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2-Chloro-1,3,2-dioxaphospholane-2-oxide

2-Chloro-1,3,2-dioxaphospholane-2-oxide structure

CAS No.: 6609-64-9

Chemical Name:: 2-Chloro-1,3,2-dioxaphospholane-2-oxide

Synonyms: 2-CHLORO-2-OXO-1,3,2-DIOXAPHOSPHOLANE;ETHYLENE CHLOROPHOSPHATE;ETHYLENE CYCL-CHLOROPHOSPHATE;Ethylene cycl-chlorophosphate (2-chloro-2-oxo-1,3,2-dioxaphospholane);Ethylene chl;2-chloro-1,3,2;CYCLIC CHLOROPHOSPHATE;Ethylene chlorophosphate, tech. 90%;Ethylene glycol chlorophosphate, 95%;2-chloro-1,3,2λ?-dioxaphospholan-2-one

CBNumber:: CB0664909

Molecular Formula:: C2H4ClO3P

Molecular Weight:: 142.48

MDL Number:: MFCD00043138

MOL File:: 6609-64-9.mol

MSDS File:: SDS

Last updated:2026-01-13 11:13:23

Product description	Number	Pack Size	Price
2-Chloro-1,3,2-dioxaphospholane 2-oxide	377953	5g	$169
2-Chloro-2-oxo-1,3,2-dioxaphospholane >95.0%(GC)(T)	C1250	5g	$85
2-Chloro-2-oxo-1,3,2-dioxaphospholane >95.0%(GC)(T)	C1250	25g	$261
2-Chloro-1,3,2-dioxaphospholane 2-oxide	159470	5g	$267
2-Chloro-1,3,2-dioxaphospholane-2-oxide(TechnicalGrade)	C365758	5g	$200
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2-Chloro-1,3,2-dioxaphospholane-2-oxide Properties

Melting point	12-14 °C
Boiling point	89-91 °C0.8 mm Hg(lit.)
Density	1.55 g/mL at 25 °C(lit.)
vapor pressure	1.06hPa at 25℃
refractive index	n20/D 1.45(lit.)
Flash point	>230 °F
storage temp.	-20°C
solubility	Chloroform (Soluble), Ethyl Acetate (Slightly)
form	Solid or Film
color	White to off-white
Water Solubility	Miscible with water and chloroform.
Sensitive	Moisture Sensitive
BRN	606582
Stability	Extremely moisture sensitive
InChI	1S/C2H4ClO3P/c3-7(4)5-1-2-6-7/h1-2H2
InChIKey	SBMUNILHNJLMBF-UHFFFAOYSA-N
SMILES	ClP1(=O)OCCO1
LogP	-0.485 at 25℃ and pH7
CAS DataBase Reference	6609-64-9(CAS DataBase Reference)
FDA UNII	7EBS5ZK92N
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS05

Signal word

Danger

Hazard statements

H314

Precautionary statements

P280-P305+P351+P338-P310

PPE

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

Hazard Codes

Risk Statements

14-34

Safety Statements

26-36/37/39-45-8-25-27

RIDADR

UN 3265 8/PG 2

WGK Germany

HazardClass

PackingGroup

HS Code

29209090

Storage Class

8A - Combustible corrosive hazardous materials

Hazard Classifications

Eye Dam. 1
Skin Corr. 1B

NFPA 704

	1
3		2
	W

2-Chloro-1,3,2-dioxaphospholane-2-oxide price More Price(25)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	377953	2-Chloro-1,3,2-dioxaphospholane 2-oxide	6609-64-9	5g	$169	2026-03-19	Buy
TCI Chemical	C1250	2-Chloro-2-oxo-1,3,2-dioxaphospholane >95.0%(GC)(T)	6609-64-9	5g	$85	2026-03-19	Buy
TCI Chemical	C1250	2-Chloro-2-oxo-1,3,2-dioxaphospholane >95.0%(GC)(T)	6609-64-9	25g	$261	2026-03-19	Buy
Usbiological	159470	2-Chloro-1,3,2-dioxaphospholane 2-oxide	6609-64-9	5g	$267	2021-12-16	Buy
TRC	C365758	2-Chloro-1,3,2-dioxaphospholane-2-oxide(TechnicalGrade)	6609-64-9	5g	$200	2021-12-16	Buy

Product number	Packaging	Price	Buy
377953	5g	$169	Buy
C1250	5g	$85	Buy
C1250	25g	$261	Buy
159470	5g	$267	Buy
C365758	5g	$200	Buy

2-Chloro-1,3,2-dioxaphospholane-2-oxide Chemical Properties,Uses,Production

Chemical Properties

clear colourless liquid

Uses

2-Chloro-1,3,2-dioxaphospholane-2-oxide is used in the synthesis of α-naphthylphosphorylcholine as a method to detect phospholipase C activity.

