Diethylene glycol monomethyl ether
- CAS No.
- 111-77-3
- Chemical Name:
- Diethylene glycol monomethyl ether
- Synonyms
- DM;2-(2-METHOXYETHOXY)ETHANOL;METHYL CARBITOL;degme;DIETHYLENE GLYCOL METHYL ETHER;METHYLDIGLYCOL;mPEG2-OH;Methyl-PEG2-alcohol;METHOXYETHOXYETHANOL;Ethanol,2-(2-methoxyethoxy)-
- CBNumber:
- CB0664404
- Molecular Formula:
- C5H12O3
- Molecular Weight:
- 120.15
- MDL Number:
- MFCD00002871
- MOL File:
- 111-77-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | −70 °C(lit.) |
|---|---|
| Boiling point | 194 °C(lit.) |
| Density | 1.023 g/mL at 25 °C(lit.) |
| vapor density | 4.14 (vs air) |
| vapor pressure | 0.2 mm Hg ( 20 °C) |
| refractive index |
n |
| Flash point | 183 °F |
| storage temp. | Store below +30°C. |
| form | Liquid |
| pka | 14.37±0.10(Predicted) |
| color | Clear |
| PH | 4-7 (200g/l, H2O, 20℃) |
| Odor | Faint pleasant odor |
| Viscosity | 3.9 mPa @ 20°C |
| explosive limit | 1.38-22.7% |
| Water Solubility | Miscible |
| Specific Heat Capacity | Cp(liquid): 2.26 J/(g·K), at 25℃ |
| Thermal Conductivity | 0.19 W/(m·K) at 25 ℃ |
| Sensitive | Hygroscopic |
| Merck | 14,6037 |
| BRN | 1697812 |
| Henry's Law Constant | 6.2×105 mol/(m3Pa) at 25℃, HSDB (2015) |
| Exposure limits | EU LTEL: 10 ppm(50.1 mg/m3) |
| Stability | Stable. Incompatible with strong oxidizing agents. Hygroscopic. Store under nitrogen. |
| Cosmetics Ingredients Functions |
SOLVENT PERFUMING FRAGRANCE VISCOSITY CONTROLLING |
| InChI | 1S/C5H12O3/c1-7-4-5-8-3-2-6/h6H,2-5H2,1H3 |
| InChIKey | SBASXUCJHJRPEV-UHFFFAOYSA-N |
| SMILES | COCCOCCO |
| LogP | -0.47 at 20℃ |
| REACH Annex XVII Substances List | 2-(2-methoxyethoxy)ethanol (DEGME) (111-77-3) |
| FDA 21 CFR | 175.105 |
| Indirect Additives used in Food Contact Substances | DIETHYLENE GLYCOL MONOMETHYL ETHER |
| CAS DataBase Reference | 111-77-3(CAS DataBase Reference) |
| EWG's Food Scores | 2-5 |
| FDA UNII | 465DDJ8G8K |
| NIST Chemistry Reference | Ethanol, 2-(2-methoxyethoxy)-(111-77-3) |
| EPA Substance Registry System | Diethylene glycol monomethyl ether (111-77-3) |
| UNSPSC Code | 12352104 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H361d | |||||||||
| Precautionary statements | P201-P202-P280-P308+P313-P405-P501 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 63 | |||||||||
| Safety Statements | 36/37 | |||||||||
| WGK Germany | 1 | |||||||||
| RTECS | KL6125000 | |||||||||
| Autoignition Temperature | 221 °C | |||||||||
| TSCA | TSCA listed | |||||||||
| HS Code | 29094200 | |||||||||
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
|||||||||
| Hazard Classifications | Repr. 1B | |||||||||
| Hazardous Substances Data | 111-77-3(Hazardous Substances Data) | |||||||||
| Toxicity | LD50 orally in rats: 9.21 g/kg (Smyth) | |||||||||
| REACH Registrations | Active | |||||||||
| NFPA 704 |
|
Diethylene glycol monomethyl ether price More Price(70)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 8.03128 | Diethylene glycol monomethyl ether for synthesis | 111-77-3 | 1L | $70.4 | 2026-04-30 | Buy |
| Sigma-Aldrich | 8.03128 | Diethylene glycol monomethyl ether for synthesis | 111-77-3 | 2.5L | $142 | 2026-04-30 | Buy |
| Sigma-Aldrich | 579548 | Diethylene glycol methyl ether ReagentPlus , ≥99.0% | 111-77-3 | 1l | $82 | 2026-04-30 | Buy |
| Sigma-Aldrich | 579548 | Diethylene glycol methyl ether ReagentPlus , ≥99.0% | 111-77-3 | 4l | $258 | 2026-04-30 | Buy |
| TCI Chemical | M0537 | Diethylene Glycol Monomethyl Ether (stabilized with BHT) >99.0%(GC) | 111-77-3 | 25mL | $19 | 2026-04-30 | Buy |
Diethylene glycol monomethyl ether Chemical Properties,Uses,Production
Chemical Properties
Diethylene glycol monomethyl ether (DEGME) is a type of glycol ether and is a colorless, stable hygroscopic liquid with an agreeable odor. It is completely miscible with water, ketones, alcohol, ethers, aromatic hydrocarbons and halogenated hydrocarbons. More specifically, it is miscible with acetone, benzene, carbon tetrachloride, ethyl ether, methanol and water. Exposure to diEGBE is unlikely to occur via inhalation unless it is heated.
