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N-Alfa-Fmoc-4-(phosphonodifluoromethyl)-L-phenylalanine

N-Alfa-Fmoc-4-(phosphonodifluoromethyl)-L-phenylalanine structure

CAS No.: 160751-44-0

Chemical Name:: N-Alfa-Fmoc-4-(phosphonodifluoromethyl)-L-phenylalanine

Synonyms: Fmoc-Phe(CF2PO3)-OH;Fmoc-L-Phe(CF2PO3)-OH;(9H-Fluoren-9-yl)MethOxy]Carbonyl Phe(CF2PO3)-OH;N-Fmoc-4-(phosphonodifluoromethyl)-L-phenylalanine;N-Alfa-Fmoc-4-(phosphonodifluoromethyl)-L-phenylalanine;N-ALPHA-FMOC-4-(PHOSPHONODIFLUOROMETHYL)-L-PHENYLALANINE;N-ALFA-FMOC-4-(PHOSPHONODIFLUOROMETHYL)-L-PHENYLALANINE USP/EP/BP;N-ALFA-FLUORENYLCARBONYL-4-(DIETHYLPHOSPHONODIFLUOROMETHYL)-L-PHENYLALANINE;N-ALPHA-9-FLUORENYLCARBONYL-4-(DIETHYLPHOSPHONODIFLUOROMETHYL)-L-PHENYLALANINE;4-(DIFLUOROPHOSPHONOMETHYL)-N-[(9H-FLUOREN-9-YLMETHOXY)CARBONYL]-L-PHENYLALANINE

CBNumber:: CB0675752

Molecular Formula:: C25H22F2NO7P

Molecular Weight:: 517.42

MDL Number:: MFCD01317828

MOL File:: 160751-44-0.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-09-12 18:48:27

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N-Alfa-Fmoc-4-(phosphonodifluoromethyl)-L-phenylalanine Properties

Density	1.475±0.06 g/cm3(Predicted)
storage temp.	2-8°C
pka	1.07±0.10(Predicted)
form	Solid
color	Pink to orange
Major Application	peptide synthesis
InChIKey	XKWYQNFAGUNPJV-QFIPXVFZSA-N
SMILES	FC(F)([P](=O)(O)O)c1ccc(cc1)C[C@H](NC(=O)OCC2c3c(cccc3)c4c2cccc4)C(=O)O
UNSPSC Code	12352209
NACRES	NA.22

SAFETY

Risk and Safety Statements

WGK Germany	WGK 2
Storage Class	11 - Combustible Solids

N-Alfa-Fmoc-4-(phosphonodifluoromethyl)-L-phenylalanine price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
ChemScene	CS-0201618	Fmoc-Phe(CF2PO3)-OH ≥98%	160751-44-0	25mg	$83	2026-06-04	Buy
ChemScene	CS-0201618	Fmoc-Phe(CF2PO3)-OH ≥98%	160751-44-0	50mg	$123	2026-06-04	Buy
ChemScene	CS-0201618	Fmoc-Phe(CF2PO3)-OH ≥98%	160751-44-0	100mg	$206	2026-06-04	Buy
ChemScene	CS-0201618	Fmoc-Phe(CF2PO3)-OH ≥98%	160751-44-0	250mg	$339	2026-06-04	Buy
ChemScene	CS-0201618	Fmoc-Phe(CF2PO3)-OH ≥98%	160751-44-0	1g	$1208	2026-06-04	Buy

Product number	Packaging	Price	Buy
CS-0201618	25mg	$83	Buy
CS-0201618	50mg	$123	Buy
CS-0201618	100mg	$206	Buy
CS-0201618	250mg	$339	Buy
CS-0201618	1g	$1208	Buy

N-Alfa-Fmoc-4-(phosphonodifluoromethyl)-L-phenylalanine Chemical Properties, Uses, Production

Uses

4-(Difluorophosphonomethyl)-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-phenylalanine is used as a reactant in the synthesis of small molecule PTP1B inhibitors of insulin signaling.

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

N-Alfa-Fmoc-4-(phosphonodifluoromethyl)-L-phenylalanine synthesis

Synthesis of N-Alfa-Fmoc-4-(phosphonodifluoromethyl)-L-phenylalanine from 4-Bromomethylbenzoic acid

N-Alfa-Fmoc-4-(phosphonodifluoromethyl)-L-phenylalanine Preparation Products And Raw materials

Raw materials

L-Phenylalanine, 4-[(diethoxyphosphinyl)difluoromethyl]-N-[(9H-fluoren-9-ylmethoxy)carbonyl]- Phosphonic acid, P-[4-(bromomethyl)benzoyl]-, diethyl ester Phosphonic acid, P-[[4-(bromomethyl)phenyl]difluoromethyl]-, diethyl ester Fmoc-L-4-Iodophenylalanine 4-Bromomethyl benzoyl bromide 96

4-Bromomethylbenzoic acid

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Preparation Products

N-Alfa-Fmoc-4-(phosphonodifluoromethyl)-L-phenylalanine Suppliers

Global Suppliers ( 50)

