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Methyl D-(-)-4-hydroxy-phenylglycinate

Methyl D-(-)-4-hydroxy-phenylglycinate structure

CAS No.: 37763-23-8

Chemical Name:: Methyl D-(-)-4-hydroxy-phenylglycinate

Synonyms: Δ3-Flomoxef sodium;Flufenamic Acid Impurity 11;D- methyl p-hydroxyphenylglycine;METHYL DL-4-HYDROXYPHENYLGLYCINE HCL;Methyl D-(-)-4-hydroxy-phenylglycine;D-4-Hydroxyphenylglycine methyl ester;4-Hydroxy-D-phenylglycine methyl ester;METHYL D-(-)-4-HYDROXY-PHENYLGLYCINATE;methyl (R)-amino(4-hydroxyphenyl)acetate;(R)-α-(p-Hydroxyphenyl)glycine methyl ester

CBNumber:: CB6842727

Molecular Formula:: C9H11NO3

Molecular Weight:: 181.19

MDL Number:: MFCD07778088

MOL File:: 37763-23-8.mol

MSDS File:: SDS

Last updated:2025-09-25 17:15:13

Product description	Number	Pack Size	Price
MethylD-(-)-4-Hydroxy-phenylglycinate	M338538	100mg	$50
MethylD-(-)-4-Hydroxy-phenylglycinate	M338538	1g	$70
MethylD-(-)-4-Hydroxy-phenylglycinate	M338538	5g	$135
MethylD-(-)-4-Hydroxy-phenylglycinate	M338538	10g	$215
MethylD-(-)-4-Hydroxy-phenylglycinate	M338538	25g	$485
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Methyl D-(-)-4-hydroxy-phenylglycinate Properties

Melting point	169-172°C
Boiling point	303.2±27.0 °C(Predicted)
Density	1.248±0.06 g/cm3(Predicted)
vapor pressure	0.083Pa at 25℃
storage temp.	Room Temperature
solubility	DMSO (Slightly), Ethanol (Slightly, Sonicated), Methanol (Slightly)
form	Solid
pka	9.74±0.26(Predicted)
color	White to Off-White
InChI	InChI=1S/C9H11NO3/c1-13-9(12)8(10)6-2-4-7(11)5-3-6/h2-5,8,11H,10H2,1H3
InChIKey	SZBDOFWNZVHVGR-UHFFFAOYSA-N
SMILES	C(OC)(=O)C(N)C1=CC=C(O)C=C1

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338

Methyl D-(-)-4-hydroxy-phenylglycinate price More Price(20)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	M338538	MethylD-(-)-4-Hydroxy-phenylglycinate	37763-23-8	100mg	$50	2021-12-16	Buy
TRC	M338538	MethylD-(-)-4-Hydroxy-phenylglycinate	37763-23-8	1g	$70	2021-12-16	Buy
TRC	M338538	MethylD-(-)-4-Hydroxy-phenylglycinate	37763-23-8	5g	$135	2021-12-16	Buy
TRC	M338538	MethylD-(-)-4-Hydroxy-phenylglycinate	37763-23-8	10g	$215	2021-12-16	Buy
TRC	M338538	MethylD-(-)-4-Hydroxy-phenylglycinate	37763-23-8	25g	$485	2021-12-16	Buy

Product number	Packaging	Price	Buy
M338538	100mg	$50	Buy
M338538	1g	$70	Buy
M338538	5g	$135	Buy
M338538	10g	$215	Buy
M338538	25g	$485	Buy

Methyl D-(-)-4-hydroxy-phenylglycinate Chemical Properties,Uses,Production

Uses

Methyl D-(-)-4-Hydroxy-phenylglycinate is useful for the synthesis (+)-radicamine B. Also, it is used for the preparation of amoxicillin.

