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ChemicalBook >> CAS DataBase List >>D-4-Hydroxyphenylglycine Methyl ester hydrochloride

D-4-Hydroxyphenylglycine Methyl ester hydrochloride

D-4-Hydroxyphenylglycine Methyl ester hydrochloride Structure
D-4-Hydroxyphenylglycine Methyl ester hydrochloride structure
CAS No.
57591-61-4
Chemical Name:
D-4-Hydroxyphenylglycine Methyl ester hydrochloride
Synonyms
Amoxicillin Impurity 17;Amoxicillin Impurity 49;Cefadroxil Impurity 1 HCl;Cefadroxil Impurity 2 HCl;Amoxicillin Impurity 1 HCl;Cefadroxil Impurity 10 HCl;D-P-HYDROXY-PHENYLGLYCINE METHYL ESTER;D-(-)-P-HYDROXYPHENYLGLYCINE METHYL ESTE;D-4-Hydroxyphenylglycine methyl ester HCl;D-(-)-a-P-Hydroxyl phenylglycine dane salt
CBNumber:
CB1501690
Molecular Formula:
C9H12ClNO3
Molecular Weight:
217.65
MDL Number:
MFCD01862152
MOL File:
57591-61-4.mol
MSDS File:
SDS
Last updated:2026-01-13 11:14:21
Product description Number Pack Size Price
(R)-Amino-(4-hydroxyphenyl)acetic acid methyl ester hydrochloride 97% 534927 5g $76.5
(R)-Amino-(4-hydroxyphenyl)acetic acid methyl ester hydrochloride A611555 100g $820
(R)-AMINO-(4-HYDROXYPHENYL)ACETIC ACID METHYL ESTER HYDROCHLORIDE 97.00% AAA0005115 5G $926.31
(R)-Amino-(4-hydroxyphenyl)aceticAcidMethylEsterHCl 53789 100g $1175
(R)-Amino-(4-hydroxyphenyl)aceticAcidMethylEsterHCl 53789 5G $605
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D-4-Hydroxyphenylglycine Methyl ester hydrochloride Properties

Melting point 187-190 °C(lit.)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility Aqueous Acid (Slightly), DMSO (Slightly, Heated), Methanol (Slightly)
form Solid
color White to Off-White
Stability Hygroscopic
Major Application peptide synthesis
InChI InChI=1/C9H11NO3.ClH/c1-13-9(12)8(10)6-2-4-7(11)5-3-6;/h2-5,8,11H,10H2,1H3;1H/t8-;/s3
InChIKey UYCKVJUNDXPDJH-JNODIIHCNA-N
SMILES C1(=CC=C(O)C=C1)[C@@H](N)C(=O)OC.Cl |&1:7,r|
CAS DataBase Reference 57591-61-4
UNSPSC Code 12352106
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P305+P351+P338
PPE Eyeshields, Gloves, type N95 (US)
WGK Germany  3
Storage Class 11 - Combustible Solids

D-4-Hydroxyphenylglycine Methyl ester hydrochloride price More Price(23)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 534927 (R)-Amino-(4-hydroxyphenyl)acetic acid methyl ester hydrochloride 97% 57591-61-4 5g $76.5 2025-07-31 Buy
TRC A611555 (R)-Amino-(4-hydroxyphenyl)acetic acid methyl ester hydrochloride 57591-61-4 100g $820 2021-12-16 Buy
American Custom Chemicals Corporation AAA0005115 (R)-AMINO-(4-HYDROXYPHENYL)ACETIC ACID METHYL ESTER HYDROCHLORIDE 97.00% 57591-61-4 5G $926.31 2021-12-16 Buy
Medical Isotopes, Inc. 53789 (R)-Amino-(4-hydroxyphenyl)aceticAcidMethylEsterHCl 57591-61-4 100g $1175 2021-12-16 Buy
Medical Isotopes, Inc. 53789 (R)-Amino-(4-hydroxyphenyl)aceticAcidMethylEsterHCl 57591-61-4 5G $605 2021-12-16 Buy
Product number Packaging Price Buy
534927 5g $76.5 Buy
A611555 100g $820 Buy
AAA0005115 5G $926.31 Buy
53789 100g $1175 Buy
53789 5G $605 Buy

D-4-Hydroxyphenylglycine Methyl ester hydrochloride Chemical Properties,Uses,Production

Chemical Properties

White to Off-White Solid

Uses

D-4-Hydroxyphenylglycine Methyl ester hydrochloride is used in the production of antiviral peptides and beta-lactam anti-biotics.