Diethylene glycol monomethyl ether is a solvent for dyes, oils, fats, waxes, many natural and synthetic resins, nitrocellulose and cellulose acetate. It is used as a high-boiling solvent in such formulations as printing inks ond pastes, stamp pad inks, textile dye pastes, lacquers, and synthetic resin coatings. Its presence in lacquers eases brushability and flow-out, and minimizes lifting of undercoats.
DEGME is an ethylene-series or E-series glycol ether and is sold by Dow under the tradename Methyl CARBITOL™ solvent. DEGME has a high dilution ratio and a low evaporation rate.It is stable under recommended storage conditions and readily biodegradable.
Occurrence
Has apparently not been reported to occur in nature.
Uses
Diethylene glycol monomethyl ether(DGME) is used as a thermally stable solvent for many substances, such as nitrocellulose, lacquers, varnishes, and dyes.
Uses
Diethylene glycol monomethyl ether is an industrial solvent and is also commonly used as a Fuel System Icing Inhibitor (FSII) in jet fuels.
Uses
Diethylene glycol monomethyl ether is used in textile dye pastes, in lacquer industrial for thinners and quick drying varnishes; solvent for wood stains, hydraulic brake fluid diluent, and as a coupling agent for miscible organic aqueous systems.
Diethylene glycol monoethyl ether is used as a solvent in lacquer, varnishes, and enamels. It is also used in cosmetic products and dermatological preparations and as a solvent in some medicine products. It enhances the percutaneous absorption through the skin and mucosal barriers. It is used in some drugs to enhance absorption.
Diethylene glycol monobutyl ether is used as a solvent in paints, dyes, inks detergents, and cleaners.
Used in the same way as 2-ethoxyethanol where a solvent with a higher boiling point is required.
Definition
ChEBI: A hydroxypolyether that is the monomethyl ether derivative of diethylene glycol.
Preparation
A by-product in the manufacture of ethylene glycol monomethyl ether (Arctander, 1969).
General Description
Colorless liquid with a sweet odor. Floats and mixes with water.
Air & Water Reactions
Oxidizes readily in air to form unstable peroxides that may explode spontaneously [Bretherick 1979 p.151-154, 164]. Water soluble.
Reactivity Profile
2-(2-Methoxyethoxy)ethanol is a ether-alcohol derivative. The ether being relatively unreactive. Flammable and/or toxic gases are generated by the combination of alcohols with alkali metals, nitrides, and strong reducing agents. They react with oxoacids and carboxylic acids to form esters plus water. Oxidizing agents convert alcohols to aldehydes or ketones. Alcohols exhibit both weak acid and weak base behavior. They may initiate the polymerization of isocyanates and epoxides.
Health Hazard
DGME is a mild to moderate toxicant via ingestion or absorption through the skin. High doses produced lowering of hemoglobin levels and increased relative kidney weight. Renaldamagemay occurnear the lethal dose. Eye contact of the liquid can result in mild to moderate irritation
LD50 value, oral (guinea pigs): 4160 mg/kg
Preliminary developmental toxicity test in pregnant mice dosed with DGME indicated teratogenicity of this compound (Hardin et al. 1987; Cheever et al. 1988). Earlier, Doe (1984) reported no teratogenic property of DGME when administered subcutaneously in rats up to 100 mL/kg. In comparison, EGME produced effects at 40 mL/kg..
Fire Hazard
2-(2-Methoxyethoxy)ethanol is combustible.
