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ChemicalBook >> CAS DataBase List >>D-4-Hydroxyphenylglycine Methyl ester hydrochloride

D-4-Hydroxyphenylglycine Methyl ester hydrochloride

D-4-Hydroxyphenylglycine Methyl ester hydrochloride Structure
D-4-Hydroxyphenylglycine Methyl ester hydrochloride structure
CAS No.
57591-61-4
Chemical Name:
D-4-Hydroxyphenylglycine Methyl ester hydrochloride
Synonyms
Amoxicillin Impurity 17;Amoxicillin Impurity 49;Cefadroxil Impurity 1 HCl;Cefadroxil Impurity 2 HCl;Amoxicillin Impurity 1 HCl;Cefadroxil Impurity 10 HCl;D-P-HYDROXY-PHENYLGLYCINE METHYL ESTER;D-(-)-P-HYDROXYPHENYLGLYCINE METHYL ESTE;D-4-Hydroxyphenylglycine methyl ester HCl;D-(-)-a-P-Hydroxyl phenylglycine dane salt
CBNumber:
CB1501690
Molecular Formula:
C9H11NO3.ClH
Molecular Weight:
217.65
MDL Number:
MFCD01862152
MOL File:
57591-61-4.mol
MSDS File:
SDS
Last updated:2026-05-27 23:39:19
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D-4-Hydroxyphenylglycine Methyl ester hydrochloride Properties

Melting point 187-190 °C(lit.)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility Aqueous Acid (Slightly), DMSO (Slightly, Heated), Methanol (Slightly)
form Solid
color White to Off-White
Stability Hygroscopic
Major Application peptide synthesis
InChI InChI=1/C9H11NO3.ClH/c1-13-9(12)8(10)6-2-4-7(11)5-3-6;/h2-5,8,11H,10H2,1H3;1H/t8-;/s3
InChIKey UYCKVJUNDXPDJH-JNODIIHCNA-N
SMILES C1(=CC=C(O)C=C1)[C@@H](N)C(=O)OC.Cl |&1:7,r|
CAS DataBase Reference 57591-61-4
UNSPSC Code 12352106
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P305+P351+P338
PPE Eyeshields, Gloves, type N95 (US)
WGK Germany  3
Storage Class 11 - Combustible Solids

D-4-Hydroxyphenylglycine Methyl ester hydrochloride price More Price(43)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 534927 (R)-Amino-(4-hydroxyphenyl)acetic acid methyl ester hydrochloride 97% 57591-61-4 5g $163 2026-04-30 Buy
TRC TRC-A611555-5G (R)-Amino-(4-hydroxyphenyl)acetic Acid Methyl Ester Hydrochloride 57591-61-4 5g $152 2026-06-03 Buy
TRC TRC-A611555-10G (R)-Amino-(4-hydroxyphenyl)acetic Acid Methyl Ester Hydrochloride 57591-61-4 10g $238 2026-06-03 Buy
Biosynth FH42266 D-4-hydroxyphenylglycine methyl ester HCl 57591-61-4 1kg $900 2026-06-04 Buy
Biosynth FH42266 D-4-hydroxyphenylglycine methyl ester HCl 57591-61-4 0.5kg $900 2026-06-04 Buy
Product number Packaging Price Buy
534927 5g $163 Buy
TRC-A611555-5G 5g $152 Buy
TRC-A611555-10G 10g $238 Buy
FH42266 1kg $900 Buy
FH42266 0.5kg $900 Buy

D-4-Hydroxyphenylglycine Methyl ester hydrochloride Chemical Properties,Uses,Production

Chemical Properties

White to Off-White Solid

Uses

D-4-Hydroxyphenylglycine Methyl ester hydrochloride is used in the production of antiviral peptides and beta-lactam anti-biotics.