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

Methanol

67-56-1

4-Hydroxy-D-(-)-2-phenylglycine

22818-40-2

D-4-Hydroxyphenylglycine Methyl ester hydrochloride

57591-61-4

General procedure for the synthesis of D-p-hydroxyphenylglycine methyl ester hydrochloride from methanol and (R)-2-amino-2-(4-hydroxyphenyl)acetic acid: under nitrogen protection and -15 °C, thionyl chloride (1.5 mL, 33.0 mmol) was slowly added dropwise to anhydrous methanol (25 mL) in (R)-4-hydroxyphenylglycine (5.00 g, 29.91 mmol) ) suspension while stirring. The reaction mixture was gradually warmed to room temperature and stirred continuously overnight. Subsequently, the yellow solution was refluxed for 30 min. Upon completion of the reaction, the solvent was removed by concentration under reduced pressure to give D-p-hydroxyphenylglycine methyl ester hydrochloride in the form of an off-white solid. The hydrochloride was stirred in ether (15 mL), filtered, washed with ether (2 × 15 mL) and dried to give the final D-p-hydroxyphenylglycine methyl ester hydrochloride (6.50 g, 100%) in white solid form with a melting point of 189-191 °C; [α]20D = -120.9 (c 1 , 1M HCl), literature value [α]25D = -121.1 (c 1 , 1M HCl); IR spectrum (KBr) νmax/cm-1: 3339 (broad peak, OH), 1740 (C=O), 1595 (aryl ring); 1H NMR (300 MHz, DMSO-d6) δ: 3.68 (3H, s, OCH3), 5.11 (1H, s, CH), 6.80 (2H, d, J = 8.5 Hz. H), 7.25 (2H, d, J = 8.5 Hz, aryl H), 8.70 (3H, broad peak, NH3+), 9.86 (1H, s, OH).

References

[1] Tetrahedron Asymmetry, 2013, vol. 24, # 20, p. 1265 - 1275
[2] European Journal of Medicinal Chemistry, 2018, vol. 145, p. 649 - 660
[3] Synthesis, 2012, vol. 44, # 6, p. 875 - 880
[4] Croatica Chemica Acta, 2003, vol. 76, # 1, p. 23 - 36
[5] Heterocycles, 2009, vol. 78, # 6, p. 1477 - 1483

D-4-Hydroxyphenylglycine Methyl ester hydrochloride Preparation Products And Raw materials

Raw materials

Methanol 4-Hydroxy-D-(-)-2-phenylglycine

Preparation Products

D-4-Hydroxyphenylglycine Methyl ester hydrochloride Suppliers

Global( 238)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Chuanghai Biotechnology Co., Ltd 		+8615350571055 Sibel@chuanghaibio.com China 8753 58
Hebei Zhuanglai Chemical Trading Co.,Ltd 		+8613343047651 admin@zlchemi.com China 3692 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21595 55
Hubei xin bonus chemical co. LTD 		86-13657291602 linda@hubeijusheng.com CHINA 22963 58
Standardpharm Co. Ltd. 		86-714-3992388 overseasales1@yongstandards.com United States 14332 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49977 58
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29795 58
SIMAGCHEM CORP 		+86-5922680277 +86-13806087780 sale@simagchem.com China 17346 58
Hefei TNJ Chemical Industry Co.,Ltd. 		+86-0551-65418671 +8618949823763 sales@tnjchem.com China 34563 58
Supplier Advantage
Hebei Chuanghai Biotechnology Co., Ltd 		58
Hebei Zhuanglai Chemical Trading Co.,Ltd 		58
Henan Tianfu Chemical Co.,Ltd. 		55
Hubei xin bonus chemical co. LTD 		58
Standardpharm Co. Ltd. 		58
Alchem Pharmtech,Inc. 		58
CONIER CHEM AND PHARMA LIMITED 		58
career henan chemical co 		58
SIMAGCHEM CORP 		58
Hefei TNJ Chemical Industry Co.,Ltd. 		58

