Flucloxacillin sodium

Flucloxacillin sodium Properties

Melting point	176-178°C
Boiling point	677℃
RTECS	XH8680000
Flash point	>110°(230°F)
storage temp.	2-8°C
solubility	H2O: soluble20mg/mL, clear
form	powder
color	white to beige
Water Solubility	Soluble in water
Sensitive	Light Sensitive
Major Application	forensics and toxicology veterinary
InChIKey	OTEANHMVDHZOPB-SLINCCQESA-M
SMILES	C([C@H]1C(S[C@]2([H])[C@H](NC(C3=C(ON=C3C3C(=CC=CC=3Cl)F)C)=O)C(=O)N12)(C)C)(=O)O.[NaH] \|&1:1,4,6,r\|
CAS DataBase Reference	1847-24-1(CAS DataBase Reference)
FDA UNII	05F65O42VK
UNSPSC Code	12352200
NACRES	NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS08
Signal word	Warning
Hazard statements	H317-H334
Precautionary statements	P261-P280g-P284-P304+P340-P342+P311a-P501a
WGK Germany	3
Storage Class	11 - Combustible Solids
Toxicity	LD50 oral in rabbit: > 8gm/kg

Flucloxacillin sodium price More Price(53)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	SML1023	Flucloxacillin sodium ≥95% (HPLC)	1847-24-1	10mg	$129	2026-04-30	Buy
Sigma-Aldrich	F0150000	Flucloxacillin sodium European Pharmacopoeia (EP) Reference Standard		250 mg	$167	2026-04-30	Buy
Sigma-Aldrich	BP158	Flucloxacillin sodium British Pharmacopoeia (BP) Reference Standard	1847-24-1	250MG	$294	2026-04-30	Buy
Sigma-Aldrich	32353	Flucloxacillin sodium VETRANAL	1847-24-1	100mg	$100	2026-04-30	Buy
Sigma-Aldrich	F0150000	Flucloxacillin sodium European Pharmacopoeia (EP) Reference Standard	1847-24-1	F0150000	$151	2023-06-20	Buy

Product number	Packaging	Price	Buy
SML1023	10mg	$129	Buy
F0150000	250 mg	$167	Buy
BP158	250MG	$294	Buy
32353	100mg	$100	Buy
F0150000	F0150000	$151	Buy

Flucloxacillin sodium Chemical Properties,Uses,Production

Chemical Properties

White Solid

Uses

Antibacterial;Peptidoglycan synthesis inhibitor

Uses

Flucloxacillin, a new semisynthetic penicillin

Uses

Flucloxacillin sodium has been used as a β-lactam antibiotic to study its effects on methicillin-resistantStaphylococcus aureus(MRSA) ΔfloAmutant.

Definition

ChEBI: Flucloxacillin sodium is an organic sodium salt. It contains a flucloxacillin(1-).

General Description

Flucloxacillin sodium, a sodium salt of flucloxacillin, is a member of the penicillin class.

Biochem/physiol Actions

Flucloxacillin exhibits antimicrobial property.

Synthesis

5250-39-5

1847-24-1

To the reaction flask was added 100 g of deionized water and 20.0 g of 6-aminopenicillanic acid (6-APA) was slowly added under stirring conditions, after which the reaction system was cooled to 0-5 °C. Accurately weighed 10.6 g of sodium carbonate and dissolved in 100 mL of deionized water to prepare a 1 mol/L solution of sodium carbonate. Keeping the reaction temperature below 10 °C, the sodium carbonate solution was slowly added dropwise to the reaction flask to obtain an aqueous sodium salt solution of 6-APA. Next, 28.0 g of 3-(2-chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylic acid chloride was added to the reaction system and the addition time was controlled to be within 1 hour. The reaction system was stirred at 20~25°C for 4 hours. After completion of the reaction, the pH of the reaction solution was slowly adjusted to 2.5 with 1 mol/L dilute hydrochloric acid. 400 g of ethyl acetate was added to the reaction flask, and liquid-liquid partitioning was carried out after thorough stirring to separate the ethyl acetate phase. The ethyl acetate phase was washed sequentially with 200 g of saturated sodium chloride solution and then dried with 20 g of anhydrous sodium sulfate for 30 min to obtain an ethyl acetate solution of flucloxacillinic acid. A 1 mol/L solution of sodium isooctanoate was prepared by accurately weighing 18.0 g of sodium isooctanoate and dissolving it in 108 mL of ethyl acetate. This sodium isooctanoate solution was slowly added dropwise to the ethyl acetate solution of flucloxacillinic acid, and after the dropwise addition was completed, a white solid was gradually precipitated in the system. The reaction system was cooled to 5-10°C and crystallization was continued for 3 hours. The solid was collected by filtration, washed twice with ethyl acetate and subsequently dried under vacuum at 50 °C to obtain 41.3 g of flucloxacillin sodium monohydrate, the purity of the product was 99.8% as determined by HPLC and the yield was 90.6%.