Flammability and Explosibility

Non flammable

Synthesis

67-56-1

22818-40-2

37763-23-8

Step 1: (R)-2-Amino-2-(4-hydroxyphenyl)acetic acid (D-4-hydroxyphenylglycine, 10.0 g, 60.1 mmol) was dissolved in methanol (200 mL), thionyl chloride (8 mL) was added slowly dropwise, and the reaction was stirred for 10 hours at room temperature. After completion of the reaction, the mixture was concentrated under reduced pressure and the residue was washed twice with ether to afford methyl (R)-2-amino-2-(4-hydroxyphenyl)acetate (D-4-hydroxyphenylglycine methyl ester, 13.0 g, 60.0 mmol, 100% yield) as a white solid.1H NMR (300 MHz, DMSO-d6) δ 3.68 (s, 3H), 5.07 (s, 1H), 6.85 (d, J = 8.5 Hz, 2H), 7.29 (d, J = 8.6 Hz, 2H), 9.03 (s, 3H), 10.02 (s, 1H). Step 2: Methyl (R)-2-amino-2-(4-hydroxyphenyl)acetate (D-4-hydroxyphenylglycine methyl ester, 0.302 g, 1.39 mmol) was dissolved in freshly prepared glyoxylate (1.27 g, 13.8 mmol) and copper(II) sulfate pentahydrate (0.35 g, 1.40 mmol) in a 2.5 M pyridine buffer and a 0.5 M acetic acid in aqueous solution and stirred for 10 h at room temperature. The reaction solution was extracted with dichloromethane (3 × 10 mL), the organic layers were combined, washed with 0.5 M HCl (3 × 20 mL), dried, filtered and concentrated under reduced pressure. The residue was purified by fast column chromatography (silica gel, chloroform elution) to afford methyl 2-(4-hydroxyphenyl)-2-oxoacetate (0.109 g, 6.06 mmol, 44% yield) as a clear oil.1H NMR (300 MHz, CDCl3) δ 3.99 (s, 3H), 5.41 (br s, 1H), 6.95 (d, J = 8.8 Hz, 2H), 8.00 (d, J = 8.8 Hz, 2H).

References

[1] Journal of Medicinal Chemistry, 2002, vol. 45, # 18, p. 3946 - 3952
[2] Patent: WO2013/33093, 2013, A1. Location in patent: Page/Page column 137; 138
[3] Angewandte Chemie - International Edition, 1997, vol. 37, # 19, p. 2708 - 2714
[4] Organic Letters, 2015, vol. 17, # 4, p. 1018 - 1021
[5] Journal of the American Chemical Society, 1978, vol. 100, p. 4555 - 4568

Methyl D-(-)-4-hydroxy-phenylglycinate Preparation Products And Raw materials

Raw materials

Methanol 4-Hydroxy-D-(-)-2-phenylglycine

Preparation Products

Cefprozil

Methyl D-(-)-4-hydroxy-phenylglycinate Suppliers

Global( 243)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD	+86-13017695106 +86-13676922317	jiuyitime@fdachem.com	China	16513	58
Frapp's ChemicalNFTZ Co., Ltd.	+86 (576) 8169-6106	sales@frappschem.com	China	880	50
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29735	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21597	55
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418679 +8618949832763	info@tnjchem.com	China	2988	55
Jinan Finer Chemical Co., Ltd	+86-531-88989536 +86-15508631887	sales@finerchem.com	China	2950	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22963	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29795	58
Hebei Yanxi Chemical Co., Ltd.	+8618531123677	faithe@yan-xi.com	China	5853	58

Supplier	Advantage
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD	58
Frapp's ChemicalNFTZ Co., Ltd.	50
Capot Chemical Co.,Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55
Hefei TNJ Chemical Industry Co.,Ltd.	55
Jinan Finer Chemical Co., Ltd	58
Hubei xin bonus chemical co. LTD	58
Alchem Pharmtech,Inc.	58
career henan chemical co	58
Hebei Yanxi Chemical Co., Ltd.	58

