PAPP
- CAS No.
- 1814-64-8
- Chemical Name:
- PAPP
- Synonyms
- 163;LY165;LY-165;LY 165;p-Nh2-pe-tfmpp;PAPP (LY-165,163) SELECTIVE 5-HT1A SERO;1-(2-(4-Aminophenyl)ethyl)-4-(3-trifluoromethylphenyl)piperazine;4-[2-[4-[3-(Trifluoromethyl)phenyl]-1-piperazinyl]ethyl]benzenamine;Benzenamine, 4-(2-(4-(3-(trifluoromethyl)phenyl)-1-piperazinyl)ethyl)-;PAPP, p-Aminophenethyl-m-trifluoromethylphenyl piperazine, 4-[2-[4-[3-(Trifluoromethyl)phenyl]-1-piperazinyl]ethyl]benzeneamine
- CBNumber:
- CB0504467
- Molecular Formula:
- C19H22F3N3
- Molecular Weight:
- 349.39
- MDL Number:
- MFCD00055098
- MOL File:
- 1814-64-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 83-85 °C |
|---|---|
| Boiling point | 464.1±45.0 °C(Predicted) |
| Density | 1.218±0.06 g/cm3(Predicted) |
| solubility | 0.1 M HCl: slightly soluble |
| pka | 7.85±0.10(Predicted) |
| form | solid |
| color | off-white |
| InChI | 1S/C19H22F3N3/c20-19(21,22)16-2-1-3-18(14-16)25-12-10-24(11-13-25)9-8-15-4-6-17(23)7-5-15/h1-7,14H,8-13,23H2 |
| InChIKey | GAAKALASJNGQKD-UHFFFAOYSA-N |
| SMILES | Nc1ccc(CCN2CCN(CC2)c3cccc(c3)C(F)(F)F)cc1 |
| FDA UNII | 8HAJ699EWG |
| UNSPSC Code | 12352202 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| PPE | Eyeshields, Gloves, type N95 (US) |
|---|---|
| WGK Germany | 3 |
| Storage Class | 11 - Combustible Solids |
PAPP price More Price(15)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | S009 | LY-165,163 solid | 1814-64-8 | 25mg | $110 | 2025-07-31 | Buy |
| Usbiological | 454023 | LY-165,163 | 1814-64-8 | 1mg | $319 | 2026-06-03 | Buy |
| Usbiological | 454023 | LY-165,163 | 1814-64-8 | 5mg | $475 | 2026-06-03 | Buy |
| ChemScene | CS-0086702 | LY 165163 99.24% | 1814-64-8 | 5mg | $173 | 2026-06-04 | Buy |
| ChemScene | CS-0086702 | LY 165163 99.24% | 1814-64-8 | 10mg | $282 | 2026-06-04 | Buy |
PAPP Chemical Properties, Uses, Production
Uses
LY-165,163 is a selective 5-HT1A and 5-HT1D serotonin receptor antagonist.
Definition
ChEBI: LY-165163 is a N-arylpiperazine that is piperazine susbtituted by 2-(4-aminophenyl)ethyl and 3-(trifluoromethyl)phenyl groups at positions 1 and 4, respectively. It is a selective 5-HT1A serotonin receptor agonist and 5-HT1D serotonin receptor antagonist. It has a role as a geroprotector and a serotonergic agonist. It is a N-arylpiperazine, a N-alkylpiperazine, a member of (trifluoromethyl)benzenes, a substituted aniline and a primary arylamine. It is functionally related to a 1-(3-(trifluoromethyl)phenyl)piperazine.
Biological Activity
Selective 5-HT1A serotonin receptor agonist and 5-HT1D serotonin receptor antagonist.
PAPP Preparation Products And Raw materials
Raw materials
Preparation Products
PAPP Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44871 | 58 |
| Jinan Jiuli Biotechnology Co. , Ltd. | 15865264761 | 486064515@qq.com | China | 5000 | 58 |
| Beijing Biocreative Technology Co., Ltd. | 15522676233 | 3007606172@qq.com | China | 1246 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
| TargetMol Chemicals Inc. | 13564774135 | marketing@targetmol.com | United States | 19950 | 58 |
| Supplier | Advantage |
|---|---|
| TargetMol Chemicals Inc. | 58 |
| Energy Chemical | 58 |
| Jinan Jiuli Biotechnology Co. , Ltd. | 58 |
| Beijing Biocreative Technology Co., Ltd. | 58 |
| TargetMol Chemicals Inc. | 58 |
| TargetMol Chemicals Inc. | 58 |
