4-Bromomethylbenzoic acid
- CAS No.
- 6232-88-8
- Chemical Name:
- 4-Bromomethylbenzoic acid
- Synonyms
- 4-(BROMOMETHYL)BENZOIC ACID;4-Bromomethylbenzoic;ALPHA-BROMO-P-TOLUIC ACID;A-BROMO-P-TOLUIC ACID;α-bromo-p-toluic acid;ALPHA-BROMO-P-TOLUYLIC ACID;P-(BROMOMETHYL)BENZOIC ACID;AKOS BBS-00006715;Eprosartan USP RC D;RARECHEM AL BO 0068
- CBNumber:
- CB6317157
- Molecular Formula:
- C8H7BrO2
- Molecular Weight:
- 215.04
- MDL Number:
- MFCD00002567
- MOL File:
- 6232-88-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 224-229 °C(lit.) |
|---|---|
| Boiling point | 252.95°C (rough estimate) |
| Density | 1.5313 (rough estimate) |
| refractive index | 1.5500 (estimate) |
| storage temp. | Store below +30°C. |
| pka | 4.10±0.10(Predicted) |
| form | Crystalline Powder |
| color | White to beige |
| Water Solubility | Soluble in water. |
| BRN | 1862870 |
| InChI | InChI=1S/C8H7BrO2/c9-5-6-1-3-7(4-2-6)8(10)11/h1-4H,5H2,(H,10,11) |
| InChIKey | CQQSQBRPAJSTFB-UHFFFAOYSA-N |
| SMILES | C(O)(=O)C1=CC=C(CBr)C=C1 |
| CAS DataBase Reference | 6232-88-8(CAS DataBase Reference) |
| EPA Substance Registry System | Benzoic acid, 4-(bromomethyl)- (6232-88-8) |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS05 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H318-H314-H315-H319-H335 | |||||||||
| Precautionary statements | P309-P310-P260-P264-P280-P301+P330+P331+P310-P303+P361+P353+P310+P363-P304+P340+P310-P305+P351+P338+P310-P405-P501-P305+P351+P338 | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi,C | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| RIDADR | 3261 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 19-21 | |||||||||
| Hazard Note | Irritant | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29163900 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
4-Bromomethylbenzoic acid price More Price(65)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 159549 | 4-(Bromomethyl)benzoic acid 97% | 6232-88-8 | 5g | $56.1 | 2026-04-30 | Buy |
| Sigma-Aldrich | 1238251 | Eprosartan Related Compound D United States Pharmacopeia (USP) Reference Standard | 6232-88-8 | 15mg | $511 | 2024-03-01 | Buy |
| TCI Chemical | B0845 | 4-(Bromomethyl)benzoic Acid >97.0%(GC)(T) | 6232-88-8 | 5g | $24 | 2026-04-30 | Buy |
| TCI Chemical | B0845 | 4-(Bromomethyl)benzoic Acid >97.0%(GC)(T) | 6232-88-8 | 25g | $66 | 2026-04-30 | Buy |
| Usbiological | 261668 | 4-(Bromomethyl) benzoic acid Asreported | 6232-88-8 | 5g | $282 | 2026-06-03 | Buy |
4-Bromomethylbenzoic acid Chemical Properties, Uses, Production
Chemical Properties
white to beige crystalline powder
Uses
4-(Bromomethyl)benzoic Acid is an intermediate in the synthesis of Eprosartan (E590100), a prototype of the imidazoleacrylic acid angiotensin II receptor antagonists used as an antihypertensive agent.
Uses
4-(Bromomethyl)benzoic acid acts as an intermediate in the synthesis of eprosartan, which is used as an antihypertensive agent. Further, it is used in the preparation of 5,10,15,20-tetra(m-hydroxyphenyl)chlorin (temoporfin), which is a second generation photosensitizer. In addition to this, it is used in the preparation of 4-(5-arylidene-2,4-dioxothiazolidin-3-yl) methylbenzoic acids.
Uses
4-(Bromomethyl)benzoic acid was used in the chemical modification of 5,10,15,20-tetra(m-hydroxyphenyl)chlorin (temoporfin), second generation photosensitizer. It was also used in the synthesis of 4-(5-arylidene-2,4-dioxothiazolidin-3-yl) methylbenzoic acids.
Synthesis
99-94-5
6232-88-8
In a 100 mL round-bottomed flask, 40 mL of carbon tetrachloride was added as solvent, 3.00 g of p-methylbenzoic acid as starting material, 4.00 g of N-bromosuccinimide (NBS) as bromination reagent, and 0.1 g of azobisisobutyronitrile (AIBN) as initiator. The reaction mixture was stirred and refluxed at 90 °C and the reaction process was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the mixture was cooled to room temperature followed by filtration. The filter cake was washed with warm water to remove the succinimide by-products generated in the reaction. After drying, 4.02 g of p-bromomethylbenzoic acid was obtained with a melting point of 231-232°C in 84% yield.
Purification Methods
Crystallise the acid from pKEst Me2CO. [Beilstein 9 IV 1745.]
References
[1] Chemistry - A European Journal, 2018, vol. 24, # 7, p. 1619 - 1630
[2] Organic Process Research and Development, 1998, vol. 2, # 4, p. 261 - 269
[3] Patent: CN108570012, 2018, A. Location in patent: Paragraph 0020; 0024; 0025
[4] Patent: CN108623537, 2018, A. Location in patent: Paragraph 0046; 0047; 0048
[5] Journal of Organic Chemistry, 1998, vol. 63, # 17, p. 6023 - 6026
4-Bromomethylbenzoic acid Preparation Products And Raw materials
Raw materials
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Preparation Products
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| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jinan Liheng Biotechnology Co., Ltd. | 0531-18763987518 18763987518 | levi@lihengpharm.com | China | 1760 | 58 |
| Shenyang Maud Pharmaceutical Technology Co., Ltd. | 024-23982345 | 1020788318@qq.com | China | 2246 | 58 |
| Shanghai Finechem Biotechnology Co., Ltd. | 15821337685 | hwh-chem@163.com | China | 94 | 58 |
| Shandong Xinmuyuan Chemical Technology Co., Ltd | 19105383610 | 83809669@qq.com | China | 402 | 58 |
| Changzhou Share Chemical Co., Ltd | 0519-82619998 | wu@sharechem.com | China | 29 | 54 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| INTATRADE GmbH | +49 3493/605464 | sales@intatrade.de | Germany | 3563 | 66 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TAIYUAN RHF CO.,LTD. | +86 351 7031519 | sales@RHFChem.com | China | 2334 | 56 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
View Latest Price from 4-Bromomethylbenzoic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-03-20 | 4-Bromomethylbenzoic acid
6232-88-8
|
$10.00 | 1KG | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2021-07-02 | 4-Bromomethylbenzoic acid
6232-88-8
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd | ||
 |
2019-07-06 | 4-Bromomethylbenzoic acid
6232-88-8
|
$1.00 | 1kg | 99% | Career Henan Chemical Co |
-
- 4-Bromomethylbenzoic acid
6232-88-8
- $10.00
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- 4-Bromomethylbenzoic acid
6232-88-8
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- 4-Bromomethylbenzoic acid
6232-88-8
- $1.00
- 99%
- Career Henan Chemical Co
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