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

Methanol

67-56-1

4-Hydroxy-D-(-)-2-phenylglycine

22818-40-2

D-4-Hydroxyphenylglycine Methyl ester hydrochloride

57591-61-4

General procedure for the synthesis of D-p-hydroxyphenylglycine methyl ester hydrochloride from methanol and (R)-2-amino-2-(4-hydroxyphenyl)acetic acid: under nitrogen protection and -15 °C, thionyl chloride (1.5 mL, 33.0 mmol) was slowly added dropwise to anhydrous methanol (25 mL) in (R)-4-hydroxyphenylglycine (5.00 g, 29.91 mmol) ) suspension while stirring. The reaction mixture was gradually warmed to room temperature and stirred continuously overnight. Subsequently, the yellow solution was refluxed for 30 min. Upon completion of the reaction, the solvent was removed by concentration under reduced pressure to give D-p-hydroxyphenylglycine methyl ester hydrochloride in the form of an off-white solid. The hydrochloride was stirred in ether (15 mL), filtered, washed with ether (2 × 15 mL) and dried to give the final D-p-hydroxyphenylglycine methyl ester hydrochloride (6.50 g, 100%) in white solid form with a melting point of 189-191 °C; [α]20D = -120.9 (c 1 , 1M HCl), literature value [α]25D = -121.1 (c 1 , 1M HCl); IR spectrum (KBr) νmax/cm-1: 3339 (broad peak, OH), 1740 (C=O), 1595 (aryl ring); 1H NMR (300 MHz, DMSO-d6) δ: 3.68 (3H, s, OCH3), 5.11 (1H, s, CH), 6.80 (2H, d, J = 8.5 Hz. H), 7.25 (2H, d, J = 8.5 Hz, aryl H), 8.70 (3H, broad peak, NH3+), 9.86 (1H, s, OH).

References

[1] Tetrahedron Asymmetry, 2013, vol. 24, # 20, p. 1265 - 1275
[2] European Journal of Medicinal Chemistry, 2018, vol. 145, p. 649 - 660
[3] Synthesis, 2012, vol. 44, # 6, p. 875 - 880
[4] Croatica Chemica Acta, 2003, vol. 76, # 1, p. 23 - 36
[5] Heterocycles, 2009, vol. 78, # 6, p. 1477 - 1483

D-4-Hydroxyphenylglycine Methyl ester hydrochloride Preparation Products And Raw materials

Raw materials

Methanol 4-Hydroxy-D-(-)-2-phenylglycine

Preparation Products

D-4-Hydroxyphenylglycine Methyl ester hydrochloride Suppliers

Global( 240)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai Kangtuo Chemical Co., Ltd. 021-69185552 13701777608 kangtuochem@163.com China 4224 55
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Yangzhou Aoxin Chemical Co., Ltd 0514-87754778 13901446058 sales@aochem.com China 69 66
Beijing HwrkChemical Technology Co., Ltd 89508211 18501085097 sales.bj@hwrkchemical.com China 9407 55
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Beijing Ouhe Technology Co., Ltd 13552068683 13522913783 2355560935@qq.com China 11777 60
Adamas Reagent, Ltd. 400-6009262 15618770481 yhx@titansci.com China 14098 59
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Chemsky（shanghai）International Co.,Ltd. 021-50135380 shchemsky@sina.com China 32273 50
Beijing Isomersyn Technology CO;LTD 010-82954736 13391601435 sales@isomersyn.com China 3294 57
Supplier Advantage
Shanghai Kangtuo Chemical Co., Ltd. 55
J & K SCIENTIFIC LTD. 76
Yangzhou Aoxin Chemical Co., Ltd 66
Beijing HwrkChemical Technology Co., Ltd 55
Energy Chemical 61
Beijing Ouhe Technology Co., Ltd 60
Adamas Reagent, Ltd. 59
Shanghai Hanhong Scientific Co.,Ltd. 64
Chemsky（shanghai）International Co.,Ltd. 50
Beijing Isomersyn Technology CO;LTD 57