View Lastest Price from D-4-Hydroxyphenylglycine Methyl ester hydrochloride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
D-4-Hydroxyphenylglycine Methyl ester hydrochloride pictures 2026-01-30 D-4-Hydroxyphenylglycine Methyl ester hydrochloride
57591-61-4
 US $10.00 / KG 1KG 99% 10 mt Hebei Chuanghai Biotechnology Co., Ltd
D-4-Hydroxyphenylglycine Methyl ester hydrochloride pictures 2025-04-15 D-4-Hydroxyphenylglycine Methyl ester hydrochloride
57591-61-4
 US $10.00 / kg 1kg 99% 20ton Hebei Zhuanglai Chemical Trading Co.,Ltd
D-4-Hydroxyphenylglycine Methyl ester hydrochloride pictures 2021-11-03 D-4-Hydroxyphenylglycine Methyl ester hydrochloride
57591-61-4
 US $10.00 / Kg/Bag 1Kg/Bag 99% 20 Tons Hebei Zhanyao Biotechnology Co. Ltd

D-4-Hydroxyphenylglycine Methyl ester hydrochloride Spectrum

D-4-Hydroxyphenylglycine Methyl ester hydrochloride(57591-61-4)1HNMRD-4-Hydroxyphenylglycine Methyl ester hydrochloride(57591-61-4)IR

57591-61-4(D-4-Hydroxyphenylglycine Methyl ester hydrochloride)Related Search:

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Methyl (R)-2-Amino-2-(4-hydroxyphenyl)acetate Hydrochloride Amoxicillin Impurity 17 D(-)4-HYDROXY-ALPA-PHENYL GLYCINE METHYL ESTER HYDROCHLORIDE D-4-Hydroxyphenylglycine methyl ester HCl D-(-)-P-HYDROXYPHENYLGLYCINE METHYL ESTE D-4-Hydroxyphenylglycine methyl ester hydrochloride D-p-hydroxyphenyl-glycine methyl hydrochloride (R)-Amino-(4-hydroxyphenyl)acetic acid methyl ester hydrochloride D-p-Hydroxyphenylglycine methyl ester hydrochloride (R)-methyl 2-amino-2-(4-hydroxyphenyl)acetate hydrochloride REF DUPL: D-4-Hydroxyphenylglycine methyl ester HCl Benzeneacetic acid, a-aMino-4-hydroxy-, Methyl ester,hydrochloride (1:1), (aR)- (R)-AMino-(4-hydroxyphenyl)acetic acid Methyl ester hydrochloride 97% D-4-Hydroxyphenylglycine Methyl ester hydrochloride, 95+% D-P-HYDROXY-PHENYLGLYCINE METHYL ESTER Methyl (R)-a-amino-4-hydroxybenzeneacetate HCl (R)-Amino-(4-hydroxyphenyl)acetic acid methyl ester HCl (R)-Amino-(4-hydroxyphenyl)acetic acid methyl ester hydrochloride (R)-METHYL 2-AMINO-2-(4-HYDROXYPHENYL)ACETATE HCL Methyl (2R)-2-Amino-2-(4-Hydroxyphenyl)acetate,Hydrochloride D 2-(4-Hydroxyphenyl)-D-glycine methyl ester hydrochloride P Hydroxy Phenyl Glycine Methyl ester Hydrochloride D(-) Para Hydroxy Phenyl Glycine Methyl Ester / hcl methyl(2R)-2-amino-2-(4-hydroxyphenyl)acetate,hydrochloride D-4-Hydroxyphenylglycine Methyl ester hydrochloride USP/EP/BP (R)-Amino-(4-hydroxyphenyl)acetic acid methyl ester hydrochl... Cefadroxil Impurity 1 HCl Methyl D-(-)-4-hydroxy-phenylglycinate hydrochloride D-(-)-a-P-Hydroxyl phenylglycine dane salt Amoxicillin Impurity 1 HCl Cefadroxil Impurity 10 HCl Cefadroxil Impurity 2 HCl Amoxicillin Impurity 49 57591-61-4 ESTER bc0001