L-p-Hydroxyphenylglycine methyl EST
- CAS No.
- 127369-30-6
- Chemical Name:
- L-p-Hydroxyphenylglycine methyl EST
- Synonyms
- Amoxicillin Impurity 19;Cefadroxil Impurity 9 HCl;Cefadroxil Impurity 11 HCl;L-p-Hydroxyphenylglycine methyl EST;Methyl L-(-)-4-Hydroxyphenylglycinate;methyl (2S)-2-amino-2-(4-hydroxyphenyl)acetate;Methyl L-(-)-4-Hydroxyphenylglycinate(HCl Salt);(S)-Methyl 2-amino-2-(4-hydroxyphenyl)acetate HCl;S-4-Hydroxyphenylglycine methyl ester hydrochloride;(S)-Methyl 2-amino-2-(4-hydroxyphenyl)acetate HCl ee
- CBNumber:
- CB0504629
- Molecular Formula:
- C9H12ClNO3
- Molecular Weight:
- 217.64948
- MDL Number:
- MFCD01862153
- MOL File:
- 127369-30-6.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P301+P312-P302+P352-P304+P340-P305+P351+P338 |
L-p-Hydroxyphenylglycine methyl EST price More Price(43)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | TRC-M339063-250MG | Methyl (2S)-2-amino-2-(4-hydroxyphenyl)acetate Hydrochloride | 127369-30-6 | 250mg | $65 | 2026-06-03 | Buy |
| TRC | TRC-M339063-2.5G | Methyl (2S)-2-amino-2-(4-hydroxyphenyl)acetate Hydrochloride | 127369-30-6 | 2.5g | $302 | 2026-06-03 | Buy |
| TRC | TRC-M339063-1G | Methyl (2S)-2-amino-2-(4-hydroxyphenyl)acetate Hydrochloride | 127369-30-6 | 1g | $179 | 2026-06-03 | Buy |
| Biosynth | CFA36930 | (S)-Methyl 2-amino-2-(4-hydroxyphenyl)acetate HCl ee | 127369-30-6 | 10g | $354 | 2026-06-04 | Buy |
| Activate Scientific | AS46513-B | (S)-Methyl 2-amino-2-(4-hydroxyphenyl)acetate HCl 97%EE | 127369-30-6 | 1g | $24 | 2026-06-04 | Buy |
L-p-Hydroxyphenylglycine methyl EST Chemical Properties,Uses,Production
Uses
Methyl (2S)-2-amino-2-(4-hydroxyphenyl)acetate Hydrochloride acts as a reagent in the synthesis of Amoxicillin, an antibiotic for the treatment of bacterial infection.
Synthesis
67-56-1
22818-40-2
57591-61-4
General procedure for the synthesis of D-p-hydroxyphenylglycine methyl ester hydrochloride from methanol and (R)-2-amino-2-(4-hydroxyphenyl)acetic acid: under nitrogen protection and -15 °C, thionyl chloride (1.5 mL, 33.0 mmol) was slowly added dropwise to anhydrous methanol (25 mL) in (R)-4-hydroxyphenylglycine (5.00 g, 29.91 mmol) ) suspension while stirring. The reaction mixture was gradually warmed to room temperature and stirred continuously overnight. Subsequently, the yellow solution was refluxed for 30 min. The reaction mixture was concentrated under reduced pressure to give D-p-hydroxyphenylglycine methyl ester hydrochloride in the form of an off-white solid. The hydrochloride was stirred in ether (15 mL), filtered, washed with ether (2 x 15 mL) and dried to give the final D-p-hydroxyphenylglycine methyl ester hydrochloride (6.50 g, 100%) as a white solid with a melting point of 189-191 °C; specific optical rotation [α]20D = -120.9 (c 1, 1M HCl), literature value [α]25D = - 121.1 (c 1, 1M HCl); IR spectra (KBr) νmax/cm-1: 3339 (broad peak), 1740 (C=O), 1595; NMR hydrogen spectrum (300 MHz, DMSO-d6) δH: 3.68 (3H, single peak, OCH3), 5.11 (1H, single peak, C(2)H), 6.80 (2H, double peak. J=8.5 Hz, aromatic H), 7.25 (2H, double peak, J=8.5 Hz, aromatic H), 8.70 (3H, broad peak, NH3), 9.86 (1H, single peak, OH).
References
[1] Tetrahedron Asymmetry, 2013, vol. 24, # 20, p. 1265 - 1275
[2] European Journal of Medicinal Chemistry, 2018, vol. 145, p. 649 - 660
[3] Synthesis, 2012, vol. 44, # 6, p. 875 - 880
[4] Croatica Chemica Acta, 2003, vol. 76, # 1, p. 23 - 36
[5] Heterocycles, 2009, vol. 78, # 6, p. 1477 - 1483
L-p-Hydroxyphenylglycine methyl EST Preparation Products And Raw materials
L-p-Hydroxyphenylglycine methyl EST Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66113011 13913916777 | cfzhang@aikonchem.com | China | 19902 | 55 |
| SynAsst Chemical. | 021-60343070 | China | 12731 | 55 | |
| Amatek Scientific Co. Ltd. | 0512-56316828 4008675858 | sales@amateksci.com | China | 9849 | 55 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Sichuan Ampebiochem Co., Ltd. | 028-65294243 18682730901 | sales@ampebiochem.com | China | 1000 | 58 |
| LABTER PHARMATECH(BEIJING) CO.,LTD | 010-56330744 18310155299 | sales@labter.com.cn | China | 19999 | 55 |
| BePharm Ltd | 400-685-9117 | market@bepharm.com | China | 15081 | 60 |
| Grader reagent | 18221735425 | sales@xinpingchem.com | China | 9925 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
View Lastest Price from L-p-Hydroxyphenylglycine methyl EST manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-12-19 | Methyl L-(-)-4-Hydroxyphenylglycinate(HCl Salt)
127369-30-6
|
10mg | 90%+ | 10g | Guangzhou PI PI BIOTECH INC |
-
- Methyl L-(-)-4-Hydroxyphenylglycinate(HCl Salt)
127369-30-6
- 90%+
- Guangzhou PI PI BIOTECH INC