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai GL Peptide Ltd.	+86-21-61263310 13764994101	fisherwang@glschina.com	China	8059	55
Shanghai YuanYe Biotechnology Co., Ltd.	15026964105	2881489226@qq.com	China	89667	60
Wuxi Asia Peptide Biotechnology Limited Company	0510-83583050 13771062561	willsun@peptide-search.com	China	6713	58
Nanjing Peptide Biotech Ltd.	025-58361106-805 15951641583	zhao.xu@njpeptide.com	China	9976	55
Amatek Scientific Co. Ltd.	0512-56316828 400-867-5858;400-867-5858	info@amateksci.com	China	28760	58
Kanghua (Shanghai) New Drug Development Co., Ltd.	021-61263370 18516560301	xingli@glbiochem.com	China	5637	58
Nanjing Meihao Pharmaceutical Technology Co., Ltd.	meitaochem@126.com	meitaochem@126.com	China	19087	58
Shanghai Jifeng Biotechnology Co., Ltd.	021-61263377 15023907684	15800684150@163.com	China	7994	58
Alfa Chemistry	+1-5166625404;	Info@alfa-chemistry.com	United States	20000	58
GL Biochem (Shanghai) Ltd.	+86-021-61263370 +86-18901917034		CHINA	3904	58

Supplier	Advantage
Shanghai GL Peptide Ltd.	55
Shanghai YuanYe Biotechnology Co., Ltd.	60
Wuxi Asia Peptide Biotechnology Limited Company	58
Nanjing Peptide Biotech Ltd.	55
Amatek Scientific Co. Ltd.	58
Kanghua (Shanghai) New Drug Development Co., Ltd.	58
Nanjing Meihao Pharmaceutical Technology Co., Ltd.	58
Shanghai Jifeng Biotechnology Co., Ltd.	58
Alfa Chemistry	58
GL Biochem (Shanghai) Ltd.	58

N-Alfa-Fmoc-4-(phosphonodifluoromethyl)-L-phenylalanine Spectrum

N-ALFA-FMOC-4-(PHOSPHONODIFLUOROMETHYL)-L-PHENYLALANINE(160751-44-0)¹HNMR

160751-44-0 (N-Alfa-Fmoc-4-(phosphonodifluoromethyl)-L-phenylalanine) Related Search:

4-(Phosphonomethyl)-D,L-phenylalanine N-Alfa-Fmoc-4-(phosphonodifluoromethyl)-L-phenylalanine 4-(Phosphonodifluoromethyl)-L-phenylalanine Difluoromethylphosphonic acid diethyl ester Dimethyl(4-methylbenzyl)phosphonate

Fmoc-L-4-phosphonomethylphenylalanine (4-Methylbenzyl)phosphonic acid Diethyl 4-methylbenzylphosphonate 4-Methylphenyl-L-alanine 4-Phosphonomethyl-L-Phenylalanine

FMOC-L-4-Methylphe

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4-(DIFLUOROPHOSPHONOMETHYL)-N-[(9H-FLUOREN-9-YLMETHOXY)CARBONYL]-L-PHENYLALANINE (4-(DIETHYLPHOSPHONO)DIFLUOROMETHYL)-N-(FLUOREN-9-YL-METHOXYCARBONYL)-L-PHENYLALANINE 4-[(DITHYLPHOSPHONO)DIFLUOROMETHYL]-N-(FLUOREN-9-YLMETHOXYCARBONYL)-L-PHENYLALAMINE (2S)-3-{4-[difluoro(phosphono)methyl]phenyl}-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid 3-{4-[(DIETHOXYPHOSPHORYL)DIFLUOROMETHYL]PHENYL}-2-{[(9H-FLUOREN-9-YLMETHOXY)CARBONYL]AMINO}PROPANOI N-ALPHA-9-FLUORENYLCARBONYL-4-(DIETHYLPHOSPHONODIFLUOROMETHYL)-L-PHENYLALANINE N-ALPHA-FMOC-4-(PHOSPHONODIFLUOROMETHYL)-L-PHENYLALANINE 4-(DIETHYLPHOSPHONO)DIFLUOROMETHYL)-N-(FLUOREN-9-YL-METHOXYCARBONY)-L-PHENYLALANINE N-ALFA-FLUORENYLCARBONYL-4-(DIETHYLPHOSPHONODIFLUOROMETHYL)-L-PHENYLALANINE (9H-Fluoren-9-yl)MethOxy]Carbonyl Phe(CF2PO3)-OH Fmoc-Phe(CF2PO3)-OH L-Phenylalanine,4-(difluorophosphonomethyl)-N-[(9H-fluoren-9-ylmethoxy)carbonyl]- N-ALFA-FMOC-4-(PHOSPHONODIFLUOROMETHYL)-L-PHENYLALANINE USP/EP/BP (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-(difluoro(phosphono)methyl)phenyl)propanoic acid N-Fmoc-4-(phosphonodifluoromethyl)-L-phenylalanine Fmoc-L-Phe(CF2PO3)-OH N-Alfa-Fmoc-4-(phosphonodifluoromethyl)-L-phenylalanine 160751-44-0 C25H22F2NO7P