View Lastest Price from D-4-Hydroxyphenylglycine Methyl ester hydrochloride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
D-4-Hydroxyphenylglycine Methyl ester hydrochloride pictures 2026-03-20 D-4-Hydroxyphenylglycine Methyl ester hydrochloride
57591-61-4
 $10.00 1KG 99% 10 mt Hebei Chuanghai Biotechnology Co., Ltd
D-4-Hydroxyphenylglycine Methyl ester hydrochloride pictures 2025-04-15 D-4-Hydroxyphenylglycine Methyl ester hydrochloride
57591-61-4
 $10.00 1kg 99% 20ton Hebei Zhuanglai Chemical Trading Co.,Ltd
D-4-Hydroxyphenylglycine Methyl ester hydrochloride pictures 2021-11-03 D-4-Hydroxyphenylglycine Methyl ester hydrochloride
57591-61-4
 $10.00 1Kg/Bag 99% 20 Tons Hebei Zhanyao Biotechnology Co. Ltd

D-4-Hydroxyphenylglycine Methyl ester hydrochloride Spectrum

D-4-Hydroxyphenylglycine Methyl ester hydrochloride(57591-61-4)1HNMRD-4-Hydroxyphenylglycine Methyl ester hydrochloride(57591-61-4)IR

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Methyl (R)-2-Amino-2-(4-hydroxyphenyl)acetate Hydrochloride Amoxicillin Impurity 17 D(-)4-HYDROXY-ALPA-PHENYL GLYCINE METHYL ESTER HYDROCHLORIDE D-4-Hydroxyphenylglycine methyl ester HCl D-(-)-P-HYDROXYPHENYLGLYCINE METHYL ESTE D-4-Hydroxyphenylglycine methyl ester hydrochloride D-p-hydroxyphenyl-glycine methyl hydrochloride (R)-Amino-(4-hydroxyphenyl)acetic acid methyl ester hydrochloride D-p-Hydroxyphenylglycine methyl ester hydrochloride (R)-methyl 2-amino-2-(4-hydroxyphenyl)acetate hydrochloride REF DUPL: D-4-Hydroxyphenylglycine methyl ester HCl Benzeneacetic acid, a-aMino-4-hydroxy-, Methyl ester,hydrochloride (1:1), (aR)- (R)-AMino-(4-hydroxyphenyl)acetic acid Methyl ester hydrochloride 97% D-4-Hydroxyphenylglycine Methyl ester hydrochloride, 95+% D-P-HYDROXY-PHENYLGLYCINE METHYL ESTER Methyl (R)-a-amino-4-hydroxybenzeneacetate HCl (R)-Amino-(4-hydroxyphenyl)acetic acid methyl ester HCl (R)-Amino-(4-hydroxyphenyl)acetic acid methyl ester hydrochloride (R)-METHYL 2-AMINO-2-(4-HYDROXYPHENYL)ACETATE HCL Methyl (2R)-2-Amino-2-(4-Hydroxyphenyl)acetate,Hydrochloride D 2-(4-Hydroxyphenyl)-D-glycine methyl ester hydrochloride P Hydroxy Phenyl Glycine Methyl ester Hydrochloride D(-) Para Hydroxy Phenyl Glycine Methyl Ester / hcl methyl(2R)-2-amino-2-(4-hydroxyphenyl)acetate,hydrochloride D-4-Hydroxyphenylglycine Methyl ester hydrochloride USP/EP/BP (R)-Amino-(4-hydroxyphenyl)acetic acid methyl ester hydrochl... Cefadroxil Impurity 1 HCl Methyl D-(-)-4-hydroxy-phenylglycinate hydrochloride D-(-)-a-P-Hydroxyl phenylglycine dane salt Amoxicillin Impurity 1 HCl Cefadroxil Impurity 10 HCl Cefadroxil Impurity 2 HCl Amoxicillin Impurity 49 D-4-Hydroxyphenylglycine Methyl ester hydrochlorid 57591-61-4 ESTER bc0001