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VU0650786

VU0650786 Structure
VU0650786 structure
CAS No.
1809085-30-0
Chemical Name:
VU0650786
Synonyms
VU0650786;VU0650786, 10 mM in DMSO;(7R)-2-{[(5-chloropyridin-2-yl)oxy]methyl}-5-(2-fluoropyridin-3-yl)-7-methyl-4H,5H,6H,7H-pyrazolo[1,5-a]pyrazin-4-one;Pyrazolo[1,5-a]pyrazin-4(5H)-one, 2-[[(5-chloro-2-pyridinyl)oxy]methyl]-5-(2-fluoro-3-pyridinyl)-6,7-dihydro-7-methyl-, (7R)-;inhibit,anxiolytic activity,antidepressant,Inhibitor,VU-0650786,mGlu3 NAM,VU0650786,mGluR,Metabotropic glutamate receptors,VU 0650786
CBNumber:
CB05419870
Molecular Formula:
C18H15ClFN5O2
Molecular Weight:
387.8
MDL Number:
MOL File:
1809085-30-0.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-11 19:39:08
Product description Number Pack Size Price
VU0650786 JXC08530 25mg $1237.25
VU0650786 JXC08530 50mg $1721
VU0650786 99.55% CS-0030141 5mg $325
VU0650786 99.55% CS-0030141 10mg $455
VU0650786 99.55% CS-0030141 25mg $921
Request For Quotation

VU0650786 Properties

Boiling point 587.4±50.0 °C(Predicted)
Density 1.49±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : 250 mg/mL (644.66 mM);Water : < 0.1 mg/mL (insoluble)
form Solid
pka 0.99±0.22(Predicted)
color White to off-white

VU0650786 price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Biosynth JXC08530 VU0650786 1809085-30-0 25mg $1237.25 2026-06-04 Buy
Biosynth JXC08530 VU0650786 1809085-30-0 50mg $1721 2026-06-04 Buy
ChemScene CS-0030141 VU0650786 99.55% 1809085-30-0 5mg $325 2026-06-04 Buy
ChemScene CS-0030141 VU0650786 99.55% 1809085-30-0 10mg $455 2026-06-04 Buy
ChemScene CS-0030141 VU0650786 99.55% 1809085-30-0 25mg $921 2026-06-04 Buy
Product number Packaging Price Buy
JXC08530 25mg $1237.25 Buy
JXC08530 50mg $1721 Buy
CS-0030141 5mg $325 Buy
CS-0030141 10mg $455 Buy
CS-0030141 25mg $921 Buy

VU0650786 Chemical Properties,Uses,Production

Uses

VU0650786 is a potent and selective CNS penetrant negative allosteric modulator of metabotropic glutamate receptor subtype 3 (mGlu3 NAM), with an IC50 of 392 nM. VU0650786 has antidepressant and anxiolytic activity in rodents[1].

in vivo

VU0650786 (VU786) (i.p., 30 mg/kg) increases the proportion of c-Fos-positive cells by approximately 4-fold, enhances synaptic strength in cone cell subpopulations, weakens thalamocortical long-term depression (LTD), and reduces passive coping in acute models of antidepressant-like activity in inducible cFos-EGFP mice[2].
The pharmacokinetic parameters of VU0650786 (compound 106) in rats[1].

ParametersIV (0.2 mg/kg)
t1/2 (min)42
CL plasma (mL/min/kg)37
VSS (L/kg)1.6

IC 50

mGluR3: 392 nM (IC50)

References

[1] Engers JL, et al. Discovery of a Selective and CNS Penetrant Negative Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 3 with Antidepressant and Anxiolytic Activity in Rodents. J Med Chem. 2015 Sep 24;58(18):7485-500. DOI:10.1021/acs.jmedchem.5b01005
[2] Max E Joffe, et al. mGlu2 and mGlu3 Negative Allosteric Modulators Divergently Enhance Thalamocortical Transmission and Exert Rapid Antidepressant-like Effects. Neuron. 2020 Jan 8;105(1):46-59.e3. DOI:10.1016/j.neuron.2019.09.044

VU0650786 Preparation Products And Raw materials

Raw materials

Preparation Products

VU0650786 Suppliers

Global( 28)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32467 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
TargetMol Chemicals Inc. 		+1-781-999-5354; support@targetmol.com United States 39040 58
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266 China 4849 55
Shanghai Beckham Medical Technology Co., Ltd 13816613772 huahero21@sina.com China 2790 55
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9804 58
Shanghai Changyu Medical Technology Co. Ltd. +86-13301875428 sales@changyuhe.com China 299 58
Fan De(Beijing) Biotechnology Co., Ltd. 15911056312 liming@bio-fount.com China 9729 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11218 58
Shanghai hongqu biomedical technology co. LTD 88888888888 hongquchem@qq.com China 5132 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
InvivoChem 		58
TargetMol Chemicals Inc. 		58
Shanghai Lollane Biological Technology Co.,Ltd. 55
Shanghai Beckham Medical Technology Co., Ltd 55
Shanghai EFE Biological Technology Co., Ltd. 58
Shanghai Changyu Medical Technology Co. Ltd. 58
Fan De(Beijing) Biotechnology Co., Ltd. 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
Shanghai hongqu biomedical technology co. LTD 58

View Lastest Price from VU0650786 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
VU0650786 pictures 2026-05-11 VU0650786
1809085-30-0
 $97.00-347.00 99.09% 10g TargetMol Chemicals Inc.
VU0650786 pictures 2026-04-21 VU0650786
1809085-30-0
 $97.00-347.00 99.09% 10g TargetMol Chemicals Inc.
  • VU0650786 pictures
  • VU0650786
    1809085-30-0
  • $97.00-347.00
  • 99.09%
  • TargetMol Chemicals Inc.
  • VU0650786 pictures
  • VU0650786
    1809085-30-0
  • $97.00-347.00
  • 99.09%
  • TargetMol Chemicals Inc.

VU0650786 Spectrum

VU0650786(1809085-30-0)1HNMR

1809085-30-0(VU0650786)Related Search:

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VU0650786 Pyrazolo[1,5-a]pyrazin-4(5H)-one, 2-[[(5-chloro-2-pyridinyl)oxy]methyl]-5-(2-fluoro-3-pyridinyl)-6,7-dihydro-7-methyl-, (7R)- inhibit,anxiolytic activity,antidepressant,Inhibitor,VU-0650786,mGlu3 NAM,VU0650786,mGluR,Metabotropic glutamate receptors,VU 0650786 (7R)-2-{[(5-chloropyridin-2-yl)oxy]methyl}-5-(2-fluoropyridin-3-yl)-7-methyl-4H,5H,6H,7H-pyrazolo[1,5-a]pyrazin-4-one VU0650786, 10 mM in DMSO 1809085-30-0