STX140
- CAS No.
- 401600-86-0
- Chemical Name:
- STX140
- Synonyms
- STX140;2-methoxy-estra-1,3,5(10)-triene-3,17β-diol, disulfamate;Estra-1,3,5(10)-triene-3,17-diol, 2-methoxy-, disulfamate, (17β)-;(9Beta,13α,14Beta,17α)-2-Methoxyestra-1,3,5(10)-triene-3,17-diyl disulfamate
- CBNumber:
- CB05540901
- Molecular Formula:
- C19H28N2O7S2
- Molecular Weight:
- 460.56
- MDL Number:
- MOL File:
- 401600-86-0.mol
- MSDS File:
- SDS
| Boiling point | 644.8±65.0 °C(Predicted) |
|---|---|
| Density | 1.47±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMF: 30 mg/ml; DMF:PBS (pH 7.2) (1:7): 0.1 mg/ml; DMSO: 25 mg/ml; Ethanol: 14 mg/ml |
| form | A crystalline solid |
| pka | 8.81±0.70(Predicted) |
| FDA UNII | S57SQE6LE5 |
STX140 price More Price(14)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 27863 | STX140 ≥98% | 401600-86-0 | 1mg | $81 | 2026-04-30 | Buy |
| Cayman Chemical | 27863 | STX140 ≥98% | 401600-86-0 | 5mg | $357 | 2026-04-30 | Buy |
| Cayman Chemical | 27863 | STX140 ≥98% | 401600-86-0 | 10mg | $633 | 2026-04-30 | Buy |
| Biosynth | BRA60086 | (9Beta,13α,14Beta,17α)-2-Methoxyestra-1,3,5(10)-triene-3,17-diyl disulfamate | 401600-86-0 | 1mg | $250 | 2026-06-04 | Buy |
| Biosynth | BRA60086 | (9Beta,13α,14Beta,17α)-2-Methoxyestra-1,3,5(10)-triene-3,17-diyl disulfamate | 401600-86-0 | 5mg | $603.25 | 2026-06-04 | Buy |
STX140 Chemical Properties, Uses, Production
Description
STX140 is an estrogen sulfamate with anticancer activities. It inhibits steroid sulfatase with IC50 values of 39 and 0.5 nM in placental microsomes and MCF-7 cancer cells, respectively. STX140 also binds to carbonic anhydrase IX and II (Kis = 70 and 270 nM, respectively). It inhibits bovine brain tubulin assembly in a cell-free assay (IC50 = 2.2 μM) and tubule formation in human umbilical vein epithelial cells (HUVECs) when used at concentrations of 50 and 100 nM. STX140 inhibits proliferation of LNCaP, PC3, and MDA-MB-231 cancer cells, as well as wild-type A2780 cancer cells and adriamycin- and cisplatin-resistant A2780 cancer cells (IC50s = 530, 400, 618, 330, 870, and 380 nM, respectively). It reduces angiogenesis in a Matrigel™ plug assay in mice and tumor growth in MCF-7 and MDA-MB-231 mouse xenograft models when used at a dose of 20 mg/kg.
Uses
STX140 is an orally active microtubule disruptor. STX140 induces apoptosis in the hormone-independent PC-3 prostate cell lines. STX140 has anti-angiogenic and anti-tumour activities[1].
in vivo
STX140 (20mg/kg; p.o.; once daily; 60 days) leads to tumour regression and complete responses, which are maintained after the cessation of dosing[1].
| Animal Model: | Male MF-1 nu/nu mice injected with PC-3 cells[1] |
| Dosage: | 20mg/kg |
| Administration: | p.o.; once daily; 60 days |
| Result: | Led to tumour regression and complete responses. |
References
[1] S P Newman, et al. The therapeutic potential of a series of orally bioavailable anti-angiogenic microtubule disruptors as therapy for hormone-independent prostate and breast cancers. Br J Cancer. 2007 Dec 17;97(12):1673-82. DOI:10.1038/sj.bjc.6604100
STX140 Preparation Products And Raw materials
Raw materials
Preparation Products
STX140 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 400-920-5774 | sales@glpbio.cn | China | 6705 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11123 | 58 |
| Beijing Biocreative Technology Co., Ltd. | 15522676233 | 3007606172@qq.com | China | 1246 | 58 |
