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FASCAPLYSIN CHLORIDE

FASCAPLYSIN CHLORIDE Structure
FASCAPLYSIN CHLORIDE structure
CAS No.
114719-57-2
Chemical Name:
FASCAPLYSIN CHLORIDE
Synonyms
fascaplysine;FASCAPLYSIN CHLORIDE;Fascaplysin chloride hydrate;Fascaplysin (chloride)|CDK4 inhibitor;Fascaplysin, ATP-competitve CDK4 inhibitor;Pyrido[1,2-a:3,4-b']diindol-5-ium, 12,13-dihydro-13-oxo-, chloride;12,13-dihydro-13-oxo-pyrido[1,2-a:3,4-b']diindol-5-ium,monochloride;Fascaplysine hydrate, Pyrido[1,2-a:3,4-b]diindol-5-ium,12,13-dihydro-13-oxo-, chloride (9CI);3-aza-13-azoniapentacyclo[11.7.0.02,10.04,9.014,19]icosa-1(13),2(10),4,6,8,11,14,16,18-nonaen-20-one
CBNumber:
CB0503495
Molecular Formula:
C18H11ClN2O
Molecular Weight:
306.74574
MDL Number:
MFCD09752600
MOL File:
114719-57-2.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-16 07:06:08
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FASCAPLYSIN CHLORIDE Properties

storage temp. 2-8°C
solubility Soluble in DMSO (up to 20 mg/ml) or in Water (up to 2 mg/ml)
form solid
color Dark red-brown
Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months.
InChI 1S/C18H10N2O.ClH/c21-18-13-6-2-4-8-15(13)20-10-9-12-11-5-1-3-7-14(11)19-16(12)17(18)20;/h1-10H;1H
InChIKey PWUOOJVYZQILBG-UHFFFAOYSA-N
UNSPSC Code 12352200

SAFETY

Risk and Safety Statements

Hazard Codes  Xi,T
Risk Statements  36/37/38-61-45-20/21/22
Safety Statements  26-53-45-36/37/39
WGK Germany  WGK 1
Storage Class 11 - Combustible Solids

FASCAPLYSIN CHLORIDE price More Price(16)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 341251 Fascaplysin, Synthetic - CAS 114719-57-2 - Calbiochem 114719-57-2 1mg $140 2023-01-07 Buy
Cayman Chemical 21715 Fascaplysin (chloride) ≥95% 114719-57-2 1mg $54 2026-04-30 Buy
Cayman Chemical 21715 Fascaplysin (chloride) ≥95% 114719-57-2 5mg $213 2026-04-30 Buy
ChemScene CS-0045235 Fascaplysin 95.6% 114719-57-2 5mg $492 2026-06-04 Buy
ApexBio Technology BA3286 Fascaplysin 114719-57-2 5mg $367 2026-05-06 Buy
Product number Packaging Price Buy
341251 1mg $140 Buy
21715 1mg $54 Buy
21715 5mg $213 Buy
CS-0045235 5mg $492 Buy
BA3286 5mg $367 Buy

FASCAPLYSIN CHLORIDE Chemical Properties,Uses,Production

Description

Fascaplysin (114719-57-2) is a novel marine natural product isolated fromThorectandra sp.1A potent and selective inhibitor of cyclin dependent kinase 4/cyclin D1 (IC50= 0.35 μM) and is less selective for Cdk6/D1 (IC50= 3.4 μM). Displays antiangiogenic acitivity.2Fascaplysin displays high cytotoxic activity against small cell lung cancer cell lines acting via multiple mechanisms including topoisomerase I, DNA integrity and ROS.3

Uses

Fascaplysin Chloride is a selective CDK4/cyclin D1 inhibitor. Downregulates the PI3K pathway in cancer cells and also has an effect on erythrocytes and thrombosis.

in vivo

Fascaplysin suppresses the growth of S180 cell-implanted tumors in vivo[2]

IC 50

CDK4

References

[1] RAJEEV SONI. Inhibition of Cyclin-Dependent Kinase 4 (Cdk4) by Fascaplysin, a Marine Natural Product[J]. Biochemical and biophysical research communications, 2000, 275 3: Pages 877-884. DOI:10.1006/bbrc.2000.3349
[2] JING LIN  Hai M C  Xiao Jun Yan. Fascaplysin, a selective CDK4 inhibitor, exhibit anti-angiogenic activity in vitro and in vivo.[J]. Cancer Chemotherapy and Pharmacology, 2007, 59 4: 439-445. DOI:10.1007/s00280-006-0282-x
[3] HAMILTON G. Cytotoxic effects of fascaplysin against small cell lung cancer cell lines.[J]. Marine Drugs, 2014: 1377-1389. DOI:10.3390/md12031377

FASCAPLYSIN CHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

FASCAPLYSIN CHLORIDE Suppliers

Global( 29)Suppliers
Supplier Tel Email Country ProdList Advantage
Beijing HwrkChemical Technology Co., Ltd 89508211 18501085097 sales.bj@hwrkchemical.com China 9407 55
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9799 58
TargetMol Chemicals Inc. +1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
BOC Sciences 16314854226; +8616314854226 inquiry@bocsci.com United States 19852 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11123 58
Energy Chemical 400-0056266 marketing1@energy-chemical.com China 44927 58
TargetMol Chemicals Inc. 4008200310 15002144251 marketing@tsbiochem.com China 24951 58
Guangzhou Ruidi Biotechnology Co., Ltd. 020-82099279 18988941402 sales@ubiochem.com China 10000 58
Supplier Advantage
Beijing HwrkChemical Technology Co., Ltd 55
Shanghai EFE Biological Technology Co., Ltd. 58
TargetMol Chemicals Inc. 58
BOC Sciences 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
Energy Chemical 58
TargetMol Chemicals Inc. 58
Guangzhou Ruidi Biotechnology Co., Ltd. 58

View Lastest Price from FASCAPLYSIN CHLORIDE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Fascaplysin chloride pictures 2026-08-08 Fascaplysin chloride
114719-57-2
 $178.00-686.00 10g TargetMol Chemicals Inc.
Fascaplysin chloride pictures 2025-12-22 Fascaplysin chloride
114719-57-2
 10g TargetMol Chemicals Inc.

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Fascaplysin (chloride)|CDK4 inhibitor 12,13-dihydro-13-oxo-pyrido[1,2-a:3,4-b']diindol-5-ium,monochloride fascaplysine Fascaplysin chloride hydrate Fascaplysine hydrate, Pyrido[1,2-a:3,4-b]diindol-5-ium,12,13-dihydro-13-oxo-, chloride (9CI) FASCAPLYSIN CHLORIDE Pyrido[1,2-a:3,4-b']diindol-5-ium, 12,13-dihydro-13-oxo-, chloride Fascaplysin, ATP-competitve CDK4 inhibitor 3-aza-13-azoniapentacyclo[11.7.0.02,10.04,9.014,19]icosa-1(13),2(10),4,6,8,11,14,16,18-nonaen-20-one 114719-57-2 C18H11ClN2OxH2O C18H11ClN2O