References

[1] Patent: CN104910183, 2017, B. Location in patent: Paragraph 0032-0036; 0038-0042; 0043-0047; 0048-0051

Flucloxacillin sodium synthesis

Synthesis of Flucloxacillin sodium from 2-Chloro-6-fluorobenzaldehyde

Flucloxacillin sodium Preparation Products And Raw materials

Raw materials

3-(2-Chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylic acid 2-Chloro-6-fluorobenzaldehyde 6-Aminopenicillanic acid Flucloxacillin Sodium 2-ethylhexanoate

Ethyl acetate

1of2

Preparation Products

Flucloxacillin sodium Suppliers

Global( 267)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
GUANGZHOU CHANGTHINKING IMP.&EXP.CO.,LTD	020-37651955 13682223272	173901442@qq.com	China	689	58
Shanghai Boyle Chemical Co., Ltd.	021-50182298 021-50180596	sales@boylechem.com	China	2202	55
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Chemsky（shanghai）International Co.,Ltd.	021-50135380	shchemsky@sina.com	China	32273	50
Sichuan Kulinan Technology Co., Ltd	400-1166-196 18981987031	cdhxsj@163.com	China	11674	57
Wuhan Fortuna Chemical Co., Ltd	027-59207852 13308628970	buy@fortunachem.com	China	2698	58
Beijing HuaMeiHuLiBiological Chemical	010-56205725	waley188@sohu.com	China	12323	58
Shanghai T&W Pharmaceutical Co., Ltd.	+86 21 61551611		China	9874	58
The future of Shanghai Industrial Co., Ltd.	021-61552785	sales@shshiji.com	China	9531	55
Guangzhou Isun Pharmaceutical Co., Ltd	020-39119399 18927568969	isunpharm@qq.com	China	4773	55

Supplier	Advantage
GUANGZHOU CHANGTHINKING IMP.&EXP.CO.,LTD	58
Shanghai Boyle Chemical Co., Ltd.	55
J & K SCIENTIFIC LTD.	76
Chemsky（shanghai）International Co.,Ltd.	50
Sichuan Kulinan Technology Co., Ltd	57
Wuhan Fortuna Chemical Co., Ltd	58
Beijing HuaMeiHuLiBiological Chemical	58
Shanghai T&W Pharmaceutical Co., Ltd.	58
The future of Shanghai Industrial Co., Ltd.	55
Guangzhou Isun Pharmaceutical Co., Ltd	55

View Lastest Price from Flucloxacillin sodium manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-08-08	Flucloxacillin sodium 1847-24-1		1kg	99.0%	20 tons	Hangzhou ICH Biofarm Co., Ltd
2026-06-30	Flucloxacillin sodium 1847-24-1		1kg	98%	1000kg	Shaanxi Dideu New Materials Co. Ltd
2026-05-11	Flucloxacillin sodium 1847-24-1	$70.00		95.29%	10g	TargetMol Chemicals Inc.

Flucloxacillin sodium
1847-24-1
99.0%
Hangzhou ICH Biofarm Co., Ltd

Flucloxacillin sodium
1847-24-1
98%
Shaanxi Dideu New Materials Co. Ltd

Flucloxacillin sodium
1847-24-1
$70.00
95.29%
TargetMol Chemicals Inc.

