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ChemicalBook >> CAS DataBase List >>2-Chloro-1,3,2-dioxaphospholane-2-oxide

2-Chloro-1,3,2-dioxaphospholane-2-oxide

2-Chloro-1,3,2-dioxaphospholane-2-oxide Structure
2-Chloro-1,3,2-dioxaphospholane-2-oxide structure
CAS No.
6609-64-9
Chemical Name:
2-Chloro-1,3,2-dioxaphospholane-2-oxide
Synonyms
2-CHLORO-2-OXO-1,3,2-DIOXAPHOSPHOLANE;ETHYLENE CHLOROPHOSPHATE;ETHYLENE CYCL-CHLOROPHOSPHATE;Ethylene cycl-chlorophosphate (2-chloro-2-oxo-1,3,2-dioxaphospholane);Ethylene chl;2-chloro-1,3,2;CYCLIC CHLOROPHOSPHATE;4-Chlorophenyl 2-Chlorophenyl;Ethylene glycol chlorophosphate;Ethylene chlorophosphate, tech. 90%
CBNumber:
CB0664909
Molecular Formula:
C2H4ClO3P
Molecular Weight:
142.48
MDL Number:
MFCD00043138
MOL File:
6609-64-9.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-27 22:48:19
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2-Chloro-1,3,2-dioxaphospholane-2-oxide Properties

Melting point 12-14 °C
Boiling point 89-91 °C0.8 mm Hg(lit.)
Density 1.55 g/mL at 25 °C(lit.)
vapor pressure 1.06hPa at 25℃
refractive index n20/D 1.45(lit.)
Flash point >230 °F
storage temp. -20°C
solubility Chloroform (Soluble), Ethyl Acetate (Slightly)
form Solid or Film
color White to off-white
Water Solubility Miscible with water and chloroform.
Sensitive Moisture Sensitive
BRN 606582
Stability Extremely moisture sensitive
InChI 1S/C2H4ClO3P/c3-7(4)5-1-2-6-7/h1-2H2
InChIKey SBMUNILHNJLMBF-UHFFFAOYSA-N
SMILES ClP1(=O)OCCO1
LogP -0.485 at 25℃ and pH7
CAS DataBase Reference 6609-64-9(CAS DataBase Reference)
FDA UNII 7EBS5ZK92N
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Corrosion (GHS05)
GHS05
Signal word  Danger
Hazard statements  H314
Precautionary statements  P280-P305+P351+P338-P310
PPE Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
Hazard Codes  C
Risk Statements  14-34
Safety Statements  26-36/37/39-45-8-25-27
RIDADR  UN 3265 8/PG 2
WGK Germany  3
F  10
HazardClass  8
PackingGroup  II
HS Code  29209090
Storage Class 8A - Combustible corrosive hazardous materials
Hazard Classifications Eye Dam. 1
Skin Corr. 1B
REACH Registrations Inactive
NFPA 704
1
3 2
W

2-Chloro-1,3,2-dioxaphospholane-2-oxide price More Price(42)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 377953 2-Chloro-1,3,2-dioxaphospholane 2-oxide 6609-64-9 5g $169 2026-04-30 Buy
TCI Chemical C1250 2-Chloro-2-oxo-1,3,2-dioxaphospholane >95.0%(GC)(T) 6609-64-9 5g $85 2026-04-30 Buy
TCI Chemical C1250 2-Chloro-2-oxo-1,3,2-dioxaphospholane >95.0%(GC)(T) 6609-64-9 25g $261 2026-04-30 Buy
TRC TRC-C365758-5G 2-Chloro-1,3,2-dioxaphospholane-2-oxide (Technical Grade) 6609-64-9 5g $270 2026-06-03 Buy
TRC TRC-C365758-1G 2-Chloro-1,3,2-dioxaphospholane-2-oxide (Technical Grade) 6609-64-9 1g $78 2026-06-03 Buy
Product number Packaging Price Buy
377953 5g $169 Buy
C1250 5g $85 Buy
C1250 25g $261 Buy
TRC-C365758-5G 5g $270 Buy
TRC-C365758-1G 1g $78 Buy

2-Chloro-1,3,2-dioxaphospholane-2-oxide Chemical Properties, Uses, Production

Chemical Properties

clear colourless liquid

Uses

2-Chloro-1,3,2-dioxaphospholane-2-oxide is used in the synthesis of α-naphthylphosphorylcholine as a method to detect phospholipase C activity.

