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Methyl D-(-)-4-hydroxy-phenylglycinate

Methyl D-(-)-4-hydroxy-phenylglycinate structure

CAS No.: 37763-23-8

Chemical Name:: Methyl D-(-)-4-hydroxy-phenylglycinate

Synonyms: Δ3-Flomoxef sodium;Flufenamic Acid Impurity 11;D- methyl p-hydroxyphenylglycine;METHYL DL-4-HYDROXYPHENYLGLYCINE HCL;Methyl D-(-)-4-hydroxy-phenylglycine;D-4-Hydroxyphenylglycine methyl ester;4-Hydroxy-D-phenylglycine methyl ester;METHYL D-(-)-4-HYDROXY-PHENYLGLYCINATE;methyl (R)-amino(4-hydroxyphenyl)acetate;(R)-α-(p-Hydroxyphenyl)glycine methyl ester

CBNumber:: CB6842727

Molecular Formula:: C9H11NO3

Molecular Weight:: 181.19

MDL Number:: MFCD07778088

MOL File:: 37763-23-8.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 06:29:08

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Methyl D-(-)-4-hydroxy-phenylglycinate Properties

Melting point	169-172°C
Boiling point	303.2±27.0 °C(Predicted)
Density	1.248±0.06 g/cm3(Predicted)
vapor pressure	0.083Pa at 25℃
storage temp.	Room Temperature
solubility	DMSO (Slightly), Ethanol (Slightly, Sonicated), Methanol (Slightly)
form	Solid
pka	9.74±0.26(Predicted)
color	White to Off-White
InChI	InChI=1S/C9H11NO3/c1-13-9(12)8(10)6-2-4-7(11)5-3-6/h2-5,8,11H,10H2,1H3
InChIKey	SZBDOFWNZVHVGR-UHFFFAOYSA-N
SMILES	C(OC)(=O)C(N)C1=CC=C(O)C=C1

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338
REACH Registrations	Active

Methyl D-(-)-4-hydroxy-phenylglycinate price More Price(44)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Usbiological	283505	Methyl D-(-)-4-hydroxy-phenylglycInate Asreported	37763-23-8	1g	$356	2026-06-03	Buy
Usbiological	283505	Methyl D-(-)-4-hydroxy-phenylglycInate Asreported	37763-23-8	2g	$492	2026-06-03	Buy
Usbiological	283505	Methyl D-(-)-4-hydroxy-phenylglycInate Asreported	37763-23-8	5g	$666	2026-06-03	Buy
Usbiological	283505	Methyl D-(-)-4-hydroxy-phenylglycInate Asreported	37763-23-8	10g	$902	2026-06-03	Buy
Usbiological	283505	Methyl D-(-)-4-hydroxy-phenylglycInate Asreported	37763-23-8	25g	$1238	2026-06-03	Buy

Product number	Packaging	Price	Buy
283505	1g	$356	Buy
283505	2g	$492	Buy
283505	5g	$666	Buy
283505	10g	$902	Buy
283505	25g	$1238	Buy

Methyl D-(-)-4-hydroxy-phenylglycinate Chemical Properties, Uses, Production

Uses

Methyl D-(-)-4-Hydroxy-phenylglycinate is useful for the synthesis (+)-radicamine B. Also, it is used for the preparation of amoxicillin.