Flucloxacillin sodium Spectrum

Flucloxacillin sodium(1847-24-1)¹HNMR

1847-24-1(Flucloxacillin sodium)Related Search:

Kresoxim-methyl Sodium sulfate Bensulfuron methyl Flucloxacillin Benzoxazole

Methylparaben Sodium chloride Sodium bicarbonate Sodium benzoate Sodium acetate

Dicloxacillin sodium Sodium chlorite Trisodium phosphate Famoxadone Methyl salicylate

Sodium hydroxide Metsulfuron methyl Diclofenac sodium

1of4

(2s-(2-alpha,5-alpha,6-beta))-al sodium [2S-(2alpha,5alpha,6beta)]-6-[[[3-(2-chloro-6-fluorophenyl)-5-methylisoxazol-4-yl]carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate Flucloxacillin sodium BP98 3-dimethyl-7-oxo-henyl)-5-methyl-4-isoxazolyl)carbonyl)amino)-monosodiums 4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylicacid,6-(((3-(2-chloro-6-fluorop 5-methyl-3-(2-chloro-6-fluorophenyl)-4-isoxazolylpenicillinsodium floxacillinsodium floxapensodium flucloxacillinsodiumsalt mfi-pc monosodiumflucloxacillin Sodium (2S,5R,6R)-6-[[3-(2-chloro-6-fluorophenyl)-5-methyl-1,2-oxazole-4-carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate FLUCLOXACILLINACID Staphylex Sodium (2S,5R,6R)-6-[[[3-(2-Chloro-6-fluorophenyl)-5-methyl-4-isoxazolyl]carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid Sodium Staphylex Sodiu 4-Thia-1-azabicyclo3.2.0heptane-2-carboxylic acid, 6-3-(2-chloro-6-fluorophenyl)-5-methyl-4-isoxazolylcarbonylamino-3,3-dimethyl-7-oxo-, monosodium salt, (2S,5R,6R)- 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[[3-(2-chloro-6-fluorophenyl)-5-methyl-4-isoxazolyl]carbonyl]amino]-3,3-dimethyl-7-oxo-, monosodium salt, [2S-(2α,5α,6β)]- 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[3-(2-chloro-6-fluorophenyl)-5-methyl-4-isoxazolecarboxamido]-3,3-dimethyl-7-oxo-, sodium salt (7CI) NSC 277175 Sodium [3-(2-chloro-6-fluorophenyl)-5-methyl-4-isoxazolyl]penicillin Sodium flucloxacillin 6α-[[(5-Methyl-3-(2-chloro-6-fluorophenyl)isoxazol-4-yl)carbonyl]amino]penicillanic acid sodium salt Gulpen Flucloxacillin SodiuM oral (2S,5R,6R)-6-[[3-(2-chloro-6-fluoro-phenyl)-5-methyl-oxazole-4-carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid sodium salt FLUCLOXACILLIN SODIUM MONO BRL 2039 sodium FK 900 sodium Flucloxacilli FLUCLOXACILLIN SODIUM Flucloxacillin Sodium Anhydrous (2S,5R,6R)-6-(3-(2-Chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid,sodium salt Flucloxacillin sodium CRS in sodium oxaciL ucL Flucloxacillin sodium USP/EP/BP sodium 6-(3-(2-chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate Flucloxacillin SodiumQ: What is Flucloxacillin Sodium Q: What is the CAS Number of Flucloxacillin Sodium Q: What is the storage condition of Flucloxacillin Sodium Q: What are the applications of Flucloxacillin Sodium sodium (2S,5R,6R)-6-[3-(2-chloro-6-fluorophenyl)-5-methyl-1,2-oxazole-4-amido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate C13696000 Flucloxacillin sodium Phenylbutazone Impurity 29 Flucloxacillin sodium RS Flucloxacillin sodium (Standard) Flucloxacillin SodiuM Sterile 1847-24-1 C19H16ClFN3O5SNa C19H17ClFN3O5S C19H16ClFN3NaO5S C19H16CIFN3O5SNaH2O Isoquinolines ,Quinolines ,Quinaldines Peptide Synthesis/Antibiotics API Intermediates & Fine Chemicals Pharmaceuticals APIs 1847-24-1