Uses

Ethylene chlorophosphate is used in the syntheses of 2-methacryloyoxyethylphophocholine, phosphatidylcholines, 2',3'-O-16-hentriacontanyliden-adenosine-5'-phosphocholine and hexadecylphosphocholine. It is also involved the synthesis of alpha-naphthylphosphorylcholine, which is used to detect phospholipase C activity. It is an important reactant for the synthesis of a zwitterionic silane, UV-polymerizable lipids utilizing Chabrier reaction and block copolymers of poly(aliphatic ester) clickable polyphosphoester.

Uses

2-Chloro-1,3,2-dioxaphospholane 2-oxide may be used in the synthesis of:

  • 2-methacryloyloxyethylphosphorylcholine
  • miltefosine (hexadecylphosphocholine, MT) analogs
  • phosphoric acid 2-trimethylamino-ethyl ester undec-10-enyl ester
  • uridine nucleolipid, (2′,3′-O-16-hentriacontanyliden-uridine-5′-phosphocholine, PUPC)
  • adenosine nucleoamphiphile, (2′,3′-O-16-hentriacontanyliden-adenosine-5′-phosphocholine, PAPC)
  • structurally related phospholipids which are either conformationally restricted or flexible
  • phosphatidylcholines

General Description

2-Chloro-1,3,2-dioxaphospholane 2-oxide (COP) is a cyclic chlorophosphate reagent that can be prepared from 2-chloro-1,3,2-dioxaphospholane by reacting with molecular oxygen.

Purification Methods

It should be distilled under high vacuum as some polymerisation occurs at -1atmospheric pressure. It has IR bands at 3012, 2933, 1477, 1366, 1325, 1040, 924 and 858 cm . It is hydrolysed to HOCH2CH2OPO3H2 in 30minutes in H2O at 100o [IR: Cox & Westheimer J Am Chem Soc 80 5441 1958]. [Beilstein 1 IV 2419.]

2-Chloro-1,3,2-dioxaphospholane-2-oxide synthesis

107-21-1
6609-64-9
Synthesis of 2-Chloro-1,3,2-dioxaphospholane-2-oxide from Ethylene glycol

2-Chloro-1,3,2-dioxaphospholane-2-oxide Preparation Products And Raw materials

Raw materials

2-Chloro-1,3,2-dioxaphospholane 1,2-Bis(trimethylsilyloxy)ethane Ethylene glycol

Preparation Products

1,3,2-Dioxaphospholane, 2-ethoxy-, 2-oxide 2-Hydroxy-1,3,2-dioxaphospholane 2-oxide 1,3,2-Dioxaphospholane, 2-(2,2,2-trifluoroethoxy)-, 2-oxide

2-Chloro-1,3,2-dioxaphospholane-2-oxide Suppliers

Global Suppliers ( 235)
Supplier Tel Email Country ProdList Advantage
Yangzhou modier Electronic Materials Co., Ltd 13761402923 19975033992 market@modeltemol.com China 7830 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
INTATRADE GmbH +49 3493/605464 sales@intatrade.de Germany 3563 66
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Ark Pharm, Inc. 847-367-3680 sales@arkpharminc.com United States 1669 56
Beijing HwrkChemical Technology Co., Ltd 89508211 18501085097 sales.bj@hwrkchemical.com China 9407 55
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
JinYan Chemicals(ShangHai) Co.,Ltd. 13817811078 sales@jingyan-chemical.com China 9963 60
Supplier Advantage
Yangzhou modier Electronic Materials Co., Ltd 58
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
INTATRADE GmbH 66
Alfa Aesar 84
TCI (Shanghai) Development Co., Ltd. 81
Ark Pharm, Inc. 56
Beijing HwrkChemical Technology Co., Ltd 55
Energy Chemical 61
JinYan Chemicals(ShangHai) Co.,Ltd. 60

