BTdCPU manufacturers
- BTdCPU
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- $110.00
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2026-08-25
- CAS:1257423-87-2
- Min. Order: 1KG
- Purity: 0.99
- Supply Ability: 20 tons
- BTdCPU
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- $148.00
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2026-07-27
- CAS:1257423-87-2
- Purity: 99.59%
- Supply Ability: 10g
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| Product Name: | BTdCPU | | Synonyms: | BTdCPU;eIF2–GTP–tRNAiMetTernaryCompInhib, BTdCPU;Urea, N-1,2,3-benzothiadiazol-6-yl-N'-(3,4-dichlorophenyl)-;1-(benzo[d][1,2,3]thiadiazol-6-yl)-3-(3,4-dichlorophenyl)urea;Inhibitor,BTdCPU,Phosphatase,inhibit,Apoptosis;BTdCPU, 10 mM in DMSO | | CAS: | 1257423-87-2 | | MF: | C13H8Cl2N4OS | | MW: | 339.2 | | EINECS: | | | Product Categories: | API | | Mol File: | 1257423-87-2.mol |  |
| | BTdCPU Chemical Properties |
| density | 1.664±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMSO: ≥ 250 mg/mL (737.03 mM) | | pka | 11.75±0.43(Predicted) | | form | Solid | | color | White to off-white | | InChI | InChI=1S/C13H8Cl2N4OS/c14-9-3-1-7(5-10(9)15)16-13(20)17-8-2-4-11-12(6-8)21-19-18-11/h1-6H,(H2,16,17,20) | | InChIKey | NUUSUAWULNXMGF-UHFFFAOYSA-N | | SMILES | N(C1C=C2SN=NC2=CC=1)C(NC1=CC=C(Cl)C(Cl)=C1)=O |
| | BTdCPU Usage And Synthesis |
| Uses | BTdCPU is a potent heme regulated inhibitor kinase (HRI) activator that promotes eIF2α phosphorylation and induces apoptosis in Dexamethasone (HY-14648) (Dex)-resistant cancer cells. BTdCPU can be used in the study of cancers such as multiple myeloma and Dex-resistant multiple myeloma[1][2]. | | in vivo | BTdCPU (175 mg/kg; i.p.; single daily for 21 days) inhibits tumor growth without toxicity in mice xenograft breast tumors model[2]. | Animal Model: | Female nude mice (mice xenograft breast tumors model)[2]. | | Dosage: | 175 mg/kg | | Administration: | Intraperitoneal injection; single daily for 21 days | | Result: | Led to complete tumor stasis,which persisted for the remainder of the 3-week study
Showed good safety in mice.
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| | References | [1] Burwick N, et al. The eIF2-alpha kinase HRI is a novel therapeutic target in multiple myeloma. Leuk Res. 2017 Apr;55:23-32. DOI:10.1016/j.leukres.2017.01.007
[2] Chen T, et al. Chemical genetics identify eIF2α kinase heme-regulated inhibitor as an anticancer target. Nat Chem Biol. 2011 Jul 17;7(9):610-6. DOI:10.1038/nchembio.613 |
| | BTdCPU Preparation Products And Raw materials |
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