Uses

Ethylene chlorophosphate is used in the syntheses of 2-methacryloyoxyethylphophocholine, phosphatidylcholines, 2',3'-O-16-hentriacontanyliden-adenosine-5'-phosphocholine and hexadecylphosphocholine. It is also involved the synthesis of alpha-naphthylphosphorylcholine, which is used to detect phospholipase C activity. It is an important reactant for the synthesis of a zwitterionic silane, UV-polymerizable lipids utilizing Chabrier reaction and block copolymers of poly(aliphatic ester) clickable polyphosphoester.

Uses

2-Chloro-1,3,2-dioxaphospholane 2-oxide may be used in the synthesis of:

2-methacryloyloxyethylphosphorylcholine
miltefosine (hexadecylphosphocholine, MT) analogs
phosphoric acid 2-trimethylamino-ethyl ester undec-10-enyl ester
uridine nucleolipid, (2′,3′-O-16-hentriacontanyliden-uridine-5′-phosphocholine, PUPC)
adenosine nucleoamphiphile, (2′,3′-O-16-hentriacontanyliden-adenosine-5′-phosphocholine, PAPC)
structurally related phospholipids which are either conformationally restricted or flexible
phosphatidylcholines

General Description

2-Chloro-1,3,2-dioxaphospholane 2-oxide (COP) is a cyclic chlorophosphate reagent that can be prepared from 2-chloro-1,3,2-dioxaphospholane by reacting with molecular oxygen.

Purification Methods

It should be distilled under high vacuum as some polymerisation occurs at -1atmospheric pressure. It has IR bands at 3012, 2933, 1477, 1366, 1325, 1040, 924 and 858 cm . It is hydrolysed to HOCH2CH2OPO3H2 in 30minutes in H2O at 100o [IR: Cox & Westheimer J Am Chem Soc 80 5441 1958]. [Beilstein 1 IV 2419.]

2-Chloro-1,3,2-dioxaphospholane-2-oxide synthesis

Synthesis of 2-Chloro-1,3,2-dioxaphospholane-2-oxide from Ethylene glycol

2-Chloro-1,3,2-dioxaphospholane-2-oxide Preparation Products And Raw materials

Raw materials

2-Chloro-1,3,2-dioxaphospholane 1,2-Bis(trimethylsilyloxy)ethane Ethylene glycol

Preparation Products

1,3,2-Dioxaphospholane, 2-ethoxy-, 2-oxide 2-Hydroxy-1,3,2-dioxaphospholane 2-oxide 1,3,2-Dioxaphospholane, 2-(2,2,2-trifluoroethoxy)-, 2-oxide

2-Chloro-1,3,2-dioxaphospholane-2-oxide Suppliers

Global( 232)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Chemsigma International Co., Ltd.	+86-2558742998 +86-19951791336	info@chemsigma.com	China	1801	58
Hebei Chuanghai Biotechnology Co., Ltd	+8615350571055	Sibel@chuanghaibio.com	China	8743	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29640	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-2158073036	info@dakenam.com	China	13816	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21594	55
Shanghai Time Chemicals CO., Ltd.	+86-021-57951555 +8617317452075	jack.li@time-chemicals.com	China	1803	55
Nanjing ChemLin Chemical Industry Co., Ltd.	025-83697070	product@chemlin.com.cn	CHINA	3009	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29830	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49977	58
Richest Group Ltd	18017061086	oled@richest-group.com	CHINA	5600	58

Supplier	Advantage
Chemsigma International Co., Ltd.	58
Hebei Chuanghai Biotechnology Co., Ltd	58
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55
Shanghai Time Chemicals CO., Ltd.	55
Nanjing ChemLin Chemical Industry Co., Ltd.	60
career henan chemical co	58
CONIER CHEM AND PHARMA LIMITED	58
Richest Group Ltd	58