Flammability and Explosibility

Non flammable

Synthesis

67-56-1

22818-40-2

37763-23-8

Step 1: (R)-2-Amino-2-(4-hydroxyphenyl)acetic acid (D-4-hydroxyphenylglycine, 10.0 g, 60.1 mmol) was dissolved in methanol (200 mL), thionyl chloride (8 mL) was added slowly dropwise, and the reaction was stirred for 10 hours at room temperature. After completion of the reaction, the mixture was concentrated under reduced pressure and the residue was washed twice with ether to afford methyl (R)-2-amino-2-(4-hydroxyphenyl)acetate (D-4-hydroxyphenylglycine methyl ester, 13.0 g, 60.0 mmol, 100% yield) as a white solid.1H NMR (300 MHz, DMSO-d6) δ 3.68 (s, 3H), 5.07 (s, 1H), 6.85 (d, J = 8.5 Hz, 2H), 7.29 (d, J = 8.6 Hz, 2H), 9.03 (s, 3H), 10.02 (s, 1H). Step 2: Methyl (R)-2-amino-2-(4-hydroxyphenyl)acetate (D-4-hydroxyphenylglycine methyl ester, 0.302 g, 1.39 mmol) was dissolved in freshly prepared glyoxylate (1.27 g, 13.8 mmol) and copper(II) sulfate pentahydrate (0.35 g, 1.40 mmol) in a 2.5 M pyridine buffer and a 0.5 M acetic acid in aqueous solution and stirred for 10 h at room temperature. The reaction solution was extracted with dichloromethane (3 × 10 mL), the organic layers were combined, washed with 0.5 M HCl (3 × 20 mL), dried, filtered and concentrated under reduced pressure. The residue was purified by fast column chromatography (silica gel, chloroform elution) to afford methyl 2-(4-hydroxyphenyl)-2-oxoacetate (0.109 g, 6.06 mmol, 44% yield) as a clear oil.1H NMR (300 MHz, CDCl3) δ 3.99 (s, 3H), 5.41 (br s, 1H), 6.95 (d, J = 8.8 Hz, 2H), 8.00 (d, J = 8.8 Hz, 2H).

References

[1] Journal of Medicinal Chemistry, 2002, vol. 45, # 18, p. 3946 - 3952
[2] Patent: WO2013/33093, 2013, A1. Location in patent: Page/Page column 137; 138
[3] Angewandte Chemie - International Edition, 1997, vol. 37, # 19, p. 2708 - 2714
[4] Organic Letters, 2015, vol. 17, # 4, p. 1018 - 1021
[5] Journal of the American Chemical Society, 1978, vol. 100, p. 4555 - 4568

Methyl D-(-)-4-hydroxy-phenylglycinate Preparation Products And Raw materials

Raw materials

Methanol 4-Hydroxy-D-(-)-2-phenylglycine

Preparation Products

Cefprozil

Methyl D-(-)-4-hydroxy-phenylglycinate Suppliers

Global Suppliers ( 244)

Supplier	Tel	Email	Country	ProdList	Advantage
Jiangxi Zhiyan Biopharmaceutical Technology Co., Ltd	13970866816; 13732973797	fa@zybiopharma.com	China	46	58
Shanghai Peiling Biological Technology Co., Ltd	13127581762 13127581762	peilingchem@sina.com	China	507	58
Hubei Science Chemical Co., Ltd	15994282563 15994282563	3775234439@qq.com	China	2225	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
PharmaBlock Sciences (Nanjing),Inc.	025-86918202 4000255188	sales@pharmablock.com	China	5000	55
TAIYUAN RHF CO.,LTD.	+86 351 7031519	sales@RHFChem.com	China	2334	56
Yangzhou Aoxin Chemical Co., Ltd	0514-87754778 13901446058	sales@aochem.com	China	69	66
Beijing Ouhe Technology Co., Ltd	13552068683 13522913783	2355560935@qq.com	China	11777	60
Jia Xing Isenchem Co.,Ltd	0573-85285100 18627885956	isenchem@163.com	China	9389	66
Pure Chemistry Scientific Inc.	001-857-928-2050 or 1-888-588-9418	sales@chemreagents.com	United States	10174	62

Supplier	Advantage
Jiangxi Zhiyan Biopharmaceutical Technology Co., Ltd	58
Shanghai Peiling Biological Technology Co., Ltd	58
Hubei Science Chemical Co., Ltd	58
J & K SCIENTIFIC LTD.	76
PharmaBlock Sciences (Nanjing),Inc.	55
TAIYUAN RHF CO.,LTD.	56
Yangzhou Aoxin Chemical Co., Ltd	66
Beijing Ouhe Technology Co., Ltd	60
Jia Xing Isenchem Co.,Ltd	66
Pure Chemistry Scientific Inc.	62