View Lastest Price from Methyl D-(-)-4-hydroxy-phenylglycinate manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-02-13	Methyl D-(-)-4-hydroxy-phenylglycinate 37763-23-8	US $0.00 / Kg/Drum	1KG	98%min	1000kgs	WUHAN FORTUNA CHEMICAL CO., LTD
2025-12-19	Methyl D-(-)-4-Hydroxyphenylglycinate 37763-23-8	US $0.00-0.00 / mg	10mg	90%+	10g	Guangzhou PI PI BIOTECH INC
2025-10-13	(R)-Methyl 2-amino-2-(4-hydroxyphenyl)acetate 37763-23-8	US $2.00-5.00 / kg	1kg	99%	100kg	ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Methyl D-(-)-4-hydroxy-phenylglycinate
37763-23-8
US $0.00 / Kg/Drum
98%min
WUHAN FORTUNA CHEMICAL CO., LTD

Methyl D-(-)-4-Hydroxyphenylglycinate
37763-23-8
US $0.00-0.00 / mg
90%+
Guangzhou PI PI BIOTECH INC

(R)-Methyl 2-amino-2-(4-hydroxyphenyl)acetate
37763-23-8
US $2.00-5.00 / kg
99%
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Methyl D-(-)-4-hydroxy-phenylglycinate Spectrum

Methyl D-(-)-4-hydroxy-phenylglycinate(37763-23-8)¹HNMR

37763-23-8(Methyl D-(-)-4-hydroxy-phenylglycinate)Related Search:

CHLOROPHOSPHONAZO III DL-P-Hydroxyphenylglycine 4-Hydroxy-L-phenylglycine D-2-Phenylglycine 4-Aminophenylacetic acid

4-Hydroxy-D-(-)-2-phenylglycine Methyl acrylate Basic Violet 1 2-Hydroxyphenylacetic acid Methyl glycolate

Methanol METHYL 2-AMINO-2-(4-HYDROXYPHENYL)ACETATE Methylparaben Kresoxim-methyl 4-Hydroxybenzoic acid

Paraquat dichloride Acetonitrile 4-Hydroxybenzaldehyde

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D-(-)-alpha-p-Hydroxy-phenylglycine methyl ester METHYL D-(-)-4-HYDROXY-PHENYLGLYCINATE (S)-Methyl 2-aMino-2-(4-hydroxyphenyl)acetate Benzeneacetic acid, α-aMino-4-hydroxy-, Methyl ester,(aR)- Methyl D-(-)-4-hydroxyphenylglycinate, 95+% methyl (R)-amino(4-hydroxyphenyl)acetate D-(-)-|á-P-HYDROXY PHENYLGLYCINE METHYL ESTER (R)-Amino(4-hydroxyphenyl)acetic acid methyl ester (R)-α-(p-Hydroxyphenyl)glycine methyl ester 4-Hydroxy-D-phenylglycine methyl ester D-4-Hydroxyphenylglycine methyl ester METHYL DL-4-HYDROXYPHENYLGLYCINE HCL Methyl D-(-)-4-hydroxy-phenylglycine D(-) Alpha Parahydroxy Phenylglycine Methyl Ester 2-amino-2-(4-hydroxyphenyl)acetic acid methyl ester Cefadroxil Impurity 1 (Methyl (2R)-2-Amino-2-(4-Hydroxyphenyl)acetate) Benzeneacetic acid, a-amino-4-hydroxy-, methyl ester, (aR)- Benzeneacetic acid, α-amino-4-hydroxy-, methyl ester, (αR)- PHPGMe Methyl D-(-)4-hydroxy-phenylglycinate D- methyl p-hydroxyphenylglycine Methyl D-(-)-4-hydroxy-phenylglycinate USP/EP/BP Δ3-Flomoxef sodium Methyl (R)-2-amino-2-(4-hydroxyphenyl)acetate (R)-Methyl 2-amino-2-(4-hydroxyphenyl)acetate,98% D-(-)-α-p-Hydroxy-Phenylglycine methyl ester Methyl (αR)-α-amino-4-hydroxybenzeneacetate Methyl -(-)-4-hydroxy-phenylglycinate（mixture of D and L) Flufenamic Acid Impurity 11 (alphaR)-alpha-Amino-4-hydroxy-phenyl-acetic acid methyl ester 37763-23-8 Antidote / Antibiotic / Antimicrobial