View Lastest Price from 2-Chloro-1,3,2-dioxaphospholane-2-oxide manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-03-20	2-Chloro-1,3,2-dioxaphospholane-2-oxide 6609-64-9	US $19.90 / kg	1kg	99%	10 mt	Hebei Chuanghai Biotechnology Co., Ltd
2025-04-04	2-Chloro-1,3,2-dioxaphospholane-2-oxide 6609-64-9	US $0.00-0.00 / KG	1KG	98%	1ton	Henan Aochuang Chemical Co.,Ltd.
2025-01-03	2-Chloro-1,3,2-dioxaphospholane-2-oxide 6609-64-9	US $990.00 / Kg	0.100Kg	98	5000 Kg	R&D Scientific Inc.

2-Chloro-1,3,2-dioxaphospholane-2-oxide
6609-64-9
US $19.90 / kg
99%
Hebei Chuanghai Biotechnology Co., Ltd

2-Chloro-1,3,2-dioxaphospholane-2-oxide
6609-64-9
US $0.00-0.00 / KG
98%
Henan Aochuang Chemical Co.,Ltd.

2-Chloro-1,3,2-dioxaphospholane-2-oxide
6609-64-9
US $990.00 / Kg
98
R&D Scientific Inc.

2-Chloro-1,3,2-dioxaphospholane-2-oxide Spectrum

2-Chloro-1,3,2-dioxaphospholane-2-oxide(6609-64-9)MS 2-Chloro-1,3,2-dioxaphospholane-2-oxide(6609-64-9)¹HNMR 2-Chloro-1,3,2-dioxaphospholane-2-oxide(6609-64-9)¹³CNMR 2-Chloro-1,3,2-dioxaphospholane-2-oxide(6609-64-9)IR1

6609-64-9(2-Chloro-1,3,2-dioxaphospholane-2-oxide)Related Search:

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Ethylene cycl-chlorophosphate (2-chloro-2-oxo-1,3,2-dioxaphospholane) 2-Chloro-1,3-dioxa-2-phosphacyclopentane 2-oxide Ethylene chlorophosphate, tech. 90% 2-Chloro-2-oxo-1,3,2-dioxaphospholane, Ethylene cycl-chlorophosphate 2-Chloro-1,3,2-dioxaphospholane-2-oxide, Ethylene cycl-chlorophosphate 1,3,2-Dioxaphospholane, 2-chloro-, 2-oxide CYCLIC CHLOROPHOSPHATE Ethylene glycol chlorophosphate, 95% 2-Chloro-1,3,2-dioxaphospholane-2-oxide,95% Ethylene chl ETHYLENE CHLOROPHOSPHATE ETHYLENE CYCL-CHLOROPHOSPHATE 2-CHLORO-2-OXO-1,3,2-DIOXAPHOSPHOLANE 2-CHLORO-1,3,2-DIOXAPHOSPHOLANE-2-OXIDE 2-Chloro-1,2,3-dioxaphospholane-2-oxide 2-Chloro-2-oxo-1,3,2-dioxaphospholane > 2-chloro-2-oxo-1,3, 2-dioxophosphorus heterocyclopentane 2-Chloro-1,3,2-dioxaphospholane-2-oxide/ Ethylene Chlorophosphate 2-Chloro-1,3,2-dioxaphospholane-2-oxide (Technical Grade) 2-chloro-1,3,2λ?-dioxaphospholan-2-one 2-chloro-1,3,2 2-chloro-2-oxo-1,3, 2-dioxophosphoheterocyclopentane 2-Chloro-2-Oxido-1,3,2- Dioxaphospholane 2-chloro-1,3,2lambda5-dioxaphospholane 2-oxide 2-chloro-1,3,2lambda5-dioxaphospholan-2-one 2-chloro-1,3,2-dioxyphosphoruscyclopentane-2-oxy 6609-64-9 C2H4ClO3P Organic Building Blocks Phosphorus Halides Phosphorus Compounds Building Blocks Phosphorylating Agents DNA / RNA Synthesis Phosphorylation Biochemistry Nucleosides, Nucleotides & Related Reagents Phosphorylating and Phosphorothioating Agents Phosphorylation Protecting Agents, Phosphorylating Agents & Condensing Agents Synthetic Organic Chemistry