View Latest Price from Methyl D-(-)-4-hydroxy-phenylglycinate manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-11	Methyl D-(-)-4-hydroxy-phenylglycinate 37763-23-8		1KG	98%min	1000kgs	WUHAN FORTUNA CHEMICAL CO., LTD
2026-08-25	(R)-Methyl 2-amino-2-(4-hydroxyphenyl)acetate 37763-23-8	$2.00-5.00	1kg	99%	100kg	ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
2025-12-19	Methyl D-(-)-4-Hydroxyphenylglycinate 37763-23-8		10mg	90%+	10g	Guangzhou PI PI BIOTECH INC

Methyl D-(-)-4-hydroxy-phenylglycinate
37763-23-8
$0.00
98%min
WUHAN FORTUNA CHEMICAL CO., LTD

(R)-Methyl 2-amino-2-(4-hydroxyphenyl)acetate
37763-23-8
$2.00-5.00
99%
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Methyl D-(-)-4-Hydroxyphenylglycinate
37763-23-8
90%+
Guangzhou PI PI BIOTECH INC

Methyl D-(-)-4-hydroxy-phenylglycinate Spectrum

Methyl D-(-)-4-hydroxy-phenylglycinate(37763-23-8)¹HNMR

37763-23-8 (Methyl D-(-)-4-hydroxy-phenylglycinate) Related Search:

Paraquat dichloride 4-Hydroxybenzoic acid Kresoxim-methyl Methylparaben Methanol

Methyl glycolate 2-Hydroxyphenylacetic acid Basic Violet 1 DL-P-Hydroxyphenylglycine 4-Hydroxy-L-phenylglycine

D-2-Phenylglycine 4-Aminophenylacetic acid 4-Hydroxy-D-(-)-2-phenylglycine Methyl acrylate Acetonitrile

Chlorophosphonazo III Methyl 2-amino-2-(4-hydroxyphenyl)acetate 4-Hydroxybenzaldehyde

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D-(-)-alpha-p-Hydroxy-phenylglycine methyl ester METHYL D-(-)-4-HYDROXY-PHENYLGLYCINATE (S)-Methyl 2-aMino-2-(4-hydroxyphenyl)acetate Benzeneacetic acid, α-aMino-4-hydroxy-, Methyl ester,(aR)- Methyl D-(-)-4-hydroxyphenylglycinate, 95+% methyl (R)-amino(4-hydroxyphenyl)acetate D-(-)-|á-P-HYDROXY PHENYLGLYCINE METHYL ESTER (R)-Amino(4-hydroxyphenyl)acetic acid methyl ester (R)-α-(p-Hydroxyphenyl)glycine methyl ester 4-Hydroxy-D-phenylglycine methyl ester D-4-Hydroxyphenylglycine methyl ester METHYL DL-4-HYDROXYPHENYLGLYCINE HCL Methyl D-(-)-4-hydroxy-phenylglycine D(-) Alpha Parahydroxy Phenylglycine Methyl Ester 2-amino-2-(4-hydroxyphenyl)acetic acid methyl ester Cefadroxil Impurity 1 (Methyl (2R)-2-Amino-2-(4-Hydroxyphenyl)acetate) Benzeneacetic acid, a-amino-4-hydroxy-, methyl ester, (aR)- Benzeneacetic acid, α-amino-4-hydroxy-, methyl ester, (αR)- PHPGMe Methyl D-(-)4-hydroxy-phenylglycinate D- methyl p-hydroxyphenylglycine Methyl D-(-)-4-hydroxy-phenylglycinate USP/EP/BP Δ3-Flomoxef sodium Methyl (R)-2-amino-2-(4-hydroxyphenyl)acetate (R)-Methyl 2-amino-2-(4-hydroxyphenyl)acetate,98% D-(-)-α-p-Hydroxy-Phenylglycine methyl ester Methyl (αR)-α-amino-4-hydroxybenzeneacetate Methyl -(-)-4-hydroxy-phenylglycinate（mixture of D and L) Flufenamic Acid Impurity 11 (alphaR)-alpha-Amino-4-hydroxy-phenyl-acetic acid methyl ester Methyl (alphaR)-alpha-amino-4-hydroxybenzeneacetate 37763-23-8 Antidote / Antibiotic / Antimicrobial