophthalic anhydride Erythromycin Estolate Dibutyl phthalate Glutaric anhydride
Phthalonitrile Tetrabromophthalic anhydride Tetrahydromethyl-1,3-isobenzofurandione Maleic anhydride Phthalic anhydride
Phthalimide Phthalamide 3-Nitrophthalic anhydride

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1,2-Cyclohexanedicarboxylic Acid anhydride 1,3-Isobenzofurandione, hexahydro- 3-Isobenzofurandione,hexahydro-1 Araldite HT 907 hexahydro-3-isobenzofurandione Lekutherm Hardener H NT 907 CALCIUM 2-NAPTHYLPHOSPHATE 3a,4,5,6,7,7a-Hexahydro-2-benzofuran-1,3-dione 3a,4,5,6,7,7a-Hexahydro-1,3-isobenzofurandione 8-Oxabicyclo[4.3.0]nonane-7,9-dione 1,2-Cyclohexanedicarboxylic anhydride, cis and trans mixture,98% C6H10(CO)2O 3a,4,5,6,7,7a-hexahydroisobenzofuran-1,3-quinone Hexahydro-isobenzofuran-1,3-dione Hexahydrophthalic an 1,2-Cyclohexanedicarboxylic anhydride, Mixture of cis and trans, trans≤2% 1,2-Cyclohexanedicarboxylic anhydride, 99%, mixture of cis and trans, trans≤2% Hexahydrophthalic anhydride, 99%, 99% 1,2-Cyclohexanedicarboxylic anhydride, cis and trans, 97% 1,2-Cyclohexanedicarboxylic anhydride, predoMinantly cis 95% Methylhexahydrophthalic anhydride Manufacturer / In stock factory 1,2-CYCLOHEXANEDICARBOXYLIC ANHYDRIDE HEXAHYDROPHTHALIC ANHYDRIDE Hexahydro benzoicanhydride 1,2-CYCLOHEXANEDICARBOXYLIC ANHYDRIDE, 9 5% 1,2-cyclohexanedicarboxylic anhydride, mixed isomers 1,2-cyclohexanedicarboxylic anhydride, predominantly cis Hexahydro-1,3-isobenzofurandione. CYCLOHEXANEDICARBOXYLIC ANHYDRIDE: HHPA HEXAHYDROPHTALICACIDANHYDRIDE Hexahydrophthalsureanhydrid 1,2-Cyclohexanedicarboxylic anhydride, cis + trans, 97% HEXAHYDROPHTHALIC ANHYDRIDE(AMH-330) Hexaphthalic anhydride RRSYY(Selfotel)-1 1,2-Cyclohexanedicarboxylic anhydride, predominantly cis HEXAHYDROPHTHALIC ANHYDRIDE（HHPA），HHPA，Hexahydrophthalic anhydride 1，2-Cyclohexanedicarboxylic Anhydride， Cis Trans HHPA cyclohexane-1,2-dicarboxylic anhydride Hexahydrophthalic Anhydride (HHPA) 85-42-7 ANHYDRIDE Organics Diels-Alder Adducts