Flammability and Explosibility
Non flammable
Safety Profile
Moderately toxic by skin contact and intraperitoneal routes. Mildly toxic by ingestion. An experimental teratogen. Other experimental reproductive effects. An eye irritant. Combustible when exposed to heat or flame; can react with oxidzing materials. Reacts violently with Ca(OCl)2, chlorosulfonic acid, and oleum. To fight fire, use dry chemical, alcohol foam, water spray or mist, CO2. When heated to decomposition it emits acrid smoke and irritating fumes. See also GLYCOL ETHERS.
Synthesis
109-86-4
107-07-3
111-77-3
Sodium hydride (60% dispersion, 21.0 g) and tetrahydrofuran (THF, 200 ml) were added to a reaction vessel equipped with a stirrer and thermometer under nitrogen protection. The mixture was stirred under cooling in an ice bath and additional THF (100 ml) was added. A THF solution of 2-methoxyethanol (20.0 g) was added slowly dropwise. After dropwise addition, stirring was continued for 1 hour. Subsequently, 2-chloroethanol (23.3 g) was added slowly dropwise under the cooling of an ice bath and gradually warmed up to room temperature and stirring was continued for 1 hour. After completion of the reaction, water (200 ml) was added to quench the reaction and the organic layer was separated. The aqueous layer was extracted four times with THF (100 ml) and all organic layers were combined. The organic layer was washed sequentially with 5% aqueous sodium hydroxide (400 ml) and saturated brine (400 ml), followed by drying with anhydrous sodium sulfate. The solvent was removed by concentration under reduced pressure and the residue was purified by distillation under reduced pressure to give diethylene glycol monomethyl ether (31.2 g).
Purification Methods
Purify as for diethylene glycol mono-n-butyl ether. [Beilstein 1 IV 2392.]
Toxics Screening Level
The initial threshold screening level (ITSL) for diethylene glycol monomethyl ether (DGME) is 190 μg/m3 based on a 24-hour averaging time.
Waste Disposal
DGME is mixed with a combustible solvent and burned in a chemical incinerator.
References
[1] Patent: US2018/230094, 2018, A1. Location in patent: Paragraph 0094; 0095
Diethylene glycol monomethyl ether Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
1of4
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| 15063339523 15063339523 | 2359472372@qq.com | China | 232 | 58 | |
| Jinan Hexin Chemical Co., Ltd | 18764033565 18764033565; | JINANHEXIN888@QQ.COM | China | 102 | 58 |
| kxenberg | 13681668984 微信同号 13681668984 | kxenberg@163.com | China | 304 | 58 |
| Wuhan Hengjiu Chemical Co., Ltd. | 17317534732 17671758929 | 616634732@qq.com | China | 1478 | 58 |
| Shandong Yaoming Chemical Co., Ltd. | 15550028560 | 472498067@qq.com | China | 356 | 58 |
| shandongyushuohuagongyouxiangongsi | 18866159232 18866159232 | 1914388224@qq.com | China | 246 | 58 |
| Shandong Qianfanshun Chemical Co., Ltd | 15610119970 | 1542002666@qq.com | China | 500 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
Related articles
- 2-(2-Methoxyethoxy)ethanol: A Versatile Solvent in Modern Chemistry
- Ethylene glycol monomethyl ether (EGME) and diethylene glycol monomethyl ether (diEGME; 2-(2-Methoxyethoxy)ethanol) are two of....
- Oct 23,2024
View Lastest Price from Diethylene glycol monomethyl ether manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-11 | 2-(2-Methoxyethoxy)Ethanol
111-77-3
|
1000KG | 99.5 | 20000MT | Gansu Jinyuantai New Material Co., Ltd. | ||
 |
2026-09-11 | 2-(2-methoxyethoxy)ethanol
111-77-3
|
1000kg | 99 | 20000mt | Anhui Royal Chemical Co., Ltd. | ||
 |
2026-05-28 | Diethylene glycol monomethyl ether
111-77-3
|
$2.00-5.00 | 1KG | 99% | 10000kg | Hebei Chuanghai Biotechnology Co,.LTD |
-
- 2-(2-Methoxyethoxy)Ethanol
111-77-3
- $0.00
- 99.5
- Gansu Jinyuantai New Material Co., Ltd.
-
- 2-(2-methoxyethoxy)ethanol
111-77-3
- $0.00
- 99
- Anhui Royal Chemical Co., Ltd.
-
- Diethylene glycol monomethyl ether
111-77-3
- $2.00-5.00
- 99%
- Hebei Chuanghai Biotechnology Co,.LTD
111-77-3(Diethylene glycol monomethyl ether)Related Search:
1of4