View Latest Price from 2-Chloro-1,3,2-dioxaphospholane-2-oxide manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Chloro-1,3,2-dioxaphospholane-2-oxide pictures 2026-03-20 2-Chloro-1,3,2-dioxaphospholane-2-oxide
6609-64-9
 $19.90 1kg 99% 10 mt Hebei Chuanghai Biotechnology Co., Ltd
2-Chloro-1,3,2-dioxaphospholane-2-oxide pictures 2025-04-04 2-Chloro-1,3,2-dioxaphospholane-2-oxide
6609-64-9
 1KG 98% 1ton Henan Aochuang Chemical Co.,Ltd.
2-Chloro-1,3,2-dioxaphospholane-2-oxide pictures 2025-01-03 2-Chloro-1,3,2-dioxaphospholane-2-oxide
6609-64-9
 $990.00 98 5000 Kg R&D Scientific Inc.

2-Chloro-1,3,2-dioxaphospholane-2-oxide Spectrum

2-Chloro-1,3,2-dioxaphospholane-2-oxide(6609-64-9)MS2-Chloro-1,3,2-dioxaphospholane-2-oxide(6609-64-9)1HNMR2-Chloro-1,3,2-dioxaphospholane-2-oxide(6609-64-9)13CNMR2-Chloro-1,3,2-dioxaphospholane-2-oxide(6609-64-9)IR1

6609-64-9 (2-Chloro-1,3,2-dioxaphospholane-2-oxide) Related Search:

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Cyclopentane Zinc oxide (Diethoxymethyl)diphenylphosphine oxide Difluorochloromethane Nitrous oxide
Dimethyl phosphorochloridate 2-Chloro-1,3,2-dioxaphospholane (4R,5R)-2-Chloro-4,5-dimethyl-1,3,2-dioxaphospholane 2-oxide

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Ethylene cycl-chlorophosphate (2-chloro-2-oxo-1,3,2-dioxaphospholane) 2-Chloro-1,3-dioxa-2-phosphacyclopentane 2-oxide Ethylene chlorophosphate, tech. 90% 2-Chloro-2-oxo-1,3,2-dioxaphospholane, Ethylene cycl-chlorophosphate 2-Chloro-1,3,2-dioxaphospholane-2-oxide, Ethylene cycl-chlorophosphate 1,3,2-Dioxaphospholane, 2-chloro-, 2-oxide CYCLIC CHLOROPHOSPHATE Ethylene glycol chlorophosphate, 95% 2-Chloro-1,3,2-dioxaphospholane-2-oxide,95% Ethylene chl ETHYLENE CHLOROPHOSPHATE ETHYLENE CYCL-CHLOROPHOSPHATE 2-CHLORO-1,3,2-DIOXAPHOSPHOLANE-2-OXIDE 2-Chloro-1,2,3-dioxaphospholane-2-oxide 2-Chloro-2-oxo-1,3,2-dioxaphospholane > 2-chloro-2-oxo-1,3, 2-dioxophosphorus heterocyclopentane 2-Chloro-1,3,2-dioxaphospholane-2-oxide/ Ethylene Chlorophosphate 2-Chloro-1,3,2-dioxaphospholane-2-oxide (Technical Grade) 2-chloro-1,3,2λ?-dioxaphospholan-2-one 2-chloro-1,3,2 2-chloro-2-oxo-1,3, 2-dioxophosphoheterocyclopentane 2-Chloro-2-Oxido-1,3,2- Dioxaphospholane 2-chloro-1,3,2lambda5-dioxaphospholane 2-oxide 2-chloro-1,3,2lambda5-dioxaphospholan-2-one 2-chloro-1,3,2-dioxyphosphoruscyclopentane-2-oxy 2-CHLORO-2-OXO-1,3,2-DIOXAPHOSPHOLANE Ethylene glycol chlorophosphate 4-Chlorophenyl 2-Chlorophenyl 6609-64-9 C2H4ClO3P Organic Building Blocks Phosphorus Halides Phosphorus Compounds Building Blocks Phosphorylating Agents DNA / RNA Synthesis Phosphorylation Biochemistry Nucleosides, Nucleotides & Related Reagents Phosphorylating and Phosphorothioating Agents Phosphorylation Protecting Agents, Phosphorylating Agents & Condensing Agents Synthetic Organic Chemistry