BTdCPU
- CAS No.
- 1257423-87-2
- Chemical Name:
- BTdCPU
- Synonyms
- BTdCPU;BTdCPU, 10 mM in DMSO;eIF2–GTP–tRNAiMetTernaryCompInhib, BTdCPU;Inhibitor,BTdCPU,Phosphatase,inhibit,Apoptosis;Urea, N-1,2,3-benzothiadiazol-6-yl-N'-(3,4-dichlorophenyl)-;1-(benzo[d][1,2,3]thiadiazol-6-yl)-3-(3,4-dichlorophenyl)urea
- CBNumber:
- CB05476529
- Molecular Formula:
- C13H8Cl2N4OS
- Molecular Weight:
- 339.2
- MDL Number:
- MOL File:
- 1257423-87-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Density | 1.664±0.06 g/cm3(Predicted) |
|---|---|
| storage temp. | 2-8°C |
| solubility | DMSO: ≥ 250 mg/mL (737.03 mM) |
| pka | 11.75±0.43(Predicted) |
| form | Solid |
| color | White to off-white |
| InChI | InChI=1S/C13H8Cl2N4OS/c14-9-3-1-7(5-10(9)15)16-13(20)17-8-2-4-11-12(6-8)21-19-18-11/h1-6H,(H2,16,17,20) |
| InChIKey | NUUSUAWULNXMGF-UHFFFAOYSA-N |
| SMILES | N(C1C=C2SN=NC2=CC=1)C(NC1=CC=C(Cl)C(Cl)=C1)=O |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
BTdCPU price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 217337 | eIF2-GTP-tRNAiMet Ternary Complex Inhibitor, BTdCPU (N,N'-diarylurea;translation Initiation Tenrary Complex Inhibitor, 1-(benzo[d][1,2,3]thiadiazol-6-yl)-3-(3,4-dichlorophenyl)urea, BTdCPU, Heme-regulated Inhibitor Kinase Activator, BTdCPU) | 1257423-87-2 | 1mg | $276 | 2026-06-03 | Buy |
| Usbiological | 217337 | eIF2-GTP-tRNAiMet Ternary Complex Inhibitor, BTdCPU (N,N'-diarylurea;translation Initiation Tenrary Complex Inhibitor, 1-(benzo[d][1,2,3]thiadiazol-6-yl)-3-(3,4-dichlorophenyl)urea, BTdCPU, Heme-regulated Inhibitor Kinase Activator, BTdCPU) | 1257423-87-2 | 5mg | $502 | 2026-06-03 | Buy |
| Usbiological | 217337 | eIF2-GTP-tRNAiMet Ternary Complex Inhibitor, BTdCPU (N,N'-diarylurea;translation Initiation Tenrary Complex Inhibitor, 1-(benzo[d][1,2,3]thiadiazol-6-yl)-3-(3,4-dichlorophenyl)urea, BTdCPU, Heme-regulated Inhibitor Kinase Activator, BTdCPU) | 1257423-87-2 | 10mg | $984 | 2026-06-03 | Buy |
| ChemScene | CS-0065564 | BTdCPU 99.03% | 1257423-87-2 | 1mg | $198 | 2026-06-04 | Buy |
| ChemScene | CS-0065564 | BTdCPU 99.03% | 1257423-87-2 | 5mg | $417 | 2026-06-04 | Buy |
BTdCPU Chemical Properties, Uses, Production
Uses
BTdCPU is a potent heme regulated inhibitor kinase (HRI) activator that promotes eIF2α phosphorylation and induces apoptosis in Dexamethasone (HY-14648) (Dex)-resistant cancer cells. BTdCPU can be used in the study of cancers such as multiple myeloma and Dex-resistant multiple myeloma[1][2].
in vivo
BTdCPU (175 mg/kg; i.p.; single daily for 21 days) inhibits tumor growth without toxicity in mice xenograft breast tumors model[2].
| Animal Model: | Female nude mice (mice xenograft breast tumors model)[2]. |
| Dosage: | 175 mg/kg |
| Administration: | Intraperitoneal injection; single daily for 21 days |
| Result: | Led to complete tumor stasis,which persisted for the remainder of the 3-week study Showed good safety in mice. |
References
[1] Burwick N, et al. The eIF2-alpha kinase HRI is a novel therapeutic target in multiple myeloma. Leuk Res. 2017 Apr;55:23-32. DOI:10.1016/j.leukres.2017.01.007
[2] Chen T, et al. Chemical genetics identify eIF2α kinase heme-regulated inhibitor as an anticancer target. Nat Chem Biol. 2011 Jul 17;7(9):610-6. DOI:10.1038/nchembio.613
BTdCPU Preparation Products And Raw materials
Raw materials
Preparation Products
BTdCPU Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Beijing HwrkChemical Technology Co., Ltd | 89508211 18501085097 | sales.bj@hwrkchemical.com | China | 9407 | 55 |
| SHANGHAI FORTUNE CHEMICAL TECHNOLOGY CO., LTD | 13816107857 | sales@fortunechem-sh.com | China | 981 | 58 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4859 | 55 | |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 8000 | 62 |
| Shanghai Chaolan Chemical Technology Center | QQ：65489617 13301690235 | Sales@ATKchemical.com | China | 9729 | 58 |
| Chuzhou KeMail Chemical Technology Co., Ltd | 0550-5196001 15000891977 | wj520wjxby@126.com | China | 1940 | 55 |
| Syntechem Co.,Ltd. | 519-88298820 15861130028 | info@syntechem.com | China | 242 | 58 |
| Shanghai Moss Medicine Technology Co., Ltd. | +86-188369842 +86-15618151133 | 188369842@qq.com | China | 1965 | 58 |
| Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9